Establishment of Intracranial-Condition Monitoring Method for Clinical Practice using Gravity MRI

• Project/Area Number: 16K09013
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Kanazawa University
• Principal Investigator: Miyati Tosiaki 金沢大学, 保健学系, 教授 (80324086)
• Co-Investigator(Kenkyū-buntansha): 間瀬 光人 名古屋市立大学, 大学院医学研究科, 教授 (60238920)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 磁気共鳴画像（MRI） / 頭蓋内環境 / 脳 / 重力 / 物性

Outline of Final Research Achievements

In this study, to noninvasively monitor the regulation and biomechanics of the brain, and to apply those in medicine, we developed a gravity magnetic resonance imaging (MRI). We assessed the gravity compensation function and the regional deformation of the brain by changing the patient position (eg; upright, supine, and head down tilt; supine and prone; and right and left lateral) using the gravity MRI system. The gravity MRI made it possible to noninvasively obtain more detailed information on the regulation function and biomechanics of the brain.

Academic Significance and Societal Importance of the Research Achievements

人類が地球上で生活する限り人体は必然的に重力の影響を受けるため，重力が脳に及ぼす形態の変化や生理的な作用は，座位，臥位などの体位によって異なる．そこで脳が体位変換時に重力によって変位変形や機能変化が生じることを利用して，磁気共鳴イメージング（MRI）検査時に体位を変えて，脳の恒常性及び組織物性の情報（例えば脳血流や頭蓋内圧の代償能や脳自体の固さ）を取得することに成功した．このグラビティMRIの手法によって，脳の恒常性や組織物性の変化が関係する病態の解明が可能になると予想される．

