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Pharmacological evaluation in Immune-enhancement of anti-neoplastics

Research Project

Project/Area Number 16K08907
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied pharmacology
Research InstitutionInternational University of Health and Welfare (2017-2018)
Kyoto University (2016)

Principal Investigator

Ishiguro Hiroshi  国際医療福祉大学, 医学部, 教授 (20422925)

Co-Investigator(Kenkyū-buntansha) 鈴木 栄治  京都大学, 医学研究科, 准教授 (00612897)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsOncology / トリプルネガティブ乳癌 / プラチナ製剤 / NK活性 / 細胞性免疫 / 治療効果予測 / 免疫チェックポイント阻害剤 / ホスト因子 / 癌 / 臨床 / 免疫学 / トランスレーショナルリサーチ / 薬理学
Outline of Final Research Achievements

Triple Negative Breast Cancer Is known to have very poor prognosis. We have conducted neoadjuvant platinum-based chemotherapy for over 40 patients and median follow-up period is now over 4 years. We have excellent prognosis for patients we treated, and we are analyzing immunological biomarker in conjunction with pharmacokinetics of platinum.

Academic Significance and Societal Importance of the Research Achievements

トリプルネガティブ乳癌は組織学的高悪性度で早期再発が多く予後不良で、明確な治療標的薬もなく治療に難渋する。更に術前化学療法で病理学的完全反応(pCR)に至らない場合は極めて予後不良である。京都大学にてCDDP含有術前化学療法を行った症例におけるEvent-free survivalは、pCR有無に関わらず同等であり、pCRによって大きな差が認められた非CDDP症例と対照的であった。non pCR症例においてもCDDPが何らかの再発抑制効果持続(NK活性)に寄与していいる可能性が示唆された。今後は免疫チェックポイント阻害剤などとの併用で更なる治療成績向上につなげていきたい。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (31 results)

All 2019 2018 2017 2016

All Journal Article (12 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 7 results) Presentation (19 results) (of which Int'l Joint Research: 10 results)

  • [Journal Article] Patients' preferences for postmenopausal hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer treatments in Japan2019

    • Author(s)
      Omori Y, Enatsu S, Cai Z, Ishiguro H
    • Journal Title

      Breast Cancer

      Volume: Epub ahead of print Issue: 5 Pages: 0-0

    • DOI

      10.1007/s12282-019-00965-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pharmacogenomic-pharmacokinetic study of selective estrogen-receptor modulators with intra-patient dose escalation in breast cancer2019

    • Author(s)
      Ishiguro H, Ohno S, Yamamoto Y, Takao S, Sato N, Fujisawa T, Kadoya T, Kuroi K, Bando H, Teramura Y, Iwata H, Tanaka S, Toi M
    • Journal Title

      Breast Cancer

      Volume: Epub ahead of print Issue: 5 Pages: 0-0

    • DOI

      10.1007/s12282-019-00952-9

    • NAID

      120007133160

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Granulocyte-Colony Stimulating Factor Producing-Metaplastic Carcinoma of the Breast with Significant Elevation of Serum Interleukin-17 and Vascular Endothelial Growth Factor Levels: A Case Report2018

    • Author(s)
      Fukui Y, Kawashima M, Kawaguchi K, Takeuchi M, Hirata M , Kataoka TR, Sakurai T, Masako Kataoka M, Kanao S, Nakamoto Y, Hirata K, Yoshimura M, Yoshikawa K, Ishiguro H, Toi M
    • Journal Title

      Int Canc Conf J

      Volume: 7(3) Issue: 3 Pages: 107-13

    • DOI

      10.1007/s13691-018-0330-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Costs associated with febrile neutropenia in Japanese patients with primary breast cancer: post-hoc analysis of a randomized clinical trial2018

    • Author(s)
      Miyake O, Murata K, Tanaka S, Ishiguro H, Toi M, Tamura K, Kawakami K
    • Journal Title

      Jpn J Clin Oncol

      Volume: 48(5) Issue: 5 Pages: 410-6

    • DOI

      10.1093/jjco/hyy030

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phase I dose-finding study of eribulin and capecitabine for metastatic breast cancer: JBCRG-18 cape study2018

    • Author(s)
      Hattori M, Ishiguro H, Masuda N, Yoshimura A, Ohtani S, Yasojima H, Morita S, Ohno S, Iwata H
    • Journal Title

