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Elucidation of the mechanism of renal dysfunction improvement by Kampo treatment

Research Project

Project/Area Number 16K09259
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionTokai University

Principal Investigator

ARAI Makoto  東海大学, 医学部, 教授 (30222722)

Co-Investigator(Kenkyū-buntansha) 梶原 景正  東海大学, 医学部, 講師 (00204397)
中田 佳延  東海大学, 医学部, 講師 (40594578)
木村 穣  東海大学, 医学部, 教授 (10146706)
石井 直明  東海大学, 健康学部, 教授 (60096196)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords黄耆 / 急性腎障害 / マウス / 血清尿素窒素 / 血清クレアチニン / シスプラチン / シスプラチンAKI / 血清クレアチニン濃度 / 漢方薬 / バイオマーカー / 慢性腎疾患 / 腎機能
Outline of Final Research Achievements

We examined an effect of Astragalus membranaceus (AM) against chronic kidney disease (CKD). Here we focused on acute kidney injury (AKI) as a promoting factor for CKD. Generally, 20 mg/kg cisplatin is used for AKI experimental model. In this situation, cisplatin-AKI is generated also in young mice (10 weeks old) as well as in old mice (52 weeks old), but few AM effects could find both groups. In reduced dose (14 mg/kg) of cisplatin treatment, we found significant increases of serum BUN or CRE and histological damages in renal tubule epithelial cells and glomeruluses especially in old mice. However, the old mice treated with Astragalus in advance could almost prevent these pathological changes. On the other hand, young mice showed no particular pathological finding, indicating AM could only prevent moderate cisplatin-AKI in old mice. However, this evidence suggests the possibility that AM improves daily generated minor problems such as moderate AKI that is promoting CKD.

Academic Significance and Societal Importance of the Research Achievements

我が国はすでに超高齢化社会を迎え、高騰する国民医療費を抑制するために慢性腎疾患(CKD)患者の透析導入遅延は喫緊の課題となっている。本来は進行したCKDの治療だけでなく、発症の予防とともに、発病初期のうちに正常に回復させることが重要であるが、西洋医学にはその進行を抑える有効な薬剤は見当たらない。本研究の成果として、漢方生薬として古来用いられてきた黄耆の腎機能改善作用に着目し、そのメカニズムの一部を解明した。黄耆は日本薬局方に収載された保険適用がある生薬で、臨床ではCKD患者の医療費抑制やQOL向上が期待できるため、本研究成果により、今後は西洋医学治療の中に積極的に応用されることが期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2019 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Administration of Astragalus membranaceus prevented kidney dysfunction in older mice following renal ischemia-reperfusion2019

    • Author(s)
      Kagemasa Kajiwara, Makoto Arai, Yoshinobu Nakada, Takaaki Kinoue
    • Journal Title

      Int Med J

      Volume: 印刷中

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Administration of Astragalus Membranaceus prevented kidney dysfunction in Cisplatin-AKI model mice2019

    • Author(s)
      Kagemasa Kajiwara, Makoto Arai, Yoshinobu Nakada, Takaaki Kinoue
    • Organizer
      56th ERA-EDTA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] シスプラチンによるAKIモデルマウスに対する黄耆の薬理効果2018

    • Author(s)
      梶原景正、新井信
    • Organizer
      第28回日本東洋医学会関東甲信越支部神奈川県部会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ADMINISTRATION OF ASTRAGALUS MEMBRANACEUS PREVENTED KIDNEY DYSFUNCTION IN MICE AND IN PATIENTS WITH CHRONIC KIDNEY DIESEASE2018

    • Author(s)
      Kagemasa Kajiwara, Makoto Arai, Yoshinobu Nakada and Takaaki Kinoue
    • Organizer
      55TH ERA-EDTA CONGRESS
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] マウス実験モデルを用いたオウギの腎機能改善効果の検討2017

    • Author(s)
      梶原景正、新井信
    • Organizer
      第68回日本東洋医学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 急性腎障害モデルマウスを用いた黄耆の薬効解析2017

    • Author(s)
      梶原景正、中田佳延、新井信
    • Organizer
      第27日本東洋医学会関東甲信越支部神奈川県部会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ダイオウ投与によりマウス腎臓で発現するNa+-H+ exchangerの機能解析2016

    • Author(s)
      梶原 景正、新井 信
    • Organizer
      第67回日本東洋医学会学術総会
    • Place of Presentation
      香川県高松市 サンポートホール高松
    • Year and Date
      2016-06-04
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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