• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Association of CKD and sdLDL-C with cognitive function in general population

Research Project

Project/Area Number 16K09141
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionJichi Medical University

Principal Investigator

Ishikawa Shizukiyo  自治医科大学, 医学部, 教授 (70306140)

Co-Investigator(Kenkyū-buntansha) 中村 剛史  自治医科大学, 医学部, 講師 (20554554)
小谷 和彦  自治医科大学, 医学部, 教授 (60335510)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsコホート研究 / sdLDLコレステロール / メタボリック・シンドローム / sdLDL / アポリポ蛋白 / 地域医療 / 心腎連関 / 認知機能
Outline of Final Research Achievements

We have conducted cohort study about association of chronic kidney disease (CKD) and small dense LDL-cholesterol (sdLDL-C) with cognitive function in Japanese general population. Total study subject were 6,434 men and women, and sdLDL-C was measured in 5,866 subjects. The value of sdLDL-C was higher in the subjects with metabolic syndrome (MetS), but that was lower in those with CKD and cognitive dysfunction in men. Whereas, the value of sdLDL-C was higher in the subjects with MetS, but no significant difference was seen in between those with and without CKD and cognitive dysfunction in women.

Academic Significance and Societal Importance of the Research Achievements

都心部では、生活習慣の欧米化に伴い、sdLDLコレステロールと心血管疾患との関連があるとの報告があるが(吹田研究)、比都市部においても同様の結果となるのかは不明であった。今回、日本の非都市部の多地域における一般住民のsdLDLコレステロールと他の疾患との関連を明らかにすることができた。コホート研究としては発症との関連を検討することができなかったため今後の課題となる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2017 2016

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 4 results) Presentation (8 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Body Mass Index and Incidence of Subarachnoid Hemorrhage in Japanese Community Residents: The Jichi Medical School Cohort Study2017

    • Author(s)
      Kawate N, Kayaba K, Hara M, Hamaguchi T, Kotani K, Ishikawa S.
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 26 Issue: 8 Pages: 1683

    • DOI

      10.1016/j.jstrokecerebrovasdis.2017.03.029

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factor VII and incidence of myocardial infarction in a Japanese population: The Jichi Medical School Cohort Study.2017

    • Author(s)
      Shiraishi T, Ishikawa S, Kario K, Kayaba K, Kajii E.
    • Journal Title

      J Clin Lab Anal

      Volume: 31 Issue: 6

    • DOI

      10.1002/jcla.22133

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction.2017

    • Author(s)
      Tsuda T, Takefuji M, Wettschureck N, Kotani K, Morimoto R, Okumura T, Kaur H, Eguchi S, Sakaguchi T, Ishihama S, Kikuchi R, Unno K, Matsushita K, Ishikawa S, Offermanns S, Murohara T.
    • Journal Title

      J Exp Med.

      Volume: 214 Issue: 7 Pages: 1877-1877

    • DOI

      10.1084/jem.20161924

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Body mass index and stroke incidence in Japanese community residents: The Jichi Medical School (JMS) Cohort Study2017

    • Author(s)
      Kawate N, Kayaba K, Hara M, Kotani K, Ishikawa S.
    • Journal Title

      Journal of Epidemiology

      Volume: 27 Issue: 7 Pages: 325-330

    • DOI

      10.1016/j.je.2016.08.007

    • NAID

      130005709466

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Progression from prehypertension to hypertension and risk of cardiovascular disease2017

    • Author(s)
      Ishikawa Y, Ishikawa J,Ishikawa S,Kario K, Kajii E.
    • Journal Title

      Journal of Epidemiology

      Volume: 27 Issue: 1 Pages: 8-13

    • DOI

      10.1016/j.je.2016.08.001

    • NAID

      130005316455

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Coffee Consumption and Incidence of Subarachnoid Hemorrhage: The Jichi Medical School Cohort Study2016

    • Author(s)
      Sakamaki T., Hara M., Kayaba K., Kotani K., Ishikawa S
    • Journal Title

      Journal of Epidemiology

      Volume: 26 Issue: 2 Pages: 71-75

    • DOI

      10.2188/jea.JE20150092

    • NAID

      130005124682

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Accuracy of Death Certificates and Assessment of Factors for Misclassification of Underlying Cause of Death.2016