      Breast Cancer

      Volume: 25(1) Issue: 1 Pages: 108-17

    • DOI

      10.1007/s12282-017-0798-4

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cross-over Mixed Analysis in a Convergent Mixed Methods Design Used to Investigate Clinical Dialogues about Cancer Treatment in the Japanese Context2018

    • Author(s)
      Hatta T, Narita K, Yanagihara K, Ishiguro H, Murayama T, Yokode M
    • Journal Title

      J Mix Methods Res

      Volume: Epub ahead of print Issue: 1 Pages: 0-0

    • DOI

      10.1177/1558689818792793

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Effects of Cryotherapy on Objective and Subjective Symptoms of Paclitaxel-Induced Neuropathy: Prospective Self-Controlled Trial2017

    • Author(s)
      Hanai A、Ishiguro H、Sozu T、Tsuda M、Yano I、Nakagawa T、Imai S、Hamabe Y、Toi M、Arai H、Tsuboyama T
    • Journal Title

      JNCI: Journal of the National Cancer Institute

      Volume: 110 Issue: 2 Pages: 141-148

    • DOI

      10.1093/jnci/djx178

    • NAID

      120006353851

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A phase I/II pharmacokinetics/pharmacodynamics study of irinotecan combined with S-1 for recurrent/metastatic breast cancer in patients with selected UGT1A1 genotypes (the JBCRG-M01 study).2017

    • Author(s)
      Ishiguro H, Saji S, Nomura S, Tanaka S, Ueno T, Onoue M, Iwata H, Yamanaka T, Sasaki Y, Toi M.
    • Journal Title

      Cancer Med.

      Volume: - Issue: 12 Pages: 1258-1258

    • DOI

      10.1002/cam4.1258

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of dose timing on the blood concentration of lapatinib in patients with breast cancer2017

    • Author(s)
      Ohgami M, Bando H, Ishiguro H, Tsuda M, Toriguchi N, Aogi K, Toi M, Masuda N, Mitsuhashi S, Kurosawa A, Homma M
    • Journal Title

      Ann Oncol

      Volume: 28 Issue: 11 Pages: 2888-2889

    • DOI

      10.1093/annonc/mdx328

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] A randomized phase II study of <i>nab</i>-paclitaxel as first-line chemotherapy in patients with HER2-negative metastatic breast cancer2017

    • Author(s)
      Tamura K,Inoue K, Masuda N,Takao S, Kashiwaba M,Tokuda Y,Iwata H,Yamamoto N, Aogi K,Saeki T, Nakayama T,Sato N,Toyama T,Ishida T, Arioka H, Saito M,Ono S, Yamauchi H, Yamada K, Watanabe J,Ishiguro H,Fujiwara Y
    • Journal Title

      Cancer Science

      Volume: 印刷中 Issue: 5 Pages: 987-994

    • DOI

      10.1111/cas.13221

    • NAID

      120006333899

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The lack of increases in circulating endothelial progenitor cell as a negative predictor for pathological response to neoadjuvant chemotherapy in breast cancer patients.2017

    • Author(s)
      Sunao Tanaka, Takayuki Ueno, Hiroshi Ishiguro, Satoshi Morita & Masakazu Toi
    • Journal Title

      npj Precision Oncology

      Volume: 1 Issue: 1 Pages: 6-6

    • DOI

      10.1038/s41698-017-0006-1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 薬物療法マネージメントのこつ 用量非依存性の薬剤有害反応2016

    • Author(s)
      古武 剛、石黒 洋
    • Journal Title

      CANCER BOARD of the BREAST

      Volume: 2 Pages: 117-120

    • NAID

      40021086738

    • Related Report
      2016 Research-status Report
  • [Presentation] Prospective Observational Cohort Study of Real World Chemotherapy Sequence for Metastatic Breast Cancer (KBCRN A001: E-SPEC Study)2018

    • Author(s)
      Nakatsukasa K, Kikawa Y, Kotake T, Yamagami K, Tsuyuki S, Yamashiro H, Suwa H, Sugie T, Okuno T, Kato H, Takahara S, Nakayama I, Ogura N, Moriguchi Y, Takada M, Suzuki E, Yoshibayashi H, Ishiguro H, Taguchi T, Toi M
    • Organizer
      ESMO 2018 Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Therapeutic drug monitoring of lapatinib for assessing lapatinib-induced skin rash in patients with breast cancer2018

