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Helicobacter pylori infection-independent adenocarcinomas of the gastroesophageal junction and gastric corpus

Research Project

Project/Area Number 16K09299
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionNational Center for Global Health and Medicine

Principal Investigator

KAWAMURA Yuki I.  国立研究開発法人国立国際医療研究センター, その他部局等, 消化器病態生理研究室長 (10392391)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords食道ー胃接合部癌 / 癌 / 食道ー胃接合部 / 食道-胃接合部
Outline of Final Research Achievements

Gastroesophageal junction cancer is apparently different from both gastric and esophageal cancers. Recently, prevalence of gastroesophageal junction cancer and gastric corpus cancer has been increasing in Japan. The recent striking increases in those types of cancer parallel the promotion of Helicobacter pylori eradication and increase in obesity. Adenocarcinomas arose in the gastroesophageal junction were classified into Barrett's adenocarcinoma and non-Barrett's adenocarcinoma. The aim of this study to identify epigenetically regulated molecular players in adenocarcinomas of the gastroesophageal junction and gastric corpus. Among candidate genes whose expression were perturbed in those types of cancer, we found that the expression of glutathione S-transferase omega 2 (GSTO2) was suppressed by aberrant DNA methylation in Barrett's adenocarcinoma but not in non-Barrett's adenocarcinoma.

Academic Significance and Societal Importance of the Research Achievements

近年、食道ー胃接合部には食道重層扁平上皮細胞の供給源となる基底細胞や、胃腺底部に存在する幹細胞とは異なる形質を有した胚性上皮細胞が存在することが示され、更にマウスモデルを用いた研究よりこの胚性上皮細胞がバレット上皮の起源となることが報告されている。本研究で見出したGSTO2分子は、ヒトおよびマウスの正常食道ー胃接合部に存在する胚性上皮細胞に限局して発現していたため、バレット食道の起源である胚性上皮細胞の生理的・病理的な動態解明に有用なマーカーとなる可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (15 results)

All 2018 2017 2016

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results)

  • [Journal Article] Clinicopathological significance of cystatin A expression in progression of esophageal squamous cell carcinoma.2018

    • Author(s)
      Shiba D, Terayama M, Yamada K, Hagiwara T, Oyama C, Tamura-Nakano M, Igari T, Yokoi C, Soma D, Nohara K, Yamashita S, Dohi T, Kawamura YI.
    • Journal Title

      Medicine

      Volume: 97 Issue: 15 Pages: e0357-e0357

    • DOI

      10.1097/md.0000000000010357

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of kallikrein-related peptidase 13 is associated with poor prognosis in esophageal squamous cell carcinoma.2018

    • Author(s)
      Nohara K, Yamada K, Yamada L, Hagiwara T, Igari T, Yokoi C, Som, D, Yamashita S, Dohi T, Kawamura YI.
    • Journal Title

      General Thoracic Cardiovascular Surgery

      Volume: 66 Issue: 6 Pages: 79-87

    • DOI

      10.1007/s11748-018-0923-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the desmosome-related molecule periplakin is associated with advanced stage and poor prognosis of esophageal squamous cell carcinoma.2018

    • Author(s)
      Yamada K, Hagiwara T, Inazuka F, Sezaki T, Igari T, Yokoi C, Nohara K, Yamashita S, Dohi T, Kawamura YI.
    • Journal Title

      Translational Cancer Research

      Volume: 7 Issue: 1 Pages: 79-87

    • DOI

      10.21037/tcr.2018.01.03

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] DNA hypermethylation and silencing of PITX1 correlated with advanced stage and poor postoperative prognosis of esophageal squamous cell carcinoma.2017

    • Author(s)
      Otsubo T, Yamada K, Hagiwara T, Oshima K, Iida K, Nishikata K, Toyoda T, Igari T, Nohara K, Yamashita S, Hattori M, Dohi T, Kawamura YI.
    • Journal Title

      Oncotarget

      Volume: 8 Pages: 84434-84448

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fatty acids in a high-fat diet potentially induce gastric parietal-cell damage and metaplasia in mice2016

