| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Infliximab (IFX) is a monoclonal antibody exerting the therapeutic effect for Crohn’s disease (CD). We examined an association study of 162 tag single nucleotide polymorphisms in 32 candidate genes with response to IFX at the 10-weeks or 1-year period of treatment for Japanese 127 CD patients, identifying 6 and 9 IFX-responsibility genes at the 10-weeks and 1-year period, respectively.
Multivariate analyses and genetic tests revealed that the best combination of polymorphisms of TRAF2 and TLR2 is useful as a biomarker for identifying responders to IFX at the 10-weeks period of treatment. Likewise, a combination of polymorphisms of CD40, P2RX7, and CASP1 is most suitable for identifying responders at the 1-year period of treatment against CD patients.
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