Utility of respiratory management in heart failure patients with preserved ejection fraction

• Project/Area Number: 16K09447
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Fukushima Medical University
• Principal Investigator: 義久 精臣 福島県立医科大学, 医学部, 教授 (40448642)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 心不全 / 睡眠時無呼吸症候群 / 慢性閉塞性肺疾患

Outline of Annual Research Achievements

左室収縮の保たれた心不全(HFpEF)における臓器連関や併存疾患による病態修飾および予後の関係、さらにHFpEFに対する呼吸補助療法の効果に関して多面的な検討を行い、論文公表を行った。具体的には、１）HFpEFにおける睡眠呼吸障害が動脈スティフネスに与える影響は左室駆出率の低下した心不全(HFrEF)とHFpEFにおいて異なること(ESC Heart fail)、２）メラトニンが睡眠および左室リモデリングに関係していること (J Pineal Res)、３）睡眠障害である周期性四肢運動障害がHFpEFの予後を悪化させること(Int J Cardiol)、4) HFpEFの原因疾患鑑別や予後予測におけるバイオマーカーや心電図所見の有用性(Circulation, J Am Heart Assoc, Am J Cardiol, J Card Fail, Clin Chim Acta, Int Heart J, J Cardiovasc Electrphysio, Cardiology)、5) HFpEFの主要な原因疾患である肺高血圧症における右心負荷と肝機能障害の関係(Int J Cardiol)、6) 肺高血圧症における血行動態とバイオマーカーの関係(Int J Cardiol, Can J Cardiol, J Card Fail, ESC Heart Fail, Plos One)、7) HFpEFにおける慢性閉塞性肺疾患による病態修飾や予後の関係について他施設共同研究のデータを用いて示した（J Cardiol)。また、 HFpEFにおける心機能変化と予後の関係、さらに心機能変化に関与する因子としての睡眠呼吸障害や呼吸補助療法の効果について検証し国際学会にて公表を行い、現在論文投稿中である。さらに、HFpEFにおける睡眠障害、睡眠呼吸障害管理の重要性、呼吸補助療法の重要性に関して、英文総説(J Atheroscler Thromb)を作成するとともに、関連学会におけるシンポジウムなどでも公表した。また、書籍などによる普及も積極的に行っており、今後も検証および治療の普及に継続して取り組んでいく予定である。

Research Products

• [Journal Article] Sleep Disordered Breathing and Cardiovascular Diseases (2019)
  • Author(s): Yoshihisa Akiomi、Takeishi Yasuchika
  • Journal Title: J Atheroscler Thromb Volume: 26 Issue: 4 Pages: 315-327
  • DOI: 10.5551/jat.RV17032
  • NAID: 130007621870
  • Peer Reviewed
• [Journal Article] Plasma levels of melatonin in dilated cardiomyopathy (2019)
  • Author(s): Misaka Tomofumi、Yoshihisa Akiomi、Yokokawa Tetsuro、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Yamaki Takayoshi、Sugimoto Koichi、Kunii Hiroyuki、Nakazato Kazuhiko、Takeishi Yasuchika
  • Journal Title: Journal of Pineal Research Volume: 66
  • DOI: 10.1111/jpi.12564
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prognostic impact of chronic obstructive pulmonary disease on adverse prognosis in hospitalized heart failure patients with preserved ejection fraction ? A report from the JASPER registry (2019)
  • Author(s): Sato Yu、Yoshihisa Akiomi、Oikawa Masayoshi、Nagai Toshiyuki、Yoshikawa Tsutomu、Saito Yoshihiko、Yamamoto Kazuhiro、Takeishi Yasuchika、Anzai Toshihisa
  • Journal Title: Journal of Cardiology Volume: 73 Pages: 459-465
  • DOI: 10.1016/j.jjcc.2019.01.005
  • Peer Reviewed
• [Journal Article] Prognostic impact of worsening renal function in hospitalized heart failure patients with preserved ejection fraction -A report from the JASPER Registry- (2019)
  • Author(s): Sato Yu、Yoshihisa Akiomi、Oikawa Masayoshi、Nagai Toshiyuki、Yoshikawa Tsutomu、Saito Yoshihiko、Yamamoto Kazuhiro、Takeishi Yasuchika、Anzai Toshihisa
  • Journal Title: Journal of Cardiac Failure Volume: 印刷中
  • DOI: 10.1016/j.cardfail.2019.04.009
  • Peer Reviewed
• [Journal Article] Hyponatremia at discharge is associated with adverse prognosis in acute heart failure syndromes with preserved ejection fraction: a report from the JASPER registry (2019)
  • Author(s): Sato Yu、Yoshihisa Akiomi、Oikawa Masayoshi、Nagai Toshiyuki、Yoshikawa Tsutomu、Saito Yoshihiko、Yamamoto Kazuhiro、Takeishi Yasuchika、Anzai Toshihisa
  • Journal Title: European Heart Journal: Acute Cardiovascular Care Volume: 印刷中
  • DOI: 10.1177/2048872618822459
  • Peer Reviewed
• [Journal Article] Soluble neprilysin does not correlate with prognosis in pulmonary hypertension (2019)
  • Author(s): Yoshihisa Akiomi、Yokokawa Tetsuro、Misaka Tomofumi、Oikawa Masayoshi、Kobayashi Atsushi、Yamaki Takayoshi、Sugimoto Koichi、Kunii Hiroyuki、Nakazato Kazuhiko、Takeishi Yasuchika
  • Journal Title: ESC Heart Failure Volume: 6 Pages: 291-296
  • DOI: 10.1002/ehf2.12404
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Incidence and subsequent prognostic impacts of gastrointestinal bleeding in patients with heart failure (2019)
