Study of Molecular Mechanisms of Heart Failure

• Project/Area Number: 16K09421
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Niigata University
• Principal Investigator: Komei Tanaka 新潟大学, 医歯学総合研究科, 客員研究員 (70572725)
• Co-Investigator(Kenkyū-buntansha): 南野 徹 新潟大学, 医歯学系, 教授 (90328063)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 心不全 / ミトコンドリア / 左室収縮能が保持された心 不全 / アディポネクチン / メタボロミクス / 左室収縮能が保持された心不全

Outline of Final Research Achievements

The prognosis of severe heart failure is unacceptably poor and it is urgent to establish new therapies for this critical condition. Some patients with heart failure do not respond to established multidisciplinary treatment and are classified as “non-responders”. The outcome is especially poor for non-responders, and underlying mechanisms are largely unknown. We examined endomyocardial biopsies and metabolomic analysis in patients with idiopathic dilated cardiomyopathy (IDCM). Patients were classified as non-responders when the left-ventricular (LV) ejection fraction and LV end-diastolic dimension did not show more than 10% improvement over the long-term after cardiac biopsy. We here demonstrate that reduction of mitofusin-1 expression impairs cardiomyocyte metabolism and may have a crucial role in the pathology of non-responsive IDCM.

Academic Significance and Societal Importance of the Research Achievements

その心不全はあらゆる心臓病の終末像であり、種々の薬物療法（β遮断薬、アンギオテンシン変換酵素阻害薬、アンギオテンシンII受容体拮抗薬、アルドステロン拮抗薬）や非薬物療法（心臓再同期療法、非侵襲的陽圧換気療法）が進歩した現在においても、癌とともに未だに予後不良な疾患群の一つである。本研究はこのような治療抵抗性の心不全患者に対する新たな治療の開発へつながるものである。

Research Products

• [Journal Article] Clinical Predictors of Recurrent Ventricular Arrhythmias in Secondary Prevention Implantable Cardioverter Defibrillator Recipients With Coronary Artery Disease ― Lower Left Ventricular Ejection Fraction and Incomplete Revascularization ― (2018)
  • Author(s): Takano Toshiki、Tanaka Komei、Ozaki Kazuyuki、Sato Akinori、Iijima Kenichi、Yanagawa Takao、Izumi Daisuke、Ozawa Takuya、Fuse Koichi、Sato Masahito、Tanabe Naohito、Minamino Tohru
  • Journal Title: Circulation Journal Volume: 82 Issue: 12 Pages: 3037-3043
  • DOI: 10.1253/circj.CJ-18-0646
  • NAID: 130007521281
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-11-24
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of Corticosteroid Treatment for Refractory Multivessel Vasospastic Coronary Angina with Hypereosinophilia (2018)
  • Author(s): Takano Toshiki、Ozaki Kazuyuki、Tanaka Komei、Yanagawa Takao、Ozawa Takuya、Minamino Tohru
  • Journal Title: Internal Medicine Volume: 57 Issue: 21 Pages: 3111-3115
  • DOI: 10.2169/internalmedicine.0886-18
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-11-01
  • Peer Reviewed / Open Access
• [Journal Article] Bidirectional Shunt Trajectory in Ventricular Septal Defect With Eisenmenger’s Syndrome (2018)
  • Author(s): Kayamori Hiromi、Kashimura Takeshi、Horii Yosuke、Kanazawa Tsutomu、Fujita Toshio、Kubota Naoki、Ikami Yasuhiro、Takano Toshiki、Okubo Takeshi、Hoyano Makoto、Yanagawa Takao、Ozawa Takuya、Ozaki Kazuyuki、Minamino Tohru
  • Journal Title: Circulation Journal Volume: 82 Issue: 11 Pages: 2925-2926
  • DOI: 10.1253/circj.CJ-18-0332
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-10-25
  • Peer Reviewed / Open Access
• [Journal Article] Atrial Fibrillation in Patients with End-stage Kidney Disease on Dialysis (2018)
  • Author(s): Watanabe H, Minamino T.
  • Journal Title: Internal Medicine Volume: 57 Issue: 16 Pages: 2285-2286
  • DOI: 10.2169/internalmedicine.0735-17
  • NAID: 130007434275
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-08-15
  • Peer Reviewed / Open Access
• [Journal Article] Prognosis of Cancer Patients with Aortic Stenosis Under Optimal Cancer Therapies and Conservative Cardiac Treatments (2018)
  • Author(s): Okura Y, Ishigaki S, Sakakibara S, Yumoto C, Hashitate M, Sekine C, Fujita T, Takayama T, Ozaki K, Sato N, Minamino T.
