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Study regarding the effects of biomarkers and advanced intensive cares on the survival among patients with out-of-hospital cardiac arrest

Research Project

Project/Area Number 16K09034
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionOsaka University

Principal Investigator

Kitamura Tetsuhisa  大阪大学, 医学系研究科, 助教 (30639810)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords救急医学 / 蘇生科学 / 院外心停止 / 臨床疫学 / 予後 / バイオマーカー / 救急 / 蘇生
Outline of Final Research Achievements

This study aimed to assess the effects of biomarkers and advanced intensive cares on the survival among patients with OHCA, and has been collected 8,721 OHCA patients from critical care medical centers in Osaka Prefecture between 2012 and 2016. In 1,516 adult patients with OHCA of cardiac origin who achieved return of spontaneous circulation (ROSC), the proportion of favorable neurological outcome (defined as cerebral performance category scale 1 or 2) decreased as the serum potassium level increased in the multivariable analysis (adjusted p for trend<0.001). In 2,894 adult patients with OHCA of non-traumatic origin who achieved ROSC, the proportions of 1-month survival with favorable neurological outcome were almost consistent, and there were no significant differences between the intra-aortic balloon pumping (IABP) use group and the non-IABP use group (adjusted odds ratio, 0.97; 95% confidence interval, 0.55-1.74) by using the propensity-score matched analysis.

Academic Significance and Societal Importance of the Research Achievements

院外心停止患者に対するバイオマーカーと高度集中治療に関する先行研究では、ガイドライン上で確立されるようなエビデンスは十分でなかった。本多施設共同前向きにおいて、高カリウム血症と院外心停止患者の予後との関係を明らかにした本解析は、院外心停止後転帰改善のための予後予測をつながり、病院搬送後の高度集中治療実施の可否などの基準を提案することができる。また、病院搬送後にIABPという循環補助デバイス導入が院外心停止患者の予後改善と明らかな関係は認められなかったことは、院外心停止患者への循環補助デバイスあり方に一石を投じ、心肺蘇生ガイドラインに貢献できるエビデンスと思われる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (35 results)

All 2019 2018 2017 2016

All Journal Article (27 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 27 results,  Open Access: 12 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results)

  • [Journal Article] Sex difference in receiving layperson cardiopulmonary resuscitation in paediatric out-of-hospital cardiac arrest: a nationwide cohort study in Japan2019

    • Author(s)
      Okubo M,* Matsuyama T,* Gibo K, Komukai S, Izawa J, Kiyohara K, Nishiyama C, Kiguchi T, Callaway CW, Iwami T, Kitamura T
    • Journal Title

      Journal of the American Heart Association

      Volume: 8(1) Issue: 1

    • DOI

      10.1161/jaha.118.010324

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Out-of-hospital cardiac arrest at home: a nationwide observation in Japan2019

    • Author(s)
      Kiyohara K, Nishiyama C, Matsuyama T, Sado J, Kitamura T, Shimamoto T, Kobayashi D, Kiguchi T, Okabayashi S, Kawamura T, Iwami T
    • Journal Title

      The American Journal of Cardiology

      Volume: 123(7) Issue: 7 Pages: 1060-1068

    • DOI

      10.1016/j.amjcard.2018.12.038

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pre-hospital advanced airway management for adult patients with out-of-hospital cardiac arrest: a nationwide cohort study2019

    • Author(s)
      Izawa J, Komukai S, Gibo K, Okubo M, Kiyohara K, Nishiyama C, Kiguchi T, Matsuyama T, Kawamura T, Iwami T, Callaway CW, Kitamura T
    • Journal Title

      The BMJ

      Volume: 364 Pages: l430-l430

    • DOI

      10.1136/bmj.l430

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Timing of advanced airway management by emergency medical services personnel following out-of-hospital cardiac arrest: a population-based cohort study2018

