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Fundamental study for the substance identified in photon counting mammography

Research Project

Project/Area Number 16K09015
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical Physics and Radiological Technology
Research InstitutionKyoto College of Medical Science (2017-2018)
Nagoya University (2016)

Principal Investigator

Kodera Yoshie  京都医療科学大学, 医療科学部, 研究員 (10124794)

Co-Investigator(Kenkyū-buntansha) 小山 修司  名古屋大学, 脳とこころの研究センター, 准教授 (20242878)
西出 裕子  岐阜医療科学大学, 保健科学部, 准教授 (80635730)
Research Collaborator Mizutani Mitsuhiro  
Watanabe Megumi  
Yoshida Naoko  
Yamamoto Shuichiro  
Hashimoto Daisuke  
Okada Masahiro  
Nakajima Ai  
Sasaki Mariko  
Suzuki Reina  
Kimura Hiroto  
Project Period (FY) 2016-10-21 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsフォトンカウンティング技術 / マンモグラフィ / 物質同定 / 実効原子番号 / コントラスト対雑音比 / 被曝低減 / ディジタルマンモグラフィ / 実効原子番号画像 / 乳腺含有率 / dense breast / フォトンカウンティング / X線 / 画像 / 癌 / 細胞・組織
Outline of Final Research Achievements

In analog systems, high contrast images are necessary to identify breast cancer. However, in the digital system, high CNR (contrast-to-noise ratio) is required. A novel energy-resolved photon-counting mammography (ERPCM) is being developed using a cadmium zinc telluride detector. The purpose of this study is to examine whether to obtain the higher CNR image using higher tube voltage, and is to create a novel fusion medical image of anatomy and physics, and explore the clinical meaning of this image. It was suggested that there is the usefulness of using high tube voltage for thicker and dense breast. On the scatterplots, it could discriminate the tumor values from normal tissue values for each case by a case. And on the fusion images, by coloring to around 20% from the top of the scatter points, the tumors on the images which the same part was diagnosed as a tumor were colored.

Academic Significance and Societal Importance of the Research Achievements

連続スペクトルを持つX線のスペクトル情報の利用は、多くの医療関係者の望むところであり、現在種々の研究開発が行われているが、いまだその最終目的は達成されていない。本研究は、独自の解析方法を用いることで精度よく生体内の物質の同定に成功し、その可視化も実現している。今後、本手法を用いることで、これまでにはない新たな生体情報の取得が可能になり、画像診断の可能性の大きく広がることが期待できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (32 results)

All 2019 2018 2017 2016

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results) Presentation (25 results) (of which Int'l Joint Research: 14 results,  Invited: 1 results)

  • [Journal Article] A novel mammographic fusion imaging technique: the first results of tumor tissues detection from resected breast tissues using energy-resolved photon counting detector2019

    • Author(s)
      Mariko Sasaki, Shuji Koyama, Yoshie Kodera, Reina Suzuki, Hiroto Kimura, Hiroto Nishide, Mitsuhiro Mizutani, Megumi Watanabe, Naoko Yoshida, Hiroaki Hayashi, Natsumi Kimoto, Shuichiro Yamamoto, Daisuke Hashimoto, Masahiro Okada
    • Journal Title

      Proc. SPIE, Medical Imaging 2019: Physics of Medical Imaging

      Volume: 10948 Pages: 3-3

    • DOI

      10.1117/12.2512271

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Physical image properties of a complementary metal-oxide-semiconductor imager for mammography systems2018

    • Author(s)
      Chizuru Okamoto, Yoshie Kodera
    • Journal Title

      Radiological Physics and Technology

      Volume: 11 Issue: 3 Pages: 284-293

    • DOI

      10.1007/s12194-018-0465-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exposure Parameters and Average Glandular Dose in a Digital Mammography System in Japan2018

    • Author(s)
      Hiroko Nishide, Kouji Ohta, Kaori Murata, Yoshie Kodera, Kazuhiro Shimamoto
    • Journal Title

      J. Med. Imaging Health Inf

      Volume: 8 Issue: 5 Pages: 1030-1034

    • DOI

      10.1166/jmihi.2018.2417

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of breast tissue using the x-ray image measured with an energy-resolved cadmium telluride series detector based on photon-counting technique2018