  • Journal Title: International Heart Journal Volume: 59 Issue: 4 Pages: 750-758
  • DOI: 10.1536/ihj.17-320
  • NAID: 130007427481
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2018-07-31
  • Peer Reviewed / Open Access
• [Journal Article] Catecholamine-Induced Senescence of Endothelial Cells and Bone Marrow Cells Promotes Cardiac Dysfunction in Mice (2018)
  • Author(s): Katsuumi G, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Wakasugi T, Nakao M, Minamino T
  • Journal Title: International Heart Journal Volume: 59 Issue: 4 Pages: 837-844
  • DOI: 10.1536/ihj.17-313
  • NAID: 130007428422
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2018-07-31
  • Peer Reviewed / Open Access
• [Journal Article] Amlodipine Inhibits Vascular Cell Senescence and Protects Against Atherogenesis Through the Mechanism Independent of Calcium Channel Blockade (2018)
  • Author(s): Kayamori H, Shimizu I, Yoshida Y, Hayashi Y, Suda M, Ikegami R, Katsuumi G, Wakasugi T, Minamino T
  • Journal Title: International Heart Journal Volume: 59 Issue: 3 Pages: 607-613
  • DOI: 10.1536/ihj.17-265
  • NAID: 130007378298
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2018-05-31
  • Peer Reviewed / Open Access
• [Journal Article] Percutaneous Coronary Intervention for a Patient with Left Main Coronary Compression Syndrome (2018)
  • Author(s): Ikegami R, Ozaki K, Ozawa T, Hirono S, Ito M, Minamino T.
  • Journal Title: Internal Medicine Volume: 57 Issue: 10 Pages: 1421-1424
  • DOI: 10.2169/internalmedicine.9534-17
  • NAID: 130006734423
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-05-15
  • Peer Reviewed / Open Access
• [Journal Article] Gamma-aminobutyric acid signaling in brown adipose tissue promotes systemic metabolic derangement in obesity. (2018)
  • Author(s): Ikegami R, Shimizu I, Sato T, Yoshida Y, Hayashi Y, Suda M, Katsuumi G, Li J, Wakasugi T, Minokoshi Y, Okamoto S, Hinoi E, Nielsen S, Jespersen NZ, Scheele C, Soga T, Minamino T
  • Journal Title: Cell Reports Volume: 24 Issue: 11 Pages: 2827-2837
  • DOI: 10.1016/j.celrep.2018.08.024
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dynamic left ventricular outflow tract obstruction complicated with takotsubo cardiomyopathy: The acute phase of takotsubo cardiomyopathy manifests latent left ventricular outflow tract obstruction (2018)
  • Author(s): Sakaguchi Yuta、Ozaki Kazuyuki、Takano Toshiki、Namba Hitomi、Tanaka Komei、Yanagawa Takao、Ozawa Takuya、Minamino Tohru
  • Journal Title: Journal of Cardiology Cases Volume: 18 Issue: 2 Pages: 60-64
  • DOI: 10.1016/j.jccase.2018.04.010
  • Peer Reviewed / Open Access
• [Journal Article] Burden of cardiovascular disease in Japanese cancer patients and survivors: a single cancer-center study in Niigata City. (2018)
  • Author(s): Okura Y, Takayama T, Ozaki K, Tanaka H, Seki H, Takenouchi T, Sato N, Minamino T.
  • Journal Title: Int J Clin Oncol. Volume: 印刷中 Issue: 2 Pages: 196-210
  • DOI: 10.1007/s10147-018-1341-0
  • Peer Reviewed / Open Access
• [Journal Article] Aortic carboxypeptidase-like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis. (2018)
  • Author(s): Teratani T, Tomita K, Suzuki T, Furuhashi H, Irie R, Nishikawa M, Yamamoto J, Hibi T, Miura S, Minamino T, Oike Y, Hokari R, and Kanai T.
