The role of exosome on the acute coronary syndrome using by OCT and MRI

• Project/Area Number: 16K09450
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Osaka City University
• Principal Investigator: YOSHIYAMA MINORU 大阪市立大学, 大学院医学研究科, 教授 (30240956)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 急性冠症候群 / 心筋保護 / マイクロRNA / 循環器

Outline of Final Research Achievements

We examined the plaque rapture, erosion and calcified nodule in acute coronary syndrome patients using by the OCT. The calcified nodule is concerned to the one of the cause in acute coronary syndrome. Cardiac function, cardiac remodeling affected the prognosis after acute cardiac myocardial infarction. The salvage rate of myocardium was related to the prognosis after acute myocardial infarction. However, the salvage rate of myocardium, and the amount of the exsome were not related to the door to balloon time. Cardiac protection to the ischemic myocardium is very important to improve the prognosis. The door to balloon time is considered to be the key factor for improving the prognosis due to protect the ischemic myocardium. However, we could not show the relationship between the time and the cardiac protection. In this study, we also could not find out for the exsome to be a new factor to protect the ischemic myocardium. We have to have a further study about cardiac protection.

Academic Significance and Societal Importance of the Research Achievements

急性冠症候群に関しては早期に治療を始めることが重要であるが、時間以外において心筋障害を少なくする因子はあると思われる。特に都会以外では早期に再灌流療法ができない地区もある。この心筋保護因子をみつけることは、社会的には極めて意義があると思われる。細胞から分泌されるエクソソームがその因子になる可能性があると思われるので、ぜひこの研究を続けていくことは重要であると考えている。

Research Products

• [Journal Article] Greater Nocturnal Blood Pressure Is Associated With Natriuretic Peptide Level in Aortic Stenosis With Preserved Ejection Fraction (2019)
  • Author(s): Tamura S, Iwata S, Ito A, Ishikawa S, Mizutani K, Izumiya Y, Yamada T, Murakami T, Shibata T, Yoshiyama M.
  • Journal Title: Circulation Journal Volume: 83 Issue: 2 Pages: 447-451
  • DOI: 10.1253/circj.CJ-18-0818
  • NAID: 130007557001
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-01-25
  • Peer Reviewed
• [Journal Article] Association between debulking area of rotational atherectomy and platform revolution speed-Frequency domain optical coherence tomography analysis (2019)
  • Author(s): Mizutani K, Hara M, Nakao K, Yamaguchi T, Okai T, Nomoto Y, Kajio K, Kaneno Y, Yamazaki T, Ehara S, Kamimori K, Izumiya Y, Yoshiyama M.
  • Journal Title: Catheter Cardiovasc Interv. Volume: - Issue: 1
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• [Journal Article] Efficacy of the current of injury in envisaging the dislodgement of leads implanted in the right atrial septum or the right ventricular septum (2019)
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  • Journal Title: Pacing Clin Electrophysiol. Volume: - Issue: 6 Pages: 603-609
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• [Journal Article] Self-expandable transcatheter aortic valve replacement is associated with frequent periprocedural stroke detected by diffusion-weighted magnetic resonance imaging. (2019)
  • Author(s): Kajio K, Mizutani K, Hara M, Nakao M, Okai T, Ito A, Takahashi Y, Iwata S, Shimono T, Izumiya Y, Murakami T, Shibata T, Yoshiyama M.
  • Journal Title: J Cardiol. Volume: S0914-5087 Issue: 1 Pages: 30026-30027
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• [Journal Article] Clinical usefulness of dobutamine stress echocardiography for the assessment of double-chambered right ventricle. (2019)
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  • Journal Title: Eur Heart J Cardiovasc Imaging. Volume: 20 Issue: 1 Pages: 120-120
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• [Journal Article] Prognostic significance of renal dysfunction and its change pattern on outcomes in patients with acute coronary syndrome treated with emergent percutaneous coronary intervention. (2018)
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• [Journal Article] Multiple coronary artery spasms triggering life-threatening ventricular arrhythmia associated with the radiofrequency ablation of ganglionated plexuses of the left atrium. (2018)
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• [Journal Article] Is elevation of N-terminal pro-B-type natriuretic peptide at discharge associated with 2-year composite endpoint of all-cause mortality and heart failure hospitalisation after transcatheter aortic valve implantation? Insights from a multicentre prospective OCEAN-TAVI registry in Japan (2018)
  • Author(s): Mizutani K, Hara M, Nakao M, Okai T, Kajio K, Murakami T, Shibata T, Yoshiyama M, Naganuma T, Yamanaka F, Higashimori A, Tada N, Takagi K, Araki M, Ueno H, Tabata M, Shirai S, Watanabe Y, Yamamoto M, Hayashida K.
  • Journal Title: BMJ Open. Volume: 8 Issue: 8 Pages: e021468-e021468
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• [Journal Article] Greater nighttime blood pressure variability is associated with left atrial enlargement in atrial fibrillation patients with preserved ejection fraction. (2018)
  • Author(s): Norioka N, Iwata S, Ito A, Tamura S, Kawai Y, Nonin S, Ishikawa S, Doi A, Hanatani A, Yoshiyama M.
