| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Although various autoantibodies are found in the serum of rheumatoid arthritis (RA), the properties and pathological mechanisms by autoantibodies in RA are unclear. In this study, we investigated how autoantibodies with sialylation are involved in RA pathology. It was found that inflammation in induced RA was exacerbated in non-sialylated IgG-producing mice. It was also found that the administration of sialylated RA autoantibodies suppressed arthritis. Further, in order to investigate this result at the biological level, a sialylated IgG-producing mouse (St6gal1LSL-Tg x AID-Cre mouse) have been generated in this study.
|