    • Author(s)
      Izawa J, Iwami T, Gibo K, Okubo M, Kajino K, Kiyohara K, Nishiyama C, Nishiuchi T, Hayashi Y, Kiguchi T, Kobayashi D, Komukai S, Kawamura T, Callaway CW, Kitamura T
    • Journal Title

      Resuscitation

      Volume: 128(7) Pages: 16-23

    • DOI

      10.1016/j.resuscitation.2018.04.024

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The profile of Japanese Association for Acute Medicine out-of-hospital cardiac arrest registry in 2014-20152018

    • Author(s)
      Kitamura T, Iwami T, Atsumi T, Endo T, Kanna T, Kuroda Y, Sakurai A, Tasaki O, Tahara Y, Tsuruta R, Tomio J, Nakata K, Nachi S, Hase M, Hayakawa M, Hiruma T, Hiasa K, Muguruma T, Yano T, Shimazu Y, Morimura N
    • Journal Title

      Acute Medicine & Surgery

      Volume: 5(3) Issue: 3 Pages: 249-258

    • DOI

      10.1002/ams2.340

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ten-Year Trends of Public-Access Defibrillation in Japanese School-Aged Patients Having Neurologically Favorable Survival After Out-of-Hospital Cardiac Arrest2018

    • Author(s)
      Kiyohara Kosuke、Nitta Masahiko、Sato Yasuto、Kojimahara Noriko、Yamaguchi Naohito、Iwami Taku、Kitamura Tetsuhisa
    • Journal Title

      The American Journal of Cardiology

      Volume: 122 Issue: 5 Pages: 890-897

    • DOI

      10.1016/j.amjcard.2018.05.021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of the 11-year nationwide trend of elderly patients with out-of-hospital cardiac arrest cases in Japan (2005-2015)2018

    • Author(s)
      Matsuyama T, Kitamura T, Kiyohara K, Kiguchi T, Kobayashi D, Nishiyama C, Iwami T, Ota B
    • Journal Title

      Resuscitation

      Volume: 131(10) Pages: 83-90

    • DOI

      10.1016/j.resuscitation.2018.08.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of different target temperatures in targeted temperature management on neurologically favorable outcome after out-of-hospital cardiac arrest: A nationwide multicenter observational study in Japan (the JAAM-OHCA registry)2018

    • Author(s)
      Irisawa Taro、Matsuyama Tasuku、Iwami Taku、Yamada Tomoki、Hayakawa Koichi、Yoshiya Kazuhisa、Noguchi Kazuo、Nishimura Tetsuro、Uejima Toshifumi、Yagi Yoshiki、Kiguchi Takeyuki、Kishimoto Masafumi、Matsuura Makoto、Hayashi Yasuyuki、Sogabe Taku、Morooka Takaya、Kitamura Tetsuhisa、Shimazu Takeshi
    • Journal Title

      Resuscitation

      Volume: 133 Pages: 82-87

    • DOI

      10.1016/j.resuscitation.2018.10.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristics and outcomes of out-of-hospital cardiac arrest occurring while in a motor vehicle2018

    • Author(s)
      Sado J, Kiyohara K, Hayashida S, Matsuyama T, Katayama Y, Hirose T, Kiguchi T, Nishiyama C, Iwami T, Kitamura Y, Sobue T, Kitamura T
    • Journal Title

      The American Journal of Cardiology

      Volume: E-pub ahead of print Issue: 11 Pages: 1-6

    • DOI

      10.1016/j.amjcard.2018.02.018

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chest compression-only versus conventional cardiopulmonary resuscitation for bystander-witnessed out-of-hospital cardiac arrest of medical origin: a propensity score-matched cohort from 143,500 patients2018

    • Author(s)
      Kitamura T, Kiyohara K, Nishiyama C, Kiguchi T, Kobayashi D, Kawamura T, Taku Iwami
    • Journal Title