  • Journal Title: J Clin Invest. Volume: 128 Issue: 4 Pages: 1581-1596
  • DOI: 10.1172/jci92863
  • Peer Reviewed / Open Access
• [Journal Article] Effects of direct oral anticoagulants at the peak phase, the trough phase, and after vascular injury (2018)
  • Author(s): Otuki S, Izumi D, Suda M, Sato A, Hasegawa Y, Yagihara N, Iijima K, Chinushi M, Fuse I, Minamino T
  • Journal Title: J Am Coll Cardiol. Volume: 71 Issue: 1 Pages: 102-104
  • DOI: 10.1016/j.jacc.2017.10.076
  • Peer Reviewed / Open Access
• [Journal Article] Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells. (2018)
  • Author(s): Si S, Nakajima-Takagi Y, Iga T, Tsuji M, Hou L, Oshima M, Koide S, Saraya A, Yamazaki S, Takubo K, Kubota Y, Minamino T, Iwama A.
  • Journal Title: Exp Hematol Volume: 63 Pages: 41-51
  • DOI: 10.1016/j.exphem.2018.04.006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Boysenberry polyphenol inhibits endothelial dysfunction and improves vascular health. (2018)
  • Author(s): Furuuchi R, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Minamino T
  • Journal Title: PLoS One. Volume: 13 Issue: 8 Pages: e0202051-e0202051
  • DOI: 10.1371/journal.pone.0202051
  • Peer Reviewed / Open Access
• [Journal Article] Aortic Regurgitation Presenting with Recurrent Detachment of a Prosthetic Valve, as the First Presenting Symptom of Cardiovascular Behçet's Disease (2018)
  • Author(s): Takayama T, Ozawa T, Sanada A, Watanabe T, Ito M, Hirono S, Aizawa Y, Minamino T.
  • Journal Title: Internal Medicine Volume: 57 Issue: 6 Pages: 823-827
  • DOI: 10.2169/internalmedicine.9603-17
  • NAID: 130006507406
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Dual Antiplatelet Therapy Guided by <i>CYP2C19</i> Polymorphisms after Implantation of Second-Generation Drug-Eluting Stents for Management of Acute Coronary Syndrome (2018)
  • Author(s): Ozawa T, Yanagawa T, Minamino T, et al
  • Journal Title: International Heart Journal Volume: 59 Issue: 1 Pages: 21-26
  • DOI: 10.1536/ihj.17-005
  • NAID: 130006321382
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Vascular senescence in cardiovascular and metabolic diseases. (2018)
  • Author(s): Katsuumi G, Shimizu I, Yoshida Y, Minamino T
  • Journal Title: Front Cardiovasc Med. Volume: 5 Pages: 18-18
  • DOI: 10.3389/fcvm.2018.00018
  • Peer Reviewed / Open Access
• [Journal Article] Catecholamine-induced senescence of endothelial cells and bone marrow cells promotes cardiac dysfunction in mice. (2018)
  • Author(s): Katsuumi G, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Wakasugi T, Nakao M, Minamino T.
  • Journal Title: Int Heart J. Volume: 印刷中
  • NAID: 130007428422
  • Peer Reviewed / Open Access
• [Journal Article] Percutaneous Coronary Intervention for a Patient with Left Main Coronary Compression Syndrome. (2018)
  • Author(s): Ikegami R, Ozaki K, Ozawa T, Hirono S, Ito M, Minamino T.
  • Journal Title: Intern Med. Volume: 印刷中
  • NAID: 130006734423
  • Peer Reviewed / Open Access
• [Journal Article] A Case of Aortic Regurgitation Presenting with Recurrent Detachment of a Prosthetic Valve, as the First Presenting Symptom of Cardiovascular Behcet's Disease (2018)
  • Author(s): Takayama T, Ozawa T, Sanada A, Watanabe T, Ito M, Hirono S, Aizawa Y, Minamino T.
  • Journal Title: Intern Med Volume: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Dual Antiplatelet Therapy Guided by CYP2C19 Polymorphisms after Implantation of Second-Generation Drug-Eluting Stents for Management of Acute Coronary Syndrome. (2018)
  • Author(s): Ozawa T, Suda M, Ikegami R, Takano T, Wakasugi T, Yanagawa T, Tanaka K, Ozaki K, Hirono S, Minamino T.
