Basic research for the development of the way how to allocate healthcare resources more efficiently and fairly

• Project/Area Number: 16K08894
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical sociology
• Research Institution: Ritsumeikan University
• Principal Investigator: Shimozuma Kojiro 立命館大学, 生命科学部, 教授 (00248254)
• Co-Investigator(Kenkyū-buntansha): 齋藤 信也 岡山大学, 保健学研究科, 教授 (10335599) ; 白岩 健 国立保健医療科学院, 保健医療経済評価研究センター, 主任研究官 (20583090) ; 村澤 秀樹 立命館大学, 生命科学部, 助教 (50770202)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 医療技術評価 / 医療資源配分 / 医療経済評価 / 資源配分の倫理 / 健康アウトカム評価 / 臨床試験 / 費用対効果 / 保険償還 / QOL評価 / マッピング / 健康効用値 / 費用効果分析 / 多基準決定分析 / MCDA / 患者選好 / 医療倫理 / QOL / 効用値 / 多基準意思決定分析(MCDA) / 生命倫理 / 政策意思決定

Outline of Final Research Achievements

1. We translated and introduce the two major mapping guidance (MAPS Reporting Statement, ISPOR Task Force Report). The results of simultaneously measured scores/values by profile-based and preference-based instruments for prostate cancer patients were analyzed. We examined the utilization of assessing utility values in a cancer clinical trial.
2. To reveal the application-related issues for multi-criteria decision analysis (MCDA), we firstly identified important criteria by systematic review and secondly underwent some web-based surveys using the criteria for lay people and healthcare professionals. The surveys revealed the difference of priority and weight between for life-threatening disease and for non-life-threatening disease and that the linearity and distance’s equality between criteria-related categories and gained scores.
3. We gathered the reference information about the issue of productivity loss and data sources.

Academic Significance and Societal Importance of the Research Achievements

医療技術の評価において、従来の医療現場の有効性と安全性のエビデンスのみを重視する時代は終わり、効率性や平等性、経済性を加味した、社会的な価値の評価を積極的に行い、それに基づいて、医療の資源配分の意思決定を行う考え方が世界中に広がりつつある。しかるに、日本はその分野の研究と政策応用で後れを取っている。本研究の成果は、特に医療経済評価におけるQOL評価が有する課題や、医療資源配分の意思決定に用いられる多角的な価値基準を統合する方法の開発や進歩に大きく貢献するものであり、学術的、社会的意義は大きい。

Research Products

• [Journal Article] Response shift-adjusted treatment effect on health-related quality of life in a randomized control trial of taxane versus S-1 for metastatic breast cancer: structural equation modeling. (2020)
  • Author(s): Murata T, Shimozuma K, et al
  • Journal Title: Value Health Volume: -
  • Peer Reviewed
• [Journal Article] Development of a multiplicative, multi-attribute utility function and eight single-attribute utility functions for the Health Utilities Index Mark 3 in Japan. (2020)
  • Author(s): Shinichi Noto, Takeru Shiroiwa, Makoto Kobayashi, Tatsunori Murata, Shunya Ikeda, Takashi Fukuda
  • Journal Title: Journal of patient-reported outcomes Volume: 4 Issue: 1 Pages: 23-23
  • DOI: 10.1186/s41687-020-00188-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Formal Implementation of Cost-Effectiveness Evaluations in Japan: A Unique Health Technology Assessment System. (2020)
  • Author(s): Hasegawa M, Komoto S, Shiroiwa T, Fukuda T
  • Journal Title: Value Health Volume: 23 Issue: 1 Pages: 43-51
  • DOI: 10.1016/j.jval.2019.10.005
  • Peer Reviewed
• [Journal Article] Development of Japanese utility weights for the Adult Social Care Outcomes Toolkit (ASCOT) SCT4. Quality of Life Research (2020)
  • Author(s): Shiroiwa T, Moriyama Y, Nakamura-Thomas H, Morikawa M, et al
  • Journal Title: Quality of Life Research Volume: 29 Issue: 1 Pages: 253-263
