Mechanism of macrophage activation by Angptl2

• Project/Area Number: 16K08845
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: University of the Ryukyus
• Principal Investigator: Umikawa Masato 琉球大学, 医学(系)研究科(研究院), 准教授 (00325838)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: Angptl2 / マクロファージ / 炎症 / マクロファージ活性化 / グルコサミノグリカン / 受容体 / 免疫グロブリン様受容体

Outline of Final Research Achievements

We demonstrated that Angptl2 activate mouse peritoneal macrophages. Although recent studies implicate Angptl2 in chronic inflammation, the mechanisms of inflammation caused by Angptl2 remain unclear.
In this study, we showed that Angptl2 directly binds to unknown substances which activates resident murine peritoneal monocytes and macrophages. These results demonstrate a novel role for Angptl2 in inflammation.

Academic Significance and Societal Importance of the Research Achievements

慢性炎症は肥満に伴う糖尿病などの生活習慣病や自己免疫疾患、アルツハイマー型認知症等の神経疾患、癌の発症から進行といった疾患に共通する基礎病態である。
本研究で明らかになったAngptl2に結合し、免疫細胞を活性化する作用を持つ生体由来の物質の解明が進めば、Angptl2の関与する炎症反応を制御することが可能になり、慢性炎症の関与する疾患の治療につながる事が期待できる。

Research Products

• [Int'l Joint Research] The Unversity of Texas/Southwestern medical center(米国)