  • Author(s): Yoshihisa Akiomi、Kanno Yuki、Ichijo Yasuhiro、Sato Yu、Takiguchi Mai、Yokokawa Tetsuro、Abe Satoshi、Misaka Tomofumi、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Yamaki Takayoshi、Kunii Hiroyuki、Takeishi Yasuchika
  • Journal Title: European Journal of Preventive Cardiology Volume: 印刷中
  • DOI: 10.1177/2047487319843069
  • Peer Reviewed
• [Journal Article] Titin in muscular dystrophy and cardiomyopathy: Urinary titin as a novel marker (2019)
  • Author(s): Misaka Tomofumi、Yoshihisa Akiomi、Takeishi Yasuchika
  • Journal Title: Clinica Chimica Acta Volume: 495 Pages: 123-128
  • DOI: 10.1016/j.cca.2019.04.005
  • Peer Reviewed
• [Journal Article] Low T3 Syndrome Is Associated With High Mortality in Hospitalized Patients With Heart Failure (2019)
  • Author(s): Sato Yu、Yoshihisa Akiomi、Kimishima Yusuke、Kiko Takatoyo、Kanno Yuki、Yokokawa Tetsuro、Abe Satoshi、Misaka Tomofumi、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Yamaki Takayoshi、Kunii Hiroyuki、Nakazato Kazuhiko、Takeishi Yasuchika
  • Journal Title: Journal of Cardiac Failure Volume: 25 Pages: 195-203
  • DOI: 10.1016/j.cardfail.2019.01.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High-sensitivity troponin T, NT-proBNP and glomerular filtration rate: A multimarker strategy for risk stratification in chronic heart failure (2019)
  • Author(s): Aimo Alberto、Yoshihisa Akiomi、Takeishi Yasuchika、Egstrup Michael、Gustafsson Ida、Gaggin Hanna K.、Eggers Kai M.、Huber Kurt、Tentzeris Ioannis、Wilson Tang W.H.、Grodin Justin L.、Passino Claudio、Emdin Michele
  • Journal Title: International Journal of Cardiology Volume: 277 Pages: 166-172
  • DOI: 10.1016/j.ijcard.2018.10.079
  • Peer Reviewed
• [Journal Article] Electrocardiographic Criteria of Right Ventricular Hypertrophy in Patients with Chronic Thromboembolic Pulmonary Hypertension after Balloon Pulmonary Angioplasty (2019)
  • Author(s): Yokokawa Tetsuro、Sugimoto Koichi、Nakazato Kazuhiko、Misaka Tomofumi、Oikawa Masayoshi、Kobayashi Atsushi、Yoshihisa Akiomi、Yamaki Takayoshi、Kunii Hiroyuki、Ishida Takafumi、Takeishi Yasuchika
  • Journal Title: Intern. Med. Volume: 印刷中 Issue: 15 Pages: 2139-2144
  • DOI: 10.2169/internalmedicine.2320-18
  • NAID: 130007686856
  • Peer Reviewed
• [Journal Article] Valvular heart disease as a possible predictor of?trastuzumab?induced cardiotoxicity in patients with breast cancer (2018)
  • Author(s): Sato Akihiko、Yoshihisa Akiomi、Miyata?Tatsumi Makiko、Oikawa Masayoshi、Kobayashi Atsushi、Ishida Takafumi、Ohtake Tohru、Takeishi Yasuchika
  • Journal Title: Molecular and Clinical Oncology Volume: 10 Pages: 37-42
  • DOI: 10.3892/mco.2018.1764
  • Peer Reviewed / Open Access
• [Journal Article] Associations between diabetes mellitus and pulmonary hypertension in chronic respiratory disease patients (2018)
  • Author(s): Takahashi Tomoko、Yoshihisa Akiomi、Sugimoto Koichi、Yokokawa Tetsuro、Misaka Tomofumi、Kaneshiro Takashi、Oikawa Masayoshi、Kobayashi Atsushi、Nakazato Kazuhiko、Ishida Takafumi、Takeishi Yasuchika
  • Journal Title: PLOS ONE Volume: 13
  • DOI: 10.1371/journal.pone.0205008
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical Significance of Get With the Guidelines?Heart Failure Risk Score in Patients With Chronic Heart Failure After Hospitalization (2018)
  • Author(s): Suzuki Satoshi、Yoshihisa Akiomi、Sato Yu、Kanno Yuki、Watanabe Shunsuke、Abe Satoshi、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Yamaki Takayoshi、Kunii Hiroyuki、Nakazato Kazuhiko、Ishida Takafumi、Takeishi Yasuchika
  • Journal Title: Journal of the American Heart Association Volume: 7
  • DOI: 10.1161/jaha.117.008316
  • Peer Reviewed / Open Access
• [Journal Article] Safety and effectiveness of transcatheter closure of atrial septal defects: Initial results in Fukushima Prefecture (2018)
  • Author(s): Kobayashi Atsushi、Kunii Hiroyuki、Yokokawa Tetsuro、Sakuma Yuya、Oikawa Masayoshi、Yoshihisa Akiomi、Yamaki Takayoshi、Nakazato Kazuhiko、Ishida Takafumi、Takeishi Yasuchika
  • Journal Title: FJMS Volume: 64 Issue: 3 Pages: 151-156
  • DOI: 10.5387/fms.2018-13
  • NAID: 130007506074
  • Peer Reviewed / Open Access