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• [Journal Article] Conversion of wide QRS tachycardia with a long RP interval in pre-excitation syndrome: What is the mechanism? (2018)
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• [Journal Article] Clinical significance of discrepant mid-wall late gadolinium enhancement in patients with nonischemic dilated cardiomyopathy. (2018)
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• [Journal Article] Associations of sensitive cardiac troponin-I with left ventricular morphology, function and prognosis in end-stage renal disease patients with preserved ejection fraction. (2018)
  • Author(s): Otsuka K, Nakanishi K, Shimada K, Nakamura H, Inanami H, Nishioka H, Fujimoto K, Kasayuki N, Yoshiyama M
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  • Peer Reviewed
• [Journal Article] Endoconduit for Transcatheter Aortic Valve Implantation (2018)
  • Author(s): Murakami T, Takahashi Y, Nishimura S, Iwata S, Yamada T, Yoshiyama M, Shibata T.
  • Journal Title: Annals of Thoracic and Cardiovascular Surgery Volume: 26 Issue: 6 Pages: 365-368
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  • NAID: 130007958411
  • ISSN: 1341-1098, 2186-1005
  • Peer Reviewed
• [Journal Article] Diagnostic value of electrocardiographic P-wave characteristics in atrial fibrillation recurrence and tachycardia-induced cardiomyopathy after catheter ablation. (2018)
  • Author(s): Doi A, Takagi M, Katayama H, Yoshiyama T, Hayashi Y, Tatsumi H, Yoshiyama M.
  • Journal Title: Heart Vessels. Volume: 33 Issue: 11 Pages: 1381-1389
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  • Peer Reviewed
• [Journal Article] Serum brain-derived neurotrophic factor level and exercise tolerance complement each other in predicting the prognosis of patients with heart failure. (2018)
  • Author(s): Shibata A, Hanatani A, Izumi Y, Kitada R, Iwata S, Yoshiyama M.
  • Journal Title: Heart Vessels. Volume: 33 Issue: 11 Pages: 1325-1333
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  • Peer Reviewed
• [Journal Article] Prevalence and Prognostic Significance of Functional Mitral and Tricuspid Regurgitation Despite Preserved Left Ventricular Ejection Fraction in Atrial Fibrillation Patients (2018)
  • Author(s): Abe Y, Akamatsu K, Ito K, Matsumura Y, Shimeno K, Naruko T, Takahashi Y, Shibata T, Yoshiyama M.
  • Journal Title: Circulation Journal Volume: 82 Issue: 5 Pages: 1451-1458
  • DOI: 10.1253/circj.CJ-17-1334
  • NAID: 130006725982
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome (2018)
  • Author(s): Sano Soichi、Oshima Kosei、Wang Ying、MacLauchlan Susan、Katanasaka Yasufumi、Sano Miho、Zuriaga Maria A.、Yoshiyama Minoru、Goukassian David、Cooper Matthew A.、Fuster Jose、Walsh Kenneth
  • Journal Title: Journal of the American College of Cardiology Volume: 71 Issue: 8 Pages: 875-886
  • DOI: 10.1016/j.jacc.2017.12.037
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impact of simple electrocardiographic markers as predictors for deterioration of left ventricular function in patients with frequent right ventricular apical pacing. (2018)
  • Author(s): Hayashi Y, Takagi M, Kakihara J, Sakamoto S, Tatsumi H, Doi A, Iwata S, Sugioka K, Yoshiyama M.
  • Journal Title: Heart Vessels. Volume: 33 Issue: 3 Pages: 299-308
  • DOI: 10.1007/s00380-017-1052-x
  • Peer Reviewed
• [Journal Article] The Use of Electronic Medical Record Data to Analyze the Association Between Atrial Fibrillation and Birth Month. (2017)
  • Author(s): Matsuda K, Park K, Tatsumi H, Kitada R, Yoshiyama M.
  • Journal Title: Online J Public Health Inform. Volume: 9 Issue: 3
  • DOI: 10.5210/ojphi.v9i3.7864
  • Peer Reviewed
• [Journal Article] Echocardiographic parameters predicting acute hemodynamically significant mitral regurgitation during transfemoral transcatheter aortic valve replacement (2017)
  • Author(s): Ito Asahiro、Iwata Shinichi、Mizutani Kazuki、Nonin Shinichi、Nishimura Shinsuke、Takahashi Yosuke、Yamada Tokuhiro、Murakami Takashi、Shibata Toshihiko、Yoshiyama Minoru
  • Journal Title: Echocardiography Volume: 35 Issue: 3 Pages: 353-360
  • DOI: 10.1111/echo.13792
  • Peer Reviewed
• [Journal Article] Patent foramen ovale and cryptogenic stroke. (2017)
  • Author(s): Nakanishi K, Yoshiyama M, Homma S.