    • Author(s)
      Ogami M, Bando H, Ishiguro H, Tsuda M, Toriguchi N, Masuda N, Toi M, Mitsuhashi S, Kurosawa A, Homma M
    • Organizer
      International Association of Therapeutic Drug Monitoring and Clinical Toxicology Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of steroid ointment application on chemotherapy-induced phlebitis: A randomized, double-blind, placebo-controlled clinical trial2017

    • Author(s)
      Hamabe Y, Hanai A, Ishiguro H, Hirota M, Kuroda T, Nomura M, Ishikawa H, Muto M
    • Organizer
      ESMO Asia 2017 Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Phase 2 study of Pembrolizumab for metastatic triple-negative breast cancer (mTNBC): Japanese Subgroup Results of KEYNOTE 0862017

    • Author(s)
      Hattori M, Tamura K, Mukai H, Miyoshi Y, Masuda N, Suzuki E, Ishiguro H, Ohtani S, Hara F, Shimamoto T, Yamamoto K, Ding Yu, Aktan G, Karantza V, Iwata H
    • Organizer
      ESMO Asia 2017 Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Effects of Frozen Gloves and Socks on Paclitaxel-Induced Peripheral Neuropathy Among Patients with Breast Cancer: A Self-Controlled Clinical Trial.2017

    • Author(s)
      Hanai A,Ishiguro H,Sozu T,Tsuda M,Yano I,Nakagawa T,Imai S,Hamabe Y,Toi M,Arai H,Tsuboyama T
    • Organizer
      The 15th International Symposium of Training Plan for Oncology Professiona
    • Place of Presentation
      Sheraton Osaka
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cisplatin based preoperative chemotherapy regimens for basal-like breast cancer potentially improve prognosis even in patients without pCR: A retrospective analysis from a single-institution2016

    • Author(s)
      Yamaguchi A,Ishiguro H,Torii M,Takada M,Suzuki E,Takeuchi M,Sato F,Toi M
    • Organizer
      ESMO Asia 2016
    • Place of Presentation
      Suntec Singapore Convention &Exhibition Center
    • Year and Date
      2016-12-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of mathematical prediction models to indentify disease-free survival events for HER2-positive primary breast cancer patients treated by neoadjuvant chemotherapy and trastuzumab2016

    • Author(s)
      Takada M,Sugimoto M,Masuda N,Iwata H,Kuroi K,Yamashiro H,Ohno S,Ishiguro H,Inamoto T,Toi M
    • Organizer
      SanAntonio Breast Cancer Symposium 2016
    • Place of Presentation
      Henry B Gonzales Convention Center
    • Year and Date
      2016-12-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Duration of fasting before taking lapatinib is associated with skin toxicity in neoadjuvant treatment of HER2 positive breast cancer : A cohort study from JBCRG-16/Neo-LaTH2016

    • Author(s)
      Tsuda M,Ishiguro H,Toriguchi N,Masuda N,Bando H,Ohgami M,Homma M,Morita S,Yamamoto N,Kuroi K,Takano T,Shimizu S,Toi M
    • Organizer
      SanAntonio Breast Cancer Symposium 2016
    • Place of Presentation
      Henry B Gonzales Convention Center
    • Year and Date
      2016-12-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラパチニブの血中濃度に及ぼす服用タイミングとタモキシフェン併用の影響(第2報)2016

    • Author(s)
      大神 正宏、坂東 裕子、石黒 洋、鳥口 尚子、津田 萌、戸井 雅和、増田 慎三、三橋 彰一、黒澤 豊彦、本間 真人
    • Organizer
      第37回日本臨床薬理学会学術総会
    • Place of Presentation
      米子コンベンションセンター/米子市文化ホール
    • Year and Date
      2016-12-01
    • Related Report
      2016 Research-status Report
  • [Presentation] Increase in circulating endothelial progenitor cells as a predictor of pCR in breast cancer patients2016

    • Author(s)
      Tanaka S,Ueno T,Ishiguro H, Toi M
    • Organizer
      ABCC2016
    • Place of Presentation
      Tokyo International Forum / Hinohara hall, St. Luke's International University
    • Year and Date
      2016-10-08
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Phase I/II pharmacokinetics/pharmacodynamics study of irinotecan and S-1 for recurrent/metastatic breast cancer in patients with select UGT1A1 genotypes (The JBCRG-M01 study)2016