  • Journal Title: Int Heart J. Volume: 印刷中
  • NAID: 130006321382
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway. (2017)
  • Author(s): Suda M, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Katsuumi G, Wakasugi T, Yoshida Y, Okuda S, Soga T, Minamino T
  • Journal Title: PLoS One. Volume: 12 Issue: 8 Pages: e0182422-e0182422
  • DOI: 10.1371/journal.pone.0182422
  • Peer Reviewed / Open Access
• [Journal Article] Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway. (2017)
  • Author(s): Kinoshita D, Nagasawa A, Shimizu I, Ito T, Yohko Y, Tsuchida M, Iwama A, Hayano T and Minamino T.
  • Journal Title: Oncotarget Volume: 印刷中 Issue: 21 Pages: 34045-34056
  • DOI: 10.18632/oncotarget.15973
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers. (2017)
  • Author(s): Nishiuchi S, Makiyama T, Aiba T, Nakajima K, Hirose S, Kohjitani H, Yamamoto Y, Harita T, Hayano M, Wuriyanghai Y, Chen J, Sasaki K, Yagihara N, Ishikawa T, Onoue K, Murakoshi N, Watanabe I, Ohkubo K, Watanabe H, Ohno S, Doi T, Shizuta S, Minamino T, et.al
  • Journal Title: Circ Cardiovasc Genet. Volume: 6 Issue: 6
  • DOI: 10.1161/circgenetics.116.001603
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical features and predictors of patients with critical limb ischemia who responded to autologous mononuclear cell transplantation for therapeutic angiogenesis. (2017)
  • Author(s): Aoyama N, Nishinari M, Ohtani S, Kanai A, Noda C, Hirata M, Miyamoto A, Watanabe M, Minamino T, Izumi T, Ako J.
  • Journal Title: Heart Vessels. Volume: 印刷中 Issue: 9 Pages: 1099-1108
  • DOI: 10.1007/s00380-017-0968-5
  • Peer Reviewed / Open Access
• [Journal Article] Inappropriate inhibition of biventricular pacing due to diaphragmatic myopotentials amplified by the selectable sensing filter. (2017)
  • Author(s): Iijima K, Ishida N, Izumi D, Minamino T.
  • Journal Title: Europace. Volume: 印刷中 Issue: 12 Pages: 2014-2014
  • DOI: 10.1093/europace/euw372
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative Analysis of PKP2 and Neighboring Genes in a Patient with Arrhythmogenic Right Ventricular Cardiomyopathy Caused by Heterozygous PKP2 Deletion. (2016)
  • Author(s): Sonoda K, Ohno S, Horie M, et al.
  • Journal Title: Europace Volume: 未定 Pages: 644-650
  • DOI: 10.1093/europace/euw038
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Manifestation of Latent Left Ventricular Outflow Tract Obstruction in the Acute Phase of Takotsubo Cardiomyopathy. (2016)
  • Author(s): Otuki S, Hasegawa K, Watanabe H, Katsuumi G, Yagihara N, Iijima K, Sato A, Izumi D, Furushima H,Chinushi M,Aizawa Y, and Minamino T.
  • Journal Title: Journal of Electrocardiology, Volume: - Issue: 3 Pages: 277-281
  • DOI: 10.1016/j.jelectrocard.2016.09.005
  • NAID: 130005171736
  • Peer Reviewed / Open Access
• [Presentation] Targeting Cardiovascular Senescence through Senescence-associated Glycoprotein. (2019)
  • Author(s): Minamino T.
  • Organizer: The 14th Annual Winter Research Meeting on Translational Heart Failure Research,
  • Int'l Joint Research / Invited
• [Presentation] Targeting Cellular Aging for Cardio-metabolic Disease. (2019)
  • Author(s): Minamino T.
  • Organizer: The 3rd Annual 2019 International Hawaii Cardiovascular Symposium,
  • Int'l Joint Research / Invited
• [Presentation] Targeting cellular aging for the treatment of cardiovascular diseases. (2018)
  • Author(s): Minamino T.
  • Organizer: “Myocardial aging and cardiometabolic disorders”
  • Int'l Joint Research / Invited
• [Presentation] Role of Cellular Aging in Cardio-metabolic Disease. (2018)
  • Author(s): Minamino T.
  • Organizer: 24th IUBMB Congress & 15th FAOBMB Congress
  • Int'l Joint Research / Invited
• [Presentation] Role of Cellular Aging in Cardio-metabolic Disease. (2018)
  • Author(s): Minamino T.
