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Analysis of onset, progression, and recurrence of acute myocardial infarction from the view of genetic and environmental factors

Research Project

Project/Area Number 16K09446
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionKyushu University of Nursing and Social Welfare (2017-2018)
Kumamoto University (2016)

Principal Investigator

Hokimoto Seiji  九州看護福祉大学, 看護福祉学部, 教授 (30535638)

Co-Investigator(Kenkyū-buntansha) 花谷 信介  熊本大学, 医学部附属病院, 非常勤診療医師 (40755443)
有馬 勇一郎  熊本大学, 大学院生命科学研究部(医), 助教 (60706414)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords動脈硬化 / ヘリコバクター・ピロリ感染 / 急性心筋梗塞 / 環境要因 / 遺伝要因 / 遺伝子多型 / ヘリコバクター・ピロリ / インターロイキン / アルデヒド脱水素酵素2 / 循環器
Outline of Final Research Achievements

We indicated that acute myocardial infarction, one of the atherosclerotic diseases, may be associated with CagA positive helicobacter pylori. Onset of acute myocardial infarction was related with pylori infection and genetic polymorphism of interleukin 1, and severity of myocardial damage after acute myocardial infarction was associated with ALDH2 polymorphism. The immunostaining of CagA protein produced by pylori was found in the endothelium of abdominal aortic aneurysm in a patient with pylori positive, but not in a pylori negative patient. For the first time, the presence of CagA protein was demonstrated in the human atherosclerotic vascular tissue.
Through this study, we clarified the risk of onset, progression, and recurrence in patients with acute myocardial infarction from the view point of environmental and genetic factors.

Academic Significance and Societal Importance of the Research Achievements

ヘリコバクター・ピロリ菌と胃癌との関連は報告されてきたが、本研究でヘリコバクター・ピロリ感染とヒト血管動脈硬化との関連性が示され、中でも急性心筋梗塞発症への関与が示唆された。特に本邦で多いピロリ菌産生のCagAタンパク質が何らかの方法で血流によって血管組織に移行し、動脈硬化の発症、進展に関連している可能性が示された。
除菌による胃癌抑制のみならず、動脈硬化性心臓血管病を抑制する可能性を示したことで、学術的にも社会的にも意義のある研究である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2018 2017 2016

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 10 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Book (2 results)

  • [Journal Article] Management of patients on antithrombotic agents undergoing emergency and elective endoscopy: joint Asian Pacific Association of Gastroenterology (APAGE) and Asian Pacific Society for Digestive Endoscopy (APSDE) practice guidelines2018

    • Author(s)
      Chan Francis K L、Goh Khean-Lee、Reddy Nageshwar、Fujimoto Kazuma、Ho Khek Yu、Hokimoto Seiji、Jeong Young-Hoon、Kitazono Takanari、Lee Hong Sik、Mahachai Varocha、Tsoi Kelvin K F、Wu Ming-Shiang、Yan Bryan P、Sugano Kentaro
    • Journal Title

      Gut

      Volume: 67 Issue: 3 Pages: 405-417

    • DOI

      10.1136/gutjnl-2017-315131

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Guidelines for Gastroenterological Endoscopy in Patients Undergoing Antithrombotic Treatment: 2017 Appendix?on Anticoagulants Including Direct Oral Anticoagulants2018

    • Author(s)
      Kato Mototsugu、Uedo Noriya、Hokimoto Seiji、Ieko Masahiro、Higuchi Kazuhide、Murakami Kazunari、Fujimoto Kazuma
    • Journal Title

      Digestive Endoscopy

      Volume: 30 Issue: 4 Pages: 433-440

    • DOI

      10.1111/den.13184

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Venous Thromboembolism Caused by Spending a Night in a Vehicle After an Earthquake (Night in a Vehicle After the 2016 Kumamoto Earthquake)2018

    • Author(s)
      Daisuke Sueta, Seiji Hokimoto, Kenji Sakamoto et al.
    • Journal Title

      Canadian Journal of Cardiology

      Volume: 1 Issue: 6 Pages: 813.e9-813.e10

    • DOI

      10.1016/j.cjca.2018.01.014

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD)2018

    • Author(s)
      Taguchi Isao、Iimuro Satoshi、Iwata Hiroshi、et.al 、Nagai Ryozo
    • Journal Title

      Circulation

      Volume: 137 Issue: 19 Pages: 1997-2009

    • DOI

      10.1161/circulationaha.117.032615

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk of Cardiovascular Disease After Earthquake Disaster2018