    • Author(s)
      Saji S,Ishiguro H,Nomura S,Iwata H,Tanaka S,Ueno T,Onoue M,Yamanaka T,Sasaki Y,Toi M
    • Organizer
      ESMO2016 Cngress
    • Place of Presentation
      Medizinische Ausstellungs- und Werbegesellschaft International Exhibitions & Advertising
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 内分泌療法or殺細胞性抗がん剤治療?-閉経後Luminal B乳癌症例における術前薬物療法を新規抗がん薬臨床開発の観点から考える-2016

    • Author(s)
      石黒 洋
    • Organizer
      第14回日本臨床腫瘍学会学術集会
    • Place of Presentation
      神戸国際展示場/神戸国際会議場
    • Year and Date
      2016-07-28
    • Related Report
      2016 Research-status Report
  • [Presentation] セルフマネジメント(マッサージ・体操・排泄姿勢)による制吐剤起因性便秘の予防: 乳癌化学療法患者に対するランダム化比較試験2016

    • Author(s)
      華井 明子、石黒 洋
    • Organizer
      第14回日本臨床腫瘍学会学術集会
    • Place of Presentation
      神戸国際展示場/神戸国際会議場
    • Year and Date
      2016-07-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 日本人乳癌患者におけるオランザピン(アプレピタント非併用) の化学療法誘発性悪心嘔吐抑制効果2016

    • Author(s)
      西村 友美 、石黒 洋 、中木村 朋美 、福井 由紀子 、前川 佳奈 、 仁尾 万里華 、山口 絢音、中山 美恵 、林 雪 、古武 剛 、 矢内 勢司 、松本 純明 、高田 正泰 、竹内 恵、鈴木 栄治 、 佐藤 史顕 、戸井 雅和
    • Organizer
      第24回日本乳癌学会学術総会
    • Place of Presentation
      東京ビックサイト
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 乳腺間質肉腫の2例2016

    • Author(s)
      矢内 勢司、松本 純弘、古武 剛、林 雪、高田 正泰、鈴木 栄治、竹内 恵、石黒 洋、佐藤 史顕、戸井 雅和
    • Organizer
      第24回日本乳癌学会学術総会
    • Place of Presentation
      東京ビックサイト
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report
  • [Presentation] ラパチニブの血中濃度に及ぼす 服用タイミングとタモキシフェン併用の影響2016

    • Author(s)
      大神 正宏,坂東 裕子,石黒 洋 ,鳥口 尚子,津田 萌,戸井 雅和,増田 慎三,武井 敬司 ,本間 真人
    • Organizer
      第33回日本TDM学会・学術大会
    • Place of Presentation
      栃木県総合文化センター
    • Year and Date
      2016-05-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 乳癌術前薬物療法後の乳房温存手術の現状と問題点HER2陽性乳癌の術前療法後の局所療法個別化を目指した治療効果予測ツール開発と今後の課題2016

    • Author(s)
      高田 正泰、杉本 昌弘、増田 慎三、岩田 広治、黒井 克昌、山城大泰、大野 真司、石黒 洋、稲本 俊、戸井 雅和
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場/リーガロイヤルホテル大阪
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 化学療法誘発性末梢神経障害に対する局所冷却の効果の検討2016

    • Author(s)
      華井 明子、石黒 洋、寒水 孝司、津田 萌、中川 貴之、今井 哲司、浜辺 陽子、戸井 雅和、荒井 秀典、坪山 直生
    • Organizer
      コ・メディカル形態機能学会第15回学術集会
    • Place of Presentation
      京都大学医学部構内 芝蘭会館
    • Related Report
      2016 Research-status Report
  • [Presentation] Cisplatin based preoperative chemotherapy regimens for basal-like breast cancer improve prognosis even in patients without pCR: A retrospective analysis from a single-institution2016

    • Author(s)
      Ayane Yamaguchi, Hiroshi Ishiguro, Masae Torii, Masahiro Takada, Eiji Suzuki, Megumi Takeuchi, Fumiaki Sato, Masakazu To
    • Organizer
      第 72 回 京滋乳癌研究会
    • Place of Presentation
      京都大学医学部構内 芝蘭会館
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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