Re-differentiation of gastric cancer tissue by eradication therapy
| Project/Area Number |
16K09283
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hiroshima University |
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Principal Investigator |
Ito Masanori 広島大学, 医歯薬保健学研究科(医), 准教授 (60325206)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ヘリコバクター・ピロリ / H. pylori / 除菌治療 / 胃がん / 低異型度上皮 / 胃癌 |
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| Outline of Final Research Achievements |
We clarify the clinic-pathological feature of gastric cancer after eradication therapy. We reported the difficulty to detect these cancers and demonstrated the usefulness of magnifying narrow band imaging (M-NBI) method for the early detection. In addition, we demonstrated that the epithelium with low grade atypia on the surface of cancer tissue was induced by re-differentiation of gastric cancer by H. pylori eradication therapy.
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| Academic Significance and Societal Importance of the Research Achievements |
本邦で急速に増加しつつある除菌後発生胃がんに対して、早期発見の困難性と、それを克服する有用な診断方法を提示することができた、これにより、胃内視鏡検診などの実施方法に改善の余地があることを示すことができた。より有効な胃内視鏡検査方法を確立することは、国民の利益に直結する事柄である。また除菌治療による腫瘍組織の再分化現象は、これまでの病理学的常識を覆すものであり、当該分野における病態解析についての道筋を開くことができた。
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Clinical Significance of Reddish Depressed Lesions Observed in the Gastric Mucosa after Helicobacter pylori Eradication.2018
Author(s)
Kotachi T, Ito M, Boda T, Kiso M, Masuda K, Hata K, Kawamura T, Sanomura Y, Yoshihara M, Tanaka S, Chayama K.
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Journal Title
Digestion.
Volume: 98
Issue: 1
Pages: 48-55
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Characteristics of gastric cancer in negative test of serum anti-Helicobacter pylori antibody and pepsinogen test: a multicenter study.2017
Author(s)
Kiso M, Yoshihara M, Ito M, Inoue K, Kato K, Nakajima S, Mabe K, Kobayashi M, Uemura N, Yada T, Oka M, Kawai T, Boda T, Kotachi T, Masuda K, Tanaka S, Chayama K.
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Journal Title
Gastric Cancer
Volume: [Epub ahead of print]
Issue: 5
Pages: 764-771
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 血清抗ヘリコバクター抗体陰性およびペプシノゲン法陰性の胃癌症例に関する多施設共同研究2016
Author(s)
木曽まり子, 吉原正治, 伊藤公訓, 井上和彦, 中島滋美, 問部克裕, 小林正夫, 上村直実, 矢田智之, 岡 正志, 河合 隆, 保田智之, 松尾泰治, 小刀崇弘, 田中信治, 茶山一彰.
Organizer
第22回日本ヘリコバクター学会学術集会
Place of Presentation
別府市
Year and Date
2016-06-24
Related Report
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