Research Products

• [Int'l Joint Research] University of Miami(米国)
• [Int'l Joint Research] Universit de Picardie Jules Verne(フランス)
• [Int'l Joint Research] マイアミ大学(米国)
• [Int'l Joint Research] ピカルディ・ジュール・ヴェルヌ大学(フランス)
• [Int'l Joint Research] マイアミ大学(米国)
• [Int'l Joint Research] ピカルディ・ジュール・ヴェルヌ大学(フランス)
• [Journal Article] Hemodynamically self-corrected ΔADC analysis in idiopathic normal pressure hydrocephalus (2019)
  • Author(s): Takatsuji-Nagaso M, Miyati T, Ohno N, Mase M, Kasai H, Shibamoto Y, Kobayashi S, Gabata T, Kitagawa K
  • Journal Title: Br J Radiol Volume: 27
  • Peer Reviewed
• [Journal Article] Time-spatial Labeling Inversion Pulse (Time-SLIP) with Pencil Beam Pulse: A Selective Labeling Technique for Observing Cerebrospinal Fluid Flow Dynamics (2018)
  • Author(s): Shibukawa S, Miyati T, Niwa T, Matsumae M, Ogino T, Horie T, Imai Y, Muro I
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 17 Issue: 3 Pages: 259-264
  • DOI: 10.2463/mrms.tn.2017-0032
  • NAID: 130007403771
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MRI-based assessment of acute effect of head-down tilt position on intracranial hemodynamics and hydrodynamics (2018)
  • Author(s): Ishida S, Miyati T, Ohno N, Hiratsuka S, Alperin N, Mase M, Gabata T
  • Journal Title: J Magn Reson Imaging Volume: 47 Issue: 2 Pages: 565-571
  • DOI: 10.1002/jmri.25781
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of a Cranial Phantom for Assessing Perfusion, Diffusion, and Biomechanics (2017)
  • Author(s): Ohno N, Miyati T, Chigusa T, Usui H, Ishida S, Hiramatsu Y, Kobayashi S, Gabata T, Alperin N
  • Journal Title: Medical Physics Volume: in press Issue: 5 Pages: 1646-1654
  • DOI: 10.1002/mp.12182
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Modified Triexponential Analysis of Intravoxel Incoherent Motion for Brain Perfusion and Diffusion (2016)
  • Author(s): Ohno N, Miyati T, Kobayashi S, Gabata T
  • Journal Title: J Magn Reson Imaging Volume: 43 Issue: 4 Pages: 818-823
  • DOI: 10.1002/jmri.25048
  • Peer Reviewed
• [Presentation] The effect of respiration on apparent diffusion coefficient of the brain (2018)
  • Author(s): Ohno N, Miyati T, Hiramatsu Y, Shimizu R, Mase M, Kobayashi S, Gabata T
  • Organizer: ISMRM 26th Scientific Meeting and Exhibition
  • Int'l Joint Research
• [Presentation] Dynamic ADC analysis of the brain in the supine and upright postures (2018)
  • Author(s): Ohno N, Miyati T, Uehara M, Hiramatsu Y, Okamoto R, Mase M, Kobayashi S, Gabata T
  • Organizer: 104th RSNA Meeting
  • Int'l Joint Research
• [Presentation] Monitoring of Intracranial Hydrodynamic and Biomechanical Properties Using MRI (2017)
  • Author(s): Miyati T
  • Organizer: NeuroTalk 2017
  • Int'l Joint Research / Invited
• [Presentation] Optimal strategy for measuring intraventricular temperature using second-order motion compensation DWI (2017)
  • Author(s): Shibukawa S, Niwa T, Ohno N, Miyati T, Horie T, Takano S, Kajihara N, Saito T, Ogino T, Imai Y
  • Organizer: ISMRM 25th Scientific Meeting and Exhibition
  • Int'l Joint Research
• [Presentation] Dynamic ADC change during cardiac cycle in human brain in sleep state (2017)
  • Author(s): Yamamori R, Miyati T, Ohno N, Hiramatsu Y, Kurita T, Miki S, Sekiya A, Hoshina Y, Gabata T
  • Organizer: ISMRM 25th Scientific Meeting and Exhibition
  • Int'l Joint Research
• [Presentation] Effect of sleep state on ADC change during cardiac cycle in human brain (2017)
  • Author(s): Hiramatsu Y, Miyati T, Yamamori R, Ohno N, Kurita T, Miki S, Sekiya A, Hoshina Y, Gabata T
  • Organizer: 103rd RSNA Meeting
  • Int'l Joint Research
• [Presentation] Apparent diffusion coefficient in brain is affected by respiration (2017)
  • Author(s): Hiramatsu Y, Miyati T, Ohno N, Mase M, Kobayashi S, Gabata T
  • Organizer: 103rd RSNA Meeting
  • Int'l Joint Research
• [Presentation] Water turnover in brain, ventricles and subarachoid spaces in normal volunteers and patients with idiopathic NPH: dynamic pet study using H215O (2017)
  • Author(s): Mase M, Hayashi E, Yamada H, Oshima N, Aoyama K, Hibino S, Ito Y, Iida A, Miyati T, Mori E
  • Organizer: Hydrocephalus 2017
  • Int'l Joint Research
• [Presentation] Self-correction of blood flow effect for fluctuation MRI in idiopathic normal pressure hydrocephalus (2016)
  • Author(s): Ohno N, Miyati T, Takatsuji M, Mase M, Osawa T, Kan H, Shibamoto Y, Gabata T
  • Organizer: 102nd RSNA Meeting
  • Place of Presentation: McCormick Place（米国）
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] Change in ADC during cardiac cycle in idiopathic normal pressure hydrocephalus decreases with shunt surgery (2016)
  • Author(s): Yamamori R, Miyati T, Ohno N, Mase M, Osawa T, Ishida S, Kasai H, Shibamoto Y
  • Organizer: 102nd RSNA Meeting
  • Place of Presentation: McCormick Place（米国）
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] Acceleration motion compensation DWI for measuring intraventricular temperature (2016)
  • Author(s): Shibukawa S, Miyati T, Ohno N, Niwa T, Imai Y, Ogino T, Muro I
  • Organizer: ISMRM 24th Scientific Meeting and Exhibition
  • Place of Presentation: Suntec Singapore Convention & Exhibition Centre（シンガポール）
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Quantification of the effect of head-down tilt posture on intracranial condition using MRI (2016)
  • Author(s): Ohno N, Miyati T, Hiratsuka S, Ishida S, Alperin N, Kobayashi S, Gabata T
  • Organizer: ISMRM 24th Scientific Meeting and Exhibition
  • Place of Presentation: Suntec Singapore Convention & Exhibition Centre（シンガポール）
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Remarks] Miyati Laboratory / ACHIVEMENT
  • URL: http://miyatilab.w3.kanazawa-u.ac.jp/publications/index.htm
• [Remarks] Miyati Laboratory
  • URL: http://miyatilab.w3.kanazawa-u.ac.jp/publications/index.htm