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Comprehensive monitoring of infectious diseases including influenza using big data in medicine

Research Project

Project/Area Number 16K09254
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionJichi Medical University

Principal Investigator

Hatakeyama Shuji  自治医科大学, 医学部, 教授 (40463864)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords感染症疫学 / 医療ビッグデータ / 抗微生物薬 / インフルエンザ / 感染症 / 内科
Outline of Final Research Achievements

Approximately 0.7 million and 260 million antibiotic prescriptions were analyzed using a public health insurance claims database in Kumamoto and a national administrative claims database in Japan, respectively. Third-generation cephalosporins, macrolides, and quinolones constituted 90% of oral antibiotic prescriptions. Approximately 70% of oral antibiotics were prescribed for acute respiratory infections and acute diarrhea. A high rate of antibiotic prescriptions was observed in children (age: 0-9 years), women, residents of western Japan and patients from small-sized health centers.
Using a public health insurance claims database, we investigated 135,000 patients diagnosed with influenza; approximately 90% of patients received anti-influenza drugs. The incidence of hospital admission within 30 days of diagnosis was 31/100,000 person-years. Anti-influenza drug prescriptions were significantly associated with a lower incidence of admission, regardless of comorbidities.

Academic Significance and Societal Importance of the Research Achievements

①大規模医療情報データベース(レセプトデータ)の利活用環境を整えた。膨大な臨床情報を、高度のデータ技術で解析するために、臨床医学とデータ工学の橋渡し人材を育成した。今後の発展研究の基礎にできる。
②地域およびわが国全体の抗菌薬耐性(AMR)対策において、重要な介入対象および効果判定の指標となるデータが得られた。
③レセプトデータによるインフルエンザ医療のモニタリングおよび医療負荷の解析方法を構築することができた。日本方式のインフルエンザの診断・治療法の効果を評価する一つの方策として利用できる可能性が示唆された。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (32 results)

All 2020 2019 2018 2017 2016

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 16 results,  Open Access: 12 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Book (13 results)

  • [Journal Article] Indications and classes of outpatient antibiotic prescriptions in Japan: A descriptive study using the national database of electronic health insurance claims, 2012?20152020

    • Author(s)
      Hashimoto Hideki、Saito Makoto、Sato Jumpei、Goda Kazuo、Mitsutake Naohiro、Kitsuregawa Masaru、Nagai Ryozo、Hatakeyama Shuji
    • Journal Title

      International Journal of Infectious Diseases

      Volume: 91 Pages: 1-8

    • DOI

      10.1016/j.ijid.2019.11.009

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effect of antithrombin added to recombinant human soluble thrombomodulin for severe community-acquired pneumonia-associated disseminated intravascular coagulation: a retrospective cohort study using a nationwide inpatient database.2020

    • Author(s)
      Suzuki J, Sasabuchi Y, Hatakeyama S, Matsui H, Sasahara T, Morisawa Y, Yamada T, Yasunaga H
    • Journal Title

      J Intensive Care

      Volume: 8 Issue: 1 Pages: 8-8

    • DOI

      10.1186/s40560-019-0419-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A nosocomial cluster of Roseomonas mucosa bacteremia possibly linked to contaminated hospital environment2020

    • Author(s)
      Okamoto Koh、Ayibieke Alafate、Saito Ryoichi、Ogura Kenichi、Magara Yuki、Ueda Reiko、Ogawa Hina、Hatakeyama Shuji
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: In press Issue: 8 Pages: 802-806

    • DOI

      10.1016/j.jiac.2020.03.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Characteristics of Saffold Virus Infection in Children2019

    • Author(s)
      Ugai Satoko、Iwaya Atsushi、Taneichi Hiromichi、Hirokawa Chika、Aizawa Yuta、Hatakeyama Shuji、Saitoh Akihiko
    • Journal Title

      The Pediatric Infectious Disease Journal

      Volume: 38 Issue: 8 Pages: 781-785

    • DOI

      10.1097/inf.0000000000002298

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Azithromycin plus β-lactam versus levofloxacin plus β-lactam for severe community-acquired pneumonia: a retrospective nationwide database analysis.2019

