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Elucidation of pathophysiology of inflammatory bowel disease focusing on fatty acid metabolism enzyme SCD1

Research Project

Project/Area Number 16K09308
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionShiga University of Medical Science

Principal Investigator

INATOMI OSAMU  滋賀医科大学, 医学部, 講師 (70530351)

Co-Investigator(Kenkyū-buntansha) 馬場 重樹  滋賀医科大学, 医学部, 講師 (40422901)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsSCD-1 / SCD1 / 脂肪酸代謝 / 消化器内科
Outline of Final Research Achievements

It was suggested that SCD-1 in the mucosal area plays an important role in the cause of exacerbation of colitis due to high fat diet. In DSS colitis, LC3 expression in colonic epithelium was significantly increased as compared to control mice, and the action was further enhanced by the administration of chloroquine. Administration of a high-fat diet did not enhance LC3 expression, and accumulation of the selective autophagy substrate p62 was observed. This indicates that high fat diet load may cause autophagy failure for some reason, and may cause deterioration of enteritis.

Academic Significance and Societal Importance of the Research Achievements

高脂肪食がクローン病を増悪させるメカニズムは長らく解明されていないが、本研究では脂肪酸代謝に関わるSCD-1とオートファージーを介した腸管局所での炎症進展機序の重要性を明らかにした。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (1 results)

All 2019

All Presentation (1 results)

  • [Presentation] オートファジーによる小胞体ストレス誘導性アポトーシスの制御を介した腸炎抑制機構の解析2019

    • Author(s)
      西田淳史、安藤朗、他
    • Organizer
      第105回日本消化器病学会総会 シンポジウム4
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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