Functional regulations and novel therapeutic strategies by glycosyl remodeling of autoantibody in rheumatoid arthritis

• Project/Area Number: 16K08829
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: Chubu University
• Principal Investigator: OHMI Yuhsuke 中部大学, 生命健康科学部, 助手 (10584758)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: シアル酸 / IgG / St6gal1 / B4galt1 / 自己免疫疾患 / 関節リウマチ / 糖鎖 / 自己抗体

Outline of Final Research Achievements

Although various autoantibodies are found in the serum of rheumatoid arthritis (RA), the properties and pathological mechanisms by autoantibodies in RA are unclear. In this study, we investigated how autoantibodies with sialylation are involved in RA pathology. It was found that inflammation in induced RA was exacerbated in non-sialylated IgG-producing mice. It was also found that the administration of sialylated RA autoantibodies suppressed arthritis. Further, in order to investigate this result at the biological level, a sialylated IgG-producing mouse (St6gal1LSL-Tg x AID-Cre mouse) have been generated in this study.

Academic Significance and Societal Importance of the Research Achievements

これまでに、関節リウマチ（RA）患者の血清IgGでは、シアル酸やガラクトースの欠損が認められていたが、その意義は不明であった。本研究の成果は、IgG上のシアル酸をターゲットにした、糖鎖欠損マウスや強制発現マウスを作製し、その機能を明らかにして来た。その結果、RAにおけるIgG上のシアル酸が病状の原因の一つであることが明らかになった。RAは罹患率が1%であり、RAの発症メカニズムの一端を解明したことは、社会的にも大変意義がある。また本研究で作成したマウスはその他の自己免疫疾患の解析にも応用可能である。

Research Products

• [Journal Article] Novel molecular mechanisms for roles of gangliosides in the nervous system elucidated by genetic engineering. (2020)
  • Author(s): Furukawa, K., Ohmi, Y., Yesmin, F., Tajima, O., Kondo, Y., Pu Zhang, P., Hashimoto, N., Ohkawa, Y., Bhuiyan, R.H., Furukawa, K.
  • Journal Title: Int. J. Mol. Sci. Volume: 21 Issue: 6 Pages: 1906-1906
  • DOI: 10.3390/ijms21061906
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Elucidation of the enigma of glycosphingolipids in the regulation of inflammation and degeneration — Great progress over the last 70 years — (2019)
  • Author(s): Koichi Furukawa, Yuhsuke Ohmi, Yuji Kondo, Robiul H. Bhuiyan, Orie Tajima, Yuki Ohkawa, Keiko Furukawa
  • Journal Title: Proceedings of the Japan Academy, Series B Volume: 95 Issue: 3 Pages: 136-149
  • DOI: 10.2183/pjab.95.011
  • NAID: 130007608536
  • ISSN: 0386-2208, 1349-2896
  • Year and Date: 2019-03-11
  • Peer Reviewed / Open Access
• [Journal Article] New era of research on cancer‐associated glycosphingolipids. (2019)
  • Author(s): Koichi Furukawa, Yuhsuke Ohmi, Yuki Ohkawa, Robiul H. Bhuiyan, Pu Zhang, Orie Tajima, Noboru Hashimoto, Kazunori Hamamura, Keiko Furukawa.
  • Journal Title: Cancer Science Volume: - Issue: 5 Pages: 1-8
  • DOI: 10.1111/cas.14005
  • Peer Reviewed / Open Access
• [Journal Article] Effective binding of sugar chains to influenza virus on the surface by bovine serum albumin localization (2019)
  • Author(s): Kawahara Toshio、Hiramatsu Hiroaki、Ohmi Yuhsuke、Sriwilaijaroen Nongluk、Suzuki Yasuo、Nakakita Shin-ichi、Watanabe Yohei、Ohno Yasuhide、Maehashi Kenzo、Ono Takao、Kanai Yasushi、Matsumoto Kazuhiko
  • Journal Title: Japanese Journal of Applied Physics Volume: 58 Issue: SI Pages: SIID03-SIID03
  • DOI: 10.7567/1347-4065/ab1b68
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface. (2019)
  • Author(s): Hashimoto N, Ito S, Tsuchida A, Bhuiyan RH, Okajima T, Yamamoto A, Furukawa K, Ohmi Y, Furukawa K.
