Development of novel strategy to stratify the risk of thyroid cancer with type II arginase gene which exhibites tumor suppressive effects
| Project/Area Number |
16K08971
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Shimura Hiroki 福島県立医科大学, 医学部, 教授 (40303416)
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| Co-Investigator(Kenkyū-buntansha) |
伊藤 祐子 福島県立医科大学, 医学部, 助手 (60402038)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 甲状腺癌 / アルギナーゼ / TTF-1 / Nkx2-1 / apoptosis / necrosis / arginase / ARG2 / Ⅱ型アルギナーゼ |
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| Outline of Final Research Achievements |
Currently, concerns about overdiagnosis of thyroid cancer are increasing worldwide, and accurate risk assessment for determining treatment plan for thyroid cancer is required. In this study, we observed the expression of the type II arginase (ARG2) gene is dramatically increased by introducing the transcription factor TTF-1 (Nkx2-1) gene into thyroid cancer cells in which the diminished TTF-1 gene expression, which is important for thyroid development and function. We found that the ARG2 gene was involved in at least a part of thyroid cancer cell death induction by TTF-1 gene. These suggested that the assessment of ARG2 gene expression level could be one of the methods to evaluate the severity and prognosis of thyroid cancer.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により，早期甲状腺癌の分子生物学的なリスク評価が可能となり，甲状腺癌の治療方針決定においても，現在乳癌等において行われている遺伝子検査による治療方針決定が甲状腺癌においても実現可能となり，世界的に過剰診療が憂慮されている甲状腺癌の診療に寄与するものと考えられる。さらなる研究により，福島県における甲状腺検査において甲状腺癌と診断される県民に対し，より正確なリスク評価に基づく診療を提供することにも寄与できるのではないかと考えられる。
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Report
(4 results)
Research Products
(67 results)
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[Journal Article] Incidence of Thyroid Cancer Among Children and Young Adults in Fukushima, Japan, Screened With 2 Rounds of Ultrasonograrhy Within 5 Years of the 2011 Fukushima Daiichi Nuclesr Power Station Accident.2018
Author(s)
Ohtsuru Akira, Midorikawa Sanae, Ohira Tetsuya, Suzuki S, Takahashi Hideto, Murakami M, Shimura Hiroki, Matsuzuka Takashi, Yasumura Seiji, Suzuki SI, Yokoya S, Hashimoto Y, Sakai A, Ohto Hitoshi, Yamashita Shunichi, Tanigawa K, Kamiya Kenji
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Journal Title
JAMA Otolaryngol Head Neck Surg.
Volume: 145-1
Issue: 1
Pages: 4-11
DOI
Related Report
Peer Reviewed
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[Journal Article] Spatial analysis of the geographical distribution of thyroid cancer cases from the first-round thyroid ultrasound examination inFukushima Prefecture.2018
Author(s)
Nakaya T, Takahashi Kunihiko, Takahashi Hideto, Yasumura Seiji, Ohira Tetsuya, Ohto Hitoshi, Ohtsuru Akira, Midorikawa Sanae, Suzuki S, Shimura Hiroki, Yamashita Shunichi, Tanigawa K, Kamiya Kenji
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Journal Title
Sci Rep.
Volume: 8-1
Issue: 1
Pages: 17661-17661
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparison of childfood thyroid cancer prevalence among 3 areas based on external radiation dose after the Fukushima Daiichi nuclear power plant accident: The Fukushima health management survey.2016
Author(s)
Ohira Tetsuya, Takahashi Hidedo, Yasumura Seiji, Ohtsuru Akira, Midorikawa Sanae, Suzuki Satoru, Fukushima Toshihiko, Shimura Hiroki, Ishikawa Tetsuo, Sakai Akira, Yamashita Shunichi, Tanigawa Koichi, Ohto Hitoshi, Abe Masafumi, Suzuki Shinichi; Fukushima Health Management Survey Group.
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Journal Title
Medicine(Baltimore).