  • Journal Title: Trends Cardiovasc Med. Volume: 27 Issue: 8 Pages: 575-581
  • DOI: 10.1016/j.tcm.2017.06.016
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• [Journal Article] The usefulness of right ventriculography to aid anchoring a pacing lead to the right ventricular septum. (2017)
  • Author(s): Shimeno K, Yoshiyama T, Abe Y, Akamatsu K, Kagawa S, Matsushita T, Matsuo M, Matsumura Y, Matsumoto R, Kamimori K, Naruko T, Doi A, Takagi M, Yoshiyama M.
  • Journal Title: Europace. Volume: - Issue: 7 Pages: 1154-1160
  • DOI: 10.1093/europace/eux165
  • Peer Reviewed
• [Journal Article] Incidence and predictors of silent cerebral thromboembolic lesions after catheter ablation for atrial fibrillation in patients treated with direct oral anticoagulants (2017)
  • Author(s): Doi Atsushi、Takagi Masahiko、Kakihara Jun、Hayashi Yusuke、Tatsumi Hiroaki、Fujimoto Kohei、Sugioka Kenichi、Yoshiyama Minoru
  • Journal Title: Heart Vessels Volume: 32 Issue: 10 Pages: 1227-1235
  • DOI: 10.1007/s00380-017-0985-4
  • Peer Reviewed
• [Journal Article] 19. Life-threatening pulmonary embolism associated with multiple venous aneurysms. (2017)
  • Author(s): Sakamoto S, Kataoka T, Okai T, Matsusaki N, Takagi M, Yoshiyama M.
  • Journal Title: J Vasc Surg Venous Lymphat Disord. Volume: 5 Issue: 3 Pages: 413-416
  • DOI: 10.1016/j.jvsv.2016.07.007
  • Peer Reviewed
• [Journal Article] Safety and Efficacy of Simultaneous Biplane Mode of 3-Dimensional Transesophageal Echocardiography-Guided Antegrade Multiple-Inflation Balloon Aortic Valvuloplasty in Patients With Severe Aortic Stenosis (2017)
  • Author(s): Mizutani, K
  • Journal Title: Circulation Journal Volume: 81 Issue: 5 Pages: 748-754
  • DOI: 10.1253/circj.CJ-16-0909
  • NAID: 130005612056
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Safety and efficacy of high-rate cutoff and long detection interval ICD programming in secondary prevention patients (2017)
  • Author(s): Hayashi, Y
  • Journal Title: Heart vessels Volume: 32 Issue: 2 Pages: 175-185
  • DOI: 10.1007/s00380-016-0850-x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The utility of T-wave alternans during the morning in the summer for the risk stratification of patients with Brugada syndrome. (2017)
  • Author(s): Sakamoto S, Takagi M, Kakihara J, Hayashi Y, Doi A, Sugioka K, Yoshiyama M.
  • Journal Title: Heart Vessels. Volume: 32 Issue: 3 Pages: 341-351
  • DOI: 10.1007/s00380-016-0882-2
  • Peer Reviewed
• [Journal Article] Administration of tolvaptan with reduction of loop diuretics ameliorates congestion with improving renal dysfunction in patients with congestive heart failure and renal dysfunction. (2017)
  • Author(s): Hanatani A, Shibata A, Kitada R, Iwata S, Matsumura Y, Doi A, Sugioka K, Takagi M, Yoshiyama M.
  • Journal Title: Heart Vessels. Volume: 32 Issue: 3 Pages: 287-294
  • DOI: 10.1007/s00380-016-0872-4
  • Peer Reviewed
• [Journal Article] Utility of 12-lead and signal-averaged Holter electrocardiograms after pilsicainide provocation for risk stratification in Brugada syndrome. (2017)
  • Author(s): Kakihara J, Takagi M, Hayashi Y, Tatsumi H, Doi A, Yoshiyama M.
  • Journal Title: Heart Vessels. Volume: ー Issue: 9 Pages: 1151-1159
  • DOI: 10.1007/s00380-017-0973-8
  • Peer Reviewed
• [Journal Article] Low-flow Mediated Constriction Incorporated Indices as Indicators of Cardiovascular Risk in Smokers Atherosclerosis (2016)
  • Author(s): Norioka, N
  • Journal Title: Atherosclerosis Volume: 251 Pages: 132-138
  • DOI: 10.1016/j.atherosclerosis.2016.06.022
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Four cases of investigational therapy with interleukin-11 against acute myocardial infarction. (2016)
  • Author(s): Nakagawa, M., Owada Y., Izumi, Y., Nonin, S., Sugioka, K., Nakatani, D., Iwata, S., Mizutani, K., Nishimura, S., It, A., Fujita, S., Daimon, T., Sawa, Y., Asakura, M., Maeda, M., Fujio, Y., Yoshiyama, M.
  • Journal Title: Heart and Vessels Volume: 31 Issue: 9 Pages: 1574-1578
  • DOI: 10.1007/s00380-015-0788-4
  • Peer Reviewed
• [Journal Article] Higher visit-to-visit intra-dialytic blood pressure is associated with the progression of aortic valve stenosis in chronic hemodialysis patients (2016)
  • Author(s): Norioka, N
  • Journal Title: Heart vessels Volume: 31 Issue: 9 Pages: 1491-1496
  • DOI: 10.1007/s00380-015-0756-z
  • Peer Reviewed
• [Journal Article] Long RP' Tachycardia With Unusual Entrainment Responses: What Is the Mechanism? (2016)
  • Author(s): Doi A, Takagi M, Fujimoto K, Kakihara J, Hayashi Y, Tatsumi H, Yoshiyama M.
