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Elderly patients with cardiovascular disease are associated with frailty

Research Project

Project/Area Number 16K09042
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionJuntendo University

Principal Investigator

Miyauchi Katsumi  順天堂大学, 医学部, 教授 (60200119)

Project Period (FY) 2016-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2019: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsフレイル / 心不全 / 虚血性心疾患 / 転倒 / 長期予後 / 心筋梗塞 / 横断研究 / 縦断研究 / 高齢者 / サルコペニア / 予測因子 / 予後規定因子 / 循環器疾患 / 冠動脈疾患患者 / 心血管事故 / Frailty / 冠動脈疾患 / 心血管疾患 / 内科
Outline of Final Research Achievements

The prevalence of physical frailty among elderly patients attending outpatient clinics was higher than that among community-dwelling elderly people, especially among patients with coronary artery disease and heart failure. Compared with the non-frail group, the frail group was more likely to be older, have a lower BMI, have lower cognitive function, osteoporosis, and a history of stroke/myocardial infarction/heart failure/malignancy/diabetes. Multivariate analysis showed that heart failure and myocardial infarction were associated with an increased risk of frailty. On the other hand, the progression of frailty due to heart failure or a history of myocardial infarction tended to be suppressed if the level of activity in daily life was high.

Academic Significance and Societal Importance of the Research Achievements

フレイル評価は現在日常臨床で評価されていないが、循環器疾患だけではなく内科疾患で通院している患者では同年代の地域住民と比べ、高いことが実証されたことやフレイルは転倒の予測因子であることが明らかになり、転倒は日常生活の質の低下や死亡と関連していることから日常臨床でのフレイル評価を実施する臨床的意義は極めて高いと考えられる。また、日常生活での運動療法もフレイルへの進展を抑制に関与することが示唆されたことから、高齢者への日常生活での歩行運動の寝たきり予防への普及への社会的アピールに繋がると考えられる。

Report

(9 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2023

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Rationale and design of Juntendo Sarcopenia Registration to explore the predictors and prognosis of sarcopenia and frailty in the elderly in <scp>TOKYO</scp> (<scp>JUSTICE‐TOKYO</scp>)2023

    • Author(s)
      Matsuno Kei、Asaoka Daisuke、Sugano Koji、Takahashi Kazuhisa、Miyauchi Katsumi
    • Journal Title

      Geriatrics &amp; Gerontology International

      Volume: 24 Issue: 1 Pages: 168-172

    • DOI

      10.1111/ggi.14779

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross-Sectional Study on the Association between Dietary Patterns and Sarcopenia in Elderly Patients with Chronic Kidney Disease Receiving Conservative Treatment2023

    • Author(s)
      Inoshita Hiroyuki、Asaoka Daisuke、Matsuno Kei、Yanagisawa Naotake、Suzuki Yusuke、Miyauchi Katsumi
    • Journal Title

      Nutrients

      Volume: 15 Issue: 23 Pages: 4994-4994

    • DOI

      10.3390/nu15234994

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Prevalence and associated factors of Sarcopenia in elderly outpatients2023

    • Author(s)
      Kei Matsuno, Daisuke Asaoka, Koji Sugano, Katsumi Miyauchi,
    • Organizer
      12th IAGG Asia/Oceania Regional Congress
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prevalence and associated factors of physical frailty among Japanese geriatric patients with chronic disease from a university hospital2023

    • Author(s)
      Kei Matsuno, Daisuke Asaoka, Koji Sugano, Katsumi Miyauchi, Kazuhisa Takahashi
    • Organizer
      19th Congress of EuGMS (European Geriatric Medicine Society )
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 保存期慢性腎臓病患者におけるサルコペニアと食事パターンの関連についての研究2023

    • Author(s)
      井下博之、浅岡大介、松野圭、宮内克己
    • Organizer
      第10回日本サルコペニアフレイル学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 高齢者サルコペニアのリスクを予測する因子の検討2023

    • Author(s)
      松野圭、浅岡大介、菅野康二、水谷多恵子、飯田茶稚、平池康子、石井みづき、戸島郁子、田嶋美幸、佐久間尚子、宮内克己
    • Organizer
      第65回日本老年医学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 高齢者喘息におけるフレイルと重症度の関連について2023

    • Author(s)
      松野圭、堀田沙織、山田朋子、菅野康二、浅岡大介、宮内克己、高橋和久
    • Organizer
      第33回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2023 Annual Research Report

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Published: 2016-04-21   Modified: 2025-01-30  

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