| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Supernumerary small marker chromosomes (SMC), which are small excess chromosomes, are chromosomal abnormalities that occur relatively frequently. In this study, structural analyses of marker chromosomes were performed using next-generation sequencing and comparative genomic hybridizations, and the origins and breakpoints of marker chromosomes were examined. As a result, it was presumed that the marker chromosome has not only simple cleavage and binding but also a complicated structure due to various developmental mechanisms such as DNA replication and chromothripsis.
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