  • Journal Title: J Cardiovasc Electrophysiol. Volume: 27 Issue: 10 Pages: 1242-1244
  • DOI: 10.1111/jce.12987
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• [Journal Article] Relationship between tissue Doppler measurements of left ventricular diastolic function and silent brain infarction in patients with non-valvular atrial fibrillation. (2016)
  • Author(s): Ishikawa S, Sugioka K, Sakamoto S, Fujita S, Ito A, Norioka N, Iwata S, Nakagawa M, Takagi M, Miki Y, Ueda M, Yoshiyama M.
  • Journal Title: Eur Heart J Cardiovasc Imaging. Volume: 印刷中 Issue: 11 Pages: 1245-1252
  • DOI: 10.1093/ehjci/jew220
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• [Journal Article] New insights into spotty calcification and plaque rupture in acute coronary syndrome: an optical coherence tomography study. (2016)
  • Author(s): Sakaguchi M, Hasegawa T, Ehara S, Matsumoto K, Mizutani K, Iguchi T, Ishii H, Nakagawa M, Shimada K, Yoshiyama M.
  • Journal Title: Heart Vessels. Volume: 31 Issue: 12 Pages: 1915-1922
  • DOI: 10.1007/s00380-016-0820-3
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• [Journal Article] Plaque surface irregularity and calcification length within carotid plaque predict secondary events in patients with coronary artery disease. (2016)
  • Author(s): Nonin S, Iwata S, Sugioka K, Fujita S, Norioka N, Ito A, Nakagawa M, Yoshiyama M.
  • Journal Title: Atherosclerosis. Volume: 256 Pages: 29-34
  • DOI: 10.1016/j.atherosclerosis.2016.11.008
  • Peer Reviewed
• [Presentation] 収縮不全を伴ったうっ血性心不全患者において経胸壁心エコー図検査で評価した右室拡大はトルバプタンの反応性を予測する (2018)
  • Author(s): 能仁信一、田村聡一郎、石川世良、伊藤朝広、岩田真一、葭山稔
  • Organizer: 日本心エコー図学会
• [Presentation] A case of successful revascularization for long RCA CTO lesion in ACS (2018)
  • Author(s): Tomohiro Yamaguchi, Kazuki Mizutani, Tsukasa Okai, Yota Nomoto, Keiko Kaｊio, Takanori Yamasaki,Kimio Kamimori, Shoichi Ehara、Minoru Yoshiyama.
  • Organizer: PCRパリ
  • Int'l Joint Research
• [Presentation] Relationship between Debulking Area of Rotational Atherectomy and Platform Revolution Speed Frequency Domain Optical Coherence Tomography Analysis (2018)
  • Author(s): Tomohiro Yamaguchi, Kazuki Mizutani, Tsukasa Okai, Yota Nomoto, Keiko Kaｊio, Takanori Yamasaki, Kimio Kamimori, Shoichi Ehara、Minoru Yoshiyama
  • Organizer: PCRパリ
  • Int'l Joint Research
• [Presentation] A case of successful rotational atherectomy for nodular calcification protruding inside stent - Insight from FD-OCT and IVUS findings (2018)
  • Author(s): Tsukasa Okai,Tomohiro Yamaguchi, Kazuki Mizutani,, Yota Nomoto, Keiko Kaｊio, Takanori Yamasaki, Kimio Kamimori, Shoichi Ehara、Minoru Yoshiyama
  • Organizer: PCRパリ
  • Int'l Joint Research
• [Presentation] A case of sufficient thrombus aspiration using Guidelinar and Filtrap (2018)
  • Author(s): Tomohiro Yamaguchi, Kazuki Mizutani, Tsukasa Okai, Yota Nomoto, Keiko Kaｊio, Takanori Yamasaki, Kimio Kamimori, Shoichi Ehara、Minoru Yoshiyama
  • Organizer: 豊橋ライブ
• [Presentation] 高度屈曲を伴った、高度石灰化病変のRCA CTOで、Reverse CARTが成立しなかった一例 (2018)
  • Author(s): 山口 智大、水谷 一輝、岡井 主、梶尾 啓子、野元 陽太、山崎 貴紀、江原 省一、紙森 公雄、葭山 稔
  • Organizer: TOPIC2018
• [Presentation] OTWバルーンを用いて石灰化病変内を穿通するBalloon Anchored Penetration(BAP)法について (2018)
  • Author(s): 山崎 貴紀、山口智大、岡井主、梶尾啓子、野元陽太、紙森公雄、江原省一、泉家康宏、葭山稔
