| Project/Area Number |
16K09024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
阿部 香代子 東京女子医科大学, 医学部, 准講師 (00318049)
中島 振一郎 慶應義塾大学, 医学部(信濃町), 助教 (60383866)
稲田 健 東京女子医科大学, 医学部, 准教授 (90365164)
河野 仁彦 東京女子医科大学, 医学部, 助教 (00646747)
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| Project Period (FY) |
2016-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 統合失調症 / MRS / GABA / グルタミン酸 / 1H-MRS / 脳神経疾患 / 放射線診断技術学 |
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| Outline of Final Research Achievements |
The purpose of this study was to measure the concentrations of glutamate, GABA, and other metabolites in the anterior cingulate cortex (ACC) using 1H-magnetic resonance spectroscopy (MRS) in schizophrenic patients and normal subjects and to compare the results between the two groups.The following results were obtained: 1) the accuracy of the MRS measurement of brain metabolites was stabilized using a variety of parameters; 2) the structure in the voxel was segmented into cerebrospinal cord, gray matter, and white matter, making it possible to calculate the cerebrospinal fluid ratio in the region of interest; 3) this cerebrospinal fluid ratio can be used to adjust the concentration of metabolites, which can be used to measure metabolites in the brain. (3) Using this cerebrospinal fluid ratio to adjust the concentration of metabolites made it possible to measure metabolites in the real body.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で撮影環境の安定性が強固となり、撮影から解析までのパイプラインを整えたことにより、今後統合失調症患者の脳内代謝産物の異常を明らかにすることができる。将来的には発症から難治化まで縦断的に、さらには疾患横断的に精神疾患の生化学的な病態の一側面を、本計測システムにより検証することができる。
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