| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Outline of Final Research Achievements |
Musculoskeletal disorders such as neck-shoulder stiffness and low back pain are one of chronic symptoms that many people suffer from. It has been reported that patients with chronic pain may also have cardiovascular dysfunctions such as orthostatic hypotension. The present study aimed to elucidate plastic change of cardiovascular response to skeletal muscle pain and its neural mechanisms, particularly focusing on inflammation which is related to pain chronicity.
Experiments were performed on anesthetized rats. To induce inflammation in skeletal muscles, carrageenan solution was intramuscularly injected a day before experiment. Pressure stimulation applied to rat's calf altered heart rate and blood pressure. When pressure stimulation was applied to an inflamed calf, increases in heart rate and blood pressure were exaggerated. Additionally, the contribution of cardiac sympathetic efferent nerves to such cardiovascular responses was suggested.
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