| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
As a factor of liver fibrosis caused by HBV infection, I hypothesized that intracellular stress increased by viral infection. When the fluctuation of intracellular stress in the presence of HBV was examined in an in vitro experimental system, the endoplasmic reticulum stress which is a typical cell stress or the antioxidant action showed little fluctuation regardless of the increase or decrease of the viral load . Since it was difficult to verify the relationship between HBV and cell stress in vitro, we tried to use an experimental system that could cause liver damage in an in vivo system as the next step. In order to search for markers that can distinguish non-invasively from control group and liver injury group, sugar chain analysis was performed using each liver tissue and serum sample. Several marker candidates were confirmed.
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