    • Author(s)
      2.Suzuki J, Sasabuchi Y, Hatakeyama S, Matsui H, Sasahara T, Morisawa Y, Yamada T, Yasunaga H
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 25 Issue: 12 Pages: 1012-1018

    • DOI

      10.1016/j.jiac.2019.05.027

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibiotic prescription among outpatients in a prefecture of Japan, 2012?2013: a retrospective claims database study2019

    • Author(s)
      Hashimoto Hideki、Matsui Hiroki、Sasabuchi Yusuke、Yasunaga Hideo、Kotani Kazuhiko、Nagai Ryozo、Hatakeyama Shuji
    • Journal Title

      BMJ Open

      Volume: 9 Issue: 4 Pages: e026251-e026251

    • DOI

      10.1136/bmjopen-2018-026251

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histoplasmosis among HIV-Infected Patients in Japan: a Case Report and Literature Review2019

    • Author(s)
      Hatakeyama Shuji、Okamoto Koh、Ogura Kenichi、Sugita Chise、Nagi Minoru
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 72 Issue: 5 Pages: 330-333

    • DOI

      10.7883/yoken.JJID.2018.354

    • NAID

      130007709114

    • ISSN
      1344-6304, 1884-2836
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significant 1, 3-β-D-glucan content in a penicillin G potassium product2018

    • Author(s)
      Suzuki J, Hatakeyama S, Morisawa Y, Yamada T.
    • Journal Title

      Jpn J Antibiot

      Volume: 71 Pages: 23-27

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significance of repeat magnetic resonance imaging in diagnosing vertebral osteomyelitis2018

    • Author(s)
      Kamiya Naoko、Hatakeyama Shuji、Kanda Naoki、Yonaha Sho、Akine Dai、Yamamoto Yu、Matsumura Masami
    • Journal Title

      Journal of General and Family Medicine

      Volume: 20 Issue: 2 Pages: 68-71

    • DOI

      10.1002/jgf2.226

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nasal diphtheria (chronic carriage) caused by nontoxigenic Corynebacterium diphtheriae.2018

    • Author(s)
      Okamoto K, Hatakeyama S, Sugita C, et al.
    • Journal Title

      J Infect Chemother.

      Volume: epub Issue: 9 Pages: 759-762

    • DOI

      10.1016/j.jiac.2018.01.015

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antimicrobial susceptibility testing of rapidly growing mycobacteria isolated in Japan.2017

    • Author(s)
      Hatakeyama S, Ohama Y, Okazaki M, et al.
    • Journal Title

      BMC Infect Dis.

      Volume: 17 Issue: 1 Pages: 197-197

    • DOI

      10.1186/s12879-017-2298-8

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dose-dependent artificial prolongation of prothrombin time by interaction between daptomycin and test reagents in patients receiving warfarin: a prospective in vivo clinical study.2017

    • Author(s)
      Saito M, Hatakeyama S, Hashimoto H, et al.
    • Journal Title

      Ann Clin Microbiol Antimicrob.

      Volume: 16 Issue: 1 Pages: 27-27

    • DOI

      10.1186/s12941-017-0203-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preemptive anti-cytomegalovirus therapy in high-risk (donor positive, recipient negative cytomegalovirus serostatus) kidney transplant recipients.2017

    • Author(s)
      Hasegawa J, Hatakeyama S, Wakai S, et al.
    • Journal Title

      Int J Infect Dis.

      Volume: 65 Pages: 50-56

    • DOI

      10.1016/j.ijid.2017.09.023

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dose-dependent effect of daptomycin on the artificial prolongation of prothrombin time in coagulation abnormalities: an in vitro verification.2017

    • Author(s)
      Hashimoto H, Saito M, Kanda N, Yamamoto T, Mieno M, Hatakeyama S.
    • Journal Title

      BMC Pharmacol Toxicol.

      Volume: 18 Issue: 1 Pages: 74-74

    • DOI

      10.1186/s40360-017-0180-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significant 1, 3-β-D-glucan content in a penicillin G potassium product.2017

    • Author(s)
      Suzuki J, Hatakeyama S, Morisawa Y, et al.
    • Journal Title

      Jpn J Antibiot.