    • Author(s)
      Hokimoto S
    • Journal Title

      Circulation Journal

      Volume: 82 Issue: 3 Pages: 650-651

    • DOI

      10.1253/circj.CJ-18-0137

    • NAID

      130006394605

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of the Mean Amplitude of Glycemic Excursions and Vascular Endothelial Dysfunction on Cardiovascular Events in Nondiabetic Patients With Coronary Artery Disease2017

    • Author(s)
      Akasaka T, Sueta D, Hokimoto S, et al.
    • Journal Title

      Journal of the American Heart Association

      Volume: 6 Issue: 5

    • DOI

      10.1161/jaha.116.004841

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validation of the high mortality rate of Malnutrition-Inflammation-Atherosclerosis syndrome: -Community-based observational study2017

    • Author(s)
      Sueta D, Hokimoto S, Sakamoto K, et al.
    • Journal Title

      International Journal of Cardiology

      Volume: 230 Pages: 97-102

    • DOI

      10.1016/j.ijcard.2016.12.072

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Variant Aldehyde Dehydrogenase 2 (<i>ALDH2*2</i>) in East Asians Interactively Exacerbates Tobacco Smoking Risk for Coronary Spasm ― Possible Role of Reactive Aldehydes ―2017

    • Author(s)
      Mizuno Y, Hokimoto S, Harada E, et al.
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 1 Pages: 96-102

    • DOI

      10.1253/circj.CJ-16-0969

    • NAID

      130005252739

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Helicobacter Pylori-seropositivity along with genetic and environmental factors predicts clinical outcome after acute coronary syndrome.2016

    • Author(s)
      Tabata N, Hokimoto S, Akasaka T, Sueta D, Arima Y, Sakamoto K, Yamamoto E, Izumiya Y, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Morita K, Oniki K, Saruwatari J, Nakagawa K, Ogawa H.
    • Journal Title

      Int J Cardiol.

      Volume: 212 Pages: 54-56

    • DOI

      10.1016/j.ijcard.2016.03.034

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Helicobacter pylori-seropositivity along with pro-inflammatory interleukin-1 polymorphisms correlated with myocardial infarction2016

    • Author(s)
      Noriaki Tabata, Seiji Hokimoto*, Tomonori Akasaka, Daisuke Sueta, Yuichiro Arima, Kenji Sakamoto, Eiichiro Yamamoto, Yasuhiro Izumiya, Megumi Yamamuro, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Hiroshige Yamabe, Kunihiko Matsui, Hisao Ogawa
    • Journal Title

      Clinical Trials and Regulatory Science in Cardiology

      Volume: 17 Pages: 9-14

    • DOI

      10.1016/j.ctrsc.2016.03.002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Helicobacter pylori Seropositivity in Patients with Interleukin-1 Polymorphisms Is Significantly Associated with ST-Segment Elevation Myocardial Infarction.2016

    • Author(s)
      Tabata N, Sueta D, Akasaka T, Arima Y, Sakamoto K, Yamamoto E, Izumiya Y, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Morita K, Oniki K, Saruwatari J, Nakagawa K, Hokimoto S.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 11 Pages: e0166240-e0166240

    • DOI

      10.1371/journal.pone.0166240

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Management and prevention of cardiovascular diseases2018

    • Author(s)
      掃本誠治
    • Organizer
      国際協力機構JICA研修 マレーシア国別
    • Related Report
      2018 Annual Research Report
  • [Presentation] 消化器・循環器領域における抗血栓療法の最近の話題2018

    • Author(s)
      掃本誠治
    • Organizer
      諫早医師会学術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 災害時における学会の役割~熊本地震を経験して~2017

    • Author(s)
      掃本誠治
    • Organizer
      第110回日本循環器学会中国・四国合同地方会教育セッション
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 新しい生体吸収性スキャフォールドの開発2017

    • Author(s)
      掃本誠治
    • Organizer
      ARIA2017
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Cytotoxin-associated Gene-A-seropositivity and Interleukin-1 Polymorphisms Influence the Development and Recurrence of Acute Coronary Syndrome2016

    • Author(s)
      Noriaki Tabata, Takayoshi Yamashita, Tomonori Akasaka, Daisuke Sueta, Yuichiro Arima, Tomokazu Ikemoto, Seiji Hokimoto
    • Organizer
      American Heart Association(AHA)2016ニューオーリンズ
    • Place of Presentation
      米国 ニューオリンズ
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] Heart View 震災時における循環器医療を改めて考える2017

    • Author(s)
      掃本誠治
    • Total Pages
      108
    • Publisher
      MEDICAL VIEW
    • Related Report
      2017 Research-status Report
  • [Book] 内科学第11版2017

    • Author(s)
      分担執筆 掃本誠治
    • Total Pages
      2385
    • Publisher
      朝倉書店
    • ISBN
      9784254322705
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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