• [Journal Article] A Multiple Biomarker Approach in Patients with Cardiac Sarcoidosis (2018)
  • Author(s): Kiko Takatoyo、Yoshihisa Akiomi、Kanno Yuki、Yokokawa Tetsuro、Abe Satoshi、Miyata-Tatsumi Makiko、Misaka Tomofumi、Oikawa Masayoshi、Kobayashi Atsushi、Ishida Takafumi、Takeishi Yasuchika
  • Journal Title: Int. Heart J. Volume: 59 Issue: 5 Pages: 996-1001
  • DOI: 10.1536/ihj.17-695
  • NAID: 130007490569
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Urinary N-terminal fragment of titin is a marker to diagnose muscular dystrophy in patients with cardiomyopathy (2018)
  • Author(s): Yoshihisa Akiomi、Kiko Takatoyo、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Takeishi Yasuchika
  • Journal Title: Clinica Chimica Acta Volume: 484 Pages: 226-230
  • DOI: 10.1016/j.cca.2018.06.001
  • Peer Reviewed
• [Journal Article] Utility of heart rate turbulence and T-wave alternans to assess risk for readmission and cardiac death in hospitalized heart failure patients (2018)
  • Author(s): Yamada Shinya、Yoshihisa Akiomi、Sato Yu、Sato Takamasa、Kamioka Masashi、Kaneshiro Takashi、Oikawa Masayoshi、Kobayashi Atsushi、Suzuki Hitoshi、Ishida Takafumi、Takeishi Yasuchika
  • Journal Title: Journal of Cardiovascular Electrophysiology Volume: 29 Pages: 1257-1264
  • DOI: 10.1111/jce.13639
  • Peer Reviewed
• [Journal Article] Change of Exhaled Acetone Concentration Levels in Patients with Acute Decompensated Heart Failure (2018)
  • Author(s): Yokokawa Tetsuro、Sato Takamasa、Suzuki Satoshi、Oikawa Masayoshi、Yoshihisa Akiomi、Kobayashi Atsushi、Yamaki Takayoshi、Kunii Hiroyuki、Nakazato Kazuhiko、Suzuki Hitoshi、Saitoh Shu-ichi、Ishida Takafumi、Shimouchi Akito、Takeishi Yasuchika
  • Journal Title: Int. Heart J. Volume: 59 Issue: 4 Pages: 808-812
  • DOI: 10.1536/ihj.17-482
  • NAID: 130006743811
  • Peer Reviewed
• [Journal Article] Association between sleep-disordered breathing and arterial stiffness in heart failure patients with reduced or preserved ejection fraction (2018)
  • Author(s): Suzuki Satoshi、Yoshihisa Akiomi、Sato Yu、Watanabe Shunsuke、Yokokawa Tetsuro、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Yamaki Takayoshi、Kunii Hiroyuki、Nakazato Kazuhiko、Suzuki Hitoshi、Saitoh Shu-ichi、Ishida Takafumi、Takeishi Yasuchika
  • Journal Title: ESC Heart Failure Volume: 5 Pages: 284-291
  • DOI: 10.1002/ehf2.12273
  • Peer Reviewed / Open Access
• [Journal Article] Association of Serum Zinc Level With Prognosis in Patients With Heart Failure (2018)
  • Author(s): Yoshihisa Akiomi、Abe Satoshi、Kiko Takatoyo、Kimishima Yusuke、Sato Yu、Watanabe Shunsuke、Kanno Yuki、Miyata-Tatsumi Makiko、Misaka Tomofumi、Sato Takamasa、Suzuki Satoshi、Oikawa Masayoshi、Kobayashi Atsushi、Yamaki Takayoshi、Kunii Hiroyuki、Nakazato Kazuhiko、Ishida Takafumi、Takeishi Yasuchika
  • Journal Title: Journal of Cardiac Failure Volume: 24 Pages: 375-383
  • DOI: 10.1016/j.cardfail.2018.02.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relation of Testosterone Levels to Mortality in Men With Heart Failure (2018)
  • Author(s): Yoshihisa Akiomi、Suzuki Satoshi、Sato Yu、Kanno Yuki、Abe Satoshi、Miyata Makiko、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Yamaki Takayoshi、Kunii Hiroyuki、Nakazato Kazuhiko、Ishida Takafumi、Takeishi Yasuchika
  • Journal Title: The American Journal of Cardiology Volume: 121 Pages: 1321-1327
  • DOI: 10.1016/j.amjcard.2018.01.052
  • Peer Reviewed / Open Access
• [Journal Article] Association between Serum Uric Acid Level and Ventricular Tachyarrhythmia in Heart Failure Patients with Implantable Cardioverter-Defibrillator (2018)
  • Author(s): Nodera Minoru、Suzuki Hitoshi、Matsumoto Yoshiyuki、Kamioka Masashi、Kaneshiro Takashi、Yoshihisa? Akiomi、Ohira Tetsuya、Takeishi Yasuchika
  • Journal Title: Cardiology Volume: 140 Pages: 47-51
  • DOI: 10.1159/000488851
  • Peer Reviewed
• [Journal Article] Liver fibrosis marker, 7S domain of collagen type IV, in patients with pre-capillary pulmonary hypertension (2018)
  • Author(s): 8.Yoshihisa A, Kimishima Y, Kiko T, Sato Y, Watanabe S, Kanno Y, Abe S, Miyata-Tatsumi M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Ishida T, Takeishi Y