    • Author(s)
      Mariko Sasaki, Shuji Koyama, Yoshie Kodera, Reina Suzuki, Ai Nakajima, Hiroko Nishide, Mitsuhiro Mizutani, Megumi Watanabe, Naoko Yoshida, Hiroaki Hayashi, Tsutomu Yamakawa, Shuichiro Yamamoto, Daisuke Hashimoto, Masahiro Okada
    • Journal Title

      Proc. SPIE, 14th International Workshop on Breast Imaging (IWBI 2018)

      Volume: 10718 Pages: 17-17

    • DOI

      10.1117/12.2317819

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Development of energy-resolved photon-counting mammography with a cadmium telluride series detector to reduce radiation exposure and increase contrast-to-noise ratio using the high-energy X-rays2018

    • Author(s)
      Reina Suzuki, Shuji Koyama, Yoshie Kodera, Ai Nakajima, Mariko Sasaki, Hiroto Kimura, Hiroaki Hayashi, Tsutomu Yamakawa, Shuichiro Yamamoto, Daisuke Hashimoto, Masahiro Okada
    • Journal Title

      Proc. SPIE, 14th International Workshop on Breast Imaging (IWBI 2018)

      Volume: 10718 Pages: 16-16

    • DOI

      10.1117/12.2317813

    • Related Report
      2018 Annual Research Report
  • [Journal Article] A proposed new image display method with high contrast-to-noise ratio using energy resolved photon-counting mammography with a CdTe series detector2018

    • Author(s)
      R. Suzuki; A. Nakajima; M. Sasaki; Y. Kodera; Y. Iida; F. Ito; Y. Koshiba; T. Yamakawa; S. Yamamoto; M. Okada; D. Hashimoto; S. Koyama
    • Journal Title

      Proc. SPIE 10573, Medical Imaging 2018: Physics of Medical Imaging

      Volume: 10573 Pages: 206-206

    • DOI

      10.1117/12.2292871

    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Journal Article] Detection of microcalcifications and tumor tissue in mammography using a CdTe-series photon-counting detector2017

    • Author(s)
      Ai Nakajima; Akiko Ihori; Hiroko Nishide; Shuji Koyama; Tsutomu Yamakawa; Shuichiro Yamamoto; Masahiro Okada; Yoshie Kodera
    • Journal Title

      Proc. SPIE 10132, Medical Imaging 2017: Physics of Medical Imaging

      Volume: 10132 Pages: 1013247-1013247

    • DOI

      10.1117/12.2253576

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] A novel mammographic fusion imaging technique: the first results of tumor tissues detection from resected breast tissues using energy-resolved photon counting detector2019

    • Author(s)
      Mariko Sasaki, Shuji Koyama, Yoshie Kodera, Reina Suzuki, Hiroto Kimura, Hiroto Nishide, Mitsuhiro Mizutani, Megumi Watanabe, Naoko Yoshida, Hiroaki Hayashi, Natsumi Kimoto, Shuichiro Yamamoto, Daisuke Hashimoto, Masahiro Okada
    • Organizer
      SPIE Medical Imaging, 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel mammographic substance discrimination technique with fusion imaging: Initial results of detection of breast cancer from resected breast tissues by energy-resolved photon counting detector2019

    • Author(s)
      Mariko Sasaki, Shuji Koyama, Yoshie Kodera, Hiroko Nishide, Mitsuhiro Mizutani, Megumi Watanaba, Naoko Yoshida, Hiroaki Hayashi, Shuichiro Yamamoto
    • Organizer
      European Congress of Radiology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Usefulness of high-energy X-ray imaging using novel energy-resolved photon-counting mammography: Contrast-to-noise ratio assessment in simulation study2019

    • Author(s)
      Reina Suzuki, Shuji Koyama, Yoshie Kodera, Mariko Sasaki, Hiroto Kimura, Shuichiro Yamamoto, Daisuke Hashimoto, Masahiro Okada
    • Organizer
      European Congress of Radiology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Image Evaluation of Photon-counting Mammography in High-Energy Band of Mammography2018

    • Author(s)
      Reina Suzuki, Mariko Sasaki, Yoshie Kodera, Tsutomu Yamakawa, Shuichiro Yamamoto, Masahiro Okada, Shuji Koyama
    • Organizer
      第74回日本放射線技術学会総会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Identification of breast tissue using the x-ray image measured with an energy-resolved cadmium telluride series detector based on photon-counting technique2018