    • Author(s)
      Hirata, Y. Sezaki, T. Tamura-Nakano, M. Oyama, C. Hagiwara, T. Ishikawa, T. Fukuda, S. Yamada, K. Higuchi, K. Dohi, T. Kawamura, Y. I.
    • Journal Title

      J Gastroenterol

      Volume: - Issue: 8 Pages: 889-903

    • DOI

      10.1007/s00535-016-1291-0

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Impact of dietary fat on cancer-predisposing luminal environment.2018

    • Author(s)
      Kawamura YI
    • Organizer
      The 37th Sapporo International Cancer Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Glutathione S-transferase omega 2 (GSTO2) is a novel tumor suppressor gene in human esophageal squamous cell carcinoma.2018

    • Author(s)
      Terayama M, Yamada K, Inazuka F, Hagiwara T, Dohi T, Kokudo N, Kawamura YI.
    • Organizer
      Digestive Disease Week Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DNAメチル化亢進により食道扁平上皮癌特異的に発現低下を認めるGSTO2~組織型特異性の検討~.2018

    • Author(s)
      寺山 仁祥、山田 和彦、野原 京子、相馬 大介、安田 秀光、橋本 政典、矢野 秀朗、萩原 輝記、土肥 多恵子、河村 由紀
    • Organizer
      第73回日本消化器外科学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] DNA hypermethylation of PITX1 correlated with poor prognosis of esophageal squamous cell carcinoma.2017

    • Author(s)
      Yamada K, Otsubo T, Hagiwara T, Oshima K, Iida K, Nishikata K, Toyoda T, Igari T, Nohara K, Soma D, Kataoka A, Yamashita S, Hattori M, Dohi T, Kawamura YI.
    • Organizer
      The 28th Annual Meeting of the European Society for Diseases of the Esophagus (ESDE)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Expression of the desmosome-related periplakin is associated with advanced stage of esophageal squamous cell carcinoma.2017

    • Author(s)
      Yamada K, Kawamura YI, Hagiwara T, Inazuka F, Sezaki T, Dohi T, Nohara K, Soma D, Yamashita S, Edamoto Y, Yano H, Hashimoto M, Kokudo N.
    • Organizer
      The 15th World Congress of the OESO
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cystatin A (CSTA) expression relates to clinico-pathological stages in esophageal squamous cell carcinoma.2017

    • Author(s)
      Terayama M, Yamada K, Soma D, Kokudo N, Kawamura YI.
    • Organizer
      The 15th World Congress of the OESO
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肥満と胃粘膜における壁細胞変化についての検討.2017

    • Author(s)
      山田和彦、河村由紀、横溝悠里子、中野(田村)美和、野原京子、相馬大介、山下智、横井千寿、猪狩亨、土肥多恵子.
    • Organizer
      第72回日本消化器外科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 高脂肪食が引き起こすマウス上部消化管病変2016

    • Author(s)
      平田 有基、瀬崎 拓人、樋口 和秀、河村 由紀、土肥 多惠子
    • Organizer
      日本消化器病学会大会
    • Place of Presentation
      神戸コンベンションセンター、神戸
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] デスモゾーム関連分子であるperiplakinの発現は予後不良因子になる.-DNAメチル化と免疫染色での検討-2016

    • Author(s)
      山田 和彦、河村 由紀、萩原 輝記、土肥 多恵子、山田 純、野原 京子、山下 智、橋本 政典、矢野 秀朗
    • Organizer
      日本消化器外科学会
    • Place of Presentation
      あわぎんホール、徳島
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 食道癌における網羅的メチル化解析より見出されたデスモソーム関連分子periplakinと臨床病理学的検討2016

    • Author(s)
      山田 和彦、河村 由紀、山田 純、野原 京子、山下 智、萩原 輝記、大坪 武史、中野(田村) 美和、瀬崎 拓人、土肥 多恵子、枝元 良広、徳原 真、橋本 政典、矢野 秀朗
    • Organizer
      日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場、大阪
    • Year and Date
      2016-04-16
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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