Attempt of intraoperative stress assessment of surgeons during digestive surgery

• Project/Area Number: 16K09176
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical and hospital managemen
• Research Institution: Kagoshima University
• Principal Investigator: SAKODA MASAHIKO 鹿児島大学, 医歯学域医学系, 客員研究員 (40418851)
• Co-Investigator(Kenkyū-buntansha): 夏越 祥次 鹿児島大学, 医歯学域医学系, 教授 (70237577) ; 南 幸次 鹿児島大学, 附属病院, 医員 (70724235) ; 飯野 聡 鹿児島大学, 医歯学域附属病院, 助教 (80598003) ; 川崎 洋太 鹿児島大学, 附属病院, 医員 (90770420)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 手術 / 外科医 / ストレス / 医療安全 / 医療事故 / 唾液アミラーゼ活性 / 心拍数 / 働き方改革

Outline of Final Research Achievements

Although the stress of patients undergoing operation has been improved by progress of surgical technology, there are no reports about the evaluation of the surgeon’s stress during operations. The purpose of this study is to estimate stress of surgeons who participates in operations objectively using physiological and biochemical methods.
The salivary amylase activity after operations were significantly increased by biochemical methods. But the individual stress seems to depend on the age, the character, experience of operation and physical condition. Therefore, further storage of measurement and analysis are needed.
It was suggested that the measurement of salivary amylase activity can use as one of objective evaluation method of an acute stress.

Academic Significance and Societal Importance of the Research Achievements

外科医自身が手術中に受けるストレスを評価することは困難が予想されたが、今回、検討した唾液アミラーゼ活性は急性ストレスの客観的評価法の一つとして利用できることが示唆された。
患者さんへのストレス軽減は、進歩する低侵襲治療の中で図られてきたが、今後、外科医や医療従事者のストレスを正確に評価し環境を改善していくことで、更なる患者さんへの好影響も期待できる。そのためには、数値化されたストレスの客観的評価が重要になってくると思われる。

Research Products

• [Journal Article] New scoring system for resectable hepatocellular carcinoma with a maximum tumor size of <5 cm based on preoperative tumor factors. (2019)
  • Author(s): Kawasaki Y, Yang SJ, Choi GH, Han DH, Lee JH, Iino S, Sakoda M, Ueno S, Natsugoe S, Choi JS.
  • Journal Title: HPB (Oxford) Volume: - Issue: 10 Pages: 1393-1399
  • DOI: 10.1016/j.hpb.2019.02.018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical Implication of the Relationship Between High Mobility Group Box-1 and Tumor Differentiation in Hepatocellular Carcinoma (2018)
  • Author(s): ANDO KEI、SAKODA MASAHIKO、UENO SHINICHI、HIWATASHI KIYOKAZU、IINO SATOSHI、MINAMI KOJI、KAWASAKI YOTA、HASHIGUCHI MOTOYUKI、TANOUE KIYONORI、MATAKI YUKO、KURAHARA HIROSHI、MAEMURA KOSEI、SHINCHI HIROYUKI、NATSUGOE SHOJI
  • Journal Title: Anticancer Research Volume: 38 Issue: 6 Pages: 3411-3418
  • DOI: 10.21873/anticanres.12609
  • Peer Reviewed
• [Journal Article] A therapeutic strategy for resectable pancreatic cancer based on risk factors of early recurrence. (2018)
  • Author(s): Kurahara H, Maemura K, Mataki Y, Sakoda M, Iino S, Kawasaki Y, Arigami T, Mori S, Kijima Y, Ueno S, Shinchi H, Natsugoe S.
  • Journal Title: Pancreas Volume: 47 Issue: 6 Pages: 753-758
  • DOI: 10.1097/mpa.0000000000001066
  • Peer Reviewed
• [Journal Article] Prognostic significance of CD68, CD163 and Folate receptor-β positive macrophages in hepatocellular carcinoma. (2018)
  • Author(s): Minami K, Hiwatashi K, Ueno S, Sakoda M, Iino S, Okumura H, Hashiguchi M, Kawasaki Y, Kurahara H, Mataki Y, Maemura K, Shinchi H, Natsugoe S.
  • Journal Title: Exp Ther Med Volume: 15(5) Pages: 4465-4476
  • DOI: 10.3892/etm.2018.5959
  • Peer Reviewed
• [Journal Article] Influence of a Shorter Duration of Post-Operative Antibiotic Prophylaxis on Infectious Complications in Patients Undergoing Elective Liver Resection. (2017)
  • Author(s): Sakoda M, Iino S, Mataki Y, Kawasaki Y, Kurahara H, Maemura K, Ueno S, Natsugoe S
  • Journal Title: Surg Infect (Larchmt) Volume: 18(2) Issue: 2 Pages: 149-156
  • DOI: 10.1089/sur.2016.170
  • Peer Reviewed
• [Journal Article] Surgical treatment for the excluded bile leakage from Spiegel lobe after right hemihepatectomy: A case report. I (2017)
  • Author(s): Fukuhisa H, Sakoda M, Hiwatashi K, Iino S, Minami K, Hashiguchi M, Kawasaki Y, Kurahara H, Mataki Y, Maemura K, Shinchi H, Ueno S, Natsugoe S
  • Journal Title: International Journal of Surgery Case Reports Volume: 39 Pages: 159-163
  • DOI: 10.1016/j.ijscr.2017.08.018
  • Peer Reviewed / Open Access
• [Journal Article] Synchronous Quadruple Cancers Including Hepatocellular Carcinoma and Liver Metastasis from Colon Cancer (2017)
  • Author(s): 鶴田祐介，迫田雅彦，又木雄弘，飯野聡，南幸次，川崎洋太，蔵原弘，前村公成，上野真一，夏越祥次
  • Journal Title: The Japanese Journal of Gastroenterological Surgery Volume: 50 Issue: 4 Pages: 326-333
  • DOI: 10.5833/jjgs.2015.0218
  • NAID: 130006306783
  • ISSN: 0386-9768, 1348-9372
  • Peer Reviewed
• [Journal Article] Bidirectional Approach of Video-Assisted Neck Surgery (BAVANS): Endoscopic complete central node dissection with craniocaudal view for treatment of thyroid cancer. (2016)
  • Author(s): Nakajo A, Arima H, Hirata M, Yamashita Y, Shinden Y, Hayashi N, Kawasaki Y, Arigami T, Uchikado Y, Mori S, Mataki Y, Sakoda M, Kijima Y, Uenosono Y, Maemura K, Natsugoe S.
  • Journal Title: Asian J Endosc Surg. Volume: 10 Issue: 1 Pages: 40-46
  • DOI: 10.1111/ases.12312
  • Peer Reviewed / Open Access
• [Journal Article] Survival Benefits of Small Anatomical Resection of the Liver for Patients with Hepatocellular Carcinoma and Impaired Liver Function, Based on New-Era Imaging Studies. (2016)
  • Author(s): Sakoda M, Ueno S, Iino S, Hiwatashi K, Minami K, Kawasaki Y, Kurahara H, Mataki Y, Maemura K, Shinchi H, Natsugoe S.
  • Journal Title: J Cancer Volume: 7(9) Issue: 9 Pages: 1029-1036
  • DOI: 10.7150/jca.15174
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 消化器外科手術中に執刀医がうけるストレス評価の試み (2019)
  • Author(s): 迫田雅彦，橋口真征，小園 勉，髙取寛之，園田智洋，飯野 聡，川崎洋太，前村公成，前之原茂穂，夏越祥次
  • Organizer: 第74回日本消化器外科学会総会
• [Presentation] 予後からみた再発肝細胞癌に対する治療戦略 (2018)
  • Author(s): 迫田雅彦，飯野 聡，橋口真征，川崎洋太，田上聖徳，福久はるひ，又木雄弘，蔵原 弘，前村公成，新地洋之，上野真一，夏越祥次
  • Organizer: 第80回日本臨床外科学会
• [Presentation] 80歳以上HCCの予後から考える高齢者に対する至適治療法 (2018)
  • Author(s): 迫田雅彦，飯野 聡，川崎洋太，橋口真征，田上聖徳，蔵原 弘，又木雄弘，前村公成，新地洋之，上野真一，夏越祥次
  • Organizer: 第56回日本癌治療学会
• [Presentation] A treatment strategy to elderly HCC is considered from the analysis of prognosis． (2018)
  • Author(s): Masahiko Sakoda, Satoshi Iino, Yota Kawasaki, Motoyuki Hashiguchi, Kiyonori Tanoue, Hiroshi Kurahara, Yuko Mataki, Kosei Maemura, Hiroyuki Shinchi, Shinichi Ueno, Shoji Natsugoe
  • Organizer: 13th IHPBA World Congress
  • Int'l Joint Research
• [Presentation] Endoscopic versus open radiofrequency ablation for treatment of hepatocellular carcinoma. (2018)
  • Author(s): Masahiko Sakoda, Satoshi Iino, Yota Kawasaki, Motoyuki Hashiguchi, Kiyonori Tanoue, Hiroshi Kurahara, Yuko Mataki, Kosei Maemura, Hiroyuki Shinchi, Shinichi Ueno, Shoji Natsugoe
  • Organizer: 第30回日本肝胆膵外科学会
• [Presentation] 消化器外科手術における外科執刀医へのストレス評価の検討 (2018)
  • Author(s): 迫田雅彦，飯野 聡，橋口真征，佐竹霜一，川崎洋太，蔵原 弘，又木雄弘，前村公成，新地洋之，上野真一，夏越祥次
  • Organizer: 第118回日本外科学会
• [Presentation] 消化器外科手術における外科執刀医へのストレス評価の検討 (2018)
  • Author(s): 迫田雅彦，飯野 聡，橋口真征，佐竹霜一，川崎洋太，蔵原 弘，又木雄弘，前村公成，新地洋之，上野真一，夏越祥次
  • Organizer: 第118回日本外科学会定期学術洲会
• [Presentation] Influence of a shorter duration of postoperative antibiotic prophylaxis on infectious complication in patients undergoing elective liver resection． (2017)
  • Author(s): Masahiko Sakoda, Satoshi Iino, Yuko Mataki, Yota Kawasaki, Motoyuki Hashiguchi, Hiroshi Kurahara, Kosei Maemura, Hiroyuki Shinchi, Shinichi Ueno, Shoji Natsugoe
  • Organizer: SIS-AP 1st international conference
  • Int'l Joint Research
• [Presentation] 80歳以上HCCの予後から考える高齢者に対する至適治療法の検討． (2017)
  • Author(s): 迫田雅彦，飯野 聡，橋口真征，佐竹霜一，川崎洋太，蔵原 弘，又木雄弘，前村公成，新地洋之，上野真一，夏越祥次
  • Organizer: 第79回日本臨床外科学会
• [Presentation] The treatment of the recurrent hepatocellular carcinoma considered from the analysis of prognosis (2017)
  • Author(s): Masahiko Sakoda，Satoshi Iino，Yota Kawasaki，Motoyuki Hashiguchi，Yuko Mataki，Hiroshi Kurahara，Kosei Maemura，Hiroyuki Shinchi，Shinichi Ueno，Shoji Natsugoe
  • Organizer: 第29回日本肝胆膵外科学会/6th A-PHPBA
  • Int'l Joint Research
• [Presentation] 腹腔鏡下肝嚢胞開窓術における ICG 蛍光法と癒着防止吸収性バリアの有用性. (2017)
  • Author(s): 迫田雅彦，飯野 聡，又木雄弘，橋口真征，川崎洋太，蔵原 弘，前村公成，新地洋之，上野真一，夏越祥次
  • Organizer: 第117回日本外科学会
• [Presentation] 予後改善を目指した肝予備能不良HCCに対する腹腔鏡下小範囲解剖学的切除の効果． (2016)
  • Author(s): 迫田雅彦，飯野 聡，又木雄弘，南 幸次，川崎洋太，橋口真征，濱田由紀，蔵原 弘，前村公成，新地洋之，上野真一，夏越祥次
  • Organizer: 第29回日本内視鏡外科学会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-12-08
• [Presentation] 肝切除術における予防抗菌薬投与期間の短縮化による影響 (2016)
  • Author(s): 迫田雅彦，飯野 聡，南 幸次，川崎洋太，蔵原 弘，又木雄弘，前村公成，大脇哲洋，新地洋之，上野真一，夏越祥次
  • Organizer: 第29回日本外科感染症学会総会
  • Place of Presentation: 京王プラザ新宿（東京都新宿区）
  • Year and Date: 2016-11-30
• [Presentation] 肝切除術における予防的抗菌薬の投与期間短縮は可能か？ (2016)
  • Author(s): 迫田雅彦，飯野 聡，又木雄弘，南 幸次，濱田由紀，川崎洋太，蔵原 弘，前村公成，新地洋之，上野真一，夏越祥次
  • Organizer: 第78回日本臨床外科学会
  • Place of Presentation: グランドプリンス新高輪（東京都港区）
  • Year and Date: 2016-11-24
• [Presentation] Survival benefits of small anatomical resection of the liver for patients with hepatocellular carcinoma and impaired liver function. (2016)
  • Author(s): Sakoda M, Ueno S, Iino S, Hiwatashi K, Minami K, Kawasaki Y, Kurahara H, Mataki Y, Maemura K, Shinchi H, Natsugoe S.
  • Organizer: 40th World Congress of the International College of Surgeons
  • Place of Presentation: 国立京都国際会議場（京都府京都市）
  • Year and Date: 2016-10-23
  • Int'l Joint Research
• [Presentation] 肝予備能不良初発肝細胞癌に対する腹腔鏡下小範囲解剖学的肝切除の意義 (2016)
  • Author(s): 迫田雅彦，飯野 聡，南 幸次，川崎洋太，蔵原 弘，又木雄弘，前村公成，新地洋之，上野真一，夏越祥次
  • Organizer: 第54回日本癌治療学会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-20