  • Organizer: The 18th World Congress of Basic and Clinical Pharmacology (WCP2018) Symposium
  • Int'l Joint Research / Invited
• [Presentation] Targeting cellular aging for the treatment of cardiovascular diseases. (2018)
  • Author(s): Minamino T.
  • Organizer: BCVS 2018 Scientific Sessions Mitochondrion and Heart Failure,
  • Int'l Joint Research / Invited
• [Presentation] White and brown adipose tissue as a therapeutic target for cardiovascular diseases. (2018)
  • Author(s): Minamino T.
  • Organizer: ESC 2018
  • Int'l Joint Research / Invited
• [Presentation] Targeting cellular aging for the treatment of cardio-metabolic disease. (2018)
  • Author(s): Minamino T.
  • Organizer: 9TH ANNUAL ALLIANCE FOR HEALTHY AGING CONFERENCE,
  • Int'l Joint Research / Invited
• [Presentation] Targeting metabolites for HF treatment. (2018)
  • Author(s): Minamino T.
  • Organizer: The 62nd Annual Scientific Meeting of the Korean Society of Cardiology,
  • Int'l Joint Research / Invited
• [Presentation] Novel Aspects of Direct Oral Anticoagulants. (2018)
  • Author(s): Minamino T.
  • Organizer: American Heart Association,
  • Int'l Joint Research / Invited
• [Presentation] 循環器疾患における糖尿病のトータルマネジメントを考える－基礎から臨床へ－ (2018)
  • Author(s): Minamino T.
  • Organizer: 第248回日本循環器学会 関東甲信越地方会
  • Invited
• [Presentation] 老化シグナルと心血管代謝ネットワーク (2018)
  • Author(s): Minamino T.
  • Organizer: 第60回日本老年医学会学術集会
  • Invited
• [Presentation] 心不全の代謝異常と分子病態からみた心臓リハビリテーションの展望 (2018)
  • Author(s): Minamino T.
  • Organizer: 第24回日本心臓リハビリテーション学会学術集会
  • Invited
• [Presentation] 老化からみた心臓リハビリテーションの展望 (2018)
  • Author(s): Minamino T.
  • Organizer: 第24回日本心臓リハビリテーション学会学術集会
  • Invited
• [Presentation] 老化制御研究からみた健康寿命延伸の展望 (2018)
  • Author(s): Minamino T.
  • Organizer: 第59回日本人間ドック学会
  • Invited
• [Presentation] 心不全発症メカニズムから見た高血圧治療戦略 (2018)
  • Author(s): Minamino T.
  • Organizer: 第41回日本高血圧学会総会
  • Invited
• [Presentation] Senolysis as a novel therapeutic strategy for cardio-metabolic disease (2018)
  • Author(s): Minamino T.
  • Organizer: 第83回日本循環器学会学術総会
  • Invited
• [Presentation] Targeting cellular senescence in cardiovascular aging. (2018)
  • Author(s): Minamino T.
  • Organizer: INTERNATIONAL SYMPOSIUM ADVANCES IN HEART FAILURE 2018
  • Int'l Joint Research / Invited
• [Presentation] 健康長寿を目指した老化関連疾患の治療方策 (2018)
  • Author(s): Minamino T.
  • Organizer: 第47回心脈管作動物質学会
  • Invited
• [Presentation] 老化から見た心血管代謝疾患の治療方策 (2018)
  • Author(s): Minamino T.
  • Organizer: 第247回日本循環器学会関東甲信越地方会
  • Invited
• [Presentation] The potential of seno-therapy for atherosclerotic disease (2018)
  • Author(s): Minamino T.
  • Organizer: 第82回日本循環器学会学術集会
  • Invited
• [Presentation] Role of cellular senescence in cardio-metabolic disease. (2017)
  • Author(s): Minamino T.
  • Organizer: Inha University Seminar 2017
  • Int'l Joint Research / Invited
• [Presentation] A critical role of cellular senescence in metabolic and cardiovascular disease. (2017)
  • Author(s): Minamino T.
  • Organizer: Pulse of Asia 2017
  • Int'l Joint Research / Invited
• [Presentation] Hypertension, Diabetes, and Vascular Aging. (2017)
  • Author(s): Minamino T.
  • Organizer: The 47th Annual Convention & Scientific Session of the Taiwan Society of Cardiology APSC-TSOC Joint Session
  • Int'l Joint Research / Invited
• [Presentation] Cellular Senescence and Age-associated Diseases (2017)
  • Author(s): Minamino T.
