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Non-specific physical symptoms in multiple chemical sensitivity: an intervention study on the physiological status and the improvement.

Research Project

Project/Area Number 16K09116
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionLouis Pasteur Center for Medical Research

Principal Investigator

Uchiyama Iwao  公益財団法人ルイ・パストゥール医学研究センター, その他部局等, 研究員(移行) (20151897)

Co-Investigator(Kenkyū-buntansha) 谷川 真理  公益財団法人ルイ・パストゥール医学研究センター, その他部局等, 研究員(移行) (50291018)
東 賢一  近畿大学, 医学部, 准教授 (80469246)
東 実千代  畿央大学, 健康科学部, 教授 (10314527)
萬羽 郁子  東京学芸大学, 教育学部, 講師 (20465470)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords化学物質過敏症 / 臭い / 脳血流 / 酸素 / 自律神経 / 免疫
Outline of Final Research Achievements

As a baseline study, we investigated the regional cerebral blood flow (rCBF) in the prefrontal area using near-infrared spectroscopic (NIRS) imaging, the peripheral arterial blood oxygen saturation (SpO2) level, and autonomic nervous activity during olfactory stimulation with some odorants in ten patients with MCS and nine controls. After one year, six patients were treated with L-carnitine administration, one patient was treated with exercise therapy, and three patients were not treated as a non-intervention group. As the results, the significant improvements in their physiological parameters were not found in the intervention group overall. However, slight improvement tendencies were found in some patients with their severe symptoms. Further study on the intervention effects appropriate for the level of the physical symptoms in multiple chemical sensitivity is required.

Academic Significance and Societal Importance of the Research Achievements

化学物質過敏症は、その疾患概念や診断指針、症状等の改善方法が明確でなく病態も未解明な部分が多い。本研究では、臭い負荷時における末梢組織における酸素の取り込み状態や自律神経系の動きに着目し、脳血流変化を同時に評価したうえで、組織内の細胞への酸素の取り込みを活性化させる効果を有するLカルニチンや運動療法等による酸素状態や過敏状態の改善効果を客観的に検証した。その結果、総じて介入群に大きな改善効果はみられなかったが、症状が比較的重い一部の患者では改善傾向がみられたことから、末梢組織における酸素の取り込み状態の改善が症状改善に寄与する可能性と、今後のさらなる研究の必要性を示唆することができた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (17 results)

All 2019 2018 2017 2016

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 6 results) Book (1 results)

  • [Journal Article] 化学物質過敏症患者の嗅覚知覚に関する検討2019

    • Author(s)
      萬羽郁子、東 賢一、東実千代、谷川真理、内山巌雄
    • Journal Title

      におい・かおり環境学会誌

      Volume: 50 Pages: 27-39

    • NAID

      130008113186

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 健康リスクの立場からみた環境過敏症の予防について2019

    • Author(s)
      東 賢一
    • Journal Title

      室内環境

      Volume: 22

    • NAID

      130007687131

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] シックハウス(室内空気汚染)問題に関する国内での取り組みについて2018

    • Author(s)
      東 賢一
    • Journal Title

      ビルと環境

      Volume: 161 Pages: 51-55

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 本態性環境不耐症―いわゆる化学物質過敏症の疾病概念・疫学・病態解明について―2017

    • Author(s)
      東 賢一
    • Journal Title

      PASKEN JOURNAL

      Volume: 26-29 Pages: 26-34

    • Related Report
      2017 Research-status Report 2016 Research-status Report
  • [Journal Article] 室内環境汚染による健康リスクと今後の課題2017

    • Author(s)
      東 賢一
    • Journal Title

      臨床環境医学

      Volume: 26 Pages: 82-86

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 化学物質過敏症2017

    • Author(s)
      内山巌雄
    • Journal Title

      日本医師会雑誌

      Volume: 146 Pages: 264-266

    • Related Report
      2017 Research-status Report
  • [Journal Article] Association of odor thresholds and responses in cerebral blood flow of the prefrontal area during olfactory stimulation in patients with multiple chemical sensitivity2016

    • Author(s)
      Azuma K, Uchiyama I, Tanigawa M, Bamba I, Azuma M, Takano H, Yoshikawa T, Sakabe K
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 12 Pages: e0168006-e0168006

    • DOI

      10.1371/journal.pone.0168006

    • NAID

      120005980899

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 脳科学的見地からみた化学物質過敏症2016

    • Author(s)
      東 賢一
    • Journal Title

      アレルギーの臨床

      Volume: 36 Pages: 21-25

    • Related Report
      2016 Research-status Report
  • [Journal Article] Chemical Sensitivity-The Frontier of Diagnosis and Treatment2016

    • Author(s)
      Sakabe K, Kimura M, Terayama H, Tsunoda M, Kiyajima E, Takano H, Azuma K, Mizukoshi A, Matsuda T, Mori C, Miyata M, Ishikawa S, Aizawa Y
    • Journal Title

      臨床環境医学

      Volume: 25 Pages: 49-54

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Effects of olfactory stimulus by odor on cerebral blood flow and peripheral blood oxygen levels in multiple chemical sensitivity2018

    • Author(s)
      ⑤Azuma K, Uchiyama I, Tanigawa M, Bamba I, Azuma M, Takano H, Yoshikawa T, Sakabe K
    • Organizer
      The 32nd International Congress on Occupational Health, Dublin, Ireland
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳科学的見地からみた環境過敏症2018

    • Author(s)
      東 賢一
    • Organizer
      第27回日本臨床環境医学会学術集会シンポジウム(於 三重大学環境・科学情報館、津市)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 健康リスクの立場からみた環境過敏症の予防について2018

    • Author(s)
      東 賢一
    • Organizer
      平成30年度室内環境学会学術大会環境過敏症分科会セミナー(於 東京工業大学大岡山キャンパス)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Effects of olfactory stimulus by odor on cerebral blood flow and peripheral blood oxygen levels in multiple chemical sensitivity2018

    • Author(s)
      Azuma K, Uchiyama I, Tanigawa M, Bamba I, Azuma M, Takano H, Yoshikawa T, Sakabe K
    • Organizer
      The 32nd International Congress on Occupational Health, Dublin, Ireland
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 化学物質過敏症有訴者に対する匂い刺激が脳血流と末梢血酸素飽和度に及ぼす影響2016

    • Author(s)
      東 賢一、内山巌雄、谷川真理、東 実千代、 萬羽郁子、高野裕久、吉川敏一、坂部 貢
    • Organizer
      第86回日本衛生学会
    • Place of Presentation
      旭川市
    • Year and Date
      2016-05-11
    • Related Report
      2016 Research-status Report
  • [Presentation] わが国の環境汚染と健康被害-補償行政から未然防止へ-2016

    • Author(s)
      内山巌雄
    • Organizer
      第25回日本臨床環境医学会学術集会
    • Place of Presentation
      郡山市
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 室内空気汚染の健康リスク2016

    • Author(s)
      東 賢一
    • Organizer
      第25回日本臨床環境医学会学術集会
    • Place of Presentation
      郡山市
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] 環境による健康リスク (日本医師会生涯教育シリーズ)2017

    • Author(s)
      内山巌雄
    • Total Pages
      368
    • Publisher
      診断と治療社
    • ISBN
      9784787823076
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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