Volume: 95(35)
Issue: 35
Pages: e4472-e4472
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Inappropriate Suppression of Thyrotropin Cocentrations in Young Patients with Thyroid Nodules Including Throid Cancer: The Fukushima Health Management Survey.2016
Author(s)
Suzuki S, Nakamura I, Suzuki S, Ohkouchi C, Mizunuma H, Midorikawa S, Fukushima T, Ito Y, Shimura H, Ohira T, Matsuzaka T Ohtsuru A, Abe M Yamashita S, Suzuki S.
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Journal Title
Thyroid
Volume: 26(5)
Issue: 5
Pages: 717-725
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Comprehensive survey results of childhood thyroid ultrasound examinations in Fukushima in the first four years after the Fukushima Daiichi Nuclear Power Plant accident.2016
Author(s)
Suzuki S, Suzuki S, Fukushima T, Midorikawa S, Shimura H, Matsuzaka T, Ishikawa T, Takahashi H, Ohtsuru A, Sakai A, Hosoya M, Yasumura S, Nollet KE, Ohira T, Ohto H, Abe M, Kamiya K, Yamashita S.
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Journal Title
Thyroid.
Volume: 26(6)
Issue: 6
Pages: 843-851
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 経皮的心房中隔閉鎖術後の体表面心エコー評価の重要性2018
Author(s)
遠藤由美子, 堀越裕子, 鈴木智世, 佐藤ゆかり, 佐久間信子, 羽田良子, 山寺幸雄, 志村浩己, 小林淳, 及川雅啓, 國井浩行, 竹石恭知
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第27回ふくしま心エコー研究会
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[Presentation] ハンズオンセミナー2018
Author(s)
國井 葉, 志村 浩己, 古川 まどか, 宮川 めぐみ, 北川 亘, 福島 光浩, 中野 恵一, 福原 隆宏, 中野 賢英
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第51回日本甲状腺外科学会学術集会
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Author(s)
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第61回日本甲状腺学会学術集会
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[Presentation] イクオリン化学発光を用いたバイオアッセイ法で測定するTSAbによるバセドウ病の診断2018
Author(s)
村上司, 野口仁志, 檜垣直幸, 廣松雄治, 江口洋幸, 谷淳一, 竹島健, 麻生好正, 鈴木國弘, 長坂昌一郎, 大塚史子, 齋藤淳, 志村浩己, 伊藤祐子, 鈴木悟, 荒木直比呂
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第61回日本甲状腺学会学術集会
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[Presentation] 福島県県民健康調査「甲状腺検査」先行検査の二次検査受診者における甲状腺自己抗体と甲状腺機能との関係2017
Author(s)
志村 浩己, 鈴木 悟, 福島 俊彦, 緑川 早苗, 松塚 崇, 伊藤 祐子, 大平 哲也, 阿部 正文, 大津留 晶, 鈴木 眞一, 山下 俊一
Organizer
第90回日本内分泌学会学術総会
Place of Presentation
ロームシアター京都, みやこめっせ
Year and Date
2017-04-20
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[Presentation] Age and gender distribution of thyroid nodular lesions found in thyroid ultrasound examination within three years after the nuclear accident: The Fukushima Health Management Survey.2017
Author(s)
Hiroki Shimura, Tomotaka Sobue, Hideto Takahashi, Seiji Yasumura, Tetsuya Ohira, Akira Ohtsuru, Sanae Midorikawa, Satoru Suzuki, Toshihiko Fukushima, Shinichi Suzuki, Hitoshi Ohto, Shunichi Yamashita
Organizer
87th Annual Meeting of the American Thyroid Association
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[Presentation] 福島県県民健康調査「甲状腺検査」の先行検査における甲状腺嚢胞と結節の性別および年齢階層別疫学的特徴2017
Author(s)
志村浩己, 祖父江友孝, 緑川早苗, 鈴木悟, 福島俊彦, 松塚崇, 高橋秀人, 安村誠司, 大平哲也, 大戸斉, 大津留晶, 鈴木眞一, 山下俊一
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[Presentation] 福島県県民健康調査「甲状腺検査」先行検査の二次検査受診者における甲状腺自己抗体と甲状腺機能との関係2017
Author(s)
志村浩己, 鈴木悟, 福島俊彦, 緑川早苗, 松塚崇, 伊藤祐子, 大平哲也, 阿部正文, 大津留晶, 鈴木眞一, 山下俊一
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第90回日本内分泌学会学術総会
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