    • Author(s)
      Mariko Sasaki, Shuji Koyama, Yoshie Kodera, Reina Suzuki, Ai Nakajima, Hiroko Nishide, Mitsuhiro Mizutani, Megumi Watanabe, Naoko Yoshida, Hiroaki Hayashi, Tsutomu Yamakawa, Shuichiro Yamamoto, Daisuke Hashimoto, Masahiro Okada
    • Organizer
      The Fourteenth International Workshop on Breast Imaging
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of energy-resolved photon-counting mammography with a cadmium telluride series detector to reduce radiation exposure and increase contrast-to-noise ratio using the high-energy X-rays2018

    • Author(s)
      Reina Suzuki, Shuji Koyama, Yoshie Kodera, Ai Nakajima, Mariko Sasaki, Hiroto Kimura, Hiroaki Hayashi, Tsutomu Yamakawa, Shuichiro Yamamoto, Daisuke Hashimoto, Masahiro Okada
    • Organizer
      The Fourteenth International Workshop on Breast Imaging
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] エネルギー弁別型フォトンカウンティングマンモグラフィ装置を用いた乳房組織鑑別の精度評価2018

    • Author(s)
      佐々木毬子,小山修司,小寺吉衞,西出裕子,水谷三浩,渡辺恵美,吉田直子,山本修一郎
    • Organizer
      第46回日本放射線技術学会秋季学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高濃度乳腺に対するエネルギー弁別型フォトンカウンティングマンモクグラフィ画像の撮影条件の検討2018

    • Author(s)
      鈴木怜奈,小山修司,小寺吉衞,佐々木毬子,木村浩都,山本修一郎,橋本大輔,岡田雅宏
    • Organizer
      第46回日本放射線技術学会秋季学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] エネルギー弁別型光子計数マンモグラフィにおける対象物の線束方向の位置の違いによる物質鑑別への影響2018

    • Author(s)
      木村浩都,小山修司,小寺吉衞,佐々木毬子,鈴木怜奈,山本修一郎,橋本大輔,岡田雅宏
    • Organizer
      第46回日本放射線技術学会秋季学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A proposed new image display method with high a contrast-to-noise ratio using energy-resolved photon-counting mammography with a CdTe-series detector2018

    • Author(s)
      Reina SUZUKI, Shuji KOYAMA, Yoshie KODERA, Ai NAKAJIMA, Mariko SASAKI, Yoko IIDA, Fukiko ITO, Yumiko KOSHIBA, Tsutomu YAMAKAWA, Shuichiro YAMAMOTO, Daisuke HASHIMOTO, Masahiro OKADA
    • Organizer
      SPIE Medical Imaging 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Study of substance identification and effective atomic number visualization in mammography using photon-counting technique2017

    • Author(s)
      Reina Suzuki, Shiori Tomida, Ai Nakajima, Akiko Ihori, Shuji Koyama, Tsutomu Yamakawa, Shuichiro Yamamoto, Masahiro Okada, Yoshie Kodera
    • Organizer
      31st International Congress and Exhibition on Computer Assisted Radiology (CAR)
    • Place of Presentation
      スペイン、バルセロナ
    • Year and Date
      2017-06-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Identification and differentiation of resected breast tissue specimens using a cadmium telluride series photon-counting X-ray detector2017

    • Author(s)
      Mariko Sasaki, Ai Nakajima, Akiko Ihori, Hiroko Nishide, Shuji Koyama, Tsutomu Yamakawa, Shuichiro. Yamamoto, Masahiro Okada, Mitsuhiro Mizutani, Yoshie Kodera
    • Organizer
      31st International Congress and Exhibition on Computer Assisted Radiology (CAR)
    • Place of Presentation
      スペイン、バルセロナ
    • Year and Date
      2017-06-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] A new imaging technique in mammography using a CdTe-series photon-counting detector2017

    • Author(s)
      Ai Nakajima, Reina Suzuki, Akiko Ihori, Shuji Koyama, Tsutomu Yamakawa, Shuichiro Yamamoto, Masahiro Okada, Yoshie Kodera
    • Organizer
      31st International Congress and Exhibition on Computer Assisted Radiology (CAR)
    • Place of Presentation
      スペイン、バルセロナ
    • Year and Date
      2017-06-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 鈴木怜奈、中嶋愛、井堀亜希子、小山修司、小寺吉衞2017

    • Author(s)
      鈴木怜奈、中嶋愛、井堀亜希子、小山修司、小寺吉衞
    • Organizer
      第73回日本放射線技術学会総会学術大会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2017-04-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Identification of resected breast specimens using X - ray spectrum with a cadmium telluride detector2017

