| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We determined whether cellular phenotypes on circulating monocytes could be helpful for discriminating IPF from idiopathic nonspecific interstitial pneumonia (iNSIP). Using flowcytometer, we found that S100A9+CD163- cell rates in classical monocytes were significantly increased in IPF relative to iNSIP, and yielded the independent association with IPF in multivariate regression analyses and a receiver operating characteristic-area under the curve of 0.838 (95% CI [0.715-0.961], p < 0.0001) for the diagnoses. In addition, he ratio yielded a ROC-AUC value of 0.719 (95% CI = 0.567-0.871) for discrimination between smokers with normal lung functions and COPD patients. Our results demonstrated increased pro-inflammatory phenotypes in circulating classical monocytes in IPF and COPD, providing novel insights to elucidate their roles in the pathogenesis of these conditions.
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