  • DOI: 10.1007/s11136-019-02287-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 癌治療とQOL-乳癌 (2019)
  • Author(s): 下妻晃二郎
  • Journal Title: 癌と化学療法 Volume: 46 Pages: 985-989
  • Open Access
• [Journal Article] Psychometric properties of the Japanese version of the EQ-5D-Y by self report and proxy report: reliability and construct validity. (2019)
  • Author(s): Shiroiwa T, Fukuda T, Shimozuma K
  • Journal Title: Qual Lif Res Volume: 28 Issue: 11 Pages: 3093-3105
  • DOI: 10.1007/s11136-019-02238-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Factors contributing to the ceiling effect of the EQ-5D-5L: an analysis of patients with prostate cancer judged “no-problems” (2019)
  • Author(s): Murasawa Hideki、Sugiyama Takayuki、Matsuoka Yuki、Okabe Takashi、Wakumoto Yoshiaki、Tanaka Nobumichi、Sugimoto Mikio、Oyama Masafumi、Fujimoto Kiyohide、Horie Shigeo、Funagoshi Masaru、Arakawa Ichiro、Noto Shinichi、Shimozuma Kojiro
  • Journal Title: Quality of Life Research Volume: 29 Issue: 3 Pages: 755-763
  • DOI: 10.1007/s11136-019-02316-4
  • Peer Reviewed / Open Access
• [Journal Article] 外科的侵襲と漢方-漢方補剤による侵襲反応モジュレーションの可能性- (2019)
  • Author(s): 齋藤信也、岩垣博巳
  • Journal Title: 漢方と最新治療 Volume: 28 Pages: 280-286
• [Journal Article] Japanese translation and cross-cultural validation of the Adult Social Care Outcomes Toolkit (ASCOT) in Japanese social service users (2019)
  • Author(s): Nakamura-Thomas H, Morikawa M, Moriyama Y, Shiroiwa T, Kyougoku M, et al
  • Journal Title: Health and Quality of Life Outcomes Volume: 17(59) Issue: 1 Pages: 1-1
  • DOI: 10.1186/s12955-019-1128-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A multicenter survey of temporal changes in chemotherapy-induced hair loss in breast cancer patients. (2019)
  • Author(s): Watanabe T, Yagata H, Saito M, Okada H, Yajima T, Tamai N, Yoshida Y, Takayama T, Imai H, Nozawa K, Sangai T, Yoshimura A, Hasegawa Y, Yamaguchi T, Shimozuma K, Ohashi Y
  • Journal Title: PLoS One Volume: 14 Issue: 1 Pages: e0208118-e0208118
  • DOI: 10.1371/journal.pone.0208118
  • Peer Reviewed / Open Access
• [Journal Article] Health utility and health related quality of life of Japanese prostate cancer patients according to progression status measured using EQ-5D-5L and FACT-P (2019)
  • Author(s): Murasawa H, Sugiyama T, Matsuoka Y, Okabe T, Hino A, Tanaka N, Sugimoto M, Oyama M, Fujimoto K, Horie S, Noto S, Shimozuma K
  • Journal Title: Qual Lif Res Volume: - Issue: 9 Pages: 1-9
  • DOI: 10.1007/s11136-019-02184-y
  • Peer Reviewed
• [Journal Article] To what extent does the EQ-5D-3L correlate with the FACT-H&N of patients with oral cancer during the perioperative period? (2019)
  • Author(s): Aoki T, Ota Y, Sasaki M, Aoyama K, Akiba T, Shirasugi Y, Naito M, Shiroiwa T
  • Journal Title: Int J Clin Oncol Volume: 24 Issue: 4 Pages: 350-358
  • DOI: 10.1007/s10147-018-1364-6
  • Peer Reviewed
• [Journal Article] Exploring the Application of Cost-Effectiveness Evaluation in the Japanese National Health Insurance System (2019)
  • Author(s): Hisayuki Ogura (a1), Shigekazu Komoto (a1), Takeru Shiroiwa (a2) and Takashi Fukuda
  • Journal Title: Int J Technol Assess Health Care Volume: - Issue: 6 Pages: 452-460
  • DOI: 10.1017/s0266462319000060
  • Peer Reviewed
• [Journal Article] 医療技術評価におけるQOL/PROの活用 (2018)
  • Author(s): 村澤秀樹、下妻晃二郎
  • Journal Title: 薬剤疫学 Volume: 23 Pages: 19-27
  • Peer Reviewed
• [Journal Article] 超高齢社会における高齢者治療の標準化－HTAベースで考える (2018)
  • Author(s): 下妻晃二郎
