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Establishment of Intracranial-Condition Monitoring Method for Clinical Practice using Gravity MRI

Research Project

Project/Area Number 16K09013
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical Physics and Radiological Technology
Research InstitutionKanazawa University

Principal Investigator

Miyati Tosiaki  金沢大学, 保健学系, 教授 (80324086)

Co-Investigator(Kenkyū-buntansha) 間瀬 光人  名古屋市立大学, 大学院医学研究科, 教授 (60238920)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords磁気共鳴画像(MRI) / 頭蓋内環境 / 脳 / 重力 / 物性
Outline of Final Research Achievements

In this study, to noninvasively monitor the regulation and biomechanics of the brain, and to apply those in medicine, we developed a gravity magnetic resonance imaging (MRI). We assessed the gravity compensation function and the regional deformation of the brain by changing the patient position (eg; upright, supine, and head down tilt; supine and prone; and right and left lateral) using the gravity MRI system. The gravity MRI made it possible to noninvasively obtain more detailed information on the regulation function and biomechanics of the brain.

Academic Significance and Societal Importance of the Research Achievements

人類が地球上で生活する限り人体は必然的に重力の影響を受けるため,重力が脳に及ぼす形態の変化や生理的な作用は,座位,臥位などの体位によって異なる.そこで脳が体位変換時に重力によって変位変形や機能変化が生じることを利用して,磁気共鳴イメージング(MRI)検査時に体位を変えて,脳の恒常性及び組織物性の情報(例えば脳血流や頭蓋内圧の代償能や脳自体の固さ)を取得することに成功した.このグラビティMRIの手法によって,脳の恒常性や組織物性の変化が関係する病態の解明が可能になると予想される.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (25 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (6 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 12 results,  Invited: 1 results) Remarks (2 results)

  • [Int'l Joint Research] University of Miami(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Universit de Picardie Jules Verne(フランス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] マイアミ大学(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] ピカルディ・ジュール・ヴェルヌ大学(フランス)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] マイアミ大学(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] ピカルディ・ジュール・ヴェルヌ大学(フランス)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Hemodynamically self-corrected ΔADC analysis in idiopathic normal pressure hydrocephalus2019

    • Author(s)
      Takatsuji-Nagaso M, Miyati T, Ohno N, Mase M, Kasai H, Shibamoto Y, Kobayashi S, Gabata T, Kitagawa K
    • Journal Title

      Br J Radiol

      Volume: 27

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time-spatial Labeling Inversion Pulse (Time-SLIP) with Pencil Beam Pulse: A Selective Labeling Technique for Observing Cerebrospinal Fluid Flow Dynamics2018

    • Author(s)
      Shibukawa S, Miyati T, Niwa T, Matsumae M, Ogino T, Horie T, Imai Y, Muro I
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 17 Issue: 3 Pages: 259-264

    • DOI

      10.2463/mrms.tn.2017-0032

    • NAID

      130007403771

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MRI-based assessment of acute effect of head-down tilt position on intracranial hemodynamics and hydrodynamics2018

    • Author(s)
      Ishida S, Miyati T, Ohno N, Hiratsuka S, Alperin N, Mase M, Gabata T
    • Journal Title

      J Magn Reson Imaging

      Volume: 47 Issue: 2 Pages: 565-571

    • DOI

      10.1002/jmri.25781

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a Cranial Phantom for Assessing Perfusion, Diffusion, and Biomechanics2017

    • Author(s)
      Ohno N, Miyati T, Chigusa T, Usui H, Ishida S, Hiramatsu Y, Kobayashi S, Gabata T, Alperin N
    • Journal Title

      Medical Physics

      Volume: in press Issue: 5 Pages: 1646-1654

    • DOI

      10.1002/mp.12182

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Modified Triexponential Analysis of Intravoxel Incoherent Motion for Brain Perfusion and Diffusion2016

    • Author(s)
      Ohno N, Miyati T, Kobayashi S, Gabata T
    • Journal Title

      J Magn Reson Imaging

      Volume: 43 Issue: 4 Pages: 818-823

    • DOI

      10.1002/jmri.25048

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] The effect of respiration on apparent diffusion coefficient of the brain2018

