| Project/Area Number |
16K09430
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
伊藤 正明 三重大学, 医学系研究科, 教授 (00223181)
土肥 薫 三重大学, 医学系研究科, 准教授 (50422837)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 掌握運動 / 血行動態 / 左室収縮機能 / 左室拡張機能 / 心不全 / 高血圧 / 運動療法 / 血圧 / 心機能 / 内科 |
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| Outline of Final Research Achievements |
The effects of the 3 min of isometric handgrip (IHG) at 30% maximal voluntary contraction (MCV) on hemodynamics were analyzed in patients with heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). IHG elevated LV end-systolic BP in both HFpEF (134±21 vs. 158±30 mmHg, p<0.01) and HFrEF (119±30 vs. 142±31 mmHg, p<0.01) with no change in stroke volume. Time constant of LV relaxation was unchanged by IHG in HFpEF, while it was prolonged in HFrEF. The effects of 3 months of IHG training on 24-hour blood pressure were evaluated in HFpEF. After 3 months of training, the change in 24-hour systolic BP in training group was -3.5±20.1mmHg. This change was not significant.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の結果から、血圧がコントロールされたHFpEF患者では、最大握力の30%(3分間）での等尺性掌握運動により、左室収縮末期血圧は134±21から158±30 mmHgに上昇にとどまることが示された。3か月間の掌握運動トレーニングに伴う降圧効果については証明されなかったが、今後、掌握運動トレーニングの期間や強度を変更し、掌握運動トレーニングの降圧効果の効果を検討する予定である。
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