Development of diagnostic methods in interstitial pneumonia via surface markers of macophages
| Project/Area Number |
16K08940
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 間質性肺炎 / 慢性閉塞性肺疾患 / 単球 / 表面マーカー / マクロファージ / CD206 / 単球マーカー / 診断マーカー |
|---|
| Outline of Final Research Achievements |
We determined whether cellular phenotypes on circulating monocytes could be helpful for discriminating IPF from idiopathic nonspecific interstitial pneumonia (iNSIP). Using flowcytometer, we found that S100A9+CD163- cell rates in classical monocytes were significantly increased in IPF relative to iNSIP, and yielded the independent association with IPF in multivariate regression analyses and a receiver operating characteristic-area under the curve of 0.838 (95% CI [0.715-0.961], p < 0.0001) for the diagnoses. In addition, he ratio yielded a ROC-AUC value of 0.719 (95% CI = 0.567-0.871) for discrimination between smokers with normal lung functions and COPD patients. Our results demonstrated increased pro-inflammatory phenotypes in circulating classical monocytes in IPF and COPD, providing novel insights to elucidate their roles in the pathogenesis of these conditions.
|
| Academic Significance and Societal Importance of the Research Achievements |
特発性間質性肺炎診断の補助診断として有用である。また喫煙者における早期COPD診断の補助診断に使用できる。
|
Report
(5 results)
Research Products
(24 results)
-
-
-
-
-
-
-
[Journal Article] The protective role of protein L-isoaspartyl (D-aspartate) O-methyltransferase for maintenance of mitochondrial morphology in A549 cell.2016
Author(s)
Ogasawara M, Otani M, Takano M, Shudou M, Inaba Y, Nirasawa S, Takahashi S, Kiyoi T, Tanaka Y, Kameda K, Kunugita N, Maeyama K, Sano K, Yamashita M, Yamauchi K.
-
Journal Title
Exp Lung Res.
Volume: 42
Pages: 245-62
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] Chaperone protein l-isoaspartate (d-aspartyl) O-methyltransferase as a novel predictor of poor prognosis in lung adenocarcinoma.2016
Author(s)
Saito H, Yamashita M, Ogasawara M, Yamada N, Niisato M, Tomoyasu M, Deguchi H, Tanita T, Ishida K, Sugai T, Yamauchi K.
-
Journal Title
Hum Pathol
Volume: 50
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