  • Journal Title: International Journal of Cardiology Volume: 258 Pages: 269-274
  • DOI: 10.1016/j.ijcard.2018.01.138
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of Urinary N-Terminal Fragment of Titin to Predict Mortality in Dilated Cardiomyopathy (2018)
  • Author(s): Yoshihisa Akiomi、Kimishima Yusuke、Kiko Takatoyo、Sato Yu、Watanabe Shunsuke、Kanno Yuki、Abe Satoshi、Miyata Makiko、Sato Takamasa、Suzuki Satoshi、Oikawa Masayoshi、Kobayashi Atsushi、Yamaki Takayoshi、Kunii Hiroyuki、Nakazato Kazuhiko、Ishida Takafumi、Takeishi Yasuchika
  • Journal Title: The American Journal of Cardiology Volume: 121 Pages: 1260-1265
  • DOI: 10.1016/j.amjcard.2018.01.046
  • Peer Reviewed / Open Access
• [Journal Article] Better clinical outcome with direct oral anticoagulants in hospitalized heart failure patients with atrial fibrillation (2018)
  • Author(s): Yoshihisa A, Sato Y, Sato T, Suzuki S, Oikawa M, Takeishi Y
  • Journal Title: BMC Cardiovascular Disorders Volume: 18 Pages: 11-11
  • DOI: 10.1186/s12872-018-0746-z
  • Peer Reviewed / Open Access
• [Journal Article] Impact of nutritional indices on mortality in patients with heart failure (2018)
  • Author(s): Yoshihisa A, Kanno Y, Watanabe S, Yokokawa T, Abe S, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Ishida T, Takeishi Y:
  • Journal Title: Open Heart Volume: 5
  • DOI: 10.1136/openhrt-2017-000730
  • Peer Reviewed / Open Access
• [Journal Article] Novel Parameter to Predict Left Ventricular Filling Pressure: Product of Log B-Type Natriuretic Peptide and Ratio of Mitral Inflow Early and Late Diastolic Filling Velocities (2018)
  • Author(s): Oikawa M, Kobayashi A, Wada K, Sato T, Suzuki S, Yoshihisa A, Nakazato K, Suzuki H, Saitoh S, Ishida T, Takeishi Y
  • Journal Title: Journal of Cardiac Failure Volume: 24 Pages: 29-32
  • DOI: 10.1016/j.cardfail.2017.10.008
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Value of High-Sensitivity Troponin T in Chronic Heart Failure (2018)
  • Author(s): Aimo A, Januzzi JL, Vergaro G, Ripoli A, Latini R, Masson S, Magnoli M, Anand IS, Cohn JN, Tavazzi L, Tognoni G, Gravning J, Ueland T, Nymo SH, Rocca HP, Genis AB, Lupon J, Boer RA, Yoshihisa A, Takeishi Y, Egstrup M, Gustafsson I, Gaggin HK, Eggers KM, Huber K, Tentzeris I, Tang WH, Grodin J, Passino C, Emdin M
  • Journal Title: Circulation Volume: 137 Pages: 286-297
  • DOI: 10.1161/circulationaha.117.031560
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Subclinical Hypothyroidism Is Associated With Adverse Prognosis in Heart Failure Patients (2018)
  • Author(s): Sato Y, Yoshihisa A, Kimishima Y, Kiko T, Watanabe S, Kanno Y, Abe S, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y
  • Journal Title: Canadian Journal of Cardiology Volume: 34 Pages: 80-87
  • DOI: 10.1016/j.cjca.2017.10.021
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations between acylcarnitine to free carnitine ratio and adverse prognosis in heart failure patients with reduced or preserved ejection fraction. (2018)
  • Author(s): Yoshihisa A, Watanabe S, Yokokawa T, Misaka T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Takeishi Y
  • Journal Title: ESC Heart Fail Volume: 4 Pages: 360-364
  • DOI: 10.1002/ehf2.12176
  • Peer Reviewed / Open Access
• [Journal Article] Cardiopulmonary exercise testing as prognostic indicators: Comparisons among heart failure patients with reduced, mid-range and preserved ejection fraction. (2017)
  • Author(s): Sato T, Yoshihisa A, Kanno Y, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Ishida T, Takeishi Y
  • Journal Title: European Journal of Preventive Cardiology Volume: 24 Pages: 1979-87
  • DOI: 10.1177/2047487317739079
  • Peer Reviewed
• [Journal Article] Associations of acid suppressive therapy with cardiac mortality in heart failure patients. (2017)
  • Author(s): Yoshihisa A, Takiguchi M, Kanno Y, Sato A, Yokokawa T, Miura S, Abe S, Misaka T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: J Am Heart Assoc Volume: 6
