| Project/Area Number |
16K09234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Research Collaborator |
Ito Yasunori
Nagata Yuka (80802016)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 食物アレルギー / 葛根湯 / 経口免疫療法 / 制御性T細胞 / 腸管粘膜免疫 / 東洋医学 |
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| Outline of Final Research Achievements |
Food allergies (FAs) represent an increasingly prevalent human health problem that affects a large proportion of the general population in developed countries. Despite the increasing prevalence of FA, there are no treatments available for FA. Oral immunotherapy (OIT) has been considered a promising approach for FAs. However, the current OIT strategy is limited in terms of the long-term efficacy and safety. We have previously demonstrated that kakkonto, a traditional Japanese herbal medicine, suppresses the occurrence of allergic symptoms in a murine model of FA. Therefore, we investigated whether kakkonto could improve the efficacy of OIT. The concomitant use of kakkonto significantly enhanced the effectiveness of OIT on the allergic symptoms by increasing regulatory T cells in the colon. These findings indicated that the combination of OIT with kakkonto represents a promising approach for FA treatment.
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| Academic Significance and Societal Importance of the Research Achievements |
病態モデルを用いて、葛根湯と経口免疫療法の併用療法が、経口免疫療法による食物アレルギーの治療効果を増加させることを明らかにした本研究成果は、未だ治療法が確立していない食物アレルギーに対する漢方薬併用した有効な治療法の確立に繋がることが考えられる。
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