| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Patients with type 2 diabetes were enrolled in this study. All subjects underwent computed tomography to analyze the plaque characteristics.Serum and circulating peripheral blood mononuclear cells (PBMNCs)were prepared from fasting blood sample.The prevalence of vulnerable plaque was 43% of subjects. MT1-MMP expression on PBMNCs in all patients with PPH was significantly elevated in cases compared to controls. In patients with vulnerable plaque, MT1-MMP expression was higher than that in without vulnerable plaque Furthermore, in multivariate analysis, increase of MT1-MMP expression on PBMNCs was independently related to the incidence of vulnerable plaque.The elevated MT1-MMP expression on PBMNCs is associated the existence of vulnerable plaque in type 2 diabetic patients with postprandial hyperglycemia. These finding suggested that the measurement of MT1-MMP on PBMNCs may become a new predictor of vulnerable plaque in postprandial hyperglycemia state.
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