| Project/Area Number |
16K09243
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Kochi University |
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Principal Investigator |
Nakamura Kumiko 高知大学, 設備サポート戦略室, 技術専門職員 (30398052)
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| Co-Investigator(Kenkyū-buntansha) |
齊藤 源顕 高知大学, 教育研究部医療学系基礎医学部門, 教授 (60273893)
清水 孝洋 高知大学, 教育研究部医療学系基礎医学部門, 准教授 (00363276)
清水 翔吾 高知大学, 教育研究部医療学系基礎医学部門, 助教 (90721853)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アンジオテンシンⅡ / 排尿 / 脳 / GABA神経系 / superoxide anion / 頻尿 / GABA / 心因性頻尿 / 排尿反射亢進 / AT1受容体阻害薬 / 中脳水道周囲灰白質 / 鼻腔内投与 |
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| Outline of Final Research Achievements |
Psychological stress leads to development of lower urinary tract dysfunctions. We previously reported that a stress related neuropeptide angiotensin II (Ang II) stimulates micturition reflex through central Ang II type 1 (AT1) receptor in rats. We investigated that the molecular mechanism which central Ang II stimulates micturition reflex in rats. The current study demonstrated that central AT1 receptor downstream signaling (phospholipase C/protein kinase C/NADPH oxidase/superoxide anion) and GABA nervous system are involved in central Ang II -induced stimulation of micturition reflex in rats.
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| Academic Significance and Societal Importance of the Research Achievements |
脳内アンジオテンシンII（Ang II）タイプ1 (AT1) 受容体下流シグナル経路活性化が排尿反射亢進（頻尿）誘発に関与することが示唆された。これらシグナル因子は、ストレスのみならず他の因子に起因する頻尿の新たな治療標的になりうることが示唆された。
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