| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Gastroesophageal junction cancer is apparently different from both gastric and esophageal cancers. Recently, prevalence of gastroesophageal junction cancer and gastric corpus cancer has been increasing in Japan. The recent striking increases in those types of cancer parallel the promotion of Helicobacter pylori eradication and increase in obesity. Adenocarcinomas arose in the gastroesophageal junction were classified into Barrett's adenocarcinoma and non-Barrett's adenocarcinoma. The aim of this study to identify epigenetically regulated molecular players in adenocarcinomas of the gastroesophageal junction and gastric corpus. Among candidate genes whose expression were perturbed in those types of cancer, we found that the expression of glutathione S-transferase omega 2 (GSTO2) was suppressed by aberrant DNA methylation in Barrett's adenocarcinoma but not in non-Barrett's adenocarcinoma.
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