|Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|Outline of Final Research Achievements
It was confirmed that WAS in NC/Nga mice reduced the number of NK cells in peripheral blood and affected the expression of opioid receptors in the brain: expression of opioid mu receptors was promoted and that of opioid kappa receptors was reduced. Thus, it appeared that CRF regulated these changes in receptor expression. After WAS, the number of NK cells in the blood decreased, and this was correlated with the appearance of eczematous lesions. These results suggest that CRF may have future therapeutic application for targeting NK cells.