    • Author(s)
      Mariko Sasaki, Akiko Ihori, Ai Nakajima,Tsutomu Yamakawa, Shuichiro Yamamoto, Masahiro Okada, Mitsuhiro Mizutani, Shuji Koyama, Yoshie Kodera
    • Organizer
      第73回日本放射線技術学会総会学術大会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2017-04-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Detection of microcalcifications and tumor tissue in mammography using a CdTe-series photon-counting detector2017

    • Author(s)
      Ai NAKAJIMA, Akiko IHORI, Hiroko NISHIDE, Shuji KOYAMA, Tsutomu YAMAKAWA, Shuichiro YAMAMOTO, Masahiro OKADA, Yoshie Kodera
    • Organizer
      SPIE 2017 MEDICAL IMAGING
    • Place of Presentation
      米国、フロリダ州、オーランド
    • Year and Date
      2017-02-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Identification of Resected Breast Specimens Using X-ray Spectrum with a Cadmium Telluride Detector2017

    • Author(s)
      Mariko Sasaki, Akiko Ihori, Shuji Koyama, Tsutomu Yamakawa, Shuichiro Yamamoto, Masahiro Okada, Yoshie Kodera
    • Organizer
      第73回日本放射線技術学会総会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] モンテカルロシミュレーションを用いた高エネルギー領域での入射光子数と 平均乳腺線量2017

    • Author(s)
      鈴木 怜奈,中嶋 愛, 井堀亜希子, 小山修司, 小寺吉衞
    • Organizer
      第73回日本放射線技術学会総会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Identification and differentiation of resected breast tissue specimens using a cadmium telluride series photon-counting X-ray detector2017

    • Author(s)
      Mariko Sasaki, Ai Nakajima, Akiko Ihori, Hiroko Nishide, Shuji Koyama, Tsutomu Yamakawa, Shuichiro Yamamoto, Masahiro Okada, Mitsuhiro Mizutani, Yoshie Kodera
    • Organizer
      CARS 2017 31th Computer assisted radiology and surgery, Barcelona, Spain
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Study of substance identification and effective atomic number visualization in mammography using photon-counting technique2017

    • Author(s)
      Suzuki Reina, Shiori Tomita, Ai Nakajima, Akiko Ihori, Shuji Koyama, Tsutomu Yamakawa, Shuichiro Yamamoto, Masahiro Okada, Yoshie Kodera
    • Organizer
      CARS 2017 31th Computer assisted radiology and surgery, Barcelona, Spain
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A new imaging technique in mammography using a CdTe-series photon-counting detector2017

    • Author(s)
      Ai Nakajima, Reina Suzuki, Akiko Ihori, Shuji Koyama, Tsutomu Yamakawa, Shuichiro Yamamoto, Masahiro Okada, Yoshie Kodera
    • Organizer
      CARS 2017 31th Computer assisted radiology and surgery, Barcelona, Spain
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] CdTe系エネルギー分解型フォトンカウンティング検出器を用いたマンモグラフィ装置の物理評価2017

    • Author(s)
      佐々木毬子,井堀亜希子,小寺吉衞,山河勉,山本修一郎,岡田雅宏,橋本大輔,小山修司
    • Organizer
      第45回日本放射線技術学会秋季学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] エネルギー分解型CdTe系検出器を用いた新しいフォトンカウンティングマンモグラフィの評価2017

    • Author(s)
      鈴木怜奈, 中嶋愛, 小寺吉衞, 山河勉, 山本修一郎, 岡田雅宏, 橋本大輔, 小山修司
    • Organizer
      第45回日本放射線技術学会秋季学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Vision for mammography in the digital era2017

    • Author(s)
      Yoshie Kodera
    • Organizer
      17th Asia Oceania Congress of Medical Physics (AOCMP) and 38th Annual Conference of Association of Medical Physicists of India (AMPICON) 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] CdTe 系フォトンカウンティング検出器を用いたマンモグラフィ装置開発における微小石灰化と腫瘍組織検出の検討2016

    • Author(s)
      小寺吉衞, 中嶋愛 , 井堀亜希子, 西出裕子, 小山修司, 山河勉, 山本修一郎, 岡田雅宏
    • Organizer
      第26回日本乳癌検診学会学術総会
    • Place of Presentation
      福岡県久留米市
    • Year and Date
      2016-11-04
    • Related Report
      2016 Research-status Report

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Published: 2016-10-24   Modified: 2020-03-30  

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