| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We investigated expressional regulation of the mucosal innate defense factor D-amino acid oxidase, DAO, and immune modulation by DAO in mammals. We have shown that DAO expression was induced by commensal microbiota through non-canonical pathway that does not involve canonical signaling molecules, MyD88 or RIPK2. We have also found that D-amino acid metabolism by DAO regulates adaptive immune system: (1) activation of immune responses through T-cell dependent signals triggered by DAO-sensitive microbiota, and (2) increase capacity of the responses through T-cell independent signals.
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