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The development of stratification tool to assess disease-specific health-related QOL in patients with advanced incurable cancer

Research Project

Project/Area Number 16K09274
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionLouis Pasteur Center for Medical Research

Principal Investigator

Sakamoto Naoyuki  公益財団法人ルイ・パストゥール医学研究センター, その他部局等, 研究員(移行) (40547981)

Co-Investigator(Kenkyū-buntansha) 岡山 哲也  京都府立医科大学, 医学部附属病院, 助教 (30636535)
石川 剛  京都府立医科大学, 医学(系)研究科(研究院), 講師 (90372846)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords末梢血インターフェロンγ産生能 / QOL層別化ツール / サイトカインプロファイリング / 疾患特異的QOL / がん関連症状 / 免疫機能パラメーター / シンプトンマネジメント / 血清サイトカインレベル / QOL / 進行がん / 癌 / 臨床
Outline of Final Research Achievements

Recently, the foci of cancer treatment shift towards quality of life (QOL) support as well as survival benefit in patients with advanced incurable cancer. Therefore, we should develop stratification tool to assess health-related QOL, resulting in simple achievement of appropriate health-related QOL management. The results of our study indicated that cancer-related symptom scale scores (e.g. fatigue, appetite loss), assessed using the Quality of Life Questionnaire (EORTC QLQ-C30), were correlated with certain cytokine levels and immunological assessment such as IFN-gamma production ability of peripheral blood may lead to stratify disease-specific health-related QOL in patients with advanced incurable cancer. We believe that these results will contribute to the development of novel symptom management strategy.

Academic Significance and Societal Importance of the Research Achievements

進行がん患者において身体機能、認知機能、社会的機能、がん関連症状の尺度スコアが血清VEGFレベル、末梢血インターフェロンγ産生能と相関関係があることを見出した。QOL問診票に加えて、血清VEGFレベル、末梢血インターフェロンγ産生能を加味して患者のQOLを評価すれば、進行がんの疾患特異的なQOLを層別化することが可能となり、がん治療を行う際、QOLを維持、改善すべき対象の選択に大変有用なツールとなりうると示唆された。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2019 2018

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Skeletal muscle mass as a predictor of the response to neo-adjuvant chemotherapy in locally advanced esophageal cancer.2019

    • Author(s)
      Ota T, Ishikawa T, Endo Y, Matsumura S, Yoshida J, Yasuda T, Okayama T, Inoue K, Dohi O, Yoshida N, Sakamoto N, Kamada K, Uchiyama K, Takagi T, Konishi H, Konishi H, Shiozaki A, Fujiwara H, Kishimoto M, Naito Y, Itoh Y.
    • Journal Title

      Medical Oncology

      Volume: 36(2) Issue: 2

    • DOI

      10.1007/s12032-018-1242-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Phase I clinical trial of adoptive transfer of expanded natural killer cells in combination with IgG1 antibody in patients with gastric or colorectal cancer.2018

    • Author(s)
      Ishikawa T, Okayama T, Sakamoto N, Ideno M, Oka K, Enoki T, Mineno J, Yoshida N, Katada K, Kamada K, Uchiyama K, Handa O, Takagi T, Konishi H, Kokura S, Uno K, Naito Y, Itoh Y.
    • Journal Title

      Int J Cancer

      Volume: 142 Issue: 12 Pages: 2599-2609

    • DOI

      10.1002/ijc.31285

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Safety and efficacy of high purity and activity NK cells therapy in combination with IgG1 antibody in patients with gastric or colorectal cancer: A phase I clinical trial2018

    • Author(s)
      Sakamoto N, Ishikawa T, Okayama T, Ideno M, Oka K, Enoki T, Mineno J, Konishi H, Kokura S, Naito Y, Itoh Y.
    • Organizer
      American Association for Cancer Research (AACR) Annual Meeting 2018. https://webcast.aacr.org/s/2018annual/CTPL04
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phase Ⅰ clinical trial of NK cell therapy combined with IgG1 antibody in patients with gastric or colorectal cancer2018

    • Author(s)
      坂元直行、石川 剛、岡山哲也、出野美津子、榎 竜嗣、峰野純一、内藤裕二、伊藤義人
    • Organizer
      第22回日本がん免疫学会総会
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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