  • Organizer: Keystone Symposia Conference Aging and Mechanisms of Aging-Related Disease
  • Int'l Joint Research / Invited
• [Presentation] 老化シグナルと心血管代謝ネットワーク (2017)
  • Author(s): Minamino T.
  • Organizer: 第17回日本抗加齢医学会総会
  • Invited
• [Presentation] Cellular senescence in cardiovascular disease - The future. (2017)
  • Author(s): Minamino T.
  • Organizer: European Society of Cardiology 2017
  • Int'l Joint Research / Invited
• [Presentation] Pathophysiological mechanisms of heart failure in diabetes. (2017)
  • Author(s): Minamino T.
  • Organizer: European Society of Cardiology 2017
  • Int'l Joint Research / Invited
• [Presentation] A critical role of cellular senescence in metabolic and cardiovascular disease. (2017)
  • Author(s): Minamino T.
  • Organizer: 6th EU-US Conference on Repair of Endogenous DNA Damage 2017
  • Int'l Joint Research / Invited
• [Presentation] Hypertension, Diabetes, and Vascular Aging. (2017)
  • Author(s): Minamino T.
  • Organizer: The Korean Society of Hypertension 2017
  • Int'l Joint Research / Invited
• [Presentation] DNA Damage and Diabetes. DNA Damage Response and Cardio-metabolic Disease. (2017)
  • Author(s): Minamino T.
  • Organizer: AHA/Japanese Circulation Society Joint Session. AHA Scientif Sessions 2017
  • Int'l Joint Research / Invited
• [Presentation] Metabolism, Adipose Tissue, and CVD. (2017)
  • Author(s): Minamino T.
  • Organizer: INTERNATIONAL SYMPOSIUM Cardiometabolic risk and Vascular Disease -from Mechanisms to Treatment- 2017
  • Int'l Joint Research / Invited
• [Book] 近未来の心不全治療薬の展望 (2019)
  • Author(s): 南野 徹
  • Total Pages: 377
  • Publisher: 心臓
• [Book] 下壁由来の心室期外収縮が心室細動のトリガーと考えられたBrugada症候群の1例 (2018)
  • Author(s): 久保田 直樹, 長谷川 祐紀, 佐藤 光希, 松尾 聖, 八木原 伸江, 飯嶋 賢一, 和泉 大輔, 南野 徹
  • Publisher: 心臓
• [Book] Cabrol graftと両側冠動脈の吻合部狭窄に対して待機的PCIを施行したMarfan症候群の一例 (2018)
  • Author(s): 山口祐美、尾崎和幸、高野俊樹、高山亜美、保屋野真、栁川貴央、岡本竹司、小澤拓也、柏村 健、名村 理、南野 徹
  • Publisher: 心臓
• [Book] 重症大動脈弁狭窄症を合併し心破裂を生じた急性心筋梗塞の一例 (2018)
  • Author(s): 松尾佑治、尾崎和幸、高野俊樹、渡邊 達、保屋野真、柳川貴央、小澤拓也、柏村 健、南野 徹
  • Publisher: 心臓
• [Book] QT短縮症候群の病態と治療（解説） (2018)
  • Author(s): 八木原伸江、渡部裕、南野徹
  • Publisher: 科学評論社
• [Book] 脂肪の量と質を制御するー老化による制御 (2018)
  • Author(s): 池上龍太郎、清水逸平、吉田陽子、南野 徹
  • Publisher: 実験医学
• [Book] 心血管代謝疾患におけるSASP因子の役割 (2018)
  • Author(s): 南野 徹
  • Publisher: 北隆館
• [Book] 血管疾患のアンチエイジング治療 (2018)
  • Author(s): 仲尾政晃、清水逸平、南野 徹
  • Publisher: 心臓
• [Book] アンチエイジング医学 (2018)
  • Author(s): 萱森裕美、南野 徹
  • Publisher: 概日リズムと循環器疾患
• [Book] 細胞老化を標的とした循環代謝制御 (2018)
  • Author(s): 南野 徹
  • Publisher: 血管