  • Journal Title: J Biol Chem. Volume: 294 Issue: 28 Pages: 10833-10845
  • DOI: 10.1074/jbc.ra118.007083
  • NAID: 120007168785
  • Peer Reviewed / Open Access
• [Journal Article] Enhancement of malignant properties of human glioma cells by ganglioside GD3/GD2. (2018)
  • Author(s): Taiji Iwasawa, Pu Zhang, Yuki Ohkawa, Hiroyuki Momota, Toshihiko Wakabayashi, Yuhsuke Ohmi, Robiul H. Bhuiyan, Keiko Furukawa, Koichi Furukawa
  • Journal Title: Int. J. Oncol. Volume: 52 Pages: 1255-1266
  • DOI: 10.3892/ijo.2018.4266
  • Peer Reviewed
• [Journal Article] Gangliosides in inflammation and neurodegeneration. (2018)
  • Author(s): Furukawa K, Ohmi Y, Tajima O, Ohkawa Y, Kondo Y, Shuting J, Hashimoto N, Furukawa K
  • Journal Title: Prog Mol Biol Transl Sci. Volume: 156 Pages: 265-287
  • DOI: 10.1016/bs.pmbts.2018.01.009
  • ISBN: 9780128123416
  • Peer Reviewed
• [Journal Article] Genome-wide CRISPR screens for Shiga toxins and Ricin reveal Golgi proteins critical for glycosylation. (2018)
  • Author(s): Songhai Tian, Khaja Muneeruddin, Mei Yuk Choi, Liang Tao, Robiul H. Bhuiyan, Yuhsuke Ohmi, Keiko Furukawa, Koichi Furukawa, Sebastian Boland, Scott A. Shaffer, Rosalyn M. Adams, Min Dong
  • Journal Title: PLoS Biol. Volume: 16(11) Issue: 11 Pages: 1-31
  • DOI: 10.1371/journal.pbio.2006951
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differential roles of gangliosides in malignant properties of melanomas. (2018)
  • Author(s): Ohmi Y, Kambe M, Ohkawa Y, Hamamura K, Tajima O, Takeuchi R, Furukawa K, Furukawa K
  • Journal Title: PLOS One Volume: 13(11) Issue: 11 Pages: e0206881-e0206881
  • DOI: 10.1371/journal.pone.0206881
  • Peer Reviewed / Open Access
• [Journal Article] Fluctuation in nano-carbon pH sensors in a liquid using CNWFETs fabricated by the self-aligned process. (2018)
  • Author(s): S. Rupesh, T. Kawahara, Y. Ohmi, Y. Ohno, K. Maehashi, K. Matsumoto, K. Okamoto, R. Utsunomiya, T. Matsuba
  • Journal Title: Proc. of 40th International Symposium on Dry Process Volume: - Pages: 189-190
  • Peer Reviewed
• [Journal Article] Effects of low temperature buffer on carbon nano wall’s growth. (2018)
  • Author(s): Singh Rupesh, Toshio Kawahara, Yuhsuke Ohmi, Yasuhide Ohno, Kenzo Maehashi, Kazuhiko Matsumoto, Kazumasa Okamoto, Risa Utsunomiya, Masamichi Yoshimura
  • Journal Title: Materials Today Commnications Volume: 17 Pages: 94-99
  • DOI: 10.1016/j.mtcomm.2018.08.012
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Loss of enzyme activity of mutated B4GALNT1 gene products found in patients with hereditary spastic paraplegia induces relatively mild neurological disorders: Similarity with phenotypes of B4galnt1 knockout mice. (2018)
  • Author(s): Robiul H. Bhuiyan, Yuhsuke Ohmi, Yuki Ohkawa, Pu Zhang, Maiko Takano, Noboru Hashimoto, Tetsuya Okajima, Keiko Furukawa, Koichi Furukawa
  • Journal Title: Neuroscience Volume: 397 Pages: 94-106
  • DOI: 10.1016/j.neuroscience.2018.11.034
  • Peer Reviewed
• [Journal Article] Anti-GD2 CAR T cells could prove transformative for H3-K27M+ diffuse midline gliomas (2018)
  • Author(s): Koichi Furukawa, Yuhsuke Ohmi, Keiko Furukawa
  • Journal Title: Translational Cancer Research Volume: 8(2) Issue: S2 Pages: 87-93
  • DOI: 10.21037/tcr.2018.08.21
  • Peer Reviewed / Open Access
• [Journal Article] Inflammatory reactions in microenviron- ments, leading to melanomagenesis (2018)
  • Author(s): Koichi Furukawa, Maiko Miyata, Mariko Kambe, Rika Takeuchi, Robiul H. Bhuiyan, Pu Zhang, Yuhsuke Ohmi, Keiko Furukawa
  • Journal Title: J. Clin. Cell. Immunol. Volume: 5:508 Issue: 03 Pages: 1-3
  • DOI: 10.4172/2155-9899.1000508
  • Peer Reviewed / Open Access
• [Journal Article] ASC amino acid transporter 2, defined by enzyme-mediated activation of radical sources, enhances malignancy of GD2-positive small-cell lung cancer. (2018)
  • Author(s): Nobutoshi Esaki, Yuki Ohkawa, Noboru Hashimoto, Yuhsuke Tsuda, Yuhsuke Ohmi, Robiul H. Bhuiyan, Norihiro Kotani, Koichi Honke, Atsushi Enomoto, Masahide Takahashi, Keiko Furukawa, Koichi Furukawa.