  • DOI: 10.1161/jaha.116.005110
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical features in extremely elderly patients with heart failure. (2017)
  • Author(s): Yokokawa T, Yoshihisa A, Kanno Y, Sato T, Suzuki S, Misaka T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Geriatrics & Gerontology International Volume: 17 Pages: 2194-2199
  • DOI: 10.1111/ggi.13060
  • Peer Reviewed
• [Journal Article] Change of Exhaled Acetone Concentration in a Diabetic Patient with Acute Decompensated Heart Failure (2017)
  • Author(s): Yokokawa T, Ichijo Y, Houtsuki Y, Matsumoto Y, Oikawa M, Yoshihisa A, Sugimoto K, Nakazato K, Suzuki H, Saitoh S, Shimouchi A, Takeishi Y
  • Journal Title: Int. Heart J. Volume: 58 Issue: 5 Pages: 828-830
  • DOI: 10.1536/ihj.16-556
  • NAID: 130006179204
  • Peer Reviewed / Open Access
• [Journal Article] Decreased cardiac mortality with nicorandil in patients with ischemic heart failure. (2017)
  • Author(s): Yoshihisa A, Sato Y, Watanabe S, Yokokawa T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Takeishi Y
  • Journal Title: BMC Cardiovasc Disord Volume: 17 Pages: 141-141
  • DOI: 10.1186/s12872-017-0577-3
  • Peer Reviewed / Open Access
• [Journal Article] Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus (2017)
  • Author(s): Yokokawa T, Sato T, Suzuki S, Oikawa M, Yoshihisa A, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Ishida T, Shimouchi A, Takeishi Y
  • Journal Title: BMC Cardiovasc Disord Volume: 17 Pages: 280-280
  • DOI: 10.1186/s12872-017-0713-0
  • Peer Reviewed / Open Access
• [Journal Article] Liver stiffness assessed by Fibrosis-4 index predicts mortality in patients with heart failure. (2017)
  • Author(s): Sato Y, Yoshihisa A, Kanno Y, Watanabe S, Yokokawa T, Abe S, Misaka T, sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Saitoh S, Takeishi Y
  • Journal Title: Open Heart Volume: 4
  • DOI: 10.1136/openhrt-2017-000598
  • Peer Reviewed / Open Access
• [Journal Article] Associations of acid suppressive therapy with cardiac mortality in heart failure patients (2017)
  • Author(s): Yoshihisa A, Takiguchi M, Kanno Y, Sato A, Yokokawa T, Miura S, Abe S, Misaka T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: J Am Heart Assoc Volume: 6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Liver stiffness assessed by Fibrosis-4 index predicts mortality in patients with heart failure (2017)
  • Author(s): Sato Y, Yoshihisa A, Kanno Y, Watanabe S, Yokokawa T, Abe S, Misaka T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Saitoh S, Takeishi Y
  • Journal Title: Open Heart Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical features in extremely elderly patients with heart failure (2017)
  • Author(s): Yokokawa T, Yoshihisa A, Kanno Y, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Geriatr Gerontol Int Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Plasma volume status predicts prognosis in patients with acute heart failure syndromes (2017)
  • Author(s): Yoshihisa A, Abe S, Sato Y, Watanabe S, Yokokawa T, Miura S, Misaka T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Saitoh S, Takeishi Y
  • Journal Title: Eur Heart J Acute Cardiovasc Care Volume: 印刷中
  • DOI: 10.1177/2048872617690889
  • Peer Reviewed
• [Journal Article] Prognostic impact of living in temporary housing in Fukushima after the Great East Japan Earthquake. (2017)
  • Author(s): Suzuki S, Yoshihisa A, Kanno Y, Watanabe S, Takiguchi M, Miura S, Yokokawa T, Sato T, Oikawa M, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: J Card Fail Volume: 23 Pages: 90-92
  • DOI: 10.1016/j.cardfail.2016.10.003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Insomnia and Cardiac Events in Patients With Heart Failure – Reply – (2017)
  • Author(s): Yoshihisa A, Kanno Y, Takeishi Y
  • Journal Title: Circ J Volume: 81 Issue: 1 Pages: 126-126
  • DOI: 10.1253/circj.CJ-16-1198
  • NAID: 130005252727
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Associations of dipeptidyl peptidase-4 inhibitors with mortality in hospitalized heart failure patients with diabetes mellitus (2016)