• [Book] 老化からみた生活習慣病診療の展望 (2018)
  • Author(s): 南野 徹
  • Publisher: 新潟医学会雑誌
• [Book] 概日リズムと生活習慣病の観点からみた睡眠薬の適正使用 (2018)
  • Author(s): 須田将吉、清水逸平、南野 徹
  • Publisher: ANTI-AGING MEDICINE
• [Book] 動脈硬化と老化 (2018)
  • Author(s): 池上 龍太郎、南野 徹
  • Publisher: 科学評論社
• [Book] 心血管代謝疾患におけるSASP因子の役 (2018)
  • Author(s): 南野 徹
  • Publisher: 北隆館
• [Book] HIV/AIDSと循環器疾患 (2017)
  • Author(s): 高野俊樹、南野 徹
  • Publisher: メディカルレビュー
• [Book] 血管老化と糖代謝異常 (2017)
  • Author(s): 南野 徹
  • Publisher: 日本循環制御医学会
• [Book] p53依存性老化シグナルと糖尿病、 (2017)
  • Author(s): 勝海悟郎、清水逸平、吉田陽子、南野 徹
  • Publisher: 医学出版
• [Book] 心血管系のアンチエイジング (2017)
  • Author(s): 須田将吉、南野 徹
  • Publisher: 医歯薬出版株式会社
• [Book] 編集後記 (2017)
  • Author(s): 須田将吉、南野 徹
  • Total Pages: 13
  • Publisher: 日本抗加齢医学会雑誌
• [Book] 「今日が一番楽しい」心地よさがアンチエイジング (2017)
  • Author(s): 南野 徹
  • Publisher: 脳心血管抗加齢研究会機関誌
• [Book] 血管再生療法 (2017)
  • Author(s): 仲尾政晃、南野 徹、
  • Publisher: 日本医学出版
• [Book] 3大ナッツで血管からアンチエイジング (2017)
  • Author(s): 南野 徹、
  • Publisher: 日経BP社
• [Book] 一歩一歩進むことで、見える世界が広がった (2017)
  • Author(s): 南野 徹、
  • Publisher: メディカルノート
• [Book] 細胞老化update アンチエイジング医学 (2017)
  • Author(s): 南野 徹、
  • Total Pages: 17
  • Publisher: 日本抗加齢医学会雑誌
• [Book] 概日リズムと生活習慣病の観点からみた睡眠薬の適正使用 (2017)
  • Author(s): 須田将吉、清水逸平、南野 徹
  • Publisher: ANTI-AGING MEDICINE
• [Book] 心不全 (2017)
  • Author(s): 清水 逸平，南野 徹
  • Publisher: 新潟医学会雑誌
• [Book] 心臓における老化シグナルの意義 (2017)
  • Author(s): 清水 逸平，南野 徹
  • Publisher: 心臓
• [Book] ケトン体の心保護作用 (2017)
  • Author(s): 勝海 悟郎，南野 徹
  • Publisher: プラクティス
• [Book] 血管の恒常性制御における細胞老化の意義 (2017)
  • Author(s): 古内 亮，清水 逸平，南野 徹
  • Publisher: Geriatric medicine
• [Book] 細胞老化 (2017)
  • Author(s): 仲尾 政晃，清水 逸平，吉田 陽子，南野 徹
  • Publisher: 一歩進んだ糖尿病循環学
• [Book] 心房細動アブレーション治療 (2017)
  • Author(s): 佐藤 光希，南野 徹
  • Publisher: 新潟医学会雑誌
• [Book] テストステロン減少が病態の顕性化に寄与したと考えられた高齢発症のQT延長症候群の１例 (2017)
  • Author(s): 長谷川祐紀，坂口 裕太，大槻 総，飯嶋 賢一， 八木原伸江，佐藤 光希，和泉 大輔，池主 雅 臣，南野 徹
  • Publisher: 心臓
• [Book] Peripheral blood mononuclear cells for limb ischemia (2017)
  • Author(s): Suda M, Shimizu I, Yoshida Y, Minamino T.
  • Publisher: Therapeutic Angiogenesis, Springer publication,
• [Book] Diabetes and adipocyte dysfunction. (2017)
  • Author(s): Yoshida Y, Shimizu I, Minamino T.
  • Publisher: Diabetes and Aging-related Complications, Springer publication,
• [Remarks] 新潟大学大学院医歯学総合研究科 循環器内科
  • URL: http://www.med.niigata-u.ac.jp/car/
• [Patent(Industrial Property Rights)] 特願 (2018)
  • Inventor(s): 南野 徹，飯島 賢一
  • Industrial Property Rights Holder: 南野 徹，飯島 賢一
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018