| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Aiming at the pathological elucidation of chronic liver failure, we compared the properties of normal and cirrhotic hepatocytes using various molecular biological techniques. In cell culture analysis, hepatocyte functions such as albumin synthesis and urea synthesis were decreased according to the progression from normal to cirrhosis. Furthermore, as a result of gene array analysis and metabolomics, hepatocytes become more immature traits on pathological condition of chronic liver failure, and its change in intracellular metabolic pathways resulted in decreased energy production capacity. This study revealed a cause of human chronic liver failure.
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