  • Journal Title: 薬学図書館 Volume: 63 Pages: 211-215
• [Journal Article] Patient-Reported Outcome Results from the Open-Label Randomized Phase III SELECT BC Trial Evaluating First-Line S-1 Therapy for Metastatic Breast Cancer. (2018)
  • Author(s): Kawahara T, Shimozuma K, Shiroiwa T, Hagiwara Y, Uemura Y, Watanabe T, Taira N, Fukuda T, Ohashi Y, Mukai H
  • Journal Title: Oncology Volume: 94 Issue: 2 Pages: 107-115
  • DOI: 10.1159/000484142
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cost-Minimization Analysis of Deep-Brain Stimulation Using National Database of Japanese Health Insurance Claims (2018)
  • Author(s): Akazawa M, Konomura K, Shiroiwa T
  • Journal Title: Neuromodulation : Journal of the International Neuromodulation Society Volume: 21 Issue: 6 Pages: 548-552
  • DOI: 10.1111/ner.12782
  • Peer Reviewed
• [Journal Article] Healthcare costs for the elderly in Japan: Analysis of medical care and long-term care claim records (2018)
  • Author(s): Akiyama N, Shiroiwa T, Fukuda T, Murashima S, Hayashida K
  • Journal Title: PLoS One Volume: 13 Issue: 5 Pages: e0190392-e0190392
  • DOI: 10.1371/journal.pone.0190392
  • Peer Reviewed / Open Access
• [Journal Article] 費用対効果以外の要素をいかに扱うべきか？-アプレイザル(総合的評価)に関する諸問題- (2018)
  • Author(s): 齋藤信也
  • Journal Title: 薬剤疫学 Volume: 23 Issue: 1 Pages: 29-39
  • DOI: 10.3820/jjpe.23.29
  • NAID: 130007403411
  • Peer Reviewed
• [Journal Article] The sexual lives of breast cancer patients: Coping with changes associated with treatment (2018)
  • Author(s): Yoshikawa A, Saito S, Kondo M, Tsuyumu Y, Taira N, Shien T, Doihara H
  • Journal Title: Clinical Nursing Studies Volume: 6 Pages: 61-75
  • Peer Reviewed
• [Journal Article] Impact of Adverse Events on Health Utility and Health-Related Quality of Life in Patients Receiving First-Line Chemotherapy for Metastatic Breast Cancer: Results from the SELECT BC Study (2018)
  • Author(s): Hagiwara Y, Shiroiwa T, Shimozuma K, Kawahara T, Uemura Y, Watanabe T, Taira N, Fukuda T, Ohashi Y, Mukai H
  • Journal Title: PharmacoEconomics Volume: 36 Issue: 2 Pages: 215-223
  • DOI: 10.1007/s40273-017-0580-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of ruxolitinib therapy on the quality of life of Japanese patients with myelofibrosis. (2018)
  • Author(s): Oritani K, Ohishi K, Okamoto S, Kirito K, Komatsu N, Tauchi T, Handa H, Saito S, Takenaka K, Shimoda K, Okada H, Amagasaki T, Wakase S, Shimozuma K, Akashi K
  • Journal Title: Curr Med Res Opin Volume: 34 Issue: 3 Pages: 531-537
  • DOI: 10.1080/03007995.2017.1415874
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Future Topic がん診療のコスト原論 - 「コスト」を考慮した効率的ながん診療と医療倫理のバランス単著2017年7月Cancer Board(3巻2号)下妻 晃二郎75-90 (2017)
  • Author(s): 下妻晃二郎
  • Journal Title: Cancer Board Volume: 3 Pages: 75-90
• [Journal Article] 本人の希望への寄り添い－サービス提供体制についてのアウトカム評価の意義とあり方 (2017)
  • Author(s): 下妻晃二郎
  • Journal Title: 健康保険 Volume: 71 Pages: 14-20
• [Journal Article] Cost-effectiveness analysis of the introduction of S-1 therapy for first-line metastatic breast cancer treatment in Japan: results from the randomized phase III SELECT BC trial. (2017)
  • Author(s): Shiroiwa T, Fukuda T, Shimozuma K, Mouri M, Hagiwara Y, Kawahara T, Ohsumi S, Hozumi Y, Sagara Y, Ohashi Y, Mukai H
  • Journal Title: BMC Cancer Volume: 17 Issue: 1 Pages: 773-773