  • Journal Title: Cancer sci. Volume: 109 Issue: 1 Pages: 141-153
  • DOI: 10.1111/cas.13448
  • Peer Reviewed / Open Access
• [Journal Article] Sialyltransferases in autoimmune diseases (2017)
  • Author(s): 大海雄介、古川鋼一
  • Journal Title: 生化学 Volume: 89 Issue: 5 Pages: 666-672
  • DOI: 10.14952/SEIKAGAKU.2017.890666
  • ISSN: 0037-1017
  • Year and Date: 2017-10-25
  • Peer Reviewed
• [Journal Article] Glycolipids: Essential regulator of neuro-inflammation, metabolism and gliomagenesis. (2017)
  • Author(s): Koichi Furukawa, Yuhsuke Ohmi, Shuting Ji, Pu Zhang, Robiul H. Bhuiyan, Yuki Ohkawa, Orie Tajima, Noboru Hashimoto, Keiko Furukawa
  • Journal Title: Biochim. Biophys. Acta Volume: 1861 Issue: 10 Pages: 2479-2484
  • DOI: 10.1016/j.bbagen.2017.06.007
  • Peer Reviewed
• [Journal Article] Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing (2016)
  • Author(s): Yamaguchi T, Yamauchi Y, Furukawa K, Ohmi Y, Ohkawa Y, Zhang Q, Okajima T, Furukawa K
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 34505-34505
  • DOI: 10.1038/srep34505
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice. (2016)
  • Author(s): Ji S, Tokizane K, Ohkawa Y, Ohmi Y, Banno R, Okajima T, Kiyama H, Furukawa K and Furukawa K.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 479(3) Issue: 3 Pages: 453-460
  • DOI: 10.1016/j.bbrc.2016.09.077
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes. (2016)
  • Author(s): Robiul Hasan Bhuiyan, Yuji Kondo, Tokiaki Yamaguchi, Noriyo Tokuda, Yuki Ohkawa, Noboru Hashimoto, Yuhsuke Ohmi, Yoshio Yamauchi, Keiko Furukawa, Tetsuya Okajima, Koichi Furukawa.
  • Journal Title: Glycobiology. Volume: 26 Pages: 984-998
  • Peer Reviewed
• [Journal Article] A therapeutic trail of human melanoma with combined small interfering RNAs targeting adaptor molecules p130Cas and paxillin activated under expression of ganglioside GD3. (2016)
  • Author(s): Makino Y, Hamamura K, Takei Y, Bhuiyan RH, Ohkawa Y, Ohmi Y, Nakashima H, Furukawa K, Furukawa K.
  • Journal Title: Biochimica et Biophysica Acta Volume: in press Issue: 8 Pages: 1753-1763
  • DOI: 10.1016/j.bbagen.2016.04.005
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis. (2016)
  • Author(s): Ohmi Y, Ise W, Harazono A, Takakura D, Fukuyama H, Baba Y, Narazaki M, Shoda H, Takahashi N, Ohkawa Y, Ji S, Sugiyama F, Fujio K, Kumanogoh A, Yamamoto K, Kawasaki N, Kurosaki T, Takahashi Y, Furukawa K.
