| Project/Area Number |
16K09066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
MAEKITA TAKAO 和歌山県立医科大学, 医学部, 准教授 (10326358)
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| Co-Investigator(Kenkyū-buntansha) |
一瀬 雅夫 帝京大学, 医学部, 副院長 (50143425)
宇都宮 洋才 和歌山県立医科大学, 共同利用施設, 准教授 (60264876)
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| Research Collaborator |
YOSHIDA TAKEICHI
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 梅 / 腸内細菌叢 / 腸内細菌 / 消化器疾患 |
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| Outline of Final Research Achievements |
We investigated the relation between gut microbiota and gastric acid secretion, and the effect of Japanese apricot (JA) on the microbiota. Healthy Japanese subjects with H.pylori-/atrophic gastritis- (Group A) and H.pylori-/atrophic gastritis+ in which gastric acid secretion has markedly reduced (Group D) were enrolled. This trial composed of 4 parts (Part 1: Group A vs Group D before JA, Part 2: all cases before vs after JA, Part 3: before vs after JA in Group A, Part 4: before vs after JA in Group D). Significant differences were observed in not the diversity but the structure of the gut microbiota in some parts of the trial. In Part 1, c_Clostridia at the class level and o_Clostridiales at the order level were significantly different. In Part 4, Bacteroidetes at phylum level was significantly different. These results show that gastric acid might be related to the structure of the gut microbiota, and JA might alter the structure in the reduced gastric acid condition.
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| Academic Significance and Societal Importance of the Research Achievements |
梅エキス投与による腸内細菌叢改善が証明されれば、病変の発生を予防する広大なる戦略構築に貢献する一助となることが予測され、健康増進に大きな福音となることが考えられる。
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