  • DOI: 10.1186/s12885-017-3774-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of a Japanese version of the BREAST-Q and the traditional psychometric test of the mastectomy module for the assessment of HRQOL and patient satisfaction following breast surgery. (2017)
  • Author(s): Saiga M, Taira N, Kimata Y, Watanabe S, Mukai Y, Shimozuma K, Mizoo T, Nogami T, Iwamoto T, Motoki T, Shien T, Matsuoka J, Doihara H
  • Journal Title: Breast Cancer Volume: 24(2) Issue: 2 Pages: 288-298
  • DOI: 10.1007/s12282-016-0703-6
  • NAID: 120006401575
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Long-term health status as measured by EQ-5D among patients with metastatic breast cancer: comparison of first-line oral S-1 and taxane therapies in the randomized phase III SELECT BC trial. (2017)
  • Author(s): Shiroiwa T, Fukuda T, Shimozuma K, Mouri M, Hagiwara Y, Doihara H, Akabane H, Kashiwaba M, Watanabe T, Ohashi Y, Mukai H
  • Journal Title: Qual Life Res Volume: 26(2) Issue: 2 Pages: 443-453
  • DOI: 10.1007/s11136-016-1388-1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Efficacy and safety of sequential use of everolimus in Japanese patients with advanced renal cell carcinoma after failure of first-line treatment with vascular endothelial growth factor receptor tyrosine kinase inhibitor: a multicenter phase II clinical trial. (2017)
  • Author(s): Oyama M, Sugiyama T, Nozawa M, Fujimoto K, Kishida T, Kimura G, Tokuda N, Hinotsu S, Shimozuma K, Akaza H, Ozono S
  • Journal Title: Jpn J Clin Oncol Volume: - Pages: 1-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 高齢者施設および在宅医療ケアにおける尿道留置カテーテルの取扱の現状と課題。 (2017)
  • Author(s): 盛次浩二、齋藤信也：高齢者施設および在宅医療ケアにおける尿道留置カテーテルの取扱の現状と課題。
  • Journal Title: 日本環境感染学会誌 Volume: 32(1) Pages: 34-41
  • NAID: 130005437600
  • Peer Reviewed
• [Journal Article] 病院経営における事務職員の重要性について-国立病院における独法化以降事務職員数変化- (2017)
  • Author(s): 高橋信夫，小林英樹，中村哲浩，丸尾芳光，岩永暁史、山本時生，藤崎沙彩，斎藤博文，沖田哲美，福永肇，齋藤信也
  • Journal Title: 医療 Volume: 71(3) Pages: 119-125
  • Peer Reviewed
• [Journal Article] Development of an Official Guideline for the Economic Evaluation of Drugs/Medical Devices in Japan (2017)
  • Author(s): T Shiroiwa, T Fukuda, S Ikeda, T Takura, K Moriwaki
  • Journal Title: Value Health Volume: 20(3) Pages: 372-378
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 特集 医療経済学のススメ 医療における経済学の活用 医療技術評価（HTA) (2016)
  • Author(s): 下妻 晃二郎
  • Journal Title: 治療 Volume: 98(4) Pages: 530-536
• [Journal Article] Comparison of Value Set Based on DCE and/or TTO Data: Scoring for EQ-5D-5L Health States in Japan. (2016)
  • Author(s): Shiroiwa T, Ikeda S, Noto S, Igarashi A, Fukuda T, Saito S, Shimozuma K
  • Journal Title: Value Health Volume: 19(5) Issue: 5 Pages: 648-654
  • DOI: 10.1016/j.jval.2016.03.1834
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 看護師の意思決定支援：文献にみる現状と課題④心不全患者の意思決定支援の特徴。 (2016)
  • Author(s): 齋藤信也
  • Journal Title: 看護技術 Volume: 62(12) Pages: 68-71
• [Journal Article] Basic Attitude of Japanese Physicians towards Healthcare Resource Allocation in a Setting of Budget Constraints. (2015)
  • Author(s): Saito S, Shiroiwa T, Fukuda T, Shimozuma K
  • Journal Title: Value Health Volume: 18(7) Issue: 3 Pages: 532-532
  • DOI: 10.1007/s40258-016-0236-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Relationship Between Partial Values and Scoring Scale for Each Criterion of the EVIDEM 10th Edition Core Model in Japan. (2019)
  • Author(s): Funagoshi M, Murasawa H, Shiroiwa T, Saito S, Shimozuma K
  • Organizer: International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Europe 2019.