      Resuscitation

      Volume: 126(5) Pages: 29-35

    • DOI

      10.1016/j.resuscitation.2018.02.017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Three-Year Follow-up After the Great East Japan Earthquake in the Incidence of Out-of-Hospital Cardiac Arrest With Cardiac Origin2018

    • Author(s)
      Sado J, Kiyohara K, Iwami T, Kitamura Y, Ando E, Ohira T, Sobue T, Kitamura T
    • Journal Title

      Circulation Journal

      Volume: 82 Issue: 3 Pages: 919-922

    • DOI

      10.1253/circj.CJ-17-1003

    • NAID

      130006394525

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic impact of serum albumin concentration for neurologically favorable outcome in patients treated with target temperature management after out-of-hospital cardiac arrest: a multicenter prospective study2018

    • Author(s)
      Matsuyama T, Iwami T, Yamada T, Hayakawa K, Yoshiya K, Irisawa T, Abe Y, Nishimura T, Uejima T, Ohishi Y, Kiguchi T, Kishi M, Kishimoto M, Nakao S, Hayashi Y, Sogabe T, Morooka T, Izawa J, Shimamoto T, Hatakeyama T, Fujii T, Sado J, Kawamura T, Shimazu T, Kitamura T
    • Journal Title

      Therapeutic Hypothermia and Temperature Management

      Volume: E-pub ahead of print Issue: 3 Pages: 1-6

    • DOI

      10.1089/ther.2017.0053

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regional variation in functional outcome after out-of-hospital cardiac arrest across 47 Prefectures in Japan2018

    • Author(s)
      Okubo M, Gibo K, Wallace DJ, Komukai S, Izawa J, Kiyohara K, Callaway CW, Iwami Y, Kitamura T
    • Journal Title

      Resuscitation

      Volume: 124(3) Pages: 21-28

    • DOI

      10.1016/j.resuscitation.2017.12.030

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Epidemiology of Out-of-Hospital Cardiac Arrest Due to Suffocation Focusing on Suffocation Due to Japanese Rice Cake: A Population-Based Observational Study From the Utstein Osaka Project2018

    • Author(s)
      Kiyohara K, Sakai T, Nishiyama C, Nishiuchi T, Hayashi Y, Iwami T, Kitamura T
    • Journal Title

      Journal of Epidemiology

      Volume: 28 Issue: 2 Pages: 67-74

    • DOI

      10.2188/jea.JE20160179

    • NAID

      130006337731

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of serum albumin concentration on favorable neurological outcome after out-of-hospital cardiac arrest (From the CRITICAL Study in Osaka, Japan)2018

    • Author(s)
      Matsuyama T, Iwami T, Yamada T, Hayakawa K, Yoshiya K, Irisawa T, Abe Y, Nishimura T, Uejima T, Ohishi Y, Kiguchi T, Kishi M, Kishimoto M, Nakao S, Hayashi Y, Sogabe T, Morooka T, Izawa J, Shimamoto T, Hatakeyama T, Fujii T, Sado J, Shimazu T, Kawamura T, Kitamura T
    • Journal Title

      The American Journal of Cardiology

      Volume: 121(2) Issue: 2 Pages: 156-161

    • DOI

      10.1016/j.amjcard.2017.10.005

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prehospital intravenous access and adrenaline administration for survival from out-of-hospital cardiac arrest: propensity score matched analyses from a population-based cohort study in Osaka, Japan2017

    • Author(s)
      Fujii T, Kitamura T, Kajino K, Kiyohara K, Nishiyama C, Nishiuchi T, Hayashi Y, Kawamura T, Iwami T
    • Journal Title

      BMJ Open

      Volume: 7(12) Issue: 12 Pages: e015055-e015055

    • DOI

      10.1136/bmjopen-2016-015055

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improving outcomes of witnessed out-of-hospital cardiac arrest after implementation of ILCOR 2010 consensus: a nationwide prospective observational population-based study2017

