Perspective biological makers for autism spectrum disorders: focus on essential amino acid and its metabolites.
| Project/Area Number |
16K08948
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kansai Medical University (2019-2020)
Doshisha University (2016-2018) |
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Principal Investigator |
MURAKAMI Yuki 関西医科大学, 医学部, 助教 (50580106)
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| Project Period (FY) |
2016-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 自閉スペクトラム症 / アミノ酸代謝 / 炎症 / トリプトファン / 神経発達症 / キヌレニン / 行動異常 / 母体環境 / 母胎環境 / 脳・神経 / トリプトファン代謝 / 自閉症スペクトラム症 |
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| Outline of Final Research Achievements |
Autism spectrum disorder (ASD) is one of the most common neurodevelopmental disorders. The diagnosis for ASD is often challenging because these diagnostic approaches are less objective and time consuming. Thus, an appropriate diagnosis needs to consider the applicability of the diagnostic approach. We measured the levels of kynurenine pathway(KP) metabolites in the serum of ASD models mice to assess the potential of KP metabolites as predictive peripheral biomarkers for neurodevelopmental disorders. We found genetical ASD model mice showed drastic changes in KP metabolite concentrations. We also found maternal inflammation dramatically changed KP metabolites in maternal serum, pointing to the ability of kynurenine to cross the placenta and change the KP metabolites which are affected as neuroactive compounds in the fetal brain. Our results suggested that KP metabolites are potential diagnostic biomarkers for neurodevelopmental disorders.
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| Academic Significance and Societal Importance of the Research Achievements |
自閉スペクトラム症（ASD）は神経発達症の一つで、生涯に渡って続く障害である。診断方法は専門的な医師による面接や保護者からの発育状態の聞き取りなど行動観察によるところが大きく、客観的診断マーカーはほとんど明らかにされていない。本研究の成果は、必須アミノ酸という重要な栄養素とその代謝産物がASDの病態に関与している可能性と、それらの測定が診断マーカーとして有用である可能性を示したことである。
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Report
(6 results)
Research Products
(21 results)
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[Journal Article] Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes.2018
Author(s)
A Sobue, N Ito, T Nagai, W Shan, K Hada, Nakajima A, Y Murakami, A Mouri, Y Yamamoto, T Nabeshima, K Saito, K Yamada
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Journal Title
Glia
Volume: 66
Issue: 5
Pages: 1034-52
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Effect of Histone Acetylation on N-Methyl-D-Aspartate 2B Receptor Subunits and Interleukin-1 Receptors in Association with Nociception-Related Somatosensory Cortex Dysfunction in A Mouse Model of Sepsis2016
Author(s)
Yukio Imamura, Nao Yoshikawa, Yuki Murkami, Satoko Mitani, Naoya Matsumoto,Hisatake Matsumoto, Tomoki Yamada, Kazuma Yamakawa, Junichiro Nakagawa, Hiroshi Ogura, Takeshi Shimazu, Takashi Jin
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Journal Title
Shock
Volume: 45(6)
Issue: 6
Pages: 660-667
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1.2016
Author(s)
Murakami Y, Ishibashi T, Tomita E, Imamura Y, Tashiro T, Watcharanurak K, Nishikawa M, Takahashi Y, Takakura Y, Mitani S, Fujigaki H, Ohta Y, Kubo H, Mamiya T, Nabeshima T, Kim HC, Yamamoto Y, Saito K.
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Journal Title
SCIENTIFIC REPORTS
Volume: 6
Issue: 1
Pages: 29920-29920
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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