  • Int'l Joint Research
• [Presentation] Health-Related Quality of Life in Japanese Patients with Prostate Cancer Using EQ-5D-5L and FACT-P: Comparisons According to Treatment Type (2018)
  • Author(s): Murasawa H, Okabe T, Wakumoto Y, Sugiyama T, Tanaka N, Matsuoka Y, Noto S, Shimozuma K
  • Organizer: ISPOR Asia Pacific 2018
  • Int'l Joint Research
• [Presentation] Importance of Criteria for Drug Reimbursement Decision- Making for Non-Life-Threatening Diseases (2018)
  • Author(s): Funagoshi M, Murasawa H, Shiroiwa T, Saito S, Shimozuma K
  • Organizer: ISPOR Europe 2018
  • Int'l Joint Research
• [Presentation] Analysis of cognitive function in elderly HER2-positive breast cancer patients receiving either trastuzumab monotherapy or trastuzumab plus chemotherapy as a postoperative adjuvant treatment: A cognitive function sub-study of a randomized, open-label, phase 3 clinical trial (RESPECT trial) (2018)
  • Author(s): Takahashi M, Sawaki M, Hagiwara Y, Uemura Y, Kawahara T, Shimozuma K, Ohashi Y, Saito T, Baba S, Kobayashi K, Mukai H, Taira N
  • Organizer: 2018 San Antonio Breast Cancer Symposium
  • Int'l Joint Research
• [Presentation] Patient-reported outcomes with trastuzumab monotherapy versus trastuzumab plus standard chemotherapy as a postoperative adjuvant therapy in HER2-positive elderly breast cancer patients (RESPECT): A randomized, open-label, phase 3 clinical trial (2018)
  • Author(s): Kobayashi K, Taira N, Sawaki M, Sagawa N, Baba S, Saito T, Kawahara T, Hagiwara Y, Uemura Y, Shimozuma K, Ohashi Y, Mukai H
  • Organizer: 2018 San Antonio Breast Cancer Symposium
  • Int'l Joint Research
• [Presentation] Subjective and objective assessment of efficacy of frozen gloves and socks to prevent nab-paclitaxel-induced peripheral neuropathy in patients with breast cancer (2018)
  • Author(s): Yamashita T, Hattori M, Nakada T, Hayashi T, Kamei K, Tatsuya T, Nagao Y, Mase T, Wada M, Mizuno T, Shimozuma K, Iwata H, Yamaguchi T
  • Organizer: 2018 San Antonio Breast Cancer Symposium
  • Int'l Joint Research
• [Presentation] Slow code の実態とそれに対する医師の基本姿勢について (2018)
  • Author(s): 齋藤信也
  • Organizer: 第30回日本生命倫理学会年次総会
• [Presentation] 医療資源の配分問題―理論、基準、評価のつながりを論じる 我が国の医療政策への応用 (2018)
  • Author(s): 齋藤信也
  • Organizer: 第30回日本生命倫理学会年次総会
  • Invited
• [Presentation] 外科的侵襲と漢方 (2018)
  • Author(s): 岩垣博巳、齋藤信也
  • Organizer: 第69回日本東洋医学会学術総会
  • Invited
• [Presentation] 超高齢社会における高齢者治療の標準化 - HTAベースで考える - (2018)
  • Author(s): 下妻晃二郎
  • Organizer: 日本薬学会第138年会
  • Invited
• [Presentation] 試行的導入の折り返し地点：本格導入に向けたよりよい評価プロセスのありかたについて.「海外の再分析・評価プロセスについて」 (2017)
  • Author(s): 齋藤信也
  • Organizer: 国際医療経済・アウトカム研究学会ISPOR日本部会2016年度シンポジウム
  • Place of Presentation: 星稜会館（東京都，千代田区）
  • Year and Date: 2017-03-30
  • Invited
• [Presentation] 看護師の看護補助者への業務の委譲についての研究 (2017)
  • Author(s): 吉川あゆみ、齋藤信也
  • Organizer: 第30回日本看護研究学会中国・四国地方会
  • Place of Presentation: 岡山コンベンションセンター（岡山県，岡山市）