  • Author(s): Sato A, Yoshihisa A, Kanno Y, Takiguchi M, Miura S, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Sato T, Suzuki S, Oikawa M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: ESC Heart Fail Volume: 3 Pages: 77-85
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Associations with eicosapentaenoic acid to arachidonic acid ratio and mortality in hospitalized heart failure patients (2016)
  • Author(s): Shunsuke Watanabe, Akiomi Yoshihisa, Yuki Kanno, Mai Takiguchi, Tetsuro Yokokawa, Akihiko Sato, Shunsuke Miura, Takeshi Shimizu, Satoshi Abe, Yasuchika Takeshi, et al
  • Journal Title: J Card Fail Volume: 22 Pages: 962-969
  • DOI: 10.1016/j.cardfail.2016.04.017
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of periodic leg movements during sleep in heart failure patients (2016)
  • Author(s): Yoshihisa A, Suzuki S, Kanno Y, Takiguchi M, Sato A, Miura S, Masuda A, Yokokawa T, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Abe S, Sato T, Oikawa M, Saitoh S, Takeishi Y.
  • Journal Title: International Journal of Cardiology Volume: 212 Pages: 11-13
  • DOI: 10.1016/j.ijcard.2016.03.007
  • Peer Reviewed
• [Journal Article] Prognostic Significance of Insomnia in Heart Failure (2016)
  • Author(s): Yuki Kanno, Akiomi Yoshihisa, Shunsuke Watanabe, Mai Takiguchi, Tetsuro Yokokawa, Akihiko Sato, Shunsuke Miura, Takeshi Shimizu, Yuichi Nakamura, Satoshi Abe, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Shu-ichi Saitoh, Yasuchika Takeishi
  • Journal Title: Circ J Volume: 80 Issue: 7 Pages: 1571-1577
  • DOI: 10.1253/circj.CJ-16-0205
  • NAID: 130005158908
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pulmonary arterial capacitance predicts cardiac events in pulmonary hypertension due to left heart disease. (2016)
  • Author(s): Koichi Sugimoto, Akiomi Yoshihisa, Kazuhiko Nakazato, Yuichiro Jin, Satoshi Suzuki, Tetsuro Yokokawa, Tomofumi Misaka, Takayoshi Yamaki, Hiroyuki Kunii, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi
  • Journal Title: PLOS ONE Volume: 11
  • DOI: 10.1371/journal.pone.0165603
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The CHA2DS2-VASc score as a predictor of high mortality in hospitalized heart failure patients (2016)
  • Author(s): Yoshihisa A, Watanabe S, Kanno Y, Takiguchi M, Sato A, Yokokawa T, Miura S, Shimizu T, Abe S, Sato T, Suzuki S, Oikawa M, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: ESC Heart Fail Volume: 3 Pages: 261-269
  • Peer Reviewed / Open Access
• [Presentation] Balloon pulmonary angioplasty improves electrocardiographic remodeling of the right ventricle in patients with chronic thromboembolic pulmonary hypertension. (2018)
  • Author(s): Yokokawa T, Sugimoto K, Nakazato K, Oikawa M, Kobayashi A, Yoshihisa A, Yamaki T, Kunii H, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] Change in left ventricular ejection fraction and its impact on prognosis in heart failure patients with mid-range ejection fraction. (2018)
  • Author(s): Kimishima Y, Yoshihisa A, Ichijo Y, Sato Y, Kiko T, Kanno Y, Takiguchi M, Yokokawa T, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] Characteristics and outcomes of recovered left ventricular ejection fraction in heart failure patients with reduced ejection fraction (2018)
  • Author(s): Kimishima Y, Yoshihisa A, Ichijo Y, Kiko T, Sato Y, Kanno Y, Takiguchi M, Yokokawa T, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Ishida T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] Characteristics and outcomes of worsening left ventricular ejection fraction in heart failure patients with preserved ejection fraction (2018)
  • Author(s): Oikawa M, Yoshihisa A, Ichijo Y, Kiko T, Kimishima Y, Sato Y, Kanno Y, Takiguchi M, Yokokawa T, Abe S, Misaka T, Sato T, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] Clinical significance of proteinuria and hematuria in chronic heart failure. (2018)
