| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The availability of highly effective anti-retroviral drugs has nearly suppressed the progression of HIV infection to AIDS. However, the reactivation of the virus upon discontinuation of medication is a major problem, as these therapeutic agents can not eliminate latently infected cells. The detailed mechanisms involved in HIV latency and reactivation still remain unknown. In this study, we established model cells capable of quantifying the transcriptional activity of HIV and aimed to elucidate the molecular mechanisms involved in HIV reactivation and latency. In this study, we found the involvement of central nervous signaling in HIV reactivation. We also identified two host factors involved in HIV latency. The scope of this study could be extended to develop novel therapeutic agents against HIV latency in the future.
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