  • Year and Date: 2017-03-19
• [Presentation] 医療経済評価に基づく資源配分の倫理的課題. 「領域横断型の生命倫理プラットフォーム形成に向けて」 (2017)
  • Author(s): 齋藤信也
  • Organizer: 国際高等研究所2016年度第2回研究会
  • Place of Presentation: 国際高等研究所（京都府，木津川市）
  • Year and Date: 2017-01-29
  • Invited
• [Presentation] がん患者のQOLーどう評価し、どう臨床実践に生かすか- (2017)
  • Author(s): 下妻 晃二郎
  • Organizer: 第6回日本がんリハビリテーション研究会
  • Place of Presentation: 慶応義塾大学日吉キャンパス（神奈川県，横浜市）
  • Year and Date: 2017-01-07
  • Invited
• [Presentation] 前立腺癌骨転移患者に対するRadium-223の費用効果分析 (2017)
  • Author(s): 竹田祐馬、村澤秀樹、下妻晃二郎
  • Organizer: 第55回日本医療・病院管理学会学術総会
• [Presentation] 研究実践ワークショップ４－QOL評価の現状と費用効果分析への応用 QOL/PRO評価の基本的な考え方 (2017)
  • Author(s): 下妻晃二郎
  • Organizer: 日本臨床疫学会第1回年次学術大会
  • Invited
• [Presentation] パネルディスカッション10 「それぞれの癌」：医療費の高額化はおさえられるか ３．効率的かつ公平な医療資源配分 (2017)
  • Author(s): 下妻晃二郎
  • Organizer: 第55回日本癌治療学会学術集会
  • Invited
• [Presentation] シンポジウム２ QOL評価研究ことはじめ (2017)
  • Author(s): 下妻晃二郎
  • Organizer: 第34回日本障害者歯科学会総会および学術大会
  • Invited
• [Presentation] Factors contributing to the ceiling effect among patients with prostate cancer who were judged to have "full-health" by EQ-5D-5L (2017)
  • Author(s): Murasawa H, Matsuoka Y, Tanaka N, Takeda Y, Uchikawa S, Noto S, Shimozuma K
  • Organizer: ISPOR 20th Annual European Congress
  • Int'l Joint Research
• [Presentation] Reliability and validity of two proxy versions of EQ-5D-5L in Japan (2017)
  • Author(s): Noto S, Igarashi A, Shiroiwa T, Fukuda T, Ikeda S, Moriwaki K, Saito S, Shimozuma K, Ishida H, Kobayashi M
  • Organizer: ISPOR 20th Annual European Congress
  • Int'l Joint Research
• [Presentation] Identification of important criteria for drug reimbursement decision-making and their relative importance (2017)
  • Author(s): Funagoshi M, Murasawa H, Shimozuma K
  • Organizer: ISPOR 20th Annual European Congress
  • Int'l Joint Research
• [Presentation] 薬剤の償還可否に関する評価基準の調査：一般、医師および薬剤師の選好 (2017)
  • Author(s): 船越大、村澤秀樹、下妻晃二郎
  • Organizer: QOL/PRO研究会第５回研究学術集会
  • Int'l Joint Research
• [Presentation] 前立腺がん患者のQOL値に関する多施設共同研究 (2017)
  • Author(s): 村澤秀樹、下妻晃二郎
  • Organizer: QOL/PRO研究会第5回学術集会
• [Presentation] 臨床倫理コンサルタント技能測定尺度開発の試み (2017)
  • Author(s): 山口三重子、下妻晃二郎、齋藤信也
  • Organizer: 第29回日本生命倫理学会年次大会
• [Presentation] Impacts of Adverse Events on Health-related Quality of Life in Patients Receiving First-line Chemotherapy for Metastatic Breast Cancer: Results from Randomized Phase III SELECT BC study (2016)
  • Author(s): Yasuhiro Hagiwara, KojiroShimozuma, TakeruShiroiwa, Takuya Kawahara, Yukari Uemura,TakanoriWatanabe, Naruto Taira, Takashi Fukuda, Yasuo Ohashi, Hirofumi Mukai
  • Organizer: International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 19th Annual European Congress
  • Place of Presentation: Vienna (Austria)
  • Year and Date: 2016-11-02
  • Int'l Joint Research