  • Journal Title: Nature Communications Volume: in press Issue: 1 Pages: 11205-11205
  • DOI: 10.1038/ncomms11205
  • NAID: 120007135549
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 抗シトルリン化タンパク質抗体は関節炎病態にどのように関与しているか? (2016)
  • Author(s): 大海雄介、古川鋼一
  • Journal Title: 分子リウマチ治療 Volume: 9 Pages: 12-17
  • Peer Reviewed
• [Journal Article] Ganglioside GD3 enhances invasiveness via Yes activation by forming a complex of GD3/PDGFRα/Yes in gliomas (2015)
  • Author(s): Yuki Ohkawa, Hiroyuki Momota, Akira Kato, Noboru Hashimoto, Yuhsuke Tsuda, Norihiro Kotani, Koichi Honke, Akio Suzumura, Keiko Furukawa, Yuhsuke Ohmi, Atsushi Natsume, Toshihiko Wakabayashi and *Furukawa K
  • Journal Title: J. Biol. Chem. Volume: 290 Issue: 32 Pages: 16043-16058
  • DOI: 10.1074/jbc.m115.708834
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Functional analysis of exosomes in cancer metastasis (2019)
  • Author(s): Yoshiki Kodama, Zhang Qing, Yuhsuke Ohmi, Satoko Yamamoto, Keiko Furukawa, Koichi Furukawa
  • Organizer: ISEV 2019
  • Int'l Joint Research
• [Presentation] シアル酸結合レクチンSiglec7のガングリオシドGD3認識に対するセラミド構造の影響 (2019)
  • Author(s): 橋本登、伊藤静香、土田明子、Robiul H. Bhuiyan、岡島徹也、山本朗仁、古川圭子、大海雄介、古川鋼一
  • Organizer: 第38回日本糖質学会
• [Presentation] 大腸癌におけるGb3の機能解析 (2019)
  • Author(s): 北沢裕昭、田中祥、藤井碧、大海雄介、大川祐樹、喬善楼、田島織絵、古川圭子、古川鋼一
  • Organizer: 第38回日本糖質学会
• [Presentation] Unique function of ganglioside GD2 in malignant melanomas (2019)
  • Author(s): Farhana Yesmin、Robiul Hasan Bhuiyan、大海雄介、岡島徹也、古川圭子、古川鋼一
  • Organizer: 第38回日本糖質学会
• [Presentation] Roles of ganglioside GD3 in the regulation of microenvironment of gliomas (2019)
  • Author(s): Pu Zhang,Yuki Ohkawa,Robiul H.Bhuiyan,Hiroyuki Momota,Toshihiko Wakabayashi,Akira Kato,Yuhsuke Ohmi,Keiko Furukawa,Tetsuya Okajima,Koichi Furukawa
  • Organizer: 第38回日本糖質学会
• [Presentation] Roles of ganglioside GD3 in the regulation of microenvironment of gliomas (2019)
  • Author(s): Pu Zhang, Okiru Komine, Yuki Ohkawa, Yuhsuke Ohmi, Robiul H. Bhuiyan, Akira Kato, Keiko Furukawa, Tetsuya Okajima, Toshihiko Wakabayashi, Koichi Furukawa
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Targeting GD2 on cancer cells by an anti-GD2 antibody is promising in a variety of cancers: Challenge by CAR T (2019)
  • Author(s): 古川鋼一、赤堀泰、大海雄介、Farhana Yasmin、浦野健、古川圭子、珠玖洋
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Unique function of ganglioside GD2 in malignant melanomas (2019)
  • Author(s): Farhana Yesmin, Robiul H. Bhuiyan, Yuhsuke Ohmi, Tetsuya Okajima, Keiko Furukawa, Koichi Furukawa
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Roles of asialo-series ganglioside GD1alpha in human cancer cell lines (2019)
