establishment of POEM for esophageal motility disorders
| Project/Area Number |
16K09291
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | アカラシア / POEM（経口内視鏡的筋層切開術） / びまん性食道攣縮 / Nutcracker食道 / 食道運動機能障害 / 先天性食道狭窄 / Jack-Hammer食道 / 上部消化管学（食道・胃・十二指腸） |
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| Outline of Final Research Achievements |
Standard treatment for esophageal achalasia was used to be laparoscopic surgery. We developed a novel minimally invasive endoscopic treatment for esophageal achalasia in 2008. It is namely POEM (Per-oral endoscopic myotomy). Success rate of POEM exceeds 97% and treatment guideline was also published (Inoue H et al. Dig Endosc 2018; 30: 563-79). Data of more than 3000 POEM cases which were collected whole Japan was also published to GIE. POEM has been accepted worldwide and now it becomes a standard first-line treatment for esophageal achalasia.
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| Academic Significance and Societal Importance of the Research Achievements |
食道アカラシアに対するPOEM手術（経口内視鏡的筋層切開術）は、2008年にわれわれが世界に先駆けて発表した。それ以来、当院だけでも2100例以上、全国でも3000例以上の患者さんにPOEM手術が施行された。保険収載もされ、また治療ガイドラインも発表されている。現在は、国際的にも食道アカラシアに対する標準術式となってきた。これまで外科手術しかなかったアカラシアに対する根治療法を、低侵襲の内視鏡治療としておこなえるようになったことは、患者への朗報であると思われる。
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Report
(5 results)
Research Products
(35 results)
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[Journal Article] Statement for gastroesophageal reflux disease after peroral endoscopic myotomy from an international multicenter experience.2020
Author(s)
Inoue H, Shiwaku H, Kobayashi Y, Chiu PWY, Hawes RH, Neuhaus H, Costamagna G, Stavropoulos SN, Fukami N, Seewald S, Onimaru M, Minami H, Tanaka S, Shimamura Y, Santi EG, Grimes K, Tajiri H.
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Journal Title
Esophagus
Volume: 17
Issue: 1
Pages: 3-10
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Multicenter Evaluation of Clinical Efficacy and Safety of Per-oral Endoscopic Myotomy in Children2019
Author(s)
Choné A, Familiari P, von Rahden B, Desai P, Inoue H, Shimamura Y, Eleftheriadis N, Yamashita K, Khashab MA, Shiwaku H, Seewald S, e.t.c
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Journal Title
Journal of Pediatric Gastroenterology and Nutrition
Volume: 69
Issue: 5
Pages: 523-527
DOI
Related Report
Peer Reviewed
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