  • Author(s): Sato T, Yoshihisa A, Ishida T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] Impact of cardiac arrhythmias on the prognosis of heart failure patient (2018)
  • Author(s): Ando T, Yamada S, Yoshihisa A, Sato T, Kamioka M, Kaneshiro T, Oikawa M, Kobayashi A, Ishida T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] Impact of combined post capillary pulmonary hypertension based on upcoming diagnostic criteria on the prognosis of pulmonary hypertension due to left-sided heart disease (2018)
  • Author(s): Sugimoto K, Yoshihisa A, Yokokawa T, Misaka T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] Impact of diabetes mellitus on the prediction for pulmonary hypertension in the patients with chronic respiratory disease. (2018)
  • Author(s): Sugimoto K, Yoshihisa A, Takahashi T, Yokokawa T, Misaka T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] Low T3 syndrome is associated with high mortality and impaired exercise capacity in hospitalized patients with heart failure (2018)
  • Author(s): Sato Y, Yoshihisa A, Kimishima Y, Kiko T, Kanno Y, Yokokawa T, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] Plasma levels of melatonin in dilated and hypertrophic cardiomyopathies. (2018)
  • Author(s): Misaka T, Yoshihisa A, Ichijo Y, Kiko T, Kimishima Y, Sato Y, Kanno Y, Takiguchi M, Yokokawa T, Abe S, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] Prognostic impact of moderate mitral regurgitation on hospitalized heart failure patients with preserved ejection fraction -a report from the JASPER registry-. (2018)
  • Author(s): Oikawa M, Yoshihisa A, Sato Y, Nagai T, Yoshikawa T, Saito Y, Yamamoto K, Takeishi Y, Anzai T.
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] Prognostic impact of periodic leg movements during sleep on patients with heart failure. (2018)
  • Author(s): Kanno Y, Yoshihisa A, Ichijo Y, Kiko T, Kimishima Y, Sato Y, Takiguchi M, Yokokawa T, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] Prognostic impact of restless legs syndrome on hospitalized heart failure patients. (2018)
  • Author(s): Misaka T, Yoshihisa A, Ichijo Y, Kiko T, Kimishima Y, Sato Y, Kanno Y, Takiguchi M, Yokokawa T, Abe S, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] Relation of systolic blood pressure on the next day to post discharge mortality in hospitalized heart failure patients with preserved ejection fraction -a report from the JASPER registry-. (2018)
  • Author(s): Sato Y, Yoshihisa A, Oikawa M, Nagai T, Yoshikawa T, Saito Y, Yamamoto K, Takeishi Y, Anzai T.
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] Soluble neprilysin does not correlate with outcome in hypertrophic cardiomyopathy. (2018)
  • Author(s): Yokokawa T, Yoshihisa A, Ichijo Y, Kiko T, Kimishima Y, Sato Y, Takiguchi M, Abe S, Misaka T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] The fibrosis-4 index predicts the mortality of patients with pulmonary hypertension due to left sided-heart disease. (2018)
  • Author(s): Sugimoto K, Yoshihisa A, Goto T, Yokokawa T, Oikawa M, Kobayashi A, Nakazato K, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] Utility of B-type natriuretic peptide for detecting cardiac amyloidosis in AL amyloidosis. (2018)
  • Author(s): Kimishima Y, Yoshihisa A, Tatsumi M, Kiko T, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] Venous congestion is the important predictor of worsening renal function in compensated heart failure. (2018)
  • Author(s): Sato T, Yoshihisa A, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2018
  • Int'l Joint Research
• [Presentation] 心サルコイドーシスの診断と治療における最新の知見：サルコイドーシス患者におけるmultiple biomarker approachの有用性(シンポジウム） (2018)
  • Author(s): 義久精臣, 喜古崇豊, 菅野優紀, 巽真希子, 及川雅啓, 小林 淳, 竹石恭知
  • Organizer: 第66回 日本心臓病学会学術集会
• [Presentation] 睡眠呼吸障害に対する陽圧呼吸療法 ～Cardiovascular Outcome Studyを考察する～：心不全二次予防における陽圧呼吸療法のエビデンス（シンポジウム） (2018)
  • Author(s): 義久精臣, 新村裕子, 三阪智史, 竹石恭知
  • Organizer: 日本睡眠学会 第43回定期学術集会
• [Presentation] Onco-Cardiologyにおける心血管超音波検査の活用法：アントラサイクリン治療早期のトロポニンI上昇は潜在性左室機能障害と関連する（パネルディスカッション） (2018)
  • Author(s): .及川雅啓, 巽真希子, 小林 淳, 義久精臣, 中里和彦, 石田隆史, 竹石恭知