  • Organizer: TOPIC2018
• [Presentation] The safety and efficacy of multiple inflation of cutting balloon after rotational atherectomy (2018)
  • Author(s): 山口 智大、水谷 一輝、岡井 主、梶尾 啓子、野元 陽太、山崎 貴紀、江原 省一、紙森 公雄、葭山 稔
  • Organizer: 日本心血管インターベンション治療学会
• [Presentation] 短期間でのcalcified noduleの急激な増悪により不安定狭心症を起こした一症例 (2018)
  • Author(s): 野元陽太、水谷一輝、山口智大、岡井主、梶尾啓子、山崎貴紀、紙森公雄、葭山稔
  • Organizer: 日本心血管インターベンション治療学会
• [Presentation] 「心房機能の運動耐容能に及ぼす影響：HFpEFとHFrEFでの違い」 (2018)
  • Author(s): 山口祐美、柴田 敦、花谷彰久、谷口耕大、清水将史、北田諒子、岩田真一、江原省一、葭山 稔
  • Organizer: 日本心臓リハビリテーション学会
• [Presentation] 運動による酸化ストレス増加は心不全患者の予後を規定する (2018)
  • Author(s): 柴田 敦、花谷彰久、山口祐美、清水将史、北田諒子、岩田真一、泉康雄、江原省一、葭山稔
  • Organizer: 日本心臓リハビリテーション学会
• [Presentation] Differences in Prevalence and Risk Factors ofSilent Brain Infarction between Patients with Paroxysmal and Persistentnonvalvular Atrial Fib-rillation (2018)
  • Author(s): 石川世良、岩田真一、伊藤朝広,田村聡一郎、河相優、吉山智貴、辰巳裕亮、土井淳史、泉家康宏、葭山稔
  • Organizer: 日本循環器学会学術集会
• [Presentation] Increase in EPA/AA Ratio Predicts Improvementin Endothelial Function in Purified Eicosapen-taenoic Acid-Treated Patients with No Coronary Artery Disease (2018)
  • Author(s): 竹本恭彦、則岡直樹、岩田真一、山口雄大、葭山稔
  • Organizer: 日本循環器学会学術集会
• [Presentation] 大腿四頭筋量と大腿四頭筋内脂肪の比較による非虚血性心不全患者の運動機能に及ぼす影響の検討 (2018)
  • Author(s): 清水将史、柴田敦、谷口耕大、池淵充彦、江原省一、葭山稔
  • Organizer: 日本循環器学会学術集会
• [Presentation] 心不全入院患者におけるうつ状態がADLの変化に与える影響 (2018)
  • Author(s): 中川夏輝、柴田敦、竹内美裕、請田敦子、栗波志帆、遠原晴美、南條幸美、葭山稔
  • Organizer: 日本循環器学会学術集会
• [Presentation] 傍His束entrainment pacingがfast-slow型房室結節リエントリー性頻拍の診断に有効であった 1例 (2018)
  • Author(s): 吉山 智貴、葭山 稔
  • Organizer: カテーテルアブレーション関連大会
• [Presentation] 心機能低下を伴う心房頻拍に対して左心耳と右室流出路からの通電が有効であった1例 (2018)
  • Author(s): 片山 恒、葭山 稔
  • Organizer: カテーテルアブレーション関連大会
• [Presentation] Double ventricular responseから誘発されたslow-fast型房室結節リエントリー性頻拍の1例 (2018)
  • Author(s): 松尾真典、土井淳史、田村尚大、片山恒、吉山智貴、辰巳裕亮、葭山稔
  • Organizer: カテーテルアブレーション関連大会
• [Presentation] CHA2DS2-VASc Score and Renal Impairment are Associated with Silent Brain Infarction in Patients with Severe Aortic Stenosis (2018)
  • Author(s): Yu Kawai 、Shinichi Iwata 、Asahiro Ito 、Soichiro Tamura 、Ryoko Kitada 、Shinichi Nonin 、Sera Ishikawa 、Atsushi Doi 、Akihisa Hanatani 、Minoru Yoshiyama
  • Organizer: 日本循環器学会学術集会
• [Presentation] Plasma Myeloperoxidase Levels are Inversely Correlated with Serum High-Density LipoproteinAssociated Paraoxonase-1 Levels in Patients with Aortic Valve Stenosis (2018)
  • Author(s): Tsukasa Matsushita 、Yoshiki Matsumura 、Nanaka Nomura 、Kenichi Nakatsuji 、Shunsuke Kagawa 、 Masanori Matsuo 、Masashi Nakagawa 、Kenji Shimeno 、Ryo Matsumoto 、Yukio Abe 、Kazuo Haze 、 Takahiko Naruko 、Minoru Yoshiyama 、Makiko Ueda
  • Organizer: 日本循環器学会学術集会
• [Presentation] Higher Central Pulse Pressure Variability is Associated with Aortic Valve Calcium Volume in Patients with Severe Aortic Stenosis (2018)
  • Author(s): Soichiro Tamura 、Shinichi Iwata 、Asahiro Ito 、Shinsuke Nishimura 、Kazuki Mizutani 、Yosuke Takahashi 、Tokuhiro Yamada 、Takashi Murakami 、 Toshihiko Shibata 、Minoru Yoshiyama
  • Organizer: 日本循環器学会学術集会
• [Presentation] Echocardiographic Parameters Predicting Acute Hemodynamically Significant Mitral Regurgitation during Transfemoral Transcatheter Aortic Valve Replacement (2018)
