Analysis of onset, progression, and recurrence of acute myocardial infarction from the view of genetic and environmental factors

• Project/Area Number: 16K09446
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kyushu University of Nursing and Social Welfare (2017-2018); Kumamoto University (2016)
• Principal Investigator: Hokimoto Seiji 九州看護福祉大学, 看護福祉学部, 教授 (30535638)
• Co-Investigator(Kenkyū-buntansha): 花谷 信介 熊本大学, 医学部附属病院, 非常勤診療医師 (40755443) ; 有馬 勇一郎 熊本大学, 大学院生命科学研究部(医), 助教 (60706414)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 動脈硬化 / ヘリコバクター・ピロリ感染 / 急性心筋梗塞 / 環境要因 / 遺伝要因 / 遺伝子多型 / ヘリコバクター・ピロリ / インターロイキン / アルデヒド脱水素酵素２ / 循環器

Outline of Final Research Achievements

We indicated that acute myocardial infarction, one of the atherosclerotic diseases, may be associated with CagA positive helicobacter pylori. Onset of acute myocardial infarction was related with pylori infection and genetic polymorphism of interleukin 1, and severity of myocardial damage after acute myocardial infarction was associated with ALDH2 polymorphism. The immunostaining of CagA protein produced by pylori was found in the endothelium of abdominal aortic aneurysm in a patient with pylori positive, but not in a pylori negative patient. For the first time, the presence of CagA protein was demonstrated in the human atherosclerotic vascular tissue.
Through this study, we clarified the risk of onset, progression, and recurrence in patients with acute myocardial infarction from the view point of environmental and genetic factors.

Academic Significance and Societal Importance of the Research Achievements

ヘリコバクター・ピロリ菌と胃癌との関連は報告されてきたが、本研究でヘリコバクター・ピロリ感染とヒト血管動脈硬化との関連性が示され、中でも急性心筋梗塞発症への関与が示唆された。特に本邦で多いピロリ菌産生のCagAタンパク質が何らかの方法で血流によって血管組織に移行し、動脈硬化の発症、進展に関連している可能性が示された。
除菌による胃癌抑制のみならず、動脈硬化性心臓血管病を抑制する可能性を示したことで、学術的にも社会的にも意義のある研究である。