    • Author(s)
      Ohno N, Miyati T, Hiramatsu Y, Shimizu R, Mase M, Kobayashi S, Gabata T
    • Organizer
      ISMRM 26th Scientific Meeting and Exhibition
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic ADC analysis of the brain in the supine and upright postures2018

    • Author(s)
      Ohno N, Miyati T, Uehara M, Hiramatsu Y, Okamoto R, Mase M, Kobayashi S, Gabata T
    • Organizer
      104th RSNA Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Monitoring of Intracranial Hydrodynamic and Biomechanical Properties Using MRI2017

    • Author(s)
      Miyati T
    • Organizer
      NeuroTalk 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Optimal strategy for measuring intraventricular temperature using second-order motion compensation DWI2017

    • Author(s)
      Shibukawa S, Niwa T, Ohno N, Miyati T, Horie T, Takano S, Kajihara N, Saito T, Ogino T, Imai Y
    • Organizer
      ISMRM 25th Scientific Meeting and Exhibition
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dynamic ADC change during cardiac cycle in human brain in sleep state2017

    • Author(s)
      Yamamori R, Miyati T, Ohno N, Hiramatsu Y, Kurita T, Miki S, Sekiya A, Hoshina Y, Gabata T
    • Organizer
      ISMRM 25th Scientific Meeting and Exhibition
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of sleep state on ADC change during cardiac cycle in human brain2017

    • Author(s)
      Hiramatsu Y, Miyati T, Yamamori R, Ohno N, Kurita T, Miki S, Sekiya A, Hoshina Y, Gabata T
    • Organizer
      103rd RSNA Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Apparent diffusion coefficient in brain is affected by respiration2017

    • Author(s)
      Hiramatsu Y, Miyati T, Ohno N, Mase M, Kobayashi S, Gabata T
    • Organizer
      103rd RSNA Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Water turnover in brain, ventricles and subarachoid spaces in normal volunteers and patients with idiopathic NPH: dynamic pet study using H215O2017

    • Author(s)
      Mase M, Hayashi E, Yamada H, Oshima N, Aoyama K, Hibino S, Ito Y, Iida A, Miyati T, Mori E
    • Organizer
      Hydrocephalus 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Self-correction of blood flow effect for fluctuation MRI in idiopathic normal pressure hydrocephalus2016

    • Author(s)
      Ohno N, Miyati T, Takatsuji M, Mase M, Osawa T, Kan H, Shibamoto Y, Gabata T
    • Organizer
      102nd RSNA Meeting
    • Place of Presentation
      McCormick Place(米国)
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Change in ADC during cardiac cycle in idiopathic normal pressure hydrocephalus decreases with shunt surgery2016

    • Author(s)
      Yamamori R, Miyati T, Ohno N, Mase M, Osawa T, Ishida S, Kasai H, Shibamoto Y
    • Organizer
      102nd RSNA Meeting
    • Place of Presentation
      McCormick Place(米国)
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Acceleration motion compensation DWI for measuring intraventricular temperature2016

    • Author(s)
      Shibukawa S, Miyati T, Ohno N, Niwa T, Imai Y, Ogino T, Muro I
    • Organizer
      ISMRM 24th Scientific Meeting and Exhibition
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre(シンガポール)
    • Year and Date
      2016-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantification of the effect of head-down tilt posture on intracranial condition using MRI2016

    • Author(s)
      Ohno N, Miyati T, Hiratsuka S, Ishida S, Alperin N, Kobayashi S, Gabata T
    • Organizer
      ISMRM 24th Scientific Meeting and Exhibition
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre(シンガポール)
    • Year and Date
      2016-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Remarks] Miyati Laboratory / ACHIVEMENT

    • URL

      http://miyatilab.w3.kanazawa-u.ac.jp/publications/index.htm

    • Related Report
      2018 Annual Research Report
  • [Remarks] Miyati Laboratory

    • URL

      http://miyatilab.w3.kanazawa-u.ac.jp/publications/index.htm

    • Related Report
      2017 Research-status Report 2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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