| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Though ionizing irradiation enhances cancer cell malignancy, its mechanism is unclear. In this study, to reveal the therapeutic target suppressing irradiation-induced malignancy of cancer cells, we investigated the mechanism of irradiation-induced migration of cancer cells. We here revealed that ion channels or receptors expressed in cell membrane such as TRPV1 channels play an important role in radiation-induced migration of cancer cells. In future study, we will further investigate appropriate target in cancer radiotherapy.
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