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Development of a novel insulin resistance index that is minimally affected by hepatic insulin clearance

Research Project

Project/Area Number 16K08935
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionTottori University

Principal Investigator

OKURA Tsuyoshi  鳥取大学, 医学部, 講師 (80510073)

Research Collaborator FUJIOKA Yohei  
NAKAMURA Risa  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsインスリン抵抗性 / 2型糖尿病 / インスリン抵抗性指標 / 糖尿病
Outline of Final Research Achievements

Increased hepatic insulin clearance (HIC) is important in the pathophysiology of type 2 diabetes mellitus (T2DM). The aim of this study is to analyze an effective insulin resistance (IR) index that is minimally affected by HIC. Our study involved 20 participants with T2DM and 21 healthy participants without diabetes (Non-DM). Participants underwent a meal tolerance test from which HOMA-IR and HIC were calculated. Participants then underwent a glucose clamp from which the glucose disposal rate (GDR) was measured. The index CPR-IR = 20/(fasting CPR × fasting plasma glucose) was correlated more strongly with GDR, than was HOMA-IR, and CPR-IR could be used to estimate GDR. In T2DM participants with HIC below the median, HOMA-IR and CPR-IR were equally well correlated with GDR. In T2DM with high HIC, CPR-IR correlated with GDR while HOMA-IR did not. CPR-IR could be a simple and effective index of insulin resistance for patients with type 2 diabetes that is minimally affected by HIC.

Academic Significance and Societal Importance of the Research Achievements

インスリン抵抗性の評価方法はグルコースクランプ法が最も精密であるが、2時間以上かかる検査であり、簡便にインスリン抵抗性を評価する方法が必要である。これまで血中インスリン値を用いたHOMA-IRが頻用されてきたが、その信頼性に疑問が生じる症例がある事が問題であった。本研究ではその原因が肝臓におけるインスリンの分解によるものであり、この影響を受けない我々が開発した血中Cペプチドを用いたCPR-IRが有効であることを報告した。本研究により、糖尿病診療や臨床研究に有効な指標が確認され、学術的、社会的にも貢献したと考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] CPR-IR is an insulin resistance index that is minimally affected by hepatic insulin clearance?A preliminary research2018

    • Author(s)
      Okura Tsuyoshi、Nakamura Risa、Fujioka Yohei、Kawamoto-Kitao Sonoko、Ito Yuichi、Matsumoto Kazuhisa、Shoji Kyoko、Sumi Keisuke、Matsuzawa Kazuhiko、Izawa Shoichiro、Ueta Etsuko、Kato Masahiko、Imamura Takeshi、Taniguchi Shin-ichi、Yamamoto Kazuhiro
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 5 Pages: 0197663-0197663

    • DOI

      10.1371/journal.pone.0197663

    • NAID

      120007146977

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Body mass index ?23 is a risk factor for insulin resistance and diabetes in Japanese people: A brief report2018

    • Author(s)
      Okura Tsuyoshi、Nakamura Risa、Fujioka Yohei、Kawamoto-Kitao Sonoko、Ito Yuichi、Matsumoto Kazuhisa、Shoji Kyoko、Sumi Keisuke、Matsuzawa Kazuhiko、Izawa Shoichiro、Ueta Etsuko、Kato Masahiko、Imamura Takeshi、Taniguchi Shin-ichi、Yamamoto Kazuhiro
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 7 Pages: 0201052-0201052

    • DOI

      10.1371/journal.pone.0201052

    • NAID

      120007146974

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 肝インスリン分解の影響を受けにくい新規インスリン抵抗性指標CPR‐IRの開発2018

    • Author(s)
      大倉毅
    • Journal Title

      Bio Clinica

      Volume: 33

    • Related Report
      2018 Annual Research Report
  • [Journal Article] グルコースクランプ法を用いた新規インスリン抵抗性指標の開発2018

    • Author(s)
      大倉毅
    • Journal Title

      Bio Clinica

      Volume: 31 Pages: 466-468

    • Related Report
      2018 Annual Research Report
  • [Journal Article] High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report2017

    • Author(s)
      Okura Tsuyoshi、Ueta Etsuko、Nakamura Risa、Fujioka Yohei、Sumi Keisuke、Matsumoto Kazuhisa、Shoji Kyoko、Matsuzawa Kazuhiko、Izawa Shoichiro、Nomi Yuri、Mihara Hitomi、Otsuka Yuzuru、Kato Masahiko、Taniguchi Shin-ichi、Yamamoto Kazuhiro
    • Journal Title

      Journal of Diabetes Research

      Volume: 2017 Pages: 1-7

    • DOI

      10.1155/2017/5139750

    • NAID

      120007146981

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum fatty acid-binding protein 4 (FABP4) concentration is associated with insulin resistance in peripheral tissues, A clinical study.2017

    • Author(s)
      Nakamura R, Okura T, Fujioka Y, Sumi K, Matsuzawa K, Izawa S, Ueta E, Kato M, Taniguchi SI, Yamamoto K.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 6 Pages: e0179737-e0179737

    • DOI

      10.1371/journal.pone.0179737

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High serum advanced glycation end products are associated with decreased insulin secretion in patients with type 2 diabetes2017

    • Author(s)
      Tsuyoshi Okura, Etsuko Ueta, Risa Nakamura, Yohei Fujioka, Keisuke Sumi, Kazuhisa matsumoto, Kyoko Shoji, Kazuhiko Matsuzawa, Shoichiro Izawa, Yuri Nomi, Hitomi Mihara, Yuzuru Otsuka, Masahiko Kato, Shin-ichi Taniguchi, Kazuhiro Yamamoto
    • Journal Title

      Journal of Diabetes Research

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 2型糖尿病における新規インスリン抵抗性指標の開発2016

    • Author(s)
      大倉 毅
    • Journal Title

      BIO Clinica

      Volume: 31 Pages: 87-89

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Presentation] 肝インスリン分解に影響する因子の検討2018

    • Author(s)
      大倉 毅、藤岡 洋平、中村 理沙、谷口 晋一、山本 一博
    • Organizer
      第5回肝臓と糖尿病・代謝研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Hepatic Insulin Clearance Is Increased in the Patients with Poorly Controlled Type 2 Diabetes2018

    • Author(s)
      Okura T, Annno M, Ito Y
    • Organizer
      American Diabetes Association 78th Scientific Sessions
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肝インスリン分解の影響を受けにくい血中Cペプチドを用いた新規インスリン抵抗性指標の開発2016

    • Author(s)
      大倉 毅, 藤岡 洋平, 中西 理沙, 角 啓佑, 松本 和久,庄司 恭子, 松澤 和彦, 伊澤 正一郎, 加藤 雅彦, 谷口 晋一, 山本 一博
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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