  • Author(s): Asahiro Ito 、Shinichi Iwata 、Kazuki Mizutani 、 Shinichi Nonin 、Shinsuke Nishimura 、Yosuke Takahashi 、Tokuhiro Yamada 、Takashi Murakami 、 Toshihiko Shibata 、Minoru Yoshiyama
  • Organizer: 日本循環器学会学術集会
• [Presentation] Right Ventricular Enlargement Predicts Responsiveness to Tolvaptan in Congestive Heart Failure Patients with Reduced Ejection Fraction (2018)
  • Author(s): Shinichi Nonin 、Shinichi Iwata 、Asahiro Ito 、 Soichiro Tamura 、Ryoko Kitada 、Yu Kawai 、Sera Ishikawa 、Atsushi Doi 、Akihisa Hanatani 、Minoru Yoshiyama
  • Organizer: 日本循環器学会学術集会
• [Presentation] The Impact of Mitral Stenosis with Annular Calcification for Worsening Heart Failure Just after Transcatheter Aortic Valve Replacement. (2018)
  • Author(s): Tsukasa Okai 、Kazuki Mizutani 、Mana Nakao 、 Keiko Kajio 、Shinsuke Nishimura 、Asahiro Ito 、 Shinichi Iwata 、Yosuke Takahashi 、Takashi Murakami 、Toshihiko Shibata 、Minoru Yoshiyama
  • Organizer: 日本循環器学会学術集会
• [Presentation] The Impact of Annulus Eccentricity and Oversizing Valve Deployment for Less Paravalvular Leakage after Transcatheter Aortic Valve Replacement (2018)
  • Author(s): Mana Nakao 、Kazuki Mizutani 、Tsukasa Okai 、 Keiko Yoshida 、Shinsuke Nishimura 、Asahiro Ito 、 Shinichi Iwata 、Yosuke Takahashi 、Takashi Murakami 、Toshihiko Shibata 、Minoru Yoshiyama
  • Organizer: 日本循環器学会学術集会
• [Presentation] Elevated Plasma Neopterin Levels in Patients with Takotsubo Cardiomyopathy (2018)
  • Author(s): Masashi Nakagawa 、Ryo Matsumoto 、Nanaka Nomura 、Kenichi Nakatsuji 、Shunsuke Kagawa 、 Tsukasa Matsushita 、Masanori Matsuo 、Kenji Shimeno 、Yoshiki Matsumura 、Yukio Abe 、Kazuo Haze 、Takahiko Naruko 、Minoru Yoshiyama 、 Makiko Ueda
  • Organizer: 日本循環器学会学術集会
• [Presentation] Enhanced Expression of Natriuretic Peptide Receptor-A and B in Neutrophils of Culprit Lesions in Patients with Acute Coronary Syndromes (2018)
  • Author(s): Masashi Nakagawa 、Ryo Matsumoto 、Nanaka Nomura 、Kenichi Nakatsuji 、Shunsuke Kagawa 、 Tsukasa Matsushita 、Masanori Matsuo 、Kenji Shimeno 、Yoshiki Matsumura 、Yukio Abe 、Kazuo Haze 、Takahiko Naruko 、Masahiko Ohsawa 、Minoru Yoshiyama 、Makiko Ueda
  • Organizer: 日本循環器学会学術集会
• [Presentation] Enhanced Expression of LOX-1 is Associated with Aortic Valve Stenosis in Patients with Bicuspid Aortic Valve (2018)
  • Author(s): Shunsuke Kagawa 、Yoshiki Matsumura 、Nanaka Nomura 、Kenichi Nakatsuji 、Tsukasa Matsushita 、 Masanori Matsuo 、Masashi Nakagawa 、Kenji Shimeno 、Ryo Matsumoto 、Yukio Abe 、Kazuo Haze 、 Takahiko Naruko 、Minoru Yoshiyama 、Makiko Ueda
  • Organizer: 日本循環器学会学術集会
• [Presentation] The Efficacy of Balloon Aortic Valvuloplasty before Non-cardiac Surgery ～Insight from Multicenter Registry～ (2018)
  • Author(s): Ayaka Ito 、Kazuki Mizutani 、Tsukasa Okai 、Keiko Yoshida 、Asahiro Ito 、Shinichi Iwata 、Minoru Yoshiyama 、Masamichi Iwasaki 、Kazato Ito 、Yoshihisa Shimada 、Toshiro Shinke
  • Organizer: 日本循環器学会学術集会
• [Presentation] Usefulness of Three Dimensional Transesophageal Echocardiography in Balloon Aortic Valvuloplasty for Patients with Aortic Stenosis (2018)
  • Author(s): 伊東 風童 、阿部 幸雄 、嶋田 芳久 、山中 祐輝 、 西浦 哲史 、矢野 健太郎 、外村 大輔 、喜納 直人 、 成子 隆彦 、福本 仁志 、葭山 稔
  • Organizer: 日本循環器学会学術集会
• [Presentation] Self-Expandable Valve Affects High Intensity Spots Detected by DW-MRI after Transcatheter Aortic Valve Replacement in Patients with Severe Aortic Stenosis (2018)
