Investigation of mechanism of central angiotensin II-induced stimulation of micturition reflex and development of its medical treatment
| Project/Area Number |
16K09243
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General internal medicine(including psychosomatic medicine)
|
|---|
| Research Institution | Kochi University |
|---|
Principal Investigator |
Nakamura Kumiko 高知大学, 設備サポート戦略室, 技術専門職員 (30398052)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
齊藤 源顕 高知大学, 教育研究部医療学系基礎医学部門, 教授 (60273893)
清水 孝洋 高知大学, 教育研究部医療学系基礎医学部門, 准教授 (00363276)
清水 翔吾 高知大学, 教育研究部医療学系基礎医学部門, 助教 (90721853)
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | アンジオテンシンⅡ / 排尿 / 脳 / GABA神経系 / superoxide anion / 頻尿 / GABA / 心因性頻尿 / 排尿反射亢進 / AT1受容体阻害薬 / 中脳水道周囲灰白質 / 鼻腔内投与 |
|---|
| Outline of Final Research Achievements |
Psychological stress leads to development of lower urinary tract dysfunctions. We previously reported that a stress related neuropeptide angiotensin II (Ang II) stimulates micturition reflex through central Ang II type 1 (AT1) receptor in rats. We investigated that the molecular mechanism which central Ang II stimulates micturition reflex in rats. The current study demonstrated that central AT1 receptor downstream signaling (phospholipase C/protein kinase C/NADPH oxidase/superoxide anion) and GABA nervous system are involved in central Ang II -induced stimulation of micturition reflex in rats.
|
| Academic Significance and Societal Importance of the Research Achievements |
脳内アンジオテンシンII（Ang II）タイプ1 (AT1) 受容体下流シグナル経路活性化が排尿反射亢進（頻尿）誘発に関与することが示唆された。これらシグナル因子は、ストレスのみならず他の因子に起因する頻尿の新たな治療標的になりうることが示唆された。
|
Report
(4 results)
Research Products
(9 results)
-
-
-
[Presentation] Central angiotensin II induces frequent urination through inhibition of GABAergic nervous system and stimulation of angiotensin II type 1 receptor downstream signaling in rats.2018
Author(s)
Shimizu S, Shimizu T, Nakamura K, Higashi Y, Aratake T, Zou S, Hamada T, Nagao Y, Ueba Y, Yamamoto M, Honda M, Saito M.
Organizer
ICS2018 (International Continence Society 48th Annual Meeting) 会期: 8.28-31, 2018 於: Pennsylvania Convention CENTER (PCC) (Philadelphia, United States)
Related Report
Int'l Joint Research
-
-
[Presentation] ストレス関連性脳内神経伝達物質アンジオテンシンIIによる排尿筋過活動誘発の分子機構解明・脳内アンジオテンシンIIタイプ1受容体を標的とした排尿筋過活動抑制効果2018
Author(s)
清水翔吾, 清水孝洋, 中村久美子, 長尾佳樹, 片岡環, 鎌田栞穂, 新武享朗, Zou Suo, 濱田朋弥, 上羽佑亮, 山本雅樹, 東洋一郎, 齊藤源顕:
Organizer
第71回日本薬理学会西南部会 会期:11.19,2018 於: 九州大学医学部百年講堂 (福岡）
Related Report
-
[Presentation] ストレス反応性脳内神経伝達物質アンジオテンシンIIによる頻尿誘発の分子機構解明・脳内アンジオテンシンⅡタイプ1受容体を標的とした頻尿抑制効果2018
Author(s)
清水翔吾, 清水孝洋, 中村久美子, 長尾佳樹, 片岡環, 鎌田栞穂, 新武享朗, Zou Suo, 東洋一郎, 齊藤源顕
Organizer
第3回黒潮カンファレンス 会期: 10.13-14, 2018 於:松江テルサ (松江)
Related Report
-
-
[Presentation] INVOLVEMENT OF BRAIN GABAA RECEPTOR FOR ANGIOTENSIN II-INDUCED FREQUENT URINATION IN THE RAT2017
Author(s)
Shimizu S, Shimizu T, Nakamura K, Aratake T, Zou S, Hamada T, Nagao Y, Yamamoto M, Honda M, Higashi Y, Saito M
Organizer
ICS2017 (International Continence Society 47th Annual Meeting) 会期: 9.12-15, 2017 於: Firenze Fiera Congress Centre Fortezza Da Basso (Florence, Italy)
Related Report
Int'l Joint Research
-