• [Presentation] Responder analyses of patient-reported outcomes for evaluating the clinical significance of first-line S-1 over taxane therapy among patients with metastatic breast cancer: the open-label randomized phase III SELECT BC trial (2016)
  • Author(s): Takuya Kawahara, Kojiro Shimozuma, Takeru Shiroiwa, Yasuhiro Hagiwara, Yukari Uemura, Takanori Watanabe, Takashi Fukuda, Yasuo Ohashi, Hirofumi Mukai
  • Organizer: 23rd International Society for Quality of life Research (ISOQOL) Annual Conference
  • Place of Presentation: Copenhagen (Denmark)
  • Year and Date: 2016-10-21
  • Int'l Joint Research
• [Presentation] 根治切除不能または転移性の腎細胞癌患者に対するエベロリムス投与前後のQOL変化 (2016)
  • Author(s): 杉山 貴之、下妻 晃二郎、小山 政史、舛森 直哉、松原 昭郎、松山 豪泰、神波 大己、西村 和郎、樋之津 史郎、赤座 英之、大園 誠一郎
  • Organizer: 第54回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県，横浜市）
  • Year and Date: 2016-10-21
• [Presentation] The results of the Veterans Health Administration's Ethics Consultation Proficiency Assessment Tool survey in Japan (2016)
  • Author(s): Mieko YAMAGUCHI, Yuki KAWAMURA, Shinya SAITO, Kojiro SHIMOZUMA, Michele Eisemann SHIMIZU
  • Organizer: American Society of Bioethics and Humanities (ASBH) 18th Annual Meeting
  • Place of Presentation: Washington DC (USA)
  • Year and Date: 2016-10-06
  • Int'l Joint Research
• [Presentation] 看護師の離職とそれに影響する因子 －特にコミットメント、エンゲイジメントに着目して (2016)
  • Author(s): 齋藤信也、川上由紀
  • Organizer: 第54回日本医療・病院管理学会学術集会
  • Place of Presentation: 東京医科歯科大学（東京都，文京区）
  • Year and Date: 2016-09-18
• [Presentation] Health utility measured with EQ5D5L in Japanese patients undergoing hemodialysis. (2016)
  • Author(s): Shinya Saito, Shinichi Noto, Masashi Miyazaki, Sigeko Takatsu, Yoshinari Oka, Hiroaki Matsuda
  • Organizer: International Society for Phamacoeconomics and Outcomes Research (ISPOR) 7th Asia-Pacific Conference
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2016-09-05
  • Int'l Joint Research
• [Presentation] A cost-effectiveness analysis of Guanfacine extended-release treatment in pediatric attention-deficit/hyperactivity disorder (2016)
  • Author(s): Maeda S,Murasawa H, Funagoshi M, Takeda Y, Shimozuma K
  • Organizer: International Society for Phamacoeconomics and Outcomes Research (ISPOR) 7th Asia-Pacific Conference
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2016-09-04
  • Int'l Joint Research
• [Presentation] Economic evaluation guideline for pharmaceuticals and medical devices in Japan. (2016)
  • Author(s): Fukuda T, Igarashi A, Ishida H, Ikeda S, Saito S, Sakamaki H, Shimozuma K, Shiroiwa T, Takura T, Tomita N, Noto S, Fukuda H, Moriwaki K, Moriyama Y, Akazawa M
  • Organizer: International Society for Phamacoeconomics and Outcomes Research (ISPOR) 7th Asia-Pacific Conference
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2016-09-04
  • Int'l Joint Research
• [Presentation] 循環器疾患のエンドオブライフケアに おける看護師の意思決定支援 システマティックレビュー (2016)
  • Author(s): 齋藤信也、長江弘子、岩城典子、高橋在也、片山陽子、酒井昌子