  • Author(s): 吉田 啓子 、水谷 一輝 、原 正彦 、中尾 真奈 、岡井 主 、 西村 慎亮 、伊藤 朝広 、岩田 真一 、高橋 洋介 、 村上 貴志 、柴田 利彦 、葭山 稔
  • Organizer: 日本循環器学会学術集会
• [Presentation] 重症大動脈弁狭窄症における血清パラオキソ ナーゼ-1 (PON-1) 値の意義 (2018)
  • Author(s): 松下 司 、野村 菜々香 、中逵 賢一 、加川 俊介 、 松尾 真典 、仲川 将志 、占野 賢司 、松本 亮 、 松村 嘉起 、阿部 幸雄 、土師 一夫 、成子 隆彦 、 葭山 稔 、上田 真喜子
  • Organizer: 日本心臓病学会学術集会
• [Presentation] HFrEF における足挙げ負荷心エコー図検査 (2018)
  • Author(s): 阿部 幸雄 、赤松 加奈子 、古川 敦子 、伊東 風童 、松村 嘉起 、土師 一夫 、成子 隆彦 、葭山 稔 、吉川 純一
  • Organizer: 日本心臓病学会学術集会
• [Presentation] 急性心筋梗塞に合併した心室重複破裂の術後に， 心室中隔穿孔の再発を認め致死的経過を辿った 一例 (2018)
  • Author(s): 藤澤 直輝 、山下 智子 、梶尾 剛 、戎野 和之 、 蒔田 直記 、竹下 宏明 、堂上 友紀 、南村 弘和 、 田口 晴之 、栁 志郎 、葭山 稔
  • Organizer: 日本心臓病学会学術集会
• [Presentation] 第二世代薬剤溶出性ステント留置後の新生内膜 厚と既存動脈硬化病変の性状との関係について: 光干渉断層撮影法での検討 (2018)
  • Author(s): 野元 陽太 、仲川 将志 、岡井 主 、梶尾 啓子 、 水谷 一輝 、山崎 貴紀 、白井 伸幸 、紙森 公雄 、 上田 真喜子 、葭山 稔
  • Organizer: 日本心臓病学会学術集会
• [Presentation] 心不全治療薬 (2018)
  • Author(s): 花谷 彰久 、柴田 敦 、岩田 真一 、葭山 稔
  • Organizer: 日本心臓病学会学術集会
• [Presentation] Echocardiographic parameters affecting hemodynamically significant acute mitral regurgitation during transfemoral transcatheter aortic valve replacement (2017)
  • Author(s): Asahiro Ito,Minoru Yoshiyama
  • Organizer: 日本循環器学会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2017-03-18
• [Presentation] メディカルスタッフに求めたい安全のための技量 (2017)
  • Author(s): 水谷一輝,Minoru Yoshiyama
  • Organizer: 日本循環器学会
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2017-03-18
• [Presentation] Impact of Left Ventricular Diastolic Function by Tissue Doppler Imaging on Silent Brain Infarction in Patients with Nonvalvular Atrial Fibrillation (2017)
  • Author(s): Sera Ishikawa,Minoru Yoshiyama
  • Organizer: 日本循環器学会
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2017-03-18
• [Presentation] Naoki Norioka,Minoru Yoshiyama (2017)
  • Author(s): Higher Central Pulse Pressure is Associated with Estimated-Glomerular Filtration Rate in Patients with Severe Aortic Stenosis and Preserved Ejection Fraction
  • Organizer: 日本循環器学会
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2017-03-18
• [Presentation] Right Ventricular Enlargement Predicts Responsiveness to Tolvaptan in Congestive Heart Failure Patients with Reduced Ejection Fraction (2017)
  • Author(s): Shinichi Nonin,Minoru Yoshiyama
  • Organizer: 日本循環器学会
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2017-03-18
• [Presentation] Utility of 12-Lead and Signal-averaged Holter Electrocardiogram after Pilsicainide Provocation for Risk Stratification in Brugada Syndrome. (2016)
  • Author(s): Jun Kakihara,Masahiko Takagi,Yusuke Hayashi,Hiroaki Tatsumi,Kohei Fujimoto, Atsushi Doi,Minoru Yoshiyama.
  • Organizer: Internationl Symposium on Progress in Clinical Pacing.
  • Place of Presentation: ローマ(イタリア)
  • Year and Date: 2016-11-28
  • Int'l Joint Research
• [Presentation] Elevated Left Ventricular Diastolic Filling Pressure by Tissue Doppler Imaging and Silent Brain Infarction in Patients With Nonvalvular Atrial Fibrillation. (2016)
  • Author(s): Sera Ishikawa. Kenichi Sugioka. Shinichi Iwata.; Naoki Norioka. Shinichi Nonin.Yu Kawai. Suwako Fujita. Asahiro Ito. Masahiko Takagi. Minoru Yoshiyama.
  • Organizer: American Heart Association’s.
