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CCR2/CD68 double positive cells were increased the expression levels of MBP protein in the duodenal mucosa of the FD patients

Research Project

Project/Area Number 16K09294
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionNippon Medical School

Principal Investigator

Futagami Seiji  日本医科大学, 医学部, 教授 (50247011)

Co-Investigator(Kenkyū-buntansha) 屋嘉比 康治  埼玉医科大学, 医学部, 教授 (90182295)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords機能性ディスペプシア / 慢性膵炎 / 早期慢性膵炎 / 膵酵素異常 / 十二指腸粘膜 / 胃排出能 / CCR2 / CD68 / GLP-1 / CB68 / 十二指腸 / urocortin / acotiamide / 感染後機能性ディスペプシア
Outline of Final Research Achievements

We have previously reported duodenal inflammation of the patients with FD. In this study, we compared duodenalinflammation of the patients with pancreatic enzyme abnormalities and early chronic pancreatitis. We have reported that early gastric emptying in early chronic pancreatitis and FD patients with pancreatic enzyme abnormalities were significantly disturbed compared to that in FD patients. However, we cannot find significant differences in inflammatory cells infiltarion and GLP-1-positive cells between two groups.

Academic Significance and Societal Importance of the Research Achievements

膵癌のハイリスク群とされている慢性膵炎に、一部の群では進展する早期慢性膵炎の病態解明を行うことは極めて重要である。さらに、日常診療中に遭遇する心窩部痛症候群の中に、早期慢性膵炎患者が少なからず存在することから、膵酵素異常を伴う機能性ディスペプシア患者群と早期慢性膵炎患者群の臨床像や消化管粘膜局所の比較検討を行うことは重要である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (6 results)

  • [Journal Article] Comparison of clinical symptoms, gastric motility and fat intake in the early chronic pancreatitis patients with anti-acid therapy-resistant functional dyspepsia patients2018

    • Author(s)
      Wakabayashi M, Futagami S, Yamawaki H, et al.
    • Journal Title

      PLoS One

      Volume: 13 Issue: 11 Pages: e0205165-e0205165

    • DOI

      10.1371/journal.pone.0205165

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Camostat mesilate, pancrelipase and rabeprazole combination therapy improves epigastric pain in early chronic pancreatitis and functional dyspepsia with pancreatic enzyme2018

    • Author(s)
      Yamawaki H, Futagami S, et al.
    • Journal Title

      Digestion

      Volume: 99 Issue: 4 Pages: 283-292

    • DOI

      10.1159/000492813

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] New classification Rome IV functional dyspepsia and subtypes2018

    • Author(s)
      Futagami S, Yamawaki H, Agawa S, et al.
    • Journal Title

      Transl Gastroenterol Hepatol

      Volume: 3 Pages: 70-70

    • DOI

      10.21037/tgh.2018.09.12

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Management of functional dyspepsia: state of the art and emerging therapies2018

    • Author(s)
      Yamawaki H, Futagami S, Wakabayashi M, et al.
    • Journal Title

      Ther Adv Chronic Dis

      Volume: 9 Issue: 1 Pages: 23-32

    • DOI

      10.1177/2040622317725479

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epigastric pain syndrome accompanying pancreatic enzyme abnormalities was overlapped with early chronic pancreatitis using endosonography.2017

    • Author(s)
      Hashimoto S, Futagami S, Yamawaki H, et al.
    • Journal Title

      J Clin Biochem Nutr

      Volume: 61 Pages: 140-145

    • NAID

      130006038740

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of cyclooxygenase-2 1195 G-carrier genotype associated with intestinal metaplasia and endoscopic findings based on Kyoto classification.2017

    • Author(s)
      Kodaka Y, Futagami S, Tatsuguchi A, et al.
    • Journal Title

      Digestion

      Volume: 96 Issue: 3 Pages: 173-183

    • DOI

      10.1159/000479864

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sleep disturbances in functional gastrointestinal disorders2016

    • Author(s)
      Futagami S, Yamawaki H, et al.
    • Journal Title

      Internal Medicine

      Volume: 55 Pages: 1509-1510

    • NAID

      130005157645

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Improvement of meal-related symptoms and epigasstric pain in patients with functional dyspepsia treated with acotiamide was associated with acylated ghrelin levels in Japan2016

    • Author(s)
      Yamawaki H, Futagami S, et al.
    • Journal Title

      Neurogastroenterol Motil

      Volume: 28 Issue: 7 Pages: 1037-1047

    • DOI

      10.1111/nmo.12805

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 早期慢性膵炎患者および機能性ディスペプシア患者を対象としたcamostat mesilate, pancrelipase, rabeprazole投与群との比較検討2018

    • Author(s)
      二神生爾、山脇博士、岩切勝彦
    • Organizer
      第15回 日本消化管学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 早期慢性膵炎および慢性膵炎疑診例に対する治療戦略-cross over試験の試み-2018

    • Author(s)
      二神生爾、山脇博士、岩切勝彦
    • Organizer
      第104回 日本消化器病学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 早期慢性膵炎及び慢性膵炎疑診例に対する治療戦略~cross over 試験の試み~2018

    • Author(s)
      山脇博士、二神生爾、岩切勝彦
    • Organizer
      第104回日本消化器病学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 早期慢性膵炎と膵酵素異常を伴うFD 患者群の鑑別診断における早期胃排出能の有用性2018

    • Author(s)
      阿川周平、山脇博士、二神生爾
    • Organizer
      第104回 日本消化器病学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 早期慢性膵炎の膵酵素とEUS スコアの経年的変化―治療介入を通して―2018

    • Author(s)
      樋口和寿、二神生爾
    • Organizer
      第104回日本消化器病学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] LPS 刺激urocortin 脳槽内投与ラットにおける消化管粘膜内炎症細胞浸潤の検討2018

    • Author(s)
      酒瀬川典子、二神生爾
    • Organizer
      第104回日本消化器病学会総会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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