  • Organizer: 第18回日本在宅医学会第21回日本在宅ケア学会学術集会合同大会
  • Place of Presentation: 東京ビッグサイト（東京都，江東区）
  • Year and Date: 2016-07-17
• [Presentation] エンド・オブ・ライフケ ア実践における看護師の意思決定支援の現状と課題 慢性腎不全患者の意思決定に焦点を当てて (2016)
  • Author(s): 富樫理恵、長江弘子、岩城典子、酒井昌子、片山陽子、蒔田麻友子、齋藤信也
  • Organizer: 第18回日本在 宅医学会第21回日本在宅ケア学会学術集会合同大会
  • Place of Presentation: 東京ビッグサイト（東京都，江東区）
  • Year and Date: 2016-07-16
• [Presentation] シンポジウム13 抗癌剤の医療経済評価-医療現場や社会への応用 (2016)
  • Author(s): 下妻 晃二郎
  • Organizer: 医療薬学フォーラム2016 第24回クリニアルファーマシーシンポジウム
  • Place of Presentation: 滋賀県立芸術劇場 びわ湖ホール（滋賀県，大津市）
  • Year and Date: 2016-06-26
  • Invited
• [Presentation] 緩和医療と費用対効果 (2016)
  • Author(s): 齋藤信也
  • Organizer: 第21回日本緩和医療学会学術大会
  • Place of Presentation: 京都国際会議場（京都府，京都市）
  • Year and Date: 2016-06-18
  • Invited
• [Presentation] 転移再発乳癌に対するタキサンとS-1の比較試験(SELECT-BC)のサブ解析と有害事象の経時的変化 (2016)
  • Author(s): 斎藤 毅, 向井 博文, 原 文堅, 松原 伸晃, 高野 利実, 朴 英進, 井本 滋, 渡辺 隆紀, 西村 令喜, 下妻 晃二郎, 大橋 靖雄
  • Organizer: 第24回日本乳癌学会学術総会
  • Place of Presentation: 東京国際フォーラム（東京都，千代田区）
  • Year and Date: 2016-06-17
• [Presentation] EQ5D-5L を用いた維持透析患者のQOLの評価～費用対効果の検証～ (2016)
  • Author(s): 宮崎 雅史、高津 成子、岡 良成、松田 浩明、尾山 貴徳、吉田 龍一、桂 佑貴、能登 真一、斎藤 信也
  • Organizer: 第61回日本透析医学会学術集会・総会
  • Place of Presentation: 大阪国際会議場（大阪府，大阪市）
  • Year and Date: 2016-06-10
• [Presentation] 根治切除不能または転移性の腎細胞癌患者 に対する1st line TKI療法不応後の エベロリムスの有効性および安全性の検討ー多施設共同第Ⅱ相試験 (2016)
  • Author(s): 杉山貴之、小山政史、野澤昌弘、藤本清秀、岸田 健、木村 剛、徳田倫章、樋之津史郎、下妻晃二郎、赤座英之、大園誠一郎
  • Organizer: 第104回日本泌尿器科学会
  • Place of Presentation: 東北大学百周年記念館（宮城県，仙台市）
  • Year and Date: 2016-04-23
• [Book] 保健医療の経済評価 (2017)
  • Author(s): 監訳：久繁哲徳、橋本秀樹
  • Total Pages: 495
  • Publisher: 篠原出版新社
  • ISBN: 9784884123956
• [Book] これからの乳癌診療2017－2018 (2017)
  • Author(s): 監修：園尾博司、編集：福田護、池田正、佐伯俊昭、鹿間直人
  • Total Pages: 160
  • Publisher: 金原出版株式会社
  • ISBN: 9784307203685
• [Book] 誰の健康が優先されるのか－医療資源の倫理学 (2017)
  • Author(s): グレッグ・ボグナー、イワオ・ヒロセ 監訳 児玉聡
  • Total Pages: 328
  • Publisher: 岩波書店
  • ISBN: 9784000612203
• [Book] CANCER BOARD OF THE BREAST - patient-reported outcome measures (PROMS) (2017)
  • Author(s): 下妻 晃二郎
  • Total Pages: 70
  • Publisher: メディカルレビュー社
• [Book] 立命館高等教育研究 大人数生命・薬学系授業におけるグループディスカッションの実践 (2017)
  • Author(s): 村澤秀樹、下妻 晃二郎
  • Total Pages: 259
  • Publisher: 立命館大学
• [Book] 「医学的無益性」と医療経済。医学的無益性と生命倫理 (2016)
  • Author(s): 板井孝壱郎、加部一彦、櫻井浩子、門岡康弘、齋藤信也、加藤太喜子、野崎亜紀子、土屋貴志
  • Total Pages: 220
  • Publisher: 山代印刷
• [Remarks]
  • URL: http://www.ritsumei.ac.jp/lifescience/
• [Remarks] 立命館大学 生命科学部 生命医科学科 医療政策・管理学研究室
  • URL: http://www.ritsumei.ac.jp/lifescience/bm/shimozuma/
• [Remarks] 立命館大学 生命科学部 生命医科学科 教員ページ（下妻）
  • URL: http://research-db.ritsumei.ac.jp/Profiles/40/0003909/profile.html
• [Remarks] 立命館大学 生命科学部 生命医科学科 医療政策・管理学研究室
  • URL: http://www.ritsumei.ac.jp/lifescience/bm/shimozuma/
• [Remarks] 立命館大学 生命科学部 生命医科学科 教員ページ（下妻）
  • URL: http://research-db.ritsumei.ac.jp/Profiles/40/0003909/profile.html