  • Place of Presentation: ニューオーリンズ(アメリカ)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] 非弁膜症性心房細動における無症候性脳梗塞と左室充満圧(E/e')との関連 (2016)
  • Author(s): 石川 世良, 杉岡 憲一, 岩田 真一, 伊藤 朝広, 河相 優, 能仁 信一, 藤田 澄吾子, 則岡 直樹, 高木 雅彦, 葭山 稔
  • Organizer: 日本心臓病学会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 2016-09-23
• [Presentation] たこつぼ型心筋症における血漿中ミエロペルオキシダーゼ値の意義 (2016)
  • Author(s): 松下 司, 吉山 智貴, 赤松 加奈子, 加川 俊介, 松尾 真典, 占野 賢司, 松本 亮, 松村 嘉起, 阿部 幸雄, 紙森 公雄, 土師 一夫, 成子 隆彦, 杉岡 憲一, 仲川 将志, 葭山 稔, 上田 真喜子
  • Organizer: 日本心臓病学会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 2016-09-23
• [Presentation] 急性心筋梗塞に対するIL-11製剤オプレルベキンを用いた心筋保護治療 (2016)
  • Author(s): 野元 陽太, 仲川 将志, 泉 康雄, 能仁 信一, 阪本 勇也, 水谷 一輝, 白井 伸幸, 杉岡 憲一, 高木 雅彦, 小和田 康子, 前田 真貴子, 中谷 大作, 朝倉 正紀, 藤尾 慈, 葭山 稔
  • Organizer: 日本心臓病学会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 2016-09-23
• [Presentation] 冠動脈疾患患者において、頸動脈plaque surface irregularityは心血管二次イベントの予測因子である (2016)
  • Author(s): 能仁 信一, 岩田 真一, 杉岡 憲一, 河相 優, 藤田 澄吾子, 石川 世良, 則岡 直樹, 伊藤 朝広, 仲川 将志, 花谷 彰久, 高木 雅彦, 葭山 稔
  • Organizer: 日本心臓病学会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 2016-09-23
• [Presentation] うっ血性心不全患者における退院後早期の夜間肺うっ血と腎機能の関連性 (2016)
  • Author(s): 花谷 彰久, 北田 諒子, 岩田 真一, 土井 淳史, 杉岡 憲一, 高木 雅彦, 葭山 稔
  • Organizer: 日本心臓病学会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 2016-09-23
• [Presentation] 藤田 澄吾子, 杉岡 憲一, 岩田 真一, 河相 優, 能仁 信一, 石川 世良, 則岡 直樹, 伊藤 朝広, 仲川 将志, 上田 真喜子, 葭山 稔 (2016)
  • Author(s): 重症大動脈弁狭窄症における近位胸部大動脈の動脈硬化についての検討 三尖弁と二尖弁大動脈弁狭窄症の比較
  • Organizer: 日本心臓病学会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 2016-09-23
• [Presentation] 大動脈弁狭窄症における近位胸部大動脈の動脈硬化についての検討 (2016)
  • Author(s): 藤田 澄吾子, 杉岡 憲一, 岩田 真一, 河相 優, 能仁 信一, 石川 世良, 則岡 直樹, 伊藤 朝広, 仲川 将志, 上田 真喜子, 葭山 稔
  • Organizer: 日本動脈硬化学会
  • Place of Presentation: 京王プラザホテル(東京都新宿区)
  • Year and Date: 2016-07-14
• [Presentation] 経食道心エコー図ガイド下による順行性大動脈弁バルーン拡張術の有効性と安全性について (2016)
  • Author(s): 水谷 一輝, 松岡 雄治郎, 阪本 勇也, 伊藤 朝広, 岩田 真一, 仲川 将志, 白井 伸幸, 杉岡 憲一, 高木 雅彦, 葭山 稔
  • Organizer: 日本心血管インターベンション治療学会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 2016-07-07
• [Presentation] ACS予後改善のための対策 血栓吸引療法を施行したST上昇型心筋梗塞症例における赤色血栓の意義 心事故との関連 (2016)
  • Author(s): 成子 隆彦, 杉岡 憲一, 仲川 将司, 葭山 稔, 上田 真喜子
  • Organizer: 日本心血管インターベンション治療学会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 2016-07-07
• [Presentation] 低速ローターアブレーションによる石灰化部切削効果の検討 OFDI解析からの視点 (2016)
  • Author(s): 水谷 一輝, 寺下 和範, 阪本 勇也, 白井 伸幸, 仲川 将志, 高木 雅彦, 葭山 稔
  • Organizer: 日本心血管インターベンション治療学会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 2016-07-07
• [Presentation] 経食道心エコーガイド下で弁輪破裂を回避し得たantegrade BAVの一例 (2016)
  • Author(s): 松岡 雄治郎, 水谷 一輝, 伊藤 朝広, 岩田 真一, 仲川 将志, 杉岡 憲一, 村上 貴志, 細野 光治, 高木 雅彦, 柴田 利彦, 葭山 稔
  • Organizer: 日本心血管インターベンション治療学会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 2016-07-07
• [Book] 日本臨床 (2018)
  • Author(s): 泉家 康宏, 葭山 稔
  • Total Pages: 6
  • Publisher: 日本臨床社