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CRF-related mechanism of stress responses in the rat brain

Research Project

Project/Area Number 16K09269
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionAichi Medical University

Principal Investigator

YAMAGUCHI Naoko  愛知医科大学, 医学部, 准教授 (50380324)

Co-Investigator(Kenkyū-buntansha) 岡田 尚志郎  愛知医科大学, 医学部, 教授 (40203989)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsストレス / コルチコトロピン放出因子 / CRF / 交感神経系 / カテコールアミン / 室傍核 / HPA系
Outline of Final Research Achievements

Stress exposure causes various stress responses. Stressful events activate sympathetic nervous system, resulting in the elevation of plasma catecholamine levels.
In this study, we examined the mechanisms in the brain, especially in the paraventricular hypothalamic nucleus (PVN), of stress-induced sympathetic activation in rats. Our results demonstrated that corticotropin-releasing factor (CRF), one of the major stress-related neuropeptides, in the brain elevated plasma noradrenaline level via activation of β-adrenoceptors in the PVN and plasma adrenaline level via activation of α-adrenoceptors in the PVN. We also revealed that GABAB receptors in the PVN mediate β-adrenoceptors-dependent elevation of plasma noradrenaline level. Furthermore, our results showed that there are differences in stress-induced sympathetic responses in the PVN between acute and chronic stress exposure.

Academic Significance and Societal Importance of the Research Achievements

ストレス反応は本来、生体の防御機構である。しかし、過剰なストレス反応はストレス不適応をもたらし、さらにはうつ病などのストレス関連疾患の発症の契機ともなりうる。このような過剰なストレス反応をもたらす中枢性調節機構については、交感神経反応制御の観点では未だ不明な点も多い。本研究は、脳内、特に交感神経反応およびストレス応答の制御中枢である視床下部室傍核におけるストレス応答調節機序について、その一端を明らかにした。さらに、交感神経系ストレス応答の調節メカニズムに関する基礎的知見蓄積の一助となり、将来的にストレス関連疾患の予防・治療法の開発に繋がると考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2019 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] GABAB receptors in the hypothalamic paraventricular nucleus mediate β-adrenoceptor-induced elevations of plasma noradrenaline in rats.2019

    • Author(s)
      Yamaguchi N, Mimura K, Okada S.
    • Journal Title

      Eur. J. Pharmacol.

      Volume: 848 Pages: 88-95

    • DOI

      10.1016/j.ejphar.2019.01.029

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Prostaglandin E2 EP3 receptor subtype in the paraventricular hypothalamic nucleus mediates the corticotropin-releasing factor-induced elevation of plasma noradrenaline level in rats.2019

    • Author(s)
      Yamaguchi N, Mimura M, Okada S.
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] GABAB receptor in the hypothalamic paraventricular nucleus mediates β-adrenoceptor activation-induced elevation of plasma noradrenaline in rats.2018

    • Author(s)
      Yamaguchi N, Mimura K, Okada S.
    • Organizer
      18th World congress of basic and clinical pharmacology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Possible role of adrenoceptors in the hypothalamic paraventricular nucleus in corticotropin-releasing factor-induced sympathetic activation in rats.2017

    • Author(s)
      Yamaguchi N, Mimura K, Okada S.
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール・長崎新聞文化ホール(長崎県長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Differential roles of adrenoceptors in the hypothalamic paraventricular nucleus in corticotropin-releasing factor-induced sympathetic activation in rats.2017

    • Author(s)
      Yamaguchi N, Sano K, Okada S.
    • Organizer
      第70回日本自律神経学会総会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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