      Volume: 71 Pages: 23-27

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Disseminated Talaromyces (Penicillium) marneffei and Mycobacterium tuberculosis coinfection in a Japanese patient with AIDS.2017

    • Author(s)
      Hatakeyama S, Yamashita T, Sakai T, et al.
    • Journal Title

      Am J Trop Med Hyg.

      Volume: 97 Issue: 1 Pages: 38-41

    • DOI

      10.4269/ajtmh.16-1004

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ナショナルデータベースを用いた日本の外来経口抗菌薬使用の包括解析(記述疫学)2019

    • Author(s)
      橋本英樹, 畠山修司
    • Organizer
      第93回感染症学会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] レセプトデータを用いた外来経口抗菌薬使用実態の疫学解析2018

    • Author(s)
      橋本英樹,畠山修司
    • Organizer
      第92回日本感染症学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Preemptive therapy for the prevention of cytomegalovirus disease in high-risk (D+/R-) kidney transplant recipients.2017

    • Author(s)
      Hasegawa J, Shirakawa H, Wakai S, Mieno M, Hatakeyama S.
    • Organizer
      The 8th International Congress of the Asia Pacific Society of Infection Control
    • Place of Presentation
      Bangkok
    • Year and Date
      2017-02-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] Gノート増刊 (診断困難症例に対するアプローチ)2019

    • Author(s)
      畠山修司
    • Total Pages
      7
    • Publisher
      羊土社
    • Related Report
      2018 Research-status Report
  • [Book] M.P.増刊号 (抗インフルエンザウイルス薬)2019

    • Author(s)
      畠山修司
    • Total Pages
      4
    • Publisher
      文光堂
    • Related Report
      2018 Research-status Report
  • [Book] プライマリケア医のための内科治療薬使い分けマニュアル(藤村昭夫編)2018

    • Author(s)
      畠山修司
    • Total Pages
      4
    • Publisher
      株式会社じほう
    • Related Report
      2018 Research-status Report
  • [Book] インフルエンザ診療ガイド2018-2019 (菅谷憲夫編)2018

    • Author(s)
      畠山修司
    • Total Pages
      7
    • Publisher
      日本医事新報社
    • Related Report
      2018 Research-status Report
  • [Book] M.P. 呼吸器感染症-成人肺炎診療ガイドライン2017に基づくこれからの実施診療2018

    • Author(s)
      畠山修司
    • Total Pages
      5
    • Publisher
      文光堂
    • Related Report
      2018 Research-status Report
  • [Book] Medical Practice(呼吸器感染症-成人肺炎診療ガイドライン2017に基づくこれからの実施診療)2018

    • Author(s)
      畠山修司
    • Total Pages
      5
    • Publisher
      文光堂
    • Related Report
      2017 Research-status Report
  • [Book] エキスパートの臨床知による検査値ハンドブック第2版2017

    • Author(s)
      畠山修司
    • Total Pages
      2
    • Publisher
      総合医学社
    • Related Report
      2017 Research-status Report
  • [Book] インフルエンザ診療ガイド2017-20182017

    • Author(s)
      畠山修司
    • Total Pages
      4
    • Publisher
      日本医事新報社
    • Related Report
      2017 Research-status Report
  • [Book] 医学と薬学(インフルエンザ合併症の診断・治療)2017

    • Author(s)
      畠山修司
    • Total Pages
      7
    • Publisher
      自然科学社
    • Related Report
      2017 Research-status Report
  • [Book] 月間災害補償 (抗菌薬が効かない!薬剤耐性菌について)2017

    • Author(s)
      畠山修司
    • Total Pages
      2
    • Publisher
      地方公務員災害補償基金
    • Related Report
      2017 Research-status Report
  • [Book] 医学と薬学2017

    • Author(s)
      畠山修司
    • Total Pages
      7
    • Publisher
      自然科学社
    • Related Report
      2016 Research-status Report
  • [Book] インフルエンザ診療ガイド2016-20172016

    • Author(s)
      畠山修司
    • Total Pages
      5
    • Publisher
      日本医事新報社
    • Related Report
      2016 Research-status Report
  • [Book] 日本エイズ学会雑誌2016

    • Author(s)
      畠山修司
    • Total Pages
      11
    • Publisher
      日本エイズ学会
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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