Identification of anti-HIV immunity information from Asia, and its application to international HIV vaccine development.

• Project/Area Number: 16K08843
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: Nagasaki University
• Principal Investigator: MORI Masahiko 長崎大学, 熱帯医学研究所, 客員研究員 (50643988)
• Research Collaborator: ARIYOSHI Koya ; YASUNAMI Michio ; GOULDER Philip ; SRIWANTHANA Busarawan ; JOOSTE Pieter
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: HIV / KIR / HLA / 南アフリカ / タイ / アジア / アフリカ / 東南アジア / 感染症 / ウィルス / 免疫学

Outline of Final Research Achievements

We identified the difference of immune cells effecting on HIV clinical outcomes between South African and Thai HIV patients. (1)Among South African population, patients with HLA-C*16:01+KIR2DL3+ had worse clinical outcome, and (2)among Thai population, patients with HLA-B*46:01+KIR2DL2+ had worse clinical outcome, and ones with HLA-C*12:03+KIR2DL2+ had better outcome.
These suggested the possibility of regional difference in efficacy of newly-developed medicine effecting through HLA-KIR pathways. These information would support the discovery and development of novel HIV medicines and treatment.

Academic Significance and Societal Importance of the Research Achievements

学術的意義：(1)これまで知られていた細胞傷害性T細胞を介した免疫系統だけでなく、ナチュラルキラー細胞を介した免疫系統でもHIV感染後臨床経過への影響を示唆する（2）ただし細胞傷害性T細胞におけるHLA-B*57のように、人種間・ウィルス型を越えウィルスを抑制するような共通したHLA-KIRの組み合わせは検出されなかった。
社会的意義：免疫系統を利用した薬剤開発においては、人種・地域毎でその効果に差が出る可能性があることを示唆した。

Research Products

• [Int'l Joint Research] University of Oxford(英国)
• [Int'l Joint Research] Ministry of public health(タイ)
• [Journal Article] The Impact of Hla Allele-Kir Pairs on Disease Outcome in Hiv-Infected Thai Population (2018)
  • Author(s): Mori Masahiko、Wichukchinda Nuanjun、Miyahara Reiko、Rojanawiwat Archawin、Pathipvanich Panita、Miura Toshiyuki、Yasunami Michio、Ariyoshi Koya、Sawanpanyalert Pathom
  • Journal Title: JAIDS Journal of Acquired Immune Deficiency Syndromes Volume: 78 Issue: 3 Pages: 1-1
  • DOI: 10.1097/qai.0000000000001676
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impact of HLA allele-KIR pairs on HIV clinical outcome in South Africa. (2018)
  • Author(s): Mori M, Leitman E, Walker B, Ndung'u T, Carrington M, Goulder P.
  • Journal Title: J Infect Dis. Volume: - Issue: 9 Pages: 1456-1463
  • DOI: 10.1093/infdis/jiy692
  • Peer Reviewed / Int'l Joint Research