  • Organizer: 日本超音波医学会 第91回学術集会
• [Presentation] Chronotropic incompetence is not associated with prognosis in heart failure patients with preserved ejection fraction and atrial fibrillation (2017)
  • Author(s): Sato T, Yoshihisa A, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2017
• [Presentation] Association between anatomical situation surrounding the esophagus and the prevalence of transmural thermal injury after pulmonary vein isolation with cryoballoon ablation. (2017)
  • Author(s): Matsumoto Y, Kaneshiro T, Nodera M, Kamioka M, Suzuki H, Yoshihisa A, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2017
• [Presentation] Associations between plasma zinc and mortality in heart failure patients. (2017)
  • Author(s): Kanno Y, Yoshihisa A, Kiko T, Kimishima Y, Sato Y, Watanabe S, Tatsumi M, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Saitoh S, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2017
• [Presentation] Associations between testosterone levels and mortality in male patients with heart failure. (2017)
  • Author(s): Suzuki S, Yoshihisa A, Kiko T, Kimishima Y, Sato Y, Watanabe S, Kanno Y, Tatsumi M, Abe S, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Saitoh S, Ishida T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2017
• [Presentation] Clinical significance of get with the guidelines-heart failure risk score in heart failure patients after hospitalization. (2017)
  • Author(s): Suzuki S, Yoshihisa A, Sato Y, Kanno Y, Watanabe S, Abe S, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2017
• [Presentation] Association between sleep disordered breathing and arterial stiffness in heart failure patients with reduced or preserved ejection fraction (2016)
  • Author(s): Suzuki S, Yoshihisa A, Sato Y, Yokokawa T, Miura S, Sato T, Watanabe S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans, US
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Liver stiffness assessed by FIB4 index predicts mortality in heart failure patients (2016)
  • Author(s): Sato Y, Yoshihisa A, Watanabe S, Yokokawa T, Miura S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans, US
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Associations between proton pump inhibitors and low cardiac mortality in patients with heart failure (2016)
  • Author(s): Takiguchi M, Yoshihisa A, Sato Y, Watanabe S, Yokokawa T, Miura S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2016
  • Place of Presentation: New Orleans, US
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Environment and cardiovascular diseases: Effects of the Great East Japan Earthquake on cardiovascular events (2016)
  • Author(s): Yoshihisa A
  • Organizer: Congress of the European Society of Cardiology 2016
  • Place of Presentation: Rome, Italy
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Book] ⅩⅥ．非薬物療法 心不全における呼吸補助療法 (2019)
  • Author(s): 義久精臣, 三阪智史, 竹石恭知
  • Publisher: 日本臨牀
• [Book] 第2章 ER・急性期病棟におけるギモン：治療編 5.急性心不全の呼吸管理のコツを教えてください. 循環器内科診療のギモン、百戦錬磨のエキスパートが答えます！ (2018)
  • Author(s): 義久精臣, 竹石恭知
  • Publisher: レジデントノート
• [Book] 睡眠障害に併存する疾患 睡眠障害と心不全 (2018)
  • Author(s): 義久精臣, 竹石恭知
  • Publisher: CLINICIAN
• [Book] 循環器疾患診療50年を振り返って―心不全におけるわが国の歩み― (2018)
  • Author(s): 義久精臣, 竹石恭知
  • Publisher: 心臓
• [Book] 診断と治療のABC 119 睡眠時無呼吸症候群 心不全に合併する中枢性無呼吸の治療 (2017)
  • Author(s): 義久精臣, 横川哲朗, 鈴木聡, 竹石恭知
  • Publisher: 最新医学社
• [Book] The Liver in Systemic Diseases (2016)
  • Author(s): Yoshihisa A, Takeishi Y
  • Publisher: Springer Japan
• [Book] 心不全の臨床 心不全の主な合併症・併存症 睡眠呼吸障害と心不全 (2016)
  • Author(s): 義久精臣, 鈴木聡, 竹石恭知
  • Publisher: 日本臨床
• [Book] ICUとCCU 急性増悪期心不全における多臓器関連 心不全における心肺連関と慢性閉塞性肺疾患 (2016)
  • Author(s): 義久精臣, 鈴木聡, 小林 淳, 竹石恭知
  • Publisher: 医学図書出版
• [Book] Heart View HFpEFとHFrEFについて考える 治す HFpEF, HFrEFに対するASV治療の課題 (2016)
  • Author(s): 義久精臣, 鈴木聡, 竹石恭知
  • Publisher: メディカルビュー
• [Remarks] 福島県立医科大学 研究者詳細
  • URL: https://www.fmu.ac.jp/kenkyu/html/725_ja.html
• [Remarks] 福島県立医科大学 研究者詳細
  • URL: http://www.fmu.ac.jp/kenkyu/html/725_ja.html
• [Remarks] http://www.fmu.ac.jp/kenkyu/html/725_ja.html