| Project/Area Number |
16K09324
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kitasato University |
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Principal Investigator |
Kobayashi Taku 北里大学, 北里研究所病院, 副センター長 (10424144)
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| Co-Investigator(Kenkyū-buntansha) |
山田 悟 北里大学, 北里研究所病院, 部長(医師) (10286487)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 糖質制限 / 腸内細菌叢 / 高脂肪食 / 食事 / 腸管免疫 / 低炭水化物 / 炎症性腸疾患 / 粘膜免疫 / 腸内細菌 / 高脂肪 / 糖質制限食 / 糖尿病 |
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| Outline of Final Research Achievements |
In order to clarify the relationship between diet and enterobacteria and intestinal immunity, the following studies were conducted by roughly dividing into (I) mouse (II) human. Bacterial flora increased in Clostridium cluster XI, Lactobacillales, and Prevotella compared with NFD group when mice were fed a high-fat or carbohydrate-restricted diet, and Bacteroides decreased considerably. . By linking with a carbohydrate-restricted diet education program for diabetic patients to examine and confirm their significance in humans, intestinal microflora in Japanese diabetic patients, intestinal microflora changes by carbohydrate-restricted diet, carbohydrate-restricted diet Most of the effective and ineffective cases were examined for the presence or absence of intestinal flora change in the discontinued cases.
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| Academic Significance and Societal Importance of the Research Achievements |
糖質制限食はカロリーについての制限がないにも関わらず、急性期の効果としての血糖コントロール改善のみならず、肥満を改善する効果もあり、その有効性は広く認知され社会的に大きなブームとなっている。この糖質制限食の腸内細菌に対する影響、腸管免疫に対する影響を科学的に調べることは非常に重要と考える。
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