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Study on age-specific and geographically specific pattern of epidemics of tuberculosis in Japan and China

Research Project

Project/Area Number 16K09061
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionSapporo Medical University

Principal Investigator

Sumi Ayako  札幌医科大学, 医学部, 准教授 (10363699)

Co-Investigator(Kenkyū-buntansha) 小林 宣道  札幌医科大学, 医学部, 教授 (80186759)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords結核 / サーベイランス / 季節性 / 気象 / 時系列解析 / スペクトル解析 / 日本 / 中国 / 感染症サーベイランス / 空間疫学
Outline of Final Research Achievements

We investigated the seasonality of age-specific tuberculosis (TB) in Japan. To allow the development of TB control strategies for different age groups, we used a time series analysis to analyse the monthly age-specific numbers of newly registered cases of all forms of active TB in Japan from January 1998 to December 2013. We defined the contribution ratio of the 1-year cycle, Q1, as the contribution of the amplitude of a 1-year cycle to the whole amplitude of the time series data. The Q1 values in the age groups corresponding to adolescence and middle life and old age were high. The peaks in the active TB epidemics for the old age occurred in August and September, 1-2 months behind the peaks for the adolescence and middle life (June and July). An active TB epidemic might be attributable to travel by public transport and irregular employment in the adolescence and middle life and immune system suppression by low winter temperatures in the old age.

Academic Significance and Societal Importance of the Research Achievements

本研究の意義は、結核の対策が今日的課題となっている中国および日本において、結核の流行を規定する要因を系統的に調査し、結核対策のための基礎資料を作ることにあった。本研究は、結核の対策が今日的課題となっている日本と中国において、結核の流行変動を時間的および空間的に把握し、結核の環境要因および伝染性要因のリスクファクターの地域差を明らかにした。得られた知見が、日本と中国はもとより、他のアジア諸国における結核対策の推進に寄与することが期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (7 results) Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (4 results) (of which Int'l Joint Research: 4 results)

  • [Int'l Joint Research] 武漢疾病予防センター(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] タンペレ大学(フィンランド)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 武漢疾病予防センター(中国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] 武漢疾病予防センター(中国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] サン・ラザロ病院(フィリピン)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] ハルビン医科大学(中国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] インド国立結核研究所(インド)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Time-series analysis of geographically specific monthly number of newly registered cases of active tuberculosis in Japan2019

    • Author(s)
      Ayako Sumi, Nobumichi Kobayashi
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 3 Pages: e0213856-e0213856

    • DOI

      10.1371/journal.pone.0213856

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of temperature in reported chickenpox cases in northern European countries: Denmark and Finland2018

    • Author(s)
      Ayako Sumi
    • Journal Title

      BMC Research Notes

      Volume: 11 Issue: 1 Pages: 377-382

    • DOI

      10.1186/s13104-018-3497-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between meteorological factors and reported cases of hand, foot, and mouth disease from 2000 to 2015 in Japan2017

    • Author(s)
      Sumi A, Toyoda S, Kanou K, Fujimoto T, Mise K, Kohei Y, Kobayashi N
    • Journal Title

      Epidemiology and Infection

      Volume: 145 Issue: 14 Pages: 2886-2911

    • DOI

      10.1017/s0950268817001820

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Role of Meteorological Conditions in Reported Chickenpox Cases in Wuhan and Hong Kong, China2017

    • Author(s)
      Chen B, Sumi A, Wang L, Zhou W, Kobayashi N
    • Journal Title

      BMC Infectious Diseases

      Volume: 17 Issue: 1 Pages: 538-546

    • DOI

      10.1186/s12879-017-2640-1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of temperature, relative humidity and rafall on dengue fever and leptospirosis infection in Manila, the Philippines2017

    • Author(s)
      Sumi A, Telan EFO, Chagan-Yasutan H, Piolo MB, Hattori T, Kobayashi N
    • Journal Title

      Epidemiology and Infection

      Volume: 145 Issue: 1 Pages: 78-86

    • DOI

      10.1017/s095026881600203x

    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 中国・インド・フィリピン・北欧との感染症発生動向に関する共同研究2017

    • Author(s)
      鷲見紋子、小林宣道
    • Journal Title

      日本衛生学会誌

      Volume: 印刷中

    • NAID

      130005680598

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Time-series analysis of monthly age-specific numbers of newly registered cases of active tuberculosis in Japan from 1998 to 20132016

    • Author(s)
      Kohei Y, Sumi A, Kobayashi N
    • Journal Title

      Epidemiology and Infection

      Volume: 144 Issue: 11 Pages: 2401-2414

    • DOI

      10.1017/s0950268816000546

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Association between meteorological factors and reported cases of hand, foot, and mouth disease in Wuhan, China, and Japan(訳:中国・武漢市および日本における手足口病報告症例数の気象との関係)2018

    • Author(s)
      Ayako Sumi, Banghua Chen, Nobumichi Kobayashi
    • Organizer
      第12回日中ウイルス学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Time series analysis of monthly age- and geographical-specific numbers of newly registered cases of active tuberculosis in Japan2017

    • Author(s)
      Sumi A, Kohei Y, Kobayashi N
    • Organizer
      The 6th International Conference on Infectious Disease Dynamics
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of temperature, relative humidity and rafall on dengue fever and leptospirosis infection in Manila, the Philippines2016

    • Author(s)
      Sumi A, Telan EFO, Chagan-Yasutan H, Piolo MB, Hattori T, Kobayashi N
    • Organizer
      The 11th Japan-China International Conference of Virology
    • Place of Presentation
      Kotohiki-so, Kagawa, Japan
    • Year and Date
      2016-07-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of temperature, relative humidity and rafall on dengue fever and leptospirosis infection in Manila, the Philippines2016

    • Author(s)
      Sumi A, Telan EFO, Chagan-Yasutan H, Piolo MB, Hattori T, Kobayashi N
    • Organizer
      Conference of International Society for Environmental Epidemiology and International Society of Exposure Science, Asia Chapter 2016
    • Place of Presentation
      Hokkaido University, Sapporo, Japan
    • Year and Date
      2016-06-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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