    • Author(s)
      Kaneko H, Hara M Mizutani K, Yoshiyama M, Yokoi K, Kabata D, Shintani A, Kitamura T
    • Journal Title

      Journal of the American Heart Association

      Volume: 6(8) Issue: 8

    • DOI

      10.1161/jaha.116.004959

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exercise-related out-of-hospital cardiac arrest among the general population in the era of public-access defibrillation: a population-based observation in Japan2017

    • Author(s)
      Kiyohara K, Nishiyama C, Kiguchi T, Nishiuchi T, Hayashi Y, Iwami T, Kitamura T
    • Journal Title

      Journal of the American Heart Association

      Volume: 6 Issue: 6

    • DOI

      10.1161/jaha.117.005786

    • NAID

      120006955494

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Out-of-hospital cardiac arrests during exercise among urban inhabitants in Japan: insights from a population-based registry of Osaka City2017

    • Author(s)
      Kiyohara K, Sado J, Matsuyama T, Nishiyama C, Kobayashi D, Kiguchi T, Hayashida S, Kitamura Y, Nakata K, Sobue T, Iwami T, Kitamura T
    • Journal Title

      Resuscitation

      Volume: 117(8) Pages: 14-17

    • DOI

      10.1016/j.resuscitation.2017.05.025

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nationwide and regional trends in survival from out-of-hospital cardiac arrest in Japan: a 10-year observation from 2005 to 20142017

    • Author(s)
      Okubo M, Kiyohara K, Iwami T, Callaway CW, Kitamura T
    • Journal Title

      Resuscitation

      Volume: 115(6) Pages: 120-128

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Impact of cardiopulmonary resuscitation duration on neurologically favourable outcome after out-of-hospital cardiac arrest: a population-based study in Japan2017

    • Author(s)
      Matsuyama T, Kitamura T, Kiyohara K, Nishiyama C, Nishiuchi T, Hayashi Y, Kawamura T, Ohta B, Iwami T
    • Journal Title

      Resuscitation

      Volume: 113 Pages: 1-7

    • DOI

      10.1016/j.resuscitation.2017.01.005

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hospital characteristics and favorable neurological outcome among patients with out-of-hospital cardiac arrest in Osaka, Japan2017

    • Author(s)
      Matsuyama T, Kiyohara K, Kitamura T, Nishiyama C, Nishiuchi T, Hayashi Y, Kawamura T, Ohta B, Iwami T
    • Journal Title

      Resuscitation

      Volume: 110 Pages: 146-153

    • DOI

      10.1016/j.resuscitation.2016.11.009

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Public-access defibrillation and out-of-hospital cardiac arrest in Japan2016

    • Author(s)
      Kitamura T,* Kiyohara K,* Sakai T, Matsuyama T, Hatakeyama T, Shimamoto T, Izawa J, Fujii T, Nishiyama C, Kawamura T, Iwami T
    • Journal Title

      The New England Journal of Medicine 2016

      Volume: 375 Issue: 17 Pages: 1649-1659

    • DOI

      10.1056/nejmsa1600011

    • NAID

      120006955490

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] High-rise buildings and neurologically favorable outcome after out-of-hospital cardiac arrest2016

    • Author(s)
      Kobayashi D, Kitamura T, Kiyohara K, Nishiyama C, Hayashida S, Fujii T, Izawa J, Shimamoto T, Matsuyama T, Hatakeyama T, Katayama Y, Kiguchi T, Kawamura T, Iwami T
    • Journal Title

      International Journal of Cardiology

      Volume: 224 Pages: 178-182

    • DOI

      10.1016/j.ijcard.2016.09.047

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Outcomes differ by first documented rhythm after witnessed out-of-hospital cardiac arrest in children; an observational study with prospective nationwide population-based cohort database in Japan2016