  • Author(s): Robiul H. Bhuiyan, Farhana Yesmin, Yuji Kondo, Yuki Ohkawa,Yuhsuke Ohmi, Pu Zhang, Tetsuya Okajima, Keiko Furukawa,Koichi Furukawa
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] マウスアストロサイト上に発現するガングリオシドの機能解析 (2019)
  • Author(s): 大海雄介, 北浦洋子, 伊藤多佳子, 伴崚太, 古川圭子, 武田明, 河原敏男, 古川鋼一
  • Organizer: 第92回日本生化学会大会
• [Presentation] 抗糸球体基底膜腎炎を標的とするシアル酸付加自己抗体の機能解析 (2019)
  • Author(s): 伴崚太, 河原敏男, 武田明, 岡島徹也, 丸山彰一, 松山誠, 古川鋼一, 大海雄介
  • Organizer: 第92回日本生化学会大会
• [Presentation] Increased readthrough of premature termination codon of B4GALNT1 gene depending on cell cycle (2019)
  • Author(s): Robiul H. Bhuiyan, Farhana Yesmin, Yuhsuke Ohmi, Yuki Ohkawa, Tetsuya Okajima, Keiko Furukawa, Koichi Furukawa
  • Organizer: 第92回日本生化学会大会
• [Presentation] Application of Ar Ion Beam Milling on Sectioning of Cells for SEM Observations (2019)
  • Author(s): Shigeyasu Tanaka, Yusuke Ohmi
  • Organizer: Microscopy & Microanalysis 2019
  • Int'l Joint Research
• [Presentation] シアル酸が関与する難治性疾患の病態メカニズムの解明 (2019)
  • Author(s): 大海雄介
  • Organizer: 第38回日本糖質学会
• [Presentation] 自己抗体IgG上の糖鎖による病態制御機構の解析 (2019)
  • Author(s): 大海 雄介、古川 剛一
  • Organizer: 第5回糖鎖免疫研究会
• [Presentation] BSA 固定化糖鎖を用いたレセプター糖鎖高密度化によるインフルエンザウイルス検出感度向上の試み (2019)
  • Author(s): 平松 宏明, 河原 敏男, 大海 雄介, 鈴木 康夫, 中北 愼一, 渡邊 洋平, 大野 恭秀, 前橋 兼三, 小野 尭生, 金井 康, 松本 和彦
  • Organizer: 日本薬学会第139年会
• [Presentation] 培養細胞断面SEM観察のためのArイオンビームによる試料作製 Sample preparation technique based on Ar ion beam irradiationfor cross-sectional SEM observations of cultured cells (2018)
  • Author(s): 田中 成泰，長岡 祥平，大海 雄介
  • Organizer: 日本顕微鏡学会第74回学術講演会
• [Presentation] 癌関連スフィンゴ糖脂質による細胞動態の分別的制御に関するタイムラプス解析 (2018)
  • Author(s): 古川 圭子, 神戸 真理子, 大海 雄介, 大川 祐樹, 竹内 理香, 田島 織絵, 安藤 弘宗, 古川 鋼一
  • Organizer: 第91回日本生化学大会
• [Presentation] 癌転移におけるエクソソームの役割の解析 (2018)
  • Author(s): 児玉 佳輝, 章 青, 大海 雄介, Hasan Bhuiyan Robiul, Yesmin Farhana, 山本 聡子, 古川 圭子, 古川 鋼一
  • Organizer: 第91回日本生化学大会
• [Presentation] グリオーマーの微小環境調節におけるガングリオシドGD3の役割 (2018)
  • Author(s): 張 璞, 大川 祐樹, 大海 雄介, Robiul H.Bhuiyan, 加藤 彰, 古川 圭子, 岡島 徹也, 若林 俊彦, 古川 鋼一
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] 糖鎖リモデリング癌細胞由来エキソソームの膜分子組成と分泌機構の解析 (2018)
  • Author(s): 小林 伊織, 大海 雄介, 古川 圭子, ブイヤン ロビウル, 張 璞, 古川 鋼一
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] Roles of asialo-series ganglioside GD1alpha in human cancer cell lines (2018)
  • Author(s): Koichi Furukawa
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] BSA固定化SGPとインフルエンザウイルスの結合活性の評価 (2018)
  • Author(s): 河原敏男、S.K.Rupesh 、平松宏明、大海雄介、鈴木康夫、林京子 、中北愼一、渡邊洋平、大野恭秀、前橋兼三、小野尭生、金井康、松本和彦
  • Organizer: 第79回応用物理学会秋季学術講演会