Research Products

• [Journal Article] Management of patients on antithrombotic agents undergoing emergency and elective endoscopy: joint Asian Pacific Association of Gastroenterology (APAGE) and Asian Pacific Society for Digestive Endoscopy (APSDE) practice guidelines (2018)
  • Author(s): Chan Francis K L、Goh Khean-Lee、Reddy Nageshwar、Fujimoto Kazuma、Ho Khek Yu、Hokimoto Seiji、Jeong Young-Hoon、Kitazono Takanari、Lee Hong Sik、Mahachai Varocha、Tsoi Kelvin K F、Wu Ming-Shiang、Yan Bryan P、Sugano Kentaro
  • Journal Title: Gut Volume: 67 Issue: 3 Pages: 405-417
  • DOI: 10.1136/gutjnl-2017-315131
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Guidelines for Gastroenterological Endoscopy in Patients Undergoing Antithrombotic Treatment: 2017 Appendix?on Anticoagulants Including Direct Oral Anticoagulants (2018)
  • Author(s): Kato Mototsugu、Uedo Noriya、Hokimoto Seiji、Ieko Masahiro、Higuchi Kazuhide、Murakami Kazunari、Fujimoto Kazuma
  • Journal Title: Digestive Endoscopy Volume: 30 Issue: 4 Pages: 433-440
  • DOI: 10.1111/den.13184
  • Peer Reviewed / Open Access
• [Journal Article] Venous Thromboembolism Caused by Spending a Night in a Vehicle After an Earthquake (Night in a Vehicle After the 2016 Kumamoto Earthquake) (2018)
  • Author(s): Daisuke Sueta, Seiji Hokimoto, Kenji Sakamoto et al.
  • Journal Title: Canadian Journal of Cardiology Volume: 1 Issue: 6 Pages: 813.e9-813.e10
  • DOI: 10.1016/j.cjca.2018.01.014
  • Peer Reviewed / Open Access
• [Journal Article] High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD) (2018)
  • Author(s): Taguchi Isao、Iimuro Satoshi、Iwata Hiroshi、et.al 、Nagai Ryozo
  • Journal Title: Circulation Volume: 137 Issue: 19 Pages: 1997-2009
  • DOI: 10.1161/circulationaha.117.032615
  • Peer Reviewed / Open Access
• [Journal Article] Risk of Cardiovascular Disease After Earthquake Disaster (2018)
  • Author(s): Hokimoto S
  • Journal Title: Circulation Journal Volume: 82 Issue: 3 Pages: 650-651
  • DOI: 10.1253/circj.CJ-18-0137
  • NAID: 130006394605
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Effects of the Mean Amplitude of Glycemic Excursions and Vascular Endothelial Dysfunction on Cardiovascular Events in Nondiabetic Patients With Coronary Artery Disease (2017)
  • Author(s): Akasaka T, Sueta D, Hokimoto S, et al.
  • Journal Title: Journal of the American Heart Association Volume: 6 Issue: 5
  • DOI: 10.1161/jaha.116.004841
  • Peer Reviewed / Open Access
• [Journal Article] Validation of the high mortality rate of Malnutrition-Inflammation-Atherosclerosis syndrome: -Community-based observational study (2017)
  • Author(s): Sueta D, Hokimoto S, Sakamoto K, et al.
  • Journal Title: International Journal of Cardiology Volume: 230 Pages: 97-102
  • DOI: 10.1016/j.ijcard.2016.12.072
  • Peer Reviewed
• [Journal Article] Variant Aldehyde Dehydrogenase 2 (<i>ALDH2*2</i>) in East Asians Interactively Exacerbates Tobacco Smoking Risk for Coronary Spasm ― Possible Role of Reactive Aldehydes ― (2017)
  • Author(s): Mizuno Y, Hokimoto S, Harada E, et al.
  • Journal Title: Circulation Journal Volume: 81 Issue: 1 Pages: 96-102
  • DOI: 10.1253/circj.CJ-16-0969
  • NAID: 130005252739
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Helicobacter Pylori-seropositivity along with genetic and environmental factors predicts clinical outcome after acute coronary syndrome. (2016)
  • Author(s): Tabata N, Hokimoto S, Akasaka T, Sueta D, Arima Y, Sakamoto K, Yamamoto E, Izumiya Y, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Morita K, Oniki K, Saruwatari J, Nakagawa K, Ogawa H.
  • Journal Title: Int J Cardiol. Volume: 212 Pages: 54-56
  • DOI: 10.1016/j.ijcard.2016.03.034
  • Peer Reviewed / Open Access
• [Journal Article] Helicobacter pylori-seropositivity along with pro-inflammatory interleukin-1 polymorphisms correlated with myocardial infarction (2016)
  • Author(s): Noriaki Tabata, Seiji Hokimoto*, Tomonori Akasaka, Daisuke Sueta, Yuichiro Arima, Kenji Sakamoto, Eiichiro Yamamoto, Yasuhiro Izumiya, Megumi Yamamuro, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Hiroshige Yamabe, Kunihiko Matsui, Hisao Ogawa
  • Journal Title: Clinical Trials and Regulatory Science in Cardiology Volume: 17 Pages: 9-14
  • DOI: 10.1016/j.ctrsc.2016.03.002
  • Peer Reviewed / Open Access
• [Journal Article] Helicobacter pylori Seropositivity in Patients with Interleukin-1 Polymorphisms Is Significantly Associated with ST-Segment Elevation Myocardial Infarction. (2016)
  • Author(s): Tabata N, Sueta D, Akasaka T, Arima Y, Sakamoto K, Yamamoto E, Izumiya Y, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Morita K, Oniki K, Saruwatari J, Nakagawa K, Hokimoto S.
  • Journal Title: PLoS One. Volume: 11 Issue: 11 Pages: e0166240-e0166240
  • DOI: 10.1371/journal.pone.0166240
  • Peer Reviewed / Open Access
• [Presentation] Management and prevention of cardiovascular diseases (2018)
  • Author(s): 掃本誠治
  • Organizer: 国際協力機構JICA研修 マレーシア国別
• [Presentation] 消化器・循環器領域における抗血栓療法の最近の話題 (2018)
  • Author(s): 掃本誠治
  • Organizer: 諫早医師会学術講演会
  • Invited
• [Presentation] 災害時における学会の役割～熊本地震を経験して～ (2017)
  • Author(s): 掃本誠治
  • Organizer: 第110回日本循環器学会中国・四国合同地方会教育セッション
  • Invited
• [Presentation] 新しい生体吸収性スキャフォールドの開発 (2017)
  • Author(s): 掃本誠治
  • Organizer: ARIA2017
  • Invited
• [Presentation] Cytotoxin-associated Gene-A-seropositivity and Interleukin-1 Polymorphisms Influence the Development and Recurrence of Acute Coronary Syndrome (2016)
  • Author(s): Noriaki Tabata, Takayoshi Yamashita, Tomonori Akasaka, Daisuke Sueta, Yuichiro Arima, Tomokazu Ikemoto, Seiji Hokimoto
  • Organizer: American Heart Association(AHA)2016ニューオーリンズ
  • Place of Presentation: 米国 ニューオリンズ
  • Int'l Joint Research
• [Book] Heart View 震災時における循環器医療を改めて考える (2017)
  • Author(s): 掃本誠治
  • Total Pages: 108
  • Publisher: MEDICAL VIEW
• [Book] 内科学第11版 (2017)
  • Author(s): 分担執筆 掃本誠治
  • Total Pages: 2385
  • Publisher: 朝倉書店
  • ISBN: 9784254322705