    • Author(s)
      Hara M, Hayashi K, Kitamura T
    • Journal Title

      European Heart Journal - Quality of Care and Clinical Outcomes

      Volume: 3 Issue: 1 Pages: 83-92

    • DOI

      10.1093/ehjqcco/qcw040

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Public-access AED pad application and outcomes for out-of-hospital cardiac arrests in Osaka, Japan2016

    • Author(s)
      Kiyohara K, Kitamura T, Sakai T, Nishiyama C, Nishiuchi T, Hayashi Y, Sakamoto T, Marukawa S, Iwami T
    • Journal Title

      Resuscitation

      Volume: 106 Pages: 70-75

    • DOI

      10.1016/j.resuscitation.2016.06.025

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics and Outcomes of Bath-Related Out-of-Hospital Cardiac Arrest in Japan2016

    • Author(s)
      Kiyohara K, Nishiyama C, Hayashida S, Matsuyama T, Hatakeyama T, Shimamoto T, Izawa J, Fujii T, Katayama Y, Iwami T, Kitamura T
    • Journal Title

      Circulation Journal

      Volume: 80 Issue: 7 Pages: 1564-1570

    • DOI

      10.1253/circj.CJ-16-0241

    • NAID

      130005158918

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 第1回JAAM多施設共同院外心停止レジストリ成果報告会: 成果報告1(プロファイル論文)2018

    • Author(s)
      北村哲久
    • Organizer
      第46回日本救急医学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Association of Serum Potassium Levels With Favorable Neurological OutcomeAfter Out-of-Hospital Cardiac Arrest: The CRITICAL Study in Osaka, Japan2018

    • Author(s)
      Shida H, Matsuyama M, Kitamura T, Kishimori T, Kiyohara K, Okabayashi S, Kawamura T, Iwami T
    • Organizer
      2018 American Heart Association Scientific Session, Resuscitation Science Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 心血管疾患の臨床疫学研究の課題と展開~臨床から地域へ、地域から臨床へ~循環器臨床疫学研究における疫学者の関わり2018

    • Author(s)
      北村哲久
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 日本からのThe New England Journal of Medicineへの挑戦~リアルワールドエビデンスの重要性~2017

    • Author(s)
      北村哲久
    • Organizer
      第45回日本救急医学会総会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Arterial hyperoxia exposure time and survival among resuscitated patients with out-of-hospital cardiac arrest, The Critical Study in Osaka, Japan2017

    • Author(s)
      Kiguchi T, Kitamura T, Kobayashi D, Nishiyama C, Fujimi S, Kawamura T, Iwami T
    • Organizer
      Resuscitation Symposium, American Heart Association Scientific Sessions 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The relationship between the targeted temperature of TTM and neurological outcome, the CRITICAL Study in Osaka, Japan2017

    • Author(s)
      Irisawa T, Matsuyama T, Kiguchi T, Kitamura T, Yoshiya K, Iwami T, Kawamura T, Shimazu T
    • Organizer
      Resuscitation Symposium, American Heart Association Scientific Sessions 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 治療的体温管理療法での導入速度についての検討―多施設研究Critical Study を通じて―2016

    • Author(s)
      西村哲郎、森岡貴勢、溝端康光、田原良雄、北村哲久、石見 拓
    • Organizer
      第44回日本救急医学会総会
    • Place of Presentation
      東京都港区高輪
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Survival after Out-of-hospital Cardiac Arrests and Arterial Oxygen Partial Pressure during Cardiopulmonary Resuscitation: The CRITICAL Study in Osaka, Japan2016

    • Author(s)
      Izawa J, Kitamura T, Hayakawa K, Yamada T, Yoshiya K, Abe Y, Uejima T, Ohishi Y, Kiguchi T, Kishi M, Kishimoto M, Nakao S, Nishimura T, Hayashi Y, Morooka T, Sogabe T, Matsuyama T, Shimazu T, Kawamura T, Iwami T
    • Organizer
      Resuscitation Symposium, American Heart Association Scientific Sessions
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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