| Project/Area Number |
16K09272
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Osaka Health Science University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
寺崎 文生 大阪医科大学, 医学部, 教授 (20236988)
宗宮 浩一 大阪医科大学, 医学部, 准教授 (20319544)
森 禎章 関西福祉科学大学, 保健医療学部, 教授 (70268192)
早崎 華 関西福祉科学大学, 保健医療学部, 教授 (90257866)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 心筋症 / ストレス / 微量元素 / たこつぼ型心筋症 / ストレス心筋症 |
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| Outline of Final Research Achievements |
The onset mechanism of Takotsubo cardiomyopathy（Stress-induced cardiomyopathy）remains unknown. However, exaggerated sympathetic stimulation triggered by a stressful event appears to play an important role in Takotsubo cardiomyopathy, and cardiac function may be damaged by excessive catecholamine release in the myocardium. In this study, we investigated the expression of stress proteins and the kinetics of trace elements in human cultured myocardial cells treated with catecholamine using mass spectrometry and X-ray fluorescence spectrometer. We found that catecholamine administration induced the overexpression of some stress proteins and changes in the kinetics of several essential trace elements in cultured myocardial cells.
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| Academic Significance and Societal Importance of the Research Achievements |
タコツボ型心筋症は、精神的、身体的ストレスを契機に発症するが、検査、処置、手術などの医療行為、地震等の自然災害での発症例が多数報告されるようになった。急性期に心原性ショック、心室細動等の致死的不整脈を起こすことから、病因の解明と血液検査等による発症早期における診断マーカーの開発が急務である。今回の研究成果は、タコツボ型心筋症の病因解明と診断マーカー開発に繋がる成果であり、今後も研究を継続する。
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