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Comprehensive study to establish preventive measures for the physical effects in elderly lung cancer patients

Research Project

Project/Area Number 16K08915
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied pharmacology
Research InstitutionOsaka City University

Principal Investigator

Kimura Tatsuo  大阪市立大学, 大学院医学研究科, 准教授 (50382049)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords肺癌 / スクリーニング / システム / 健診 / バイオバンク / COPD / 高齢者肺癌 / 副作用 / 副作用対策 / 健常人検体 / 薬理学 / 医薬品副作用 / 薬物相互作用 / 高齢者医療 / 癌化学療法
Outline of Final Research Achievements

A case registration system and a sample collection system were constructed at the Department of Respiratory Medicine, Osaka City University Hospital. When data is input from the ward / laboratory using IPAD, data is stored on the server. In cooperation with the division of laboratory, we have prepared plasma and Buffy coat and stored at -80 degrees. We also perform plasma preservation of consent cases in MedCity21 medical examination. These were submitted to the 2019 American Society of Clinical Oncology and reported to the Journal of “Ningen Dock”. This system is also used for COPD patients published at the journal of “Lung”, and a multicenter clinical trial using this system is also published “Jpn J Clin Oncol”.

Academic Significance and Societal Importance of the Research Achievements

病院における症例登録システムの構築、及び、検体採取システムの構築は、全ての研究の土台となり大変意義があります。臨床研究を行う場合、個々の症例を個人がデータを集めるのには大変な労力と時間がかかります。それらを一元管理できることにより大幅に研究環境が改善します。病院における疾患症例、及び未病状態から疾患初期の健診症例を比較検討できるようになりました。今回の研究成果としてはこれらの構築なくしてはあり得ません。今後もこのシステムを用いた研究を行っていく予定です。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2019 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Phase I/II study of intermitted erlotinib in combination with docetaxel in patients with recurrent non-small cell lung cancer (WJOG4708L).2019

    • Author(s)
      Kimura T, Kawaguchi T, Chiba Y, Yoshioka H, Watanabe K, Kijima T, Kogure Y, Oguri T, Yoshimura N, Niwa T, Kasai T, Hayashi H, Ono A, Asai K, Tanaka H, Yano S, Yamamoto N, Nakanishi Y, Nakagawa K
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 49 Issue: 10 Pages: 947-955

    • DOI

      10.1093/jjco/hyz088

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A polymorphism rs6726395 in Nrf2 contributes to the development of emphysema associated age in smokers without COPD2019

    • Author(s)
      Sugitani A, Asai K, Watanabe T, Suzumura T, Kojima K, Kubo H, Sato K, Ijiri N, Yamada K, Kimura T, Fukumoto S, Hirata K, Kawaguchi T.
    • Journal Title

      Lung

      Volume: 197 Issue: 5 Pages: 559-564

    • DOI

      10.1007/s00408-019-00251-2

    • NAID

      120006876369

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2020091

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Current Status and Future Prospects for System Calling Examinees to Have Further Lung Cancer Screening2017

    • Author(s)
      木村 達郎
    • Journal Title

      Official Journal of Japan Society of Ningen Dock

      Volume: 31 Issue: 5 Pages: 661-667

    • DOI

      10.11320/ningendock.31.661

    • NAID

      130006896810

    • ISSN
      1880-1021, 2186-5027
    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 胸部要精密検査判定と呼び出しシステムの活用 リピーター解析2019

    • Author(s)
      木村 達郎, 福本 真也, 森川 浩安, 中野 朱美, 大谷 恒史, 田内 幸枝, 上村 理沙, 河田 則文
    • Organizer
      第60回日本人間ドック学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Nrf2 Polymorphisms Contributes to Emphysema in Healthy Smokers2019

    • Author(s)
      Sugitani A, Asai K, Miyamoto A, Kojima K, Kubo H, Kyoumoto Y, Kawamoto T, Yoshida S, Okamoto A, Satou K, Yamada K, Ijiri N, Watanabe T, Tochino Y, Kanazawa H, Kimura T, Fukumoto S, Hirata K, Kawaguchi T
    • Organizer
      American Thoracic Society 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Annual lung cancer screening by chest x-ray results in higher profits for the exclusion of lung cancer.2019

    • Author(s)
      T Kimura, S Fukumoto, H Morikawa, A Nakano, K Otani, Y Tauchi, R Uemura, T Suzumura, K Ogawa, T Kawaguchi, N Kawada
    • Organizer
      2019 ASCO Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胸部要精密検査判定と呼び出しシステムの活用:3年目の解析2018

    • Author(s)
      木村 達郎
    • Organizer
      第59回 日本人間ドック学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 大学病院附属人間ドック施設における肺癌診断率の検討2017

    • Author(s)
      木村 達郎
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 胸部要精密検査判定の現況と呼び出しシステム の活用2017

    • Author(s)
      木村 達郎
    • Organizer
      第15 回日本臨床腫瘍学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 胸部要精密検査判定と呼び出しシステムの活用:2年目の解析2017

    • Author(s)
      木村 達郎
    • Organizer
      第58回日本人間ドック学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 大学病院附属人間ドック施設における胸部D2判定の現況と課題2016

    • Author(s)
      木村 達郎
    • Organizer
      第56回日本人間ドック学会学術大会
    • Place of Presentation
      まつもと市民芸術館(長野県 松本市)
    • Year and Date
      2016-07-30
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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