    • Author(s)
      Mieno M. N., Tanaka N., Arai T., Kawahara T., Kuchiba A., Ishikawa S., Sawabe M.
    • Journal Title

      J Epidemiol

      Volume: 26 Pages: 191-198

    • NAID

      130005143922

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Salt Preference and the Incidence of Cardiovascular Disease in a Japanese General Population2016

    • Author(s)
      Tadenuma S, Kanda H, Ishikawa S, Kayaba K, Gotoh T, Nakamura Y, Kajii E.
    • Journal Title

      The Jichi Medical School Cohort Study

      Volume: 8 Pages: 105-115

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship Between Serum High-Sensitivity C-Reactive Protein and Myocardial Infarction in a General Japanese Population.2016

    • Author(s)
      Sugiyama T, Ishikawa S, Kotani K, Gotoh T, Itoh Y, Kayaba K, Kajii E.
    • Journal Title

      J Clin Lab Anal

      Volume: 30 Issue: 6 Pages: 999-1002

    • DOI

      10.1002/jcla.21970

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] A pooled analysis of the association of isolated low levels of high-density lipoprotein cholesterol with cardiovascular mortality in Japan2016

    • Author(s)
      Hirata T, Sugiyama D, Nagasawa SY, Murakami Y, Saitoh S, Okayama A, Iso H, Irie F, Sairenchi T, Miyamoto Y, Yamada M, Ishikawa S, Miura K, Ueshima H, Okamura T
    • Journal Title

      Eur J Epidemiol

      Volume: 32 Issue: 7 Pages: 547

    • DOI

      10.1007/s10654-016-0203-1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Body mass index and subarachnoid hemorrhage incidence in Japanese population: The JMS Cohort Study.2017

    • Author(s)
      川手菜未、Kayaba Kazunori、Hara Motohiko、Hamaguchi Toyohiro、Kotani Kazuhiko、Ishikawa Shizukiyo.
    • Organizer
      第27回日本疫学会学術総会
    • Place of Presentation
      ベルクラシック甲府(山梨県・甲府市)
    • Year and Date
      2017-01-25
    • Related Report
      2016 Research-status Report
  • [Presentation] The long - term influence for cancer prevention by green tea consumption: The Jichi Medical School Cohort Study.2017

    • Author(s)
      Takeshima T, Ojima T, Ishikawa S, Kayaba K, Saegusa T, Goto T, Nakamura Y, Kajii E.
    • Organizer
      The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE2017).
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Factor VII and incidence of myocardial infarction in a Japanese population: The Jichi Medical School Cohort Study.2017

    • Author(s)
      Shiraishi T, Ishikawa S, Kario K, Kayaba K, Kajii E.
    • Organizer
      The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE2017).
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Physical Activity and Cardiovascular Disease Risk in Japan: The Jichi Medical School Cohort Study.2017

    • Author(s)
      Shibata Y, Hayasaka S, Ojima O, Ishikawa S, Kayaba K, Gotoh T, Nakamura Y.
    • Organizer
      The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE2017).
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Coffee consumption and all-cause mortality in Japanese community residents: the Jichi Medical School Cohort Study.2017

    • Author(s)
      Sakamaki T, Kayaba K, Hara M, Hamaguchi T, Kotani K, Ishikawa S.
    • Organizer
      The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE2017).
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Body mass index and incidence of subarachnoid hemorrhage in Japanese community residents: the Jichi Medical School Cohort Study.2017

    • Author(s)
      Kawate N, Kayaba K, Hara M, Hamaguchi T, Kotani K, Ishikawa S.
    • Organizer
      The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE2017).
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] メタボリックシンドロームと総死亡-Jichi Medical School (JMS)コホートⅠ研究.2017

    • Author(s)
      渡部 純,石川鎮清,小谷和彦,中村好一.
    • Organizer
      第76回日本公衆衛生学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 栃木県下野市の小学校区別ソーシャルキャピタルと生活習慣病との関連2016

    • Author(s)
      山下眞穂、石川鎮清、青山泰子、阿江竜介、佐野 尭、小谷和彦、古城隆雄、牧野伸子、中村好一
    • Organizer
      第75回日本公衆衛生学会総会
    • Place of Presentation
      グランフロント大阪(大阪府・大阪市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi