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Functional analysis of R3h domain containing-like, a novel skeletal satellite-cell-expressed gene, for investigating new treatment strategy of sarcopenia

Research Project

Project/Area Number 16K09229
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionChiba University

Principal Investigator

Takemoto Minoru  千葉大学, 大学院医学研究院, 特任教授 (60447307)

Co-Investigator(Kenkyū-buntansha) 石川 崇広  千葉大学, 医学部附属病院, 特任助教 (00749426)
横手 幸太郎  千葉大学, 大学院医学研究院, 教授 (20312944)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords骨格筋 / サルコペニア / 筋衛生細胞 / 老年医学
Outline of Final Research Achievements

In this study, we identified a novel skeletal satellite-cell-expressed gene, R3h domain containing-like (R3hdml). R3hdml protein was secreted from cultured myotubes into the conditioned media, suggesting that R3hdml a novel myokine. In R3hdml knock out (KO) mice, the body weight and skeletal muscle mass were lower than that in the wild type control mice. Expression levels of cell cycle-related markers within the skeletal muscle was decreased in R3hdml KO mice compared with control mice. Cardiotoxin (CTX) was injected into the skeletal muscle to induce skeletal muscle regeneration after injury; consequently, the expression of R3hdml increased during skeletal muscle regeneration. Recovery of hand grip strength after CTX injection was significantly impaired in the R3hdml KO mice and overexpression of R3hdml rescued this decreased hand grip strength. Our results indicate that R3hdml is important for skeletal muscle development as well as regeneration.

Academic Significance and Societal Importance of the Research Achievements

高齢化社会を迎えている今、健康長寿を達成するためにもサルコペニアなどの骨格筋関連疾患のメカニズムの解明と治療法の確立は急務である。骨格筋は優れた再生能力をもち、障害を受けても速やかに機能を回復する。この再生には筋衛星細胞が重要な役割をはたしている。本研究はR3hdml という新しい筋衛星細胞発現遺伝子を中心にした研究であり新しい切り口でサルコペニア発症機序の解明やさらには治療応用に繋がることが期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (51 results)

All 2018 2017 2016 2015

All Journal Article (28 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 27 results,  Open Access: 23 results,  Acknowledgement Compliant: 1 results) Presentation (23 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development2018

    • Author(s)
      Ide S, Finer G, Maezawa Y, Onay T, Souma T, Scott R, Ide K, Akimoto Y, Li C,Ye M, Zhao X, Baba Y, Minamizuka T, Jin J, Takemoto M, Yokote K, Quaggin SE
    • Journal Title

      J Am Soc Nephrol

      Volume: 29 Issue: 12 Pages: 2795-2808

    • DOI

      10.1681/asn.2017121278

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Biallelic WRN Mutations in Newly Identified Japanese Werner Syndrome Patients2018

    • Author(s)
      Maezawa Y, Kato H, Takemoto M, Watanabe A, Koshizaka M, Ishikawa T, Sargolzaeiaval F, Kuzuya M, Wakabayashi H, Kusaka T, Yokote K, Oshima J
    • Journal Title

      Mol Syndromol

      Volume: 9 Issue: 4 Pages: 214-218

    • DOI

      10.1159/000489055

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immune-mediated acquired lecithin-cholesterol acyltransferase deficiency: A case report and literature review2018

    • Author(s)
      Ishibashi R, Takemoto M, Tsurutani Y, Kuroda M, Ogawa M, Wakabayashi H, Uesugi N, Nagata M, Imai N, Hattori A, Sakamoto K, Kitamoto T, Maezawa Y, Narita I, Hiroi S, Furuta A, Miida T, Yokote K
    • Journal Title

      J Clin Lipidol

      Volume: 12 Issue: 4 Pages: 888-897

    • DOI

      10.1016/j.jacl.2018.05.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a high serum docosahexaenoic acid level as a predictor of longevity among elderly residents at a special nursing home2018

    • Author(s)
      Matsuda H, Matsuda M, Koshizaka M, Matsuda Y, Sakamoto K, Yokote K, Matsuda Y,Takemoto M
    • Journal Title

      Geriatr Gerontol Int

      Volume: 18 Issue: 6 Pages: 980-982

    • DOI

      10.1111/ggi.13297

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered cerebral blood flow in the anterior cingulate cortex is associated with neuropathic pain.2018

    • Author(s)
      Watanabe K, Hirano S, Kojima K, Nagashima K, Mukai H, Sato T, Takemoto M, Matsumoto K, Iimori T, Isose S, Omori S, Shibuya K, Sekiguchi Y, Beppu M, Amino H, Suichi T, Yokote K, Uno T, Kuwabara S, Misawa S.
    • Journal Title

      Journal of Neurology Neurosurgry Psychiatry

      Volume: 印刷中 Issue: 10 Pages: 1082-1087

    • DOI

      10.1136/jnnp-2017-316601

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-3 polyunsaturated fatty acids improve lipoprotein particle size and concentration in Japanese patients with type 2 diabetes and hypertriglyceridemia:a pilot study2018

    • Author(s)
      Ide K, Koshizaka M, Tokuyama H, Tokuyama T, Ishikawa T, Maezawa Y, Takemoto M, Yokote K
    • Journal Title

      Lipids Health Dis

      Volume: 17 Issue: 1 Pages: 51-51

    • DOI

      10.1186/s12944-018-0706-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physician-initiated clinical study of limb ulcers treated with a functional peptide, SR-0379: from discovery to a randomized, double-blind, placebo-controlled trial2018

    • Author(s)
      Nakagami H, Sugimoto K, Ishikawa T, Fujimoto T, Yamaoka T, Hayashi M, Kiyohara E, Ando H, Terabe Y, Takami Y, Yamamoto K, Takeya Y, Takemoto M, Koshizaka M, Ebihara T, Nakamura A, Nishikawa M, Yao XJ, Hanaoka H, Katayama I, Yokote K, Rakugi H
    • Journal Title

      NPJ Aging Mech Dis

      Volume: 4 Issue: 1 Pages: 2-2

    • DOI

      10.1038/s41514-018-0021-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum podocalyxin levels correlate with carotid intima media thickness, implicating its role as a novel biomarker for atherosclerosis2018

    • Author(s)
      Shoji Mayumi、Takemoto Minoru、Kobayashi Kazuki、Shoji Toshihiro、Mori Satoka、Sagara Jun-ichi、Kurosawa Hiroyuki、Hirayama Yoshiaki、Sakamoto Kenichi、Ishikawa Takahiro、Koshizaka Masaya、Maezawa Yoshiro、Yokote Koutaro
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 245-245

    • DOI

      10.1038/s41598-017-18647-6

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Continuous glucose monitoring reveals hypoglycemia risk in elderly patients with type 2 diabetes mellitus.2017

    • Author(s)
      Ishikawa T, Koshizaka M, Maezawa Y, Takemoto M, Tokuyama Y, Saito T, Yokote K.
    • Journal Title

      J Diebetes Invest

      Volume: - Issue: 1 Pages: 69-74

    • DOI

      10.1111/jdi.12676

    • Related Report
      2018 Annual Research Report 2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elevation of autoantibody level against PDCD11 in patients with transient ischemic attack2017

    • Author(s)
      Yoshida Y、Wang H、Hiwasa T、Machida T、Kobayashi E、Mine S、Tomiyoshi G、Nakamura R、Shinmen N、Kuroda H、Takizawa H、Kashiwado K、Kamitsukasa I、Shin H、Wada T、Aotsuka A、Nishi E、Ohno M、Takemoto M、Yokote K、Takahashi S、Matsushima J、Zhang Xiao-Meng、Takiguchi M、Iwadate Y
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 10 Pages: 8836-8848

    • DOI

      10.18632/oncotarget.23653

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of serum levels of antibodies against MMP1, CBX1, and CBX5 with transient ischemic attack and cerebral infarction2017

    • Author(s)
      Wang H,Zhang X-M,Tomiyoshi G,Nakamura R,Shinmen N,Kuroda H,Kimura R,Mine S,Kamitsukasa I,Wada T,Aotsuka A,Yoshida Y,Kobayashi E,Matsutani T,Iwadate Y,Sugimoto K,Mori M,Uzawa A,Muto M,Kuwabara S,Takemoto M,Kobayashi K,Kawamura H,Ishibashi R,Yokote K,Ohno M,
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 5 Pages: 5600-5613

    • DOI

      10.18632/oncotarget.23789

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The clinical characteristics of Asian patients with classical-type Hutchinson?Gilford progeria syndrome2017

    • Author(s)
      Sato-Kawano Nanae、Takemoto Minoru、Okabe Emiko、Yokote Koutaro、Matsuo Muneaki、Kosaki Rika、Ihara Kenji
    • Journal Title

      J Hum Genet

      Volume: 62 Issue: 12 Pages: 1031-1035

    • DOI

      10.1038/jhg.2017.90

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Werner syndrome: a model for sarcopenia due to accelerated aging2017

    • Author(s)
      Yamaga Masaya、Takemoto Minoru、Shoji Mayumi、Sakamoto Kenichi、Yamamoto Masashi、Ishikawa Takahiro、Koshizaka Masaya、Maezawa Yoshiro、Kobayashi Kazuki、Yokote Koutaro
    • Journal Title

      Aging

      Volume: 9 Issue: 7 Pages: 1738-1744

    • DOI

      10.18632/aging.101265

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Laparoscopic Sleeve Gastrectomy Resolves Low GHRP-2-Stimulated Growth Hormone Levels in Obese Patients2017

    • Author(s)
      Ohara Emi、Tokuyama Hirotake、Kitamoto Takumi、Kitahara Aya、Hayashi Aiko、Hayashi Hideki、Takemoto Minoru、Yokote Koutaro
    • Journal Title

      Obesity Surgery

      Volume: 27 Issue: 8 Pages: 2214-2217

    • DOI

      10.1007/s11695-017-2769-4

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Femoral osteoporosis is more common than lumbar osteoporosis in patients with Werner syndrome2017

    • Author(s)
      Mori Seijiro、Zhou Heying、Yamaga Masaya、Takemoto Minoru、Yokote Koutaro
    • Journal Title

      Geriatr Gerontol Int.

      Volume: 17 Issue: 5 Pages: 854-856

    • DOI

      10.1111/ggi.12960

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and safety of ipragliflozin and metformin for visceral fat reduction in patients with type 2 diabetes receiving treatment with dipeptidyl peptidase-4 inhibitors in Japan: a study protocol for a prospective, multicentre, blinded-endpoint phase IV randomised controlled trial (PRIME-V study)2017

    • Author(s)
      Koshizaka Masaya、Ishikawa Ko、Ishikawa Takahiro、Kobayashi Kazuki、Takemoto Minoru、Horikoshi Takuro、Shimofusa Ryota、Takahashi Sho、Nagashima Kengo、Sato Yasunori、Tatsuno Ichiro、Terano Takashi、Hashimoto Naotake、Kuribayashi Nobuichi、Uchida Daigaku、Yokote Koutaro
    • Journal Title

      BMJ Open

      Volume: 7 Issue: 5 Pages: e015766-e015766

    • DOI

      10.1136/bmjopen-2016-015766

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent trends in WRN gene mutation patterns in individuals with Werner syndrome.2017

    • Author(s)
      Yamaga M, Takemoto M, Takada-Watanabe A, Koizumi N, Kitamoto T, Sakamoto K, Ishikawa T, Koshizaka M, Maezawa Y, Yokote K
    • Journal Title

      J Am Geriatr Soc

      Volume: 印刷中 Issue: 8 Pages: 1853-1856

    • DOI

      10.1111/jgs.14906

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Outcomes of laparoscopic sleeve gastrectomy in elderly obese Japanese patients.2017

    • Author(s)
      Hayashi A, Maeda Y, Takemoto M, Tokuyama H, Koide H, Kitahara A, Hayashi H, Kitamoto T, Yamaga M, Kobayashi K, Yokote K.
    • Journal Title

      Geriatr Gerontol Int.

      Volume: - Issue: 11 Pages: 2068-2073

    • DOI

      10.1111/ggi.13022

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sitagliptin but not alpha glucosidase inhibitor reduced the serum soluble CD163, a marker for activated macrophage, in individuals with type 2 diabetes mellitus.2017

    • Author(s)
      Hattori A, Takemoto M, Tokuyama H, Koshizaka M, Yokote K.
    • Journal Title

      Diabetes Res Clin Pract.

      Volume: 126 Pages: 138-143

    • DOI

      10.1016/j.diabres.2017.02.010

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] FEMORAL OSTEOPOROSIS IS MORE COMMON THAN LUMBAR OSTEOPOROSIS IN PATIENTS WITH WERNER SYNDROME2017

    • Author(s)
      Zhou H, Yamaga M, Takemoto M, Yokote K, Mori S.
    • Journal Title

      Geriatr Gerontol Int

      Volume: -

    • Related Report
      2016 Research-status Report
  • [Journal Article] Case of Werner syndrome complicated by adrenal insufficiency due to hypothalamic dysfunction.2017

    • Author(s)
      Ide K, Baba Y, Takemoto M, Koide H, Ide S, Yamaga M, Kobayashi K, Yokote K.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 17 Issue: 2 Pages: 346-347

    • DOI

      10.1111/ggi.12809

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects.2017

    • Author(s)
      Yokote K, Chanprasert S, Lee L, Eirich K, Takemoto M, Watanabe A, Koizumi N, Lessel D, Mori T, Hisama FM, Ladd PD, Angle B, Baris H, Cefle K, Palanduz S, Ozturk S, Chateau A, Deguchi K, Easwar TK, Federico A, Fox A, Grebe TA, Hay B, Nampoothiri S, Seiter K, Streeten E, Poke G, Poot M, Posmyk R, Oshima J
    • Journal Title

      Hum Mutat

      Volume: 38 Issue: 1 Pages: 7-15

    • DOI

      10.1002/humu.23128

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Combination of cilostazol and probucol protected podocytes from lipopolysaccharide-induced injury by both anti-inflammatory and anti-oxidative mechanisms.2016

    • Author(s)
      He P, Kawamura H, Takemoto M, Maezawa Y, Ishikawa T, Ishibashi R, Sakamoto K, Shoji M, Hattori A, Yamaga M, Ide S, Ide K, Hayashi A, Tokuyama H, Kobayashi K, Yokote K.
    • Journal Title

      J Nephrol.

      Volume: - Issue: 4 Pages: 531-541

    • DOI

      10.1007/s40620-016-0361-y

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Matricellular protein CCN3 mitigates abdominal aortic aneurysm.2016

    • Author(s)
      Zhang C, van der Voort D, Shi H, Zhang R, Qing Y, Hiraoka S, Takemoto M, Yokote K, Moxon JV, Norman P, Kuivaniemi H, Atkins GB, Gerson SL, Shi GP, Golledge J, Dong N, Perbal B, Prosdocimo DA, Lin Z
    • Journal Title

      J Clin Invest

      Volume: 126 Issue: 4 Pages: 1282-1299

    • DOI

      10.1172/jci82337

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improved Glycemic Control and Vascular Function and Reduction of Abdominal Fat Accumulation with Liraglutide in a Case of Werner Syndrome with Diabetes Mellitus.2016

    • Author(s)
      Ide S, Yamamoto M, Takemoto M, Fujimoto M, Ide K, Kobayashi K, Yokote K.
    • Journal Title

      J Am Geriatr Soc

      Volume: 64 Issue: 3 Pages: 687-688

    • DOI

      10.1111/jgs.13970

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case of sarcomatoid carcinoma occurring in a patient with Werner syndrome.2016

    • Author(s)
      Mitamura Y, Azuma S, Matsumoto D, Takada-Watanabe A, Takemoto M, Yokote K, Motoshita J, Oda Y, Furue M, Takeuchi S
    • Journal Title

      J Dermatol

      Volume: 43 Issue: 11 Pages: 1362-1364

    • DOI

      10.1111/1346-8138.13399

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel podocyte gene, Semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation.2016

    • Author(s)
      Ishibashi R, Takemoto M, Akimoto Y, Ishikawa T, He P, Maezawa Y, Sakamoto K, Tsurutani Y, Ide S, Ide K, Kawamura H, Kobayashi K, Tokuyama H, Tryggvason K, Betsholtz C, Yokote K
    • Journal Title

      Scientific Report

      Volume: 6 Issue: 1 Pages: 25955-25955

    • DOI

      10.1038/srep25955

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Urinary podocalyxin levels were associated with urinary albumin levels among patients with diabetes.2015

    • Author(s)
      Shoji M, Kobayashi K, Takemoto M, Sato Y, Yokote K.
    • Journal Title

      Biomarkers

      Volume: 21(2) Issue: 2 Pages: 164-167

    • DOI

      10.3109/1354750x.2015.1118551

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Revision of the management guideline for Werner syndrome2018

    • Author(s)
      Takemoto M, Kubota Y, Mori M, Tsukamoto K, Kuzuya M and Yokote K
    • Organizer
      International Meeting on RECQ Helicases and Related Diseases 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diabetes can accelerate sarcopenia in the diaphragm2018

    • Author(s)
      Yamamoto M, Takemoto M, Matsuzaki A, Masuyama H, Koshizaka M, Maezawa Y, Yokote K
    • Organizer
      54th EASD
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of ipragliflozin and metformin for visceral fat reduction in elderly patients with type 2 diabetes: a prospective, blinded-endpoint, randomized controlled study2018

    • Author(s)
      Koshizaka M, Ishikawa K, Ishibashi R, Yokoh H, Sakamoto K, Ishikawa T, Maezawa Y, Takemoto M, Yokote K, PRIME-V Study Group
    • Organizer
      54th EASD
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ベバシズマブによるインスリン自己免疫症候群発現が疑われた一例2018

    • Author(s)
      飯村洋平、本告成淳、今中景子、竹本稔
    • Organizer
      第55回 日本糖尿病学会 関東甲信越地方会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肛門がん治療中に発症した薬剤誘発性インスリン自己免疫症候群の1例2018

    • Author(s)
      竹本稔
    • Organizer
      第640回 日本内科学会関東支部主催 関東地方会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Roles of the bHLH Transcription Factor Tcf21 in Kidney, Heart and Blood Vessels in Health and Diabetes2018

    • Author(s)
      前澤善郎、井出真太郎、馬場雄介、南塚拓也、Rizaldy Scott、Gal Finer、越坂理也、竹本稔、Susan Quaggin、横手幸太郎
    • Organizer
      第61回 日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新規筋衛星細胞発現遺伝子R3hdmlは筋衛星細胞の増殖能を制御し,骨格筋の分化再生を促進する2018

    • Author(s)
      坂本憲一、竹本稔、古市泰郎、高橋恵、秋元義弘、山本雅、石川崇広、前澤善朗、清水孝彦、眞鍋康子、藤井宣晴、横手幸太郎
    • Organizer
      第61回 日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 糖尿病腎症における転写因子Tcf21の機能解析2018

    • Author(s)
      井出真太郎、前澤善朗、Rizaldy Scott、Onay Tuncer、井出佳奈、秋元義弘、竹本稔、Quaggin Susan、横手幸太郎
    • Organizer
      第61回 日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] CT画像を用いた新たな横隔膜測定法の開発および同手法を用いた年齢や糖尿病と横隔膜肥厚の関連に関する検討2018

    • Author(s)
      山本雅、竹本稔、松崎敦、増山英則、越坂理也、前澤善朗、横手幸太郎
    • Organizer
      第61回 日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Werner遺伝子(WRN)exon9にヘテロ変異(1105C>T)を認めたWerner症候群の1例2018

    • Author(s)
      橋本重厚、長谷川浩司、渡邊亜紀、前澤善朗、竹本稔、横手幸太郎
    • Organizer
      第61回 日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] n3系多価不飽和脂肪酸は高中性脂肪血症合併2型糖尿病患者のリポ蛋白粒子サイズ及び濃度を改善させる2018

    • Author(s)
      井出佳奈、越坂理也、徳山宏丈、徳山隆彦、石川崇広、前澤善朗、竹本稔、横手幸太郎
    • Organizer
      第61回 日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] メトホルミンを対照としてイプラグリフロジンによる内臓脂肪面積の変化を検討した多施設共同無作為化比較試験PRIMEVStudy2018

    • Author(s)
      石川耕、越坂理也、石橋亮一、前澤善朗、坂本憲一、内田大学、中村晋、山賀政弥、横尾英孝、大西俊一郎、小林一貴、荻野淳、橋本尚武、徳山宏丈、大原恵美、石川崇広、正司真弓、井出真太郎、井出佳奈、小林明菜、馬場雄介、高橋翔、長嶋健吾、佐藤康憲、竹本稔、横手幸太郎
    • Organizer
      第61回 日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高齢2型糖尿病患者の内臓脂肪に対するイプラグリフロジンの効果:メトホルミン対照 多施設共同無作為化比較試験PRIMEVサブ解析2018

    • Author(s)
      越坂理也、石川耕、石橋亮一、前澤善朗、坂本憲一、内田大学、中村晋、山賀政弥、横尾英孝、大西俊一郎、小林一貴、荻野淳、橋本尚武、徳山宏丈、大原恵美、石川崇広、正司真弓、井出真太郎、井出佳奈、小林明菜、馬場雄介、高橋翔、長嶋健吾、佐藤康憲、竹本稔、横手幸太郎
    • Organizer
      第61回 日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 一特別養護老人ホーム入居者の血中多価不飽和脂肪酸濃度と生命予後に関する検討2018

    • Author(s)
      竹本稔、松田美穂、越坂理也、横手幸太郎、松田由紀夫
    • Organizer
      第60回 日本老年医学学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 早老症ウェルナー症候群の全国疫学調査およびレジストリー構築によるエビデンスの創生2018

    • Author(s)
      越坂理也、石川崇広、加藤尚也、前澤善朗、竹本稔、横手幸太郎
    • Organizer
      第60回 日本老年医学学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 横隔膜厚は肺炎患者の新たな予後予測になりうる-CT画像を用いた新たな横隔膜測定法を用いた解析から2018

    • Author(s)
      山本雅、竹本稔、越坂理也、前澤善朗、横手幸太郎
    • Organizer
      第60回 日本老年医学学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新規筋衛星細胞発現遺伝子R3hdmlの骨格筋における機能解析2017

    • Author(s)
      坂本 憲一、竹本 稔、古市 泰郎、眞鍋 康子、石川 崇広、前澤 善朗、清水 孝彦、藤井 宣晴、横手 幸太郎
    • Organizer
      第4回 骨格筋生物学研究会
    • Place of Presentation
      松本大学(長野県松本市)
    • Year and Date
      2017-03-04
    • Related Report
      2016 Research-status Report
  • [Presentation] R3h domain containing-like (R3hdml) has pivotal roles in skeletal muscle development and regeneration2017

    • Author(s)
      Sakamoto K, Takemoto M, Furuichi Y, Takahashi M, Akimoto Y, Yamamoto M, Ishikawa T, Shimizu T, Manabe Y, Fujii N, Maezawa Y, Betsholtz C, Yokote K.
    • Organizer
      American Diabetes Association (ADA) 77th Scientific Sessions
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] R3h domain containing-like (R3hdml) has crucial roles in skeletal muscle development and regeneration through the regulation of satellite cell proliferation.2017

    • Author(s)
      Sakamoto K, Takemoto M, Furuichi Y, Takahashi M, Akimoto Y, Yamamoto M, Ishikawa T, Shimizu T, Manabe Y, Fujii N, Maezawa Y, Yokote K.
    • Organizer
      Keystone Symposia - Aging and Mechanisms of Aging-Related Disease.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 新規遺伝子R3hdmlの骨格筋分化再生における機能解析2017

    • Author(s)
      坂本 憲一、竹本 稔、古市 泰郎、高橋 恵、秋元 義弘、山本 雅、石川 崇広、前澤 善朗、清水 孝彦、眞鍋 康子、藤井 宣晴、横手 幸太郎
    • Organizer
      日本糖尿病学会年次学術集会・第60回
    • Related Report
      2017 Research-status Report
  • [Presentation] 新規骨格筋発現遺伝子R3hdmlは筋衛星細胞の増殖能を制御し、骨格筋の分化再に関わる2017

    • Author(s)
      坂本 憲一、竹本 稔、古市 泰郎、高橋 恵、秋元 義弘、山本 雅、石川 崇広、前澤 善朗、清水 孝彦、眞鍋 康子、藤井 宣晴、横手 幸太郎
    • Organizer
      日本臨床分子医学会学術集会・第54回
    • Related Report
      2017 Research-status Report
  • [Presentation] 新規遺伝子R3hdmlの骨格筋における機能解析2016

    • Author(s)
      坂本 憲一、竹本 稔、古市 泰郎、眞鍋 康子、石川 崇広、前澤 善朗、清水 孝彦、藤井 宣晴、横手 幸太郎
    • Organizer
      第31回日本糖尿病合併症学会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 新規骨格筋発現遺伝子R3hdmlの機能解析2016

    • Author(s)
      坂本 憲一、竹本 稔、古市 泰郎、眞鍋 康子、石川 崇広、前澤 善朗、清水 孝彦、藤井 宣晴、横手 幸太郎
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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