• [Presentation] Effective Binding of Sugar Chains to Influenza Viruses on the Surface by the Bovine Serum Albumin Localization (2018)
  • Author(s): Toshio Kawahara, Hiroaki Hiramatsu, Yuhsuke Ohmi, Yasuo Suzuki, Shin-ichi Nakakita, Yohei Watanabe, Yasuhide Ohno, Kenzo Maehashi, Takao Ono, Yasushi Kanai, Kazuhiko Matsumoto6
  • Organizer: ACSIN-14&ICSPM26
• [Presentation] インフルエンザウイルスセンサのためのSGPのBSA固定化によるゆらぎの低減 (2018)
  • Author(s): 河原敏男、平松宏明、大海雄介、鈴木康夫、林京子、中北愼一、渡邊洋平、大野恭秀、前橋兼三、小野尭生、金井康、松本和彦
  • Organizer: 2018年日本表面真空学会学術講演会
• [Presentation] Fluctuation in nano-carbon pH sensors in a liquid using CNWFETs fabricated by the self-signed process (2018)
  • Author(s): S. Rupesh, T. Kawahara, Y. Ohmi, Y. Ohno, K. Maehashi, K. Matsumoto, K. Okamoto, R. Utsunomiya, T. Matsuba
  • Organizer: 40th International Symposium on Dry Process (DPS2018) 、(国際学会)
  • Int'l Joint Research
• [Presentation] Roles of ganglioside GD3 in the regulation of microenvironment of gliomas (2018)
  • Author(s): Koichi Furukawa
  • Organizer: 第47回日本免疫学会学術集会
• [Presentation] 糖鎖と自己免疫疾患 (2018)
  • Author(s): 大海雄介、伊勢渉、高倉大輔、高橋伸典、川崎ナナ、高橋宜聖、古川鋼一
  • Organizer: 第72回NPO法人日本口腔科学会学術集会
  • Invited
• [Presentation] Ig上のシアル酸機能の解析とSALSA法によるマウス脳組織のシアル化糖鎖構造解析 (2018)
  • Author(s): 大海 雄介、古川 剛一
  • Organizer: 第37回日本糖質学会年会
  • Invited
• [Presentation] グリア細胞の脂質ラフトにおけるガングリオシドの役割 (2017)
  • Author(s): 大海雄介
  • Organizer: 生命科学系合同年次大会
• [Presentation] 関節炎惹起性IgGのシアル酸修飾はコラーゲ ン誘発性関節炎の抑 制機能を付与する (2016)
  • Author(s): 大海 雄介、伊勢 渉、原園 景、高倉 大輔、福山 英啓、 川崎 ナナ、河原 敏男、黒崎 知博、高橋 宜聖、古川 鋼一
  • Organizer: 第35回日本糖質学会
  • Place of Presentation: 高知県・高知市 高知市文化プラザ
• [Presentation] 関節リウマチ抗原特異的抗体上のシアル酸はII型コラーゲン誘導型関節炎を抑制する (2016)
  • Author(s): 大海雄介、伊勢渉、原園景、高橋大輔、福山英啓、川崎ナナ、河原敏男、黒崎知博、高橋宜聖、古川鋼一
  • Organizer: 第89回日本生化学会
  • Place of Presentation: 宮城県・仙台市 仙台国際センター
• [Book] 糖鎖生物学 (2020)
  • Author(s): 大海雄介、古川鋼一
  • Total Pages: 306
  • Publisher: 名古屋大学出版会
  • ISBN: 9784815809812
• [Book] Glycoscience: Basic Science to Applications (2019)
  • Author(s): Koichi Furukawa, Yuhsuke Ohmi, Yuji Kondo, Yuki Ohkawa, Orie Tajima, Keiko Furukawa et al.
  • Total Pages: 405
  • Publisher: SPRINGER NATURE SINGAPORE
  • ISBN: 9789811358555
• [Book] Progress in Molecular Biology and Translational Science./ Gangliosides in Inflammation and Neurodegeneration (2018)
  • Author(s): Koichi Furukawa, Yuhsuke Ohmi, Orie Tajima, Yuki Ohkawa, Yuji Kondo, Ji Shuting, Noboru Hashimoto, Keiko Furukawa
  • Total Pages: 480
  • Publisher: Elsevior, Oxford,
  • ISBN: 9780128123416
• [Book] 脳内環境辞典 (2016)
  • Author(s): 大海雄介、高橋良輔、小峯 起、高松芳樹、萬代研二、富田泰輔、山口賀章、木下彩栄、大倉正道、華山力成、三澤日出巳、富永真琴、平井宏和、五十嵐道弘、前川洋太、矢尾育子、野口 潤、碓井理夫、竹居光太郎、菅田浩司、他
  • Total Pages: 160
  • Publisher: 株式会社 メディカルドゥ