| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We analyzed the small intestine, digestive function, and inflammation state of glial calcineurin B1-conditional knockout mice. In the small intestine, calcineurin B1 deficiency in enteric glial cells induced glial dysfunction and disorganized enteric nervous system, leading to reduced gastrointestinal motility and maldigestion/malabsorption, as well as impaired barrier function and inflammation. These findings suggest the important roles of calcineurin and